Citation Impact
Citing Papers
Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
2011
On the mechanism of sensing unfolded protein in the endoplasmic reticulum
2005
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
2006
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
Oral diseases: a global public health challenge
2019 Standout
Endoplasmic reticulum stress responses
2007
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
2011 Standout
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Myeloid-derived suppressor cells coming of age
2018 Standout
Abiotic Stress Signaling and Responses in Plants
2016 Standout
Recent Advances in the Discovery and Development of Flavonoids and their Analogues as Antitumor and Anti-HIV Agents
1998
Inflammation and metabolic disorders
2006 StandoutNature
Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β
2012
Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA
2009
Messenger RNA targeting to endoplasmic reticulum stress signalling sites
2008 Nature
Autophagy and the Integrated Stress Response
2010 Standout
A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response
2017
Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway
2009
Hallmarks of aging: An expanding universe
2023 Standout
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
2012 Standout
Evolution of Inflammation in Nonalcoholic Fatty Liver Disease: The Multiple Parallel Hits Hypothesis
2010 Standout
Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat
2011 StandoutNobel
Modulating stress responses by the UPRosome: A matter of life and death
2011
Activation of the Unfolded Protein Response by Lipid Bilayer Stress
2017
Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms
2010
Endoplasmic reticulum stress: cell life and death decisions
2005 Standout
Anticancer activities of histone deacetylase inhibitors
2006 Standout
Nonmuscle Myosin IIB Links Cytoskeleton to IRE1α Signaling during ER Stress
2012
The endoplasmic reticulum stress response in immunity and autoimmunity
2008
Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells
2010
Structure-antioxidant activity relationships of flavonoids and phenolic acids
1996 Standout
Carcinogenicity, mutagenicity and cancer preventing activities of flavonoids: A structure-system-activity relationship (SSAR) analysis
1994
One step at a time: endoplasmic reticulum-associated degradation
2008
The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum
2019
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Flavonoids: a review of probable mechanisms of action and potential applications
2001 Standout
ALG-2 Attenuates COPII Budding In Vitro and Stabilizes the Sec23/Sec31A Complex
2013 StandoutNobel
Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management
2015 Standout
ER chaperone functions during normal and stress conditions
2004
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Dynamics and functions of lipid droplets
2018 Standout
Effects of flavonoids on immune and inflammatory cell functions
1992
Guidelines for the diagnosis and therapy of adult myelodysplastic syndromes
2003
Polyphenols: food sources and bioavailability
2004 Standout
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
2011 Standout
BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response
2010
Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators
2006
Dental caries
2007 Standout
The unfolded protein response signals through high-order assembly of Ire1
2008 Nature
Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway
2014
The structure of the PERK kinase domain suggests the mechanism for its activation
2011
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
2011 Standout
COPII and the regulation of protein sorting in mammals
2011 StandoutNobel
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
2019
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
2003 StandoutNature
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
2009
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Endoplasmic Reticulum Stress Signaling in Disease
2006
RETINOID THERAPY OF CHILDHOOD CANCER
2001
Divergent Effects of PERK and IRE1 Signaling on Cell Viability
2009
Immunogenic cell death and DAMPs in cancer therapy
2012 Standout
Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
2007 Standout
Amyotrophic Lateral Sclerosis Pathogenesis: A Journey Through the Secretory Pathway
2010
How Transmembrane Proteins Sense Endoplasmic Reticulum Stress
2007
The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control
2006
The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
2018
Coping with Protein Quality Control Failure
2017
In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress
2018
Autonomous translational pausing is required for XBP1u mRNA recruitment to the ER via the SRP pathway
2016
Intracellular Signaling by the Unfolded Protein Response
2006
The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer
2017
A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
2004
Diet and Dental Caries
2015
The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
2011
Dietary effects on dental diseases
2001
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
BiP Availability Distinguishes States of Homeostasis and Stress in the Endoplasmic Reticulum of Living Cells
2010
Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress
2018
Global disease burden of conditions requiring emergency surgery
2013
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
2011
Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response
2011 Science
Structural and mutational analysis of the ribosome-arresting human XBP1u
2019
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
2009 Standout
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
2010
Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase
2011
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Inflammatory Bowel Disease
2010 Standout
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Quantitative microscopy reveals dynamics and fate of clustered IRE1α
2019
Role of Streptococcus mutans in human dental decay
1986 Standout
Pathophysiology of Sleep Apnea
2010 Standout
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
2000 Standout
Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling
2015
F-actin and a Type-II Myosin Are Required for Efficient Clustering of the ER Stress Sensor Ire1
2013
Sugar and Dental Caries: A Review of Human Studies
1982 Science
2013
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance
2015
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
2011
Stable Binding of ATF6 to BiP in the Endoplasmic Reticulum Stress Response
2005
Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1
2007
Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins
2009
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Managing the protein folding demands in the endoplasmic reticulum of plants
2016
The ER function BiP is a master regulator of ER function.
2004
Works of Masato Takeuchi being referenced
Genetic Evidence for a Role of BiP/Kar2 That Regulates Ire1 in Response to Accumulation of Unfolded Proteins
2003
On the epidemiological principles in dental caries attack.
1962
Epidemiological study on dental caries in Japanese children, before, duration and after World War II
1961
Epidemiological study on relation between dental caries incidence and sugar consumption.
1960
Intussusception among Japanese children: an epidemiologic study using an administrative database
2012
Diacylglycerol kinase δ1 transiently translocates to the plasma membrane in response to high glucose
2012
Saccharomyces cerevisiae Rot1p Is an ER-Localized Membrane Protein That May Function with BiP/Kar2p in Protein Folding
2006
Inhibitory effects of flavonol glycosides on 12-O-Tetradecanoylphorbol-13-acetate-induced tumor promotion.
1990
Good prognosis of patients with acute promyelocytic leukemia who achieved second complete remission (CR) with a new retinoid, Am80, after relapse from CR induced by all-trans-retinoic acid.
2000
Low-dose melphalan for treatment of high-risk myelodysplastic syndromes.
1996
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins
2007
An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1
2005