Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
2016 Science
Updated benchmarking of variant effect predictors using deep mutational scanning
2023
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
2017
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Precision cancer mouse models through genome editing with CRISPR-Cas9
2015
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9
2017
Genome-wide prediction of disease variant effects with a deep protein language model
2023
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
CRISPR-ERA: a comprehensive design tool for CRISPR-mediated gene editing, repression and activation: Fig. 1.
2015
Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
2015
Rapid and Scalable Characterization of CRISPR Technologies Using an E. coli Cell-Free Transcription-Translation System
2018
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
2015
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
2015
Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons
2021
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
2016
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation
2017
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria
2016
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
2015
Induced Pluripotent Stem Cells Meet Genome Editing
2016
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
2017
A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology
2018
Comparison of Cas9 activators in multiple species
2016
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors
2017
Expanding the CRISPR imaging toolset withStaphylococcus aureusCas9 for simultaneous imaging of multiple genomic loci
2016
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
2015
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
2016
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks
2015
Optimizing sgRNA structure to improve CRISPR-Cas9 knockout efficiency
2015
Applications of the CRISPR–Cas9 system in cancer biology
2015
A CRISPR toolbox to study virus–host interactions
2017
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
2016
Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
2014
Enabling functional genomics with genome engineering
2015
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
2015
CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes
2016
Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments
2018
Functional annotation of native enhancers with a Cas9–histone demethylase fusion
2015
A split-Cas9 architecture for inducible genome editing and transcription modulation
2015
The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells
2020
A decade of discovery: CRISPR functions and applications
2017
In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target
2015
Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens
2017
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
CRISPR interference-based specific and efficient gene inactivation in the brain
2018
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 Standout
High-Throughput Approaches to Pinpoint Function within the Noncoding Genome
2017
Genome-scale CRISPR pooled screens
2016
Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi
2018
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
CRISPR/Cas9-Based Engineering of the Epigenome
2017
Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
2015
Stable RNA interference rules for silencing
2013
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
2020 StandoutNobel
DrugTargetSeqR: a genomics- and CRISPR-Cas9–based method to analyze drug targets
2014
Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene
2018
Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
2015
High-throughput functional genomics using CRISPR–Cas9
2015
Directing cellular information flow via CRISPR signal conductors
2016
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
2018
Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity
2016
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
2020
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells
2015
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing
2017
Optical Pooled Screens in Human Cells
2019
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
2016
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice
2010
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells
2015
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
2015 StandoutNobel
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
2020 StandoutNobel
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
2017 StandoutNobel
Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses
2015
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
2016 Science
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination
2016
Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9
2015
Lassa virus entry requires a trigger-induced receptor switch
2014 Science
CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
2015
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning
2015 StandoutScienceNobel
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering
2016 StandoutNobel
Imaging Specific Genomic DNA in Living Cells
2016
Genomic Engineering and the Future of Medicine
2015 StandoutNobel
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
Development of Light‐Activated CRISPR Using Guide RNAs with Photocleavable Protectors
2016
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
RNA-dependent RNA targeting by CRISPR-Cas9
2018 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Synthetic CRISPR RNA-Cas9–guided genome editing in human cells
2015
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens
2018 Standout
CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape
2017
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
2016
De novo design of protein logic gates
2020 StandoutScienceNobel
Works of Martin Kampmann being referenced
A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
2013
LRP1 is a master regulator of tau uptake and spread
2020 Nature
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
2016
Use of RNA Tertiary Interaction Modules for the Crystallisation of the Spliceosomal snRNP Core Domain
2010
Facilitated diffusion in chromatin lattices: mechanistic diversity and regulatory potential
2005
Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps
2014
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 Standout
Deep mutational scanning reveals the structural basis for α-synuclein activity
2020
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
2021
Mapping the orientation of nuclear pore proteins in living cells with polarized fluorescence microscopy
2011
Weak base pairing in both seed and 3′ regions reduces RNAi off-targets and enhances si/shRNA designs
2014
Dual gene activation and knockout screen reveals directional dependencies in genetic networks
2018
Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent
2017
Fluorescence Anisotropy Reveals Order and Disorder of Protein Domains in the Nuclear Pore Complex
2010
Next-generation libraries for robust RNA interference-based genome-wide screens
2015
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine
2017
Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits
2015
Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells
2013
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
2016