Standout Papers
Citation Impact
Citing Papers
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
1997 Nature
The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain
1996
FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
2010 StandoutNobel
Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β
1997
A role for helix 3of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone
1998
Chromatin Remodeling and the Control of Gene Expression
1997
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
1997 Standout
Structure of the Histone Acetyltransferase Hat1
1998 StandoutNobel
The histone acetylase PCAF is a nuclear receptor coactivator
1998
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
1998
A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase
1998
A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans
1998
Estrogen Receptors: How Do They Signal and What Are Their Targets
2007 Standout
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo
1998
Function of Nuclear Co-repressor Protein on Thyroid Hormone Response Elements Is Regulated by the Receptor A/B Domain
1996
A TATA binding protein-associated factor functions as a coactivator for thyroid hormone receptors.
1996
Histone acetylation and transcriptional regulatory mechanisms
1998 Standout
Mechanisms That Mediate Negative Regulation of the Thyroid-stimulating Hormone α Gene by the Thyroid Hormone Receptor
1999
The rat TSHβ gene contains distinct response elements for regulation by retinoids and thyroid hormone
1997
High-Mobility Group (HMG) Protein HMG-1 and TATA-Binding Protein-Associated Factor TAFII30 Affect Estrogen Receptor-Mediated Transcriptional Activation
1997
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
5′-Flanking Sequences in Thyroid Hormone Response Element Half-sites Determine the Requirement of Retinoid X Receptor for Receptor-mediated Gene Expression
1997
Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
1999
Resistance to Thyroid Hormone Caused by Two Mutant Thyroid Hormone Receptors β, R243Q and R243W, with Marked Impairment of Function That Cannot Be Explained by Alteredin Vitro3,5,3′-Triiodothyroinine Binding Affinity1
1997
Tissue-specific Stabilization of the Thyroid Hormone β1 Nuclear Receptor by Phosphorylation
1997
Mice deficient in the steroid receptor co-activator 1(SRC-1) are resistant to thyroid hormone
1999
Hormone-Activated Phosphorylation of Human β 1 Thyroid Hormone Nuclear Receptor
1997
RSC, an Essential, Abundant Chromatin-Remodeling Complex
1996 StandoutNobel
Review: Chromatin Structural Features and Targets That Regulate Transcription
2000
The nuclear receptor ligand-binding domain: structure and function
1998
MICoA, a Novel Metastasis-associated Protein 1 (MTA1) Interacting Protein Coactivator, Regulates Estrogen Receptor-α Transactivation Functions
2003
Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein
2002
Multiple Mechanisms for Regulation of the Transcriptional Activity of Thyroid Hormone Receptors
2000
Regulation of Nuclear Receptor Transcriptional Activity by a Novel DEAD Box RNA Helicase (DP97)
2003
Nuclear receptor coactivators and corepressors.
1996
Sin3: a flexible regulator of global gene expression and genome stability
2004
What's Up and Down with Histone Deacetylation and Transcription?
1997
Nuclear-receptor interactions on DNA-response elements
2001
Transcriptional Anti-repression
1999
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα
2002 Nature
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
2017 Standout
Involvement of Thyroid Hormone and Its α Receptor in Avian Neurulation
1998
Thyroid Hormone Response Element Architecture Affects Corepressor Release from Thyroid Hormone Receptor Dimers
1998
Thyroid Hormone Response Elements Differentially Modulate the Interactions of Thyroid Hormone Receptors with Two Receptor Binding Domains in the Steroid Receptor Coactivator-1
1998
Vitamin D Receptors Repress Basal Transcription and Exert Dominant Negative Activity on Triiodothyronine-mediated Transcriptional Activity
1996
SAP30, a Component of the mSin3 Corepressor Complex Involved in N-CoR-Mediated Repression by Specific Transcription Factors
1998
NuRD and SIN3
2000
Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: Role in epithelial cancer cell invasion, proliferation and nuclear regulation
2003
The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT
1997
Nuclear receptor coactivators
1997
SAP30, a Novel Protein Conserved between Human and Yeast, Is a Component of a Histone Deacetylase Complex
1998
Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activation
1997
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Nuclear Cytoplasmic Shuttling by Thyroid Hormone Receptors
2001
Transcriptional Repression by RING Finger Protein TIF1 That Interacts with the KRAB Repressor Domain of KOX1
1996
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
1998 Standout
Modulation of estrogen receptor activity by selective coregulators
2003
Mechanism of corepressor binding and release from nuclear hormone receptors
1999
Thyroid Hormone-mediated Enhancement of Heterodimer Formation between Thyroid Hormone Receptor β and Retinoid X Receptor
1997
Thyrotropin Regulation by Thyroid Hormone in Thyroid Hormone Receptor β-Deficient Mice1
1997
p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption
1999
Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation
1999
Molecular determinants of nuclear receptor-corepressor interaction
1999
Defective Release of Corepressor by Hinge Mutants of the Thyroid Hormone Receptor Found in Patients with Resistance to Thyroid Hormone
1998
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Mechanism of the nuclear receptor molecular switch
2004
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
1998 Standout
The Differential Hormone-dependent Transcriptional Activation of Thyroid Hormone Receptor Isoforms Is Mediated by Interplay of Their Domains
1997
Rb Interacts with Histone Deacetylase to Repress Transcription
1998
Histone Octamer Transfer by a Chromatin-Remodeling Complex
1999 StandoutNobel
A structural role for hormone in the thyroid hormone receptor
1995 Nature
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
2005
A transcriptional co-repressor that interacts with nuclear hormone receptors
1995 StandoutNature
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
1998
Signal-specific co-activator domain requirements for Pit-1 activation
1998 Nature
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor
1998
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
1999 Nature
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
1998
Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo
1998
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities
2003
A Transcriptional Coactivator, Steroid Receptor Coactivator-3, Selectively Augments Steroid Receptor Transcriptional Activity
1998
Proteasomal regulation of nuclear receptor corepressor-mediated repression
1998
Transcriptional Regulatory Patterns of the Myelin Basic Protein and Malic Enzyme Genes by the Thyroid Hormone Receptors α1 and β1
1998
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Engineering polydactyl zinc-finger transcription factors
2002
Differential Recruitment of Coregulator Proteins Steroid Receptor Coactivator-1 and Silencing Mediator for Retinoid and Thyroid Receptors to the Estrogen Receptor-Estrogen Response Element by β-Estradiol and 4-Hydroxytamoxifen in Human Breast Cancer
2004
Transgenic Targeting of a Dominant Negative Corepressor to Liver Blocks Basal Repression by Thyroid Hormone Receptor and Increases Cell Proliferation
2001
Thyroid hormone receptor β is essential for development of auditory function
1996
Photoreceptor Cell Differentiation Requires Regulated Proteolysis of the Transcriptional Repressor Tramtrack
1997
Deletion of the Thyroid Hormone β1 Receptor Increases Basal and Triiodothyronine-Induced Growth Hormone Messenger Ribonucleic Acid in GH3Cells*
1997
Analysis of Estrogen Receptor Interaction with a Repressor of Estrogen Receptor Activity (REA) and the Regulation of Estrogen Receptor Transcriptional Activity by REA
2000
NURD, a Novel Complex with Both ATP-Dependent Chromatin-Remodeling and Histone Deacetylase Activities
1998
Retinoblastoma protein recruits histone deacetylase to repress transcription
1998 Nature
Histone acetylation in chromatin structure and transcription
1997 StandoutNature
Isolation and Characterization of PBP, a Protein That Interacts with Peroxisome Proliferator-activated Receptor
1997
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
2001 Standout
Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development
2000
Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression
1997
Retinoblastoma-binding Protein 2 (Rbp2) Potentiates Nuclear Hormone Receptor-mediated Transcription
2001
Controlling nuclear receptors: the circular logic of cofactor cycles
2005
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
1998 StandoutNature
Ligand-Dependent Nuclear Receptor Corepressor LCoR Functions by Histone Deacetylase-Dependent and -Independent Mechanisms
2003
A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
1996 Standout
A Novel TRβ Mutation (R383H) in Resistance to Thyroid Hormone Syndrome Predominantly Impairs Corepressor Release and Negative Transcriptional Regulation
1998
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
DNA helicases in inherited human disorders
1997
Competition between Thyroid Hormone Receptor-associated Protein (TRAP) 220 and Transcriptional Intermediary Factor (TIF) 2 for Binding to Nuclear Receptors
1999
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation
2001
The RXR heterodimers and orphan receptors
1995 Standout
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging
2004
The Dermatomyositis-Specific Autoantigen Mi2 Is a Component of a Complex Containing Histone Deacetylase and Nucleosome Remodeling Activities
1998
DNA methylation and chromatin modification
1999
Cancer-related inflammation
2008 StandoutNature
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300
1997
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
1997
A Unique Role of the β-2 Thyroid Hormone Receptor Isoform in Negative Regulation by Thyroid Hormone
1997
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
1997 Nature
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1
2003
Retinoblastoma protein represses transcription by recruiting a histone deacetylase
1998 Nature
A Nuclear Factor, ASC-2, as a Cancer-amplified Transcriptional Coactivator Essential for Ligand-dependent Transactivation by Nuclear Receptors in Vivo
1999
Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer
2005
Thyroid Hormone Activation of Transcription Is Potentiated by Activators of cAMP-dependent Protein Kinase
1996
Structural Insights into the Mode of Action of a Pure Antiestrogen
2001
Thyroid Hormone-independent Interaction between the Thyroid Hormone Receptor β2 Amino Terminus and Coactivators
2000
Cloning and Characterization of Human Prostate Coactivator ARA54, a Novel Protein That Associates with the Androgen Receptor
1999
Macrophage/Cancer Cell Interactions Mediate Hormone Resistance by a Nuclear Receptor Derepression Pathway
2006
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein
1999
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Structural organization of yeast and mammalian mediator complexes
2000 StandoutNobel
Tamoxifen-Bound Estrogen Receptor (ER) Strongly Interacts with the Nuclear Matrix Protein HET/SAF-B, a Novel Inhibitor of ER-Mediated Transactivation
2000
Gene Silencing by Chicken Ovalbumin Upstream Promoter-Transcription Factor I (COUP-TFI) Is Mediated by Transcriptional Corepressors, Nuclear Receptor-Corepressor (N-CoR) and Silencing Mediator for Retinoic Acid Receptor and Thyroid Hormone Receptor (SMRT)
1997
Transcriptional repression in development
1996
Myocyte-Specific Enhancer Factor 2 and Thyroid Hormone Receptor Associate and Synergistically Activate the α-Cardiac Myosin Heavy-Chain Gene
1997
Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice
2001 StandoutNobel
A Novel Natural Mutation in the Thyroid Hormone Receptor Defines a Dual Functional Domain That Exchanges Nuclear Receptor Corepressors and Coactivators
1998
Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT
1997
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
1998
Pbx-Hox Heterodimers Recruit Coactivator-Corepressor Complexes in an Isoform-Specific Manner
1999
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
Thyroid Hormone Resistance Syndrome Manifests as an Aberrant Interaction between Mutant T3 Receptors and Transcriptional Corepressors
1997
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen
1997
Biosynthesis of the Caenorhabditis elegans dauer pheromone
2009 StandoutNobel
Unique forms of human and mouse nuclear receptor corepressor SMRT
1999
Modulator Recognition Factor 1, an AT-Rich Interaction Domain Family Member, Is a Novel Corepressor for Estrogen Receptor α
2005
Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID
1999
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.
1996
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
The SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export
2000
Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors.
1996
The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT
1997
A Novel Role for Helix 12 of Retinoid X Receptor in Regulating Repression
1999
Transcriptional Silencing by Unliganded Thyroid Hormone Receptor β Requires a Soluble Corepressor That Interacts with the Ligand-Binding Domain of the Receptor
1996
Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO
1998
TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.
1996
DNA-independent and DNA-dependent Mechanisms Regulate the Differential Heterodimerization of the Isoforms of the Thyroid Hormone Receptor with Retinoid X Receptor
1996
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
Expression of multiple thyroid hormone receptor isoforms in rat femoral and vertebral bone and in bone marrow osteogenic cultures
1999
The coregulator exchange in transcriptional functions of nuclear receptors
2000 Standout
Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains
1998
SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor
1999
SIN3-Dependent Transcriptional Repression by Interaction with the Mad1 DNA-Binding Protein
1996
Metastasis-Associated Protein 1 Interacts with NRIF3, an Estrogen-Inducible Nuclear Receptor Coregulator
2004
HET/SAF-B overexpression causes growth arrest and multinuclearity and is associated with aneuploidy in human breast cancer.
2000
Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions
1998 Science
Generation and reproductive phenotypes of mice lacking estrogen receptor β
1998 StandoutNobel
Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
2000
Nuclear hormone receptors: ligand-activated regulators of transcription and diverse cell responses
1996
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
2009 StandoutNobel
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR.
1996
An unliganded thyroid hormone receptor causes severe neurological dysfunction
2001
Diversity and specialization of mammalian SWI/SNF complexes.
1996
Identification of a Negative Regulatory Surface within Estrogen Receptor α Provides Evidence in Support of a Role for Corepressors in Regulating Cellular Responses to Agonists and Antagonists
2002
Thyroid Hormone Resistance Syndrome Manifests as an Aberrant Interaction between Mutant T3 Receptors and Transcriptional Corepressors
1997
LIGAND CONTROL OF COREGULATOR RECRUITMENT TO NUCLEAR RECEPTORS
2004
Physiological and Molecular Basis of Thyroid Hormone Action
2001 Standout
CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.
1996
Cell Cycle Progression Stimulated by Tamoxifen-Bound Estrogen Receptor-α and Promoter-Specific Effects in Breast Cancer Cells Deficient in N-CoR and SMRT
2005
RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
1997
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
A Negative Coregulator for the Human ER
2002
Human nuclear receptor heterodimers: opportunities for detecting targets of transcriptional regulation using yeast.
1996
The Molecular Pharmacology of SERMs
1999
A Nuclear Hormone Receptor Corepressor Mediates Transcriptional Silencing by Receptors with Distinct Repression Domains
1996
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators
2004
Analysis of the Functional Role of Steroid Receptor Coactivator-1 in Ligand-Induced Transactivation by Thyroid Hormone Receptor
1997
High-Mobility Group (HMG) Protein HMG-1 and TATA-Binding Protein-Associated Factor TAFII30 Affect Estrogen Receptor-Mediated Transcriptional Activation
1997
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
2000
ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION
1998
Nuclear Receptor Coregulators: Cellular and Molecular Biology*
1999 Standout
GRIP1, a Transcriptional Coactivator for the AF-2 Transactivation Domain of Steroid, Thyroid, Retinoid, and Vitamin D Receptors
1997
Role of CBP/P300 in nuclear receptor signalling
1996 Nature
Translating the Histone Code
2001 StandoutScience
Two Separate NCoR (Nuclear Receptor Corepressor) Interaction Domains Mediate Corepressor Action on Thyroid Hormone Response Elements
1998
Expression of nuclear receptor interacting proteins TIF-1, SUG-1, receptor interacting protein 140, and corepressor SMRT in tamoxifen-resistant breast cancer.
1999
TRANSCRIPTION OF EUKARYOTIC PROTEIN-CODING GENES
2000
The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors
2000
The extreme C terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressor.
1996
Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
1996
The Nuclear Corepressors NCoR and SMRT Are Key Regulators of Both Ligand- and 8-Bromo-Cyclic AMP-Dependent Transcriptional Activity of the Human Progesterone Receptor
1998
Direct Interactions between Corepressors and Coactivators Permit the Integration of Nuclear Receptor-Mediated Repression and Activation
2002
Dominant inheritance of resistance to thyroid hormone not linked to defects in the thyroid hormone receptor alpha or beta genes may be due to a defective cofactor.
1996
Histone acetyltransferases regulate HIV-1 enhancer activity in vitro
1997
Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.
1996
Isozyme specificity in the conversion of hepoxilin A3 (HxA3) into a glutathionyl hepoxilin (HxA3-C) by the Yb2 subunit of rat liver glutathione S-transferase.
1990 StandoutNobel
Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ
1996 Science
Large-scale analysis of the human and mouse transcriptomes
2002 StandoutNobel
PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator
2005 StandoutScienceNobel
Lack of Coactivator Interaction Can Be a Mechanism for Dominant Negative Activity by Mutant Thyroid Hormone Receptors**This work was supported by the March of Dimes Foundation.
1998
Allosteric Effects of Pit-1 DNA Sites on Long-Term Repression in Cell Type Specification
2000 Science
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation
2012 StandoutNobel
Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene
1999
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1
1998
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.
1996
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3
1996
Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia
1998 Nature
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.
1998 Standout
The High Mobility Group Protein 1 Enhances Binding of the Estrogen Receptor DNA Binding Domain to the Estrogen Response Element
1998
Nuclear Receptor Corepressors Activate Rather than Suppress Basal Transcription of Genes That Are Negatively Regulated by Thyroid Hormone
1997
Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex
1997
daf-12encodes a nuclear receptor that regulates the dauer diapause and developmental age inC. elegans
2000
Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors.
1996
Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT
1997
Association of the Mediator complex with enhancers of active genes
2003 StandoutNobel
In Vivo Genomic Footprinting of Thyroid Hormone-Responsive Genes in Pituitary Tumor Cell Lines
1996
Nuclear Corepressors Enhance the Dominant Negative Activity of Mutant Receptors That Cause Resistance to Thyroid Hormone*
1998
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
1998
Works of Mats Söderström being referenced
Polarity-specific activities of retinoic acid receptors determined by a co-repressor
1995 Nature
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression
1997 Nature
Differential Effects of Nuclear Receptor Corepressor (N-CoR) Expression Levels on Retinoic Acid Receptor-Mediated Repression Support the Existence of Dynamically Regulated Corepressor Complexes
1997
The nuclear receptor corepressor (N-CoR) modulates basal and activated transcription of genes controlled by retinoic acid
2003
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
1995 StandoutNature
Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARα Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia
1998
Peroxisome Proliferator-Activated Receptors and Retinoic Acid Receptors Differentially Control the Interactions of Retinoid X Receptor Heterodimers with Ligands, Coactivators, and Corepressors
1997
Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases
1988
Differential Effects of Nuclear Receptor Corepressor (N-CoR) Expression Levels on Retinoic Acid Receptor-Mediated Repression Support the Existence of Dynamically Regulated Corepressor Complexes
1997