Citation Impact
Citing Papers
A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules
2003 StandoutScience
Lipid Rafts As a Membrane-Organizing Principle
2009 StandoutScience
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae
2000 StandoutScience
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
Capturing Chromosome Conformation
2002 StandoutScience
NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways
2004
Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin
2003
The DNA-damage response in human biology and disease
2009 StandoutNature
Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease
2005
Therapeutic strategies for Alzheimer's disease
2002
Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor
2004
Diverse and dynamic functions of the Sir silencing complex
1999
A Mec1- and PP4-Dependent Checkpoint Couples Centromere Pairing to Meiotic Recombination
2010
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
DAF-9, a cytochrome P450 regulatingC. eleganslarval development and adult longevity
2002
UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites
2008 Nature
Combinatorial Marking of Cells and Organelles with Reconstituted Fluorescent Proteins
2004 StandoutNobel
Wnt Signals and Frizzled Activity Orient Anterior-Posterior Axon Outgrowth in C. elegans
2006
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
2013 StandoutNobel
Why do worms need cholesterol?
2003
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
2003 Nature
Chromosome pairing via multiple interstitial interactions before and during meiosis in yeast
1994
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
2003 StandoutNature
TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity
2006 Nature
Pre-meiotic S phase is linked to reductional chromosome segregation and recombination
2001 StandoutNatureNobel
A Central Role for Cohesins in Sister Chromatid Cohesion, Formation of Axial Elements, and Recombination during Yeast Meiosis
1999
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction
1994
Human NPC1L1 and NPC1 can functionally substitute for the ncr genes to promote reproductive development in C. elegans
2007
Identification of genes expressed in C. elegans touch receptor neurons
2002 StandoutNatureNobel
C. elegans dauer formation and the molecular basis of plasticity
2008
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
2002
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites
2009 StandoutNobel
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
1997 Nature
Drosophila NPC1b Promotes an Early Step in Sterol Absorption from the Midgut Epithelium
2007
Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes
2000
A Global Profile of Germline Gene Expression in C. elegans
2000
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch
2002
Meiotic chromosomes: it takes two to tango
1997
γ-Secretase Complex Assembly within the Early Secretory Pathway
2005
Taking dendritic cells into medicine
2007 StandoutNatureNobel
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
2003 StandoutNature
The Single-End Invasion
2001
C. elegans Slit Acts in Midline, Dorsal-Ventral, and Anterior-Posterior Guidance via the SAX-3/Robo Receptor
2001
Hormonal Control of C. elegans Dauer Formation and Life Span by a Rieske-like Oxygenase
2006
PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1
2003
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Dauer
2007
Insights into social insects from the genome of the honeybee Apis mellifera
2006 StandoutNature
Meiotic recombination in Caenorhabditis elegans
2007
Global analysis of protein localization in budding yeast
2003 StandoutNature
Familial Alzheimer's Disease Presenilin 1 Mutations Cause Alterations in the Conformation of Presenilin and Interactions with Amyloid Precursor Protein
2005
Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1
2004
Regulation of chromatin structure by site-specific histone H3 methyltransferases
2000 StandoutNature
Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination
1998 StandoutNatureNobel
Localization of presenilin–nicastrin complexes and γ‐secretase activity to the trans‐Golgi network
2003
A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex
2004
γ-Secretase Activity Is Associated with a Conformational Change of Nicastrin
2003
Cohesin Rec8 is required for reductional chromosome segregation at meiosis
1999 StandoutNatureNobel
The role of the DNA double-strand break response network in meiosis
2004
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging
2004
Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model
2004
Evidence That Assembly of an Active γ-Secretase Complex Occurs in the Early Compartments of the Secretory Pathway
2004
Intracellular amyloid-β in Alzheimer's disease
2007 Standout
Somatic pairing of homologs in budding yeast: existence and modulation
1999
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
2005
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
2000 StandoutNature
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin
2002
DAF‐12‐dependent rescue of dauer formation in Caenorhabditis elegans by (25S)‐cholestenoic acid
2006
Pch2 Links Chromatin Silencing to Meiotic Checkpoint Control
1999
Meiotic nuclear reorganization: switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe
1997
The role of presenilin cofactors in the γ-secretase complex
2003 Nature
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling inC. elegans
2003
Meiotic Chromosomes: Integrating Structure and Function
1999
The initial substrate-binding site of γ-secretase is located on presenilin near the active site
2005
γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
2003
Intramembrane proteolysis by presenilin and presenilin-like proteases
2003
New Directions in Neuronal Migration
2002 Science
Crossing Over During Caenorhabditis elegans Meiosis Requires a Conserved MutS-Based Pathway That Is Partially Dispensable in Budding Yeast
1999
Hormonal signals produced by DAF-9/cytochrome P450 regulateC. elegansdauer diapause in response to environmental cues
2004
Axonal Ephrin-As and Odorant Receptors
2003 StandoutNobel
Meiotic Telomere Protein Ndj1p Is Required for Meiosis-Specific Telomere Distribution, Bouquet Formation and Efficient Homologue Pairing
2000
Biosynthesis of the Caenorhabditis elegans dauer pheromone
2009 StandoutNobel
CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production
2005
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
2003
In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand
2003
Mutations of a Drosophila NPC1 Gene Confer Sterol and Ecdysone Metabolic Defects
2005
A Microsatellite-Based Linkage Map of the Honeybee, Apis mellifera L.
2004
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
2002 StandoutNobel
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
2000
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
2009 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.
1994
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Genes Regulating Touch Cell Development in Caenorhabditis elegans
2001 StandoutNobel
Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved
2007
Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development inCaenorhabditis elegans
2008 StandoutNobel
MLT-10 Defines a Family of DUF644 and Proline-rich Repeat Proteins Involved in the Molting Cycle ofCaenorhabditis elegans
2010 StandoutNobel
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.
1995
THE LEPTOTENE-ZYGOTENE TRANSITION OF MEIOSIS
1998
Meiosis: how could it work?
1996
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans
2015 StandoutNobel
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Cancer Genome Landscapes
2013 StandoutScience
Translating the Histone Code
2001 StandoutScience
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Dynamics of chromosome organization and pairing during meiotic prophase in fission yeast.
1994
Genetic Control of Recombination Partner Preference in Yeast Meiosis: Isolation and Characterization of Mutants Elevated for Meiotic Unequal Sister-Chromatid Recombination
1999
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Biogenesis of γ-secretase early in the secretory pathway
2007 StandoutNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
Multiple levels of regulation specify the polarity of an asymmetric cell division in C. elegans
2000
Tam1, a telomere-associated meiotic protein, functions in chromosome synapsis and crossover interference.
1997
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis
2005
High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling
2011 Science
Identification of fission yeast nuclear markers using random polypeptide fusions with green fluorescent protein
1996 StandoutNobel
Works of Mary Sym being referenced
Crossover interference is abolished in the absence of a synaptonemal complex protein
1994
aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation
2002
MIG-13 Positions Migrating Cells along the Anteroposterior Body Axis of C. elegans
1999
A model for Niemann–Pick type C disease in the nematode Caenorhabditis elegans
2000
ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis
1993
Roles for two RecA homologs in promoting meiotic chromosome synapsis.
1995
Zip1-induced changes in synaptonemal complex structure and polycomplex assembly.
1995
Identification of Genes That Regulate a Left-Right Asymmetric Neuronal Migration in Caenorhabditis elegans
2003