Standout Papers
Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
PRMT5 Circular RNA Promotes Metastasis of Urothelial Carcinoma of the Bladder through Sponging miR-30c to Induce Epithelial–Mesenchymal Transition
2018
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis
2017
Structures of the CRISPR genome integration complex
2017 StandoutScienceNobel
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function
2017 Science
Protein stability promotes evolvability
2006 StandoutNobel
Noncoding AUG circRNAs constitute an abundant and conserved subclass of circles
2019
Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA
1995 StandoutNatureNobel
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
2018
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular
2018
Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos
2015
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
2016
Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development
2015
Exon Circularization Requires Canonical Splice Signals
2014
Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer
2017
The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency
2017
Circular RNAs in cancer: opportunities and challenges in the field
2017
The Biogenesis of Nascent Circular RNAs
2016
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
2016 Standout
Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance
2016
The RNA Binding Protein Quaking Regulates Formation of circRNAs
2015 Standout
Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor
2015
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
The Biogenesis, Functions, and Challenges of Circular RNAs
2018 Standout
Redox Regulation of NF-kappa B Activation
1997
Oscillating activity of a Ca(2+)-sensitive K+ channel. A prerequisite for migration of transformed Madin-Darby canine kidney focus cells.
1994
Role of redox potential and reactive oxygen species in stress signaling
1999
Extensive translation of circular RNAs driven by N6-methyladenosine
2017
A Novel Promoter Sequence Is Involved in the Oxidative Stress-Induced Expression of the Adult T-Cell Leukemia-Derived Factor (ADF)/Human Thioredoxin (Trx) Gene
1996
Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1
1994
Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes
2016
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Defining the optimum upper heart rate limit during exercise. A study in pacemaker patients with heart failure
2002
Circular RNAs open a new chapter in cardiovascular biology
2019
Global accumulation of circRNAs during aging in Caenorhabditis elegans
2018
Detecting circular RNAs: bioinformatic and experimental challenges
2016
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
2017
Oxidative stress and gene regulation
2000
Translation of CircRNAs
2017
Altered cell volume regulation in ras oncogene expressing NIH fibroblasts
1992
Novel biocatalysts for white biotechnology
2006
Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1
1998
Coupling mRNA processing with transcription in time and space
2014
Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB
1999
Computational Enzyme Design
2013 StandoutNobel
The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex
2017
Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR
2006 StandoutNobel
Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation
2014
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Regulation of circRNA biogenesis
2015 Standout
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Membrane Mechanisms and Intracellular Signalling in Cell Volume Regulation
1995
Exon Skipping Is Correlated with Exon Circularization
2015
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
Hydrogen peroxide as a potent activator of T lymphocyte functions
1995
Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development
2015
Conditional HIF-1α Expression Produces a Reversible Cardiomyopathy
2010
Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson’s Disease
2018
Diverse alternative back-splicing and alternative splicing landscape of circular RNAs
2016
Evolving proteins in mammalian cells using somatic hypermutation
2006 StandoutNobel
Regulation of Cell Volume in Health and Disease
1995
Binuclear [2Fe-2S] Clusters in the Escherichia coli SoxR Protein and Role of the Metal Centers in Transcription
1995
A map of human circular RNAs in clinically relevant tissues
2017
The coming of age of de novo protein design
2016 StandoutNatureNobel
The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells
2015
[26] Effects of thioredoxin on activation of transcription factor NF-κB
1995
Exon-intron circular RNAs regulate transcription in the nucleus
2015 Standout
Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues
2015
A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs
2018
P450BM3(CYP102A1): connecting the dots
2011
Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood
2015
Insights into RNA structure and function from genome-wide studies
2014 StandoutNobel
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Identification of Genomic Sequences That Mediate the Induction of the Endoplasmic Reticulum Stress Protein, ERp72, by Protein Traffic
1993
CircRNA accumulation in the aging mouse brain
2016
Engineering explored
2014 StandoutNatureNobel
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
2015 Standout
Circular RNAs: Novel Regulators of Neuronal Development
2016
Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals
2014
Amino Acid Analogs Activate NF-κB through Redox-dependent IκB-α Degradation by the Proteasome without Apparent IκB-α Phosphorylation
1998
Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine
2010 StandoutNobel
Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304
1997
Activation of ion transport pathways by changes in cell volume
1991
Oxidative stress and nuclear factor-κB activation
2000
Fibulin-5/DANCE is essential for elastogenesis in vivo
2002 StandoutNatureNobel
Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells
1995
Identifying and Characterizing circRNA-Protein Interaction
2017
Why does the myocardium fail? Insights from basic science
1998
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis
2017 Standout
Redox Regulation of Cellular Signalling
1999
Identification of a Second Region Upstream of the Mouse Heme Oxygenase-1 Gene That Functions as a Basal Level and Inducer-dependent Transcription Enhancer
1995
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
1996 StandoutNobel
Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice
1998 StandoutNobel
Chronic Phospholamban–Sarcoplasmic Reticulum Calcium ATPase Interaction Is the Critical Calcium Cycling Defect in Dilated Cardiomyopathy
1999
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
The biogenesis, biology and characterization of circular RNAs
2019 Standout
Circular RNAs: diversity of form and function
2014
The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting
2017
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
1999 Standout
Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction
2007
Creation of an Amino Acid Network of Structurally Coupled Residues in the Directed Evolution of a Thermostable Enzyme
2009
Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo
2013 Nature
Perspectives on Oxygen Sensing
1999 StandoutNobel
Rewiring the Specificity of Two-Component Signal Transduction Systems
2008
Cloning of a Novel RNA Binding Polypeptide (RA301) Induced by Hypoxia/Reoxygenation
1995
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Comparison of circular RNA prediction tools
2015
Effects of bradykinin on cell volume and intracellular pH in NIH 3T3 fibroblasts expressing the ras oncogene
1992
Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit
1996
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
A Method for Expressing and Imaging Abundant, Stable, Circular RNAs In Vivo Using tRNA Splicing
2016
Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection
2017
Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins
2015
Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies
2018
An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia
1998
Circ HIPK 3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells
2017
Role of Cysteine Residues in Regulation of p53 Function
1995
HIV-1 Proviral DNA Excision Using an Evolved Recombinase
2007 Science
Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein
1992
Regulation of solute and water balance and cell volume in the central nervous system.
1992
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation
1996
Dyssynchronous Ca 2+ Sparks in Myocytes From Infarcted Hearts
2000
Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.
1994
Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B
1995
Signaling in Myocardial Hypertrophy
1999
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
1996 Standout
Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues.
1990
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
PLANT DISEASE RESISTANCE GENES
1997 Standout
Is NF‐κB the sensor of oxidative stress?
1999
A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.
1995
Functions of glutathione and glutathione disulfide in immunology and immunopathology
1994
Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid
1997
DNA sequence-dependent deformability deduced from protein–DNA crystal complexes
1998
Structural basis for the nucleic acid binding cooperativity of bacteriophage T4 gene 32 protein: the (Lys/Arg)3(Ser/Thr)2 (LAST) motif.
1992
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1
2017
Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation
2017
Circular RNAs: analysis, expression and potential functions
2016
Integrative transcriptome sequencing reveals extensive alternative trans-splicing and cis-backsplicing in human cells
2018
The Caenorhabditis elegans Heterochronic Regulator LIN-14 Is a Novel Transcription Factor That Controls the Developmental Timing of Transcription from the Insulin/Insulin-Like Growth Factor Gene ins-33 by Direct DNA Binding
2005 StandoutNobel
Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes
1995
Vitamin E: a sensor and an information transducer of the cell oxidation state
1995
Is NF-kappaB the sensor of oxidative stress?
1999
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.
1994 StandoutNobel
Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.
1990
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
Relationship Between Na + -Ca 2+ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium
1999
Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease
1997
THE OXIDATIVE BURST IN PLANT DISEASE RESISTANCE
1997 Standout
Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription
1997 StandoutNobel
Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression.
1996
Viruses in Human Cancers
1991 StandoutScienceNobel
Selective oxidation of carbolide C–H bonds by an engineered macrolide P450 mono-oxygenase
2009
CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB
2018
A genetically engineered, protein-based optical biosensor of myosin II regulatory light chain phosphorylation.
1994
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes
2016
CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs
2016
Activation of protein kinase C by tyrosine phosphorylation in response to H 2 O 2
1997
Transposon tagging of tobacco mosaic virus resistance gene N: its possible role in the TMV-N-mediated signal transduction pathway.
1995
Directed Evolution ofVibrio fischeriLuxR for Improved Response to Butanoyl-Homoserine Lactone
2007 StandoutNobel
Creation of an Amino Acid Network of Structurally Coupled Residues in the Directed Evolution of a Thermostable Enzyme
2009
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction
2012 StandoutNobel
Antioxidant and redox regulation of gene transcription
1996 Standout
CircRNAs in the brain
2016
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.
1995
Functional Significance of Cell Volume Regulatory Mechanisms
1998 Standout
Cardiac myocyte‐specific HIF‐1α deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart
2004
Role of hydrogen peroxide in hypoxia-induced erythropoietin production
1994
Enhancement of T Cell Receptor Signaling by a Mild Oxidative Shift in the Intracellular Thiol Pool
2000
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Circular RNA identification based on multiple seed matching
2017
Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention.
1996
Signaling in Plant-Microbe Interactions
1997 Science
Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial
2010 Standout
Organophosphorus π-Conjugated Materials
2006 Standout
Works of Markus Meyer being referenced
Regulation of the transcription factors NF-κB and AP-1 by redox changes
1994
Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.
1997
Evolving strategies for enzyme engineering
2005 StandoutNobel
The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator
1990 Nature
Unaltered ryanodine receptor protein levels in ischemic cardiomvopathy
1996
Deciphering 3′ss Selection in the Yeast Genome Reveals an RNA Thermosensor that Mediates Alternative Splicing
2011
Frequency-dependence of Myocardial Energetics in Failing Human Myocardium as Quantified by a New Method for the Measurement of Oxygen Consumption in Muscle Strip Preparations
1998
Mechanistic Studies on a Novel, Highly Potent Gold-Phosphole Inhibitor of Human Glutathione Reductase
2005
circRNA Biogenesis Competes with Pre-mRNA Splicing
2014 Standout
Monoclonal Antibodies Directed against the Amino-Terminal Domain of Human TBP Cross-React with TBP from Other Species
1996
Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization.
1992
Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.
1994
Alterations in Intracellular Calcium Handling Associated With the Inverse Force-Frequency Relation in Human Dilated Cardiomyopathy
1995
H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.
1993 Standout
Structure and function in proteins
1996
Skin wounds and severed nerves heal normally in mice lacking tenascin-C.
1996
Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy
1995
Stimulation of K+ transport systems by Ha-ras
1991
Synthesis, spectral properties, and use of 6-acryloyl-2-dimethylaminonaphthalene (Acrylodan). A thiol-selective, polarity-sensitive fluorescent probe.
1983