Standout Papers

Pembrolizumab As Second-Line Therapy in Patients With Advanced ... 2015 2026 2018 2022 1.2k
  1. Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial (2019)
    Richard S. Finn, Baek‐Yeol Ryoo et al. Journal of Clinical Oncology
  2. Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study (2015)
    Joong‐Won Park, Minshan Chen et al. Liver International
  3. Phase Ib Study of Lenvatinib Plus Pembrolizumab in Patients With Unresectable Hepatocellular Carcinoma (2020)
    Richard S. Finn, Masafumi Ikeda et al. Journal of Clinical Oncology
  4. Updated efficacy and safety data from IMbrave150: Atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma (2021)
    Ann‐Lii Cheng, Shukui Qin et al. Journal of Hepatology
  5. Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial (2015)
    Jordi Bruix, Tadatoshi Takayama et al. The Lancet Oncology
  6. Management of Hepatocellular Carcinoma in Japan: Consensus-Based Clinical Practice Guidelines Proposed by the Japan Society of Hepatology (JSH) 2010 Updated Version (2011)
    Masatoshi Kudo, Namiki Izumi et al. Digestive Diseases
  7. Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial (2015)
    Andrew X. Zhu, Joon Oh Park et al. The Lancet Oncology
  8. Sunitinib Versus Sorafenib in Advanced Hepatocellular Cancer: Results of a Randomized Phase III Trial (2013)
    Ann‐Lii Cheng, Yoon‐Koo Kang et al. Journal of Clinical Oncology
  9. Prognostic staging system for hepatocellular carcinoma (CLIP score): its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score) (2003)
    Masatoshi Kudo, Hobyung Chung et al. Journal of Gastroenterology
  10. CheckMate 459: A randomized, multi-center phase III study of nivolumab (NIVO) vs sorafenib (SOR) as first-line (1L) treatment in patients (pts) with advanced hepatocellular carcinoma (aHCC) (2019)
    Thomas Yau, Richard S. Finn et al. Annals of Oncology
  11. Linifanib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma: Results of a Randomized Phase III Trial (2014)
    Călin Cainap, Shukui Qin et al. Journal of Clinical Oncology
  12. JSH Consensus-Based Clinical Practice Guidelines for the Management of Hepatocellular Carcinoma: 2014 Update by the Liver Cancer Study Group of Japan (2014)
    Masatoshi Kudo, Osamu Matsui et al. Liver Cancer
  13. Effect of Everolimus on Survival in Advanced Hepatocellular Carcinoma After Failure of Sorafenib (2014)
    Andrew X. Zhu, Masatoshi Kudo et al. JAMA
  14. Biology and significance of alpha‐fetoprotein in hepatocellular carcinoma (2019)
    Peter R. Galle, Friedrich Foerster et al. Liver International
  15. Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma (2020)
    Ann‐Lii Cheng, Chiun Hsu et al. Journal of Hepatology
  16. Liver Ultrasound Elastography: An Update to the World Federation for Ultrasound in Medicine and Biology Guidelines and Recommendations (2018)
    Giovanna Ferraioli, Vincent Wai‐Sun Wong et al. Ultrasound in Medicine & Biology
  17. Development of pre and post-operative models to predict early recurrence of hepatocellular carcinoma after surgical resection (2018)
    Anthony W.H. Chan, Jian‐Hong Zhong et al. Journal of Hepatology
  18. Survival benefit of liver resection for hepatocellular carcinoma associated with portal vein invasion (2016)
    Takashi Kokudo, Kiyoshi Hasegawa et al. Journal of Hepatology
  19. The role of hepatic resection in the treatment of hepatocellular cancer (2015)
    Sasan Roayaie, Ghalib Jibara et al. Hepatology
  20. Phase 3 randomized, open-label, multicenter study of tremelimumab (T) and durvalumab (D) as first-line therapy in patients (pts) with unresectable hepatocellular carcinoma (uHCC): HIMALAYA. (2022)
    Ghassan K. Abou‐Alfa, Stephen L. Chan et al. Journal of Clinical Oncology
  21. Trial Design and Endpoints in Hepatocellular Carcinoma: AASLD Consensus Conference (2020)
    Josep M. Llovet, Augusto Villanueva et al. Hepatology
  22. IMbrave150: Updated overall survival (OS) data from a global, randomized, open-label phase III study of atezolizumab (atezo) + bevacizumab (bev) versus sorafenib (sor) in patients (pts) with unresectable hepatocellular carcinoma (HCC). (2021)
    Richard S. Finn, Shukui Qin et al. Journal of Clinical Oncology
  23. LBA34 Primary results from the phase III LEAP-002 study: Lenvatinib plus pembrolizumab versus lenvatinib as first-line (1L) therapy for advanced hepatocellular carcinoma (aHCC) (2022)
    Masatoshi Kudo, Philippe Merle et al. Annals of Oncology
  24. CheckMate 040 cohort 5: A phase I/II study of nivolumab in patients with advanced hepatocellular carcinoma and Child-Pugh B cirrhosis (2021)
    Masatoshi Kudo, Ana Matilla et al. Journal of Hepatology
  25. Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma (2024)
    Josep M. Llovet, Roser Pinyol et al. Nature Reviews Clinical Oncology
  26. Tislelizumab vs Sorafenib as First-Line Treatment for Unresectable Hepatocellular Carcinoma (2023)
    Shukui Qin, Masatoshi Kudo et al. JAMA Oncology
  27. EMERALD-1: A phase 3, randomized, placebo-controlled study of transarterial chemoembolization combined with durvalumab with or without bevacizumab in participants with unresectable hepatocellular carcinoma eligible for embolization. (2024)
    Riccardo Lencioni, Masatoshi Kudo et al. Journal of Clinical Oncology
  28. Breakthroughs in Hepatocellular Carcinoma Therapies (2023)
    Amit G. Singal, Masatoshi Kudo et al. Clinical Gastroenterology and Hepatology
  29. Nivolumab (NIVO) plus ipilimumab (IPI) vs lenvatinib (LEN) or sorafenib (SOR) as first-line treatment for unresectable hepatocellular carcinoma (uHCC): First results from CheckMate 9DW. (2024)
    Peter R. Galle, Thomas Decaens et al. Journal of Clinical Oncology

Immediate Impact

3 by Nobel laureates 3 from Science/Nature 59 standout
Sub-graph 1 of 18

Citing Papers

The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial
2025 Standout
Changing etiology and epidemiology of hepatocellular carcinoma: Asia and worldwide
2024 Standout

Works of Masatoshi Kudo being referenced

Nivolumab (NIVO) plus ipilimumab (IPI) vs lenvatinib (LEN) or sorafenib (SOR) as first-line treatment for unresectable hepatocellular carcinoma (uHCC): First results from CheckMate 9DW.
2024 Standout
Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study
2015 Standout
and 2 more

Author Peers

Author Last Decade Papers Cites
Masatoshi Kudo 30070 17249 12714 1.4k 47.1k
Peter R. Galle 18671 15648 13107 1.2k 53.9k
Masao Omata 19210 17387 8803 1.0k 49.9k
Kazuaki Chayama 14718 15457 7216 1.4k 44.3k
Andrew X. Zhu 16657 8134 12437 415 33.7k
Vincenzo Mazzaferro 24135 14779 7444 357 36.6k
Masatoshi Makuuchi 27673 13001 11537 776 47.1k
Jordi Bruix 54115 32607 11084 372 72.1k
Gregory J. Gores 18678 19761 13911 583 61.8k
Peter Schirmacher 10370 8936 11352 673 35.7k
Irene Oi‐Lin Ng 18202 10146 10970 620 46.6k

All Works

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2026