Citation Impact
Citing Papers
Effects of an Rb mutation in the mouse
1992 StandoutNature
Are tumours immortal?
1992
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
2012 StandoutNature
The Petinoblastoma Tumor Suppressor Protein
1994
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
APC mutations occur early during colorectal tumorigenesis
1992 StandoutNature
Tumor suppressor genes
1991 Standout
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
1993 Standout
Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity
2000 StandoutNobel
Telomeres shorten during ageing of human fibroblasts
1990 StandoutNatureNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Role of Ceramide in Cellular Senescence
1995
The cell cycle and the retinoblastoma protein family
1994
Expression Profiles of p53-, p16INK4a-, and Telomere-Regulating Genes in Replicative Senescent Primary Human, Mouse, and Chicken Fibroblast Cells
2002
The essence of senescence: Figure 1.
2010 Standout
Genetic analysis of cellular senescence
1995
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
1997 Standout
The biology of replicative senescence
1997
Origins of G1 arrest in senescent human fibroblasts
1995
Oncogenes and signal transduction
1991 Standout
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Molecular themes in oncogenesis
1991 StandoutNobel
Features of replicative senescence induced by direct addition of antennapedia‐p16INK4A fusion protein to human diploid fibroblasts
1998
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
1992 StandoutNature
Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix
1994 StandoutNobel
An altered repertoire of (AP-1) at the onset of replicative senescence
1992
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
The role of senescent cells in ageing
2014 StandoutNature
The Hallmarks of Aging
2013 Standout
The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts
1996
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1
1991
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment
1991
Implantation and the placenta: key pieces of the development puzzle
1994 StandoutScience
A role for both RB and p53 in the regulation of human cellular senescence*1
1991
Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training
2010
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Telomere length predicts replicative capacity of human fibroblasts.
1992 StandoutNobel
Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication
1998
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
1995 Standout
Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state.
1993
Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.
1994
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
1992 StandoutNobel
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
1999 StandoutNobel
Relationship of the pool of intracellular valine to protein synthesis and degradation in cultured cells.
1976 StandoutNobel
The biological clock that measures the mitotic life-span of mouse embryo fibroblasts continues to function in the presence of simian virus 40 large tumor antigen.
1994
Human Fibroblast Commitment to a Senescence-Like State in Response to Histone Deacetylase Inhibitors Is Cell Cycle Dependent
1996
Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts.
1986
Tumor Suppressor Genes
1991 Science
Regulation of p16CDKN2 Expression and Its Implications for Cell Immortalization and Senescence
1996
Cancer Cell Cycles
1996 StandoutScience
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts
1999 Standout
Replicative Senescence: the Human Fibroblast Comes of Age
1990 Science
The regulation of gene expression in eukaryotic cells
1975
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
1991
The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.
1992
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
Regional and strain-specific gene expression mapping in the adult mouse brain
2000
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
1996 Standout
Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis
1999 StandoutScience
The retinoblastoma protein and cell cycle control
1995 Standout
Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.
1993
Cellular Senescence revisited: a review
1987
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
1994 StandoutScience
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
SV40‐transformed human fibroblasts: Evidence for cellular aging in precrisis cells
1985
Growth Factors and Cancer
1991 StandoutScience
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.
1994
The RNA Component of Human Telomerase
1995 StandoutScienceNobel
Large-scale analysis of the human and mouse transcriptomes
2002 StandoutNobel
Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging.
1992
A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication.
1996 StandoutNobel
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
1996
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
1996 StandoutScience
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
1998 StandoutScience
Works of Mary Beeson being referenced
Activation of Protein Kinase C-ζ by Insulin and Phosphatidylinositol-3,4,5-(PO4)3 Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance
2003
Quiescent human diploid fibroblasts
1986
Carcinogen-transformed human cells are inhibited from entry into S phase by fusion to senescent cells but cells transformed by DNA tumor viruses overcome the inhibition.
1982
Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human Fibroblasts
1990 Science
Proof that certain RNAs shuttle non-randomly between cytoplasm and nucleus
1973
Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice.
1997