Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic–Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK Inhibitor
2012
Pathophysiology of Migraine: A Disorder of Sensory Processing
2017 Standout
Distinct Roles for the Kainate Receptor Subunits GluR5 and GluR6 in Kainate-Induced Hippocampal Gamma Oscillations
2004
ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function
2008
Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation
2003
Subtype selectivity and flexibility of ionotropic glutamate receptors upon antagonist ligand binding
2006
Kainate receptors: Pharmacology, function and therapeutic potential
2008
Divergent Pharmacological Activity of Novel Marine-Derived Excitatory Amino Acids on Glutamate Receptors
2005
Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo
2004
Antiallodynic and Antihyperalgesic Effects of Selective Competitive GLUK5 (GluR5) Ionotropic Glutamate Receptor Antagonists in the Capsaicin and Carrageenan Models in Rats
2006
Kainate Receptors Are Involved in Short- and Long-Term Plasticity at Mossy Fiber Synapses in the Hippocampus
2001
Kinetics and Activation of Postsynaptic Kainate Receptors at Thalamocortical Synapses: Role of Glutamate Clearance
2001
A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors
2009
Presynaptic Modulation Controlling Neuronal Excitability and Epileptogenesis: Role of Kainate, Adenosine and Neuropeptide Y Receptors
2003
Ionotropic and metabotropic glutamate receptor structure and pharmacology
2005
Structure−Activity Relationship Studies on N3-Substituted Willardiine Derivatives Acting as AMPA or Kainate Receptor Antagonists
2006
Coassembly of Two GluR6 Kainate Receptor Splice Variants within a Functional Protein Complex
2005
Q/R Site Editing Controls Kainate Receptor Inhibition by Membrane Fatty Acids
2005
In Vitro Characterization of 5-Carboxyl-2,4-di-benzamidobenzoic Acid (NS3763), a Noncompetitive Antagonist of GLUK5 Receptors
2004
Long-Term Depression of Kainate Receptor-Mediated Synaptic Transmission
2006
Structural mechanism of glutamate receptor activation and desensitization
2014 Nature
Synthesis and Pharmacology of Willardiine Derivatives Acting as Antagonists of Kainate Receptors
2005
A Mosaic of Functional Kainate Receptors in Hippocampal Interneurons
2004
Rapid and Differential Regulation of AMPA and Kainate Receptors at Hippocampal Mossy Fibre Synapses by PICK1 and GRIP
2003
Recruitment of the Kainate Receptor Subunit Glutamate Receptor 6 by Cadherin/Catenin Complexes
2002
A Role for Ca2+ Stores in Kainate Receptor-Dependent Synaptic Facilitation and LTP at Mossy Fiber Synapses in the Hippocampus
2003
Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17
2006
Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors1The first two authors contributed equally to this work.1
2001
Ampakines and the threefold path to cognitive enhancement
2006
Glutamate receptor ion channels
2005 Standout
RIM1α and Interacting Proteins Involved in Presynaptic Plasticity Mediate Prepulse Inhibition and Additional Behaviors Linked to Schizophrenia
2010 StandoutNobel
Combined Vemurafenib and Cobimetinib in BRAF -Mutated Melanoma
2014 Standout
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses
2018 StandoutNobel
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges
2001
Evidence for glutamate receptor mediated transmission at mechanoreceptors in the skin
2001
Antagonism of recombinant and native GluK3-containing kainate receptors
2008
A view on drug resistance in cancer
2019 StandoutNature
Role of Glutamate Autoreceptors at Hippocampal Mossy Fiber Synapses
2008
Combination of vemurafenib and cobimetinib in patients with advanced BRAFV600-mutated melanoma: a phase 1b study
2014
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
2007 Standout
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade
2016
Modulation of spontaneous quantal release of neurotransmitters in the hippocampus
2001
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro
2004
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
Modulation of nociceptive dural input to the trigeminocervical complex through GluK1 kainate receptors
2015
The Receptor Tyrosine Kinase EphB2 Regulates NMDA-Dependent Synaptic Function
2001
RIM1α and RIM1β Are Synthesized from Distinct Promoters of theRIM1Gene to Mediate Differential But Overlapping Synaptic Functions
2008 StandoutNobel
The memory function of sleep
2010 Standout
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
2013 StandoutNobel
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
2008 Standout
Neurotrophins and their receptors: A convergence point for many signalling pathways
2003 Standout
Kinesin superfamily motor proteins and intracellular transport
2009 Standout
Synaptotagmin-12 Phosphorylation by cAMP-Dependent Protein Kinase Is Essential for Hippocampal Mossy Fiber LTP
2013 StandoutNobel
Synaptic plasticity at hippocampal mossy fibre synapses
2005
Subunit Composition of Kainate Receptors in Hippocampal Interneurons
2000
Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors
2005
Competitive AMPA receptor antagonists
2006
High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic but Not Metabotropic Signaling
2009
What is the mammalian dentate gyrus good for?
2008 StandoutNobel
Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP
2012 StandoutNobel
Mechanisms and functions of eph and ephrin signalling
2002 Standout
Regulation and Function of the PD-L1 Checkpoint
2018 Standout
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
Receptor trafficking and synaptic plasticity
2004
Memory enhancement: the search for mechanism-based drugs
2002
Leucine-Rich Repeat Transmembrane Proteins Are Essential for Maintenance of Long-Term Potentiation
2013 StandoutNobel
The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature
2008
PI3K and MEK inhibitor combinations: examining the evidence in selected tumor types
2013
A Critical Role of a Facilitatory Presynaptic Kainate Receptor in Mossy Fiber LTP
2001
Lead compounds discovered from libraries
2001
LTP and LTD
2004 Standout
Benzamide-Type AMPA Receptor Modulators Form Two Subfamilies with Distinct Modes of Action
2002
Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice
2005 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
2005 Standout
Targeting ferroptosis as a vulnerability in cancer
2022 Standout
Prospects for MEK inhibitors for treating cancer
2014
Kainate receptors
2006
Glutamate-based therapeutic approaches: ampakines
2005
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist
2004
The PI3K Pathway in Human Disease
2017 Standout
Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2
2007 StandoutNobel
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
2009 Nature
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
MEK Inhibition in the Treatment of Advanced Melanoma
2013
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
2004 StandoutNobel
The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis
2009
Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies
2014
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
2013 Standout
pH-Dependent Inhibition of Kainate Receptors by Zinc
2008
Long-term depression: a cascade of induction and expression mechanisms
2001
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
2012 Standout
Trans-Synaptic Eph Receptor-Ephrin Signaling in Hippocampal Mossy Fiber LTP
2002 Science
Synthesis and Pharmacological Characterization of N3-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLUK5 Kainate Receptor Antagonists
2007
Improving Prospects for Targeting RAS
2015
Synthesis of LY503430 by using a selective rearrangement of β-amino alcohols induced by DAST
2014
Diastereomeric Salt Resolution Based Synthesis of LY503430, an AMPA (α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid) Potentiator
2005
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
About Sleep's Role in Memory
2013 Standout
Multiple Molecular Determinants for Allosteric Modulation of Alternatively Spliced AMPA Receptors
2003
Induction of Mossy Fiber→CA3 Long-Term Potentiation Requires Translocation of Synaptically Released Zn2+
2001
Enantioselective Synthesis of β-Fluoroamines from β-Amino Alcohols: Application to the Synthesis of LY503430
2010
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
2011 StandoutNobel
2-Arylureidobenzoic Acids: Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5
2003
The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?
2012 StandoutNobel
RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
2008 StandoutNobel
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Works of Mary Gates being referenced
Kainate Receptor Agonists, Antagonists and Allosteric Modulators
2002
LY503430, a Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Potentiator with Functional, Neuroprotective and Neurotrophic Effects in Rodent Models of Parkinson’s Disease
2003
Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro
2001
The novel atypical antipsychotic olanzapine, but not the CCK-B antagonist LY288513, blocks apomorphine-induced disruption of pre-pulse inhibition
1997
Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro
2001
Kainate receptors are involved in synaptic plasticity
1999 Nature
Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors
2000
A first-in-human phase Ib study to evaluate the MEK inhibitor GDC-0973, combined with the pan-PI3K inhibitor GDC-0941, in patients with advanced solid tumors.
2012
Clinical combination of the MEK inhibitor GDC-0973 and the PI3K inhibitor GDC-0941: A first-in-human phase Ib study testing daily and intermittent dosing schedules in patients with advanced solid tumors.
2011
Abstract 4716: A first-in-human phase 1 study to evaluate the MEK1/2 inhibitor GDC-0973 administered daily in patients with advanced solid tumors
2011
[3H]N-2-(4-(N-Benzamido)phenyl)propyl-2- propanesulfonamide: A Novel AMPA Receptor Potentiator and Radioligand
2001