Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells
2019 StandoutNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
2013 Science
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
2009
Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
2012 StandoutScience
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
2013
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
2005
Precise genome-wide base editing by the CRISPR Nickase system in yeast
2017
Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
2012
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
2007 Science
Hallmarks of Cancer: The Next Generation
2011 Standout
Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair
2008
RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
2013
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity
2014
The DNA-damage response in human biology and disease
2009 StandoutNature
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
2005 Nature
Computed Tomography — An Increasing Source of Radiation Exposure
2007 Standout
Identification of differential protein interactors of lamin A and progerin
2010
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance
2008
Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection
2015
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
2015 StandoutNature
The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis
2005
The emerging role of nuclear architecture in DNA repair and genome maintenance
2009
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
2012
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
2009
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Cell-cycle checkpoints and cancer
2004 StandoutNature
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
2007
Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex
2010
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals
2006
XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining
2006
Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining: Table 1.
2008
Tying the loose ends together in DNA double strand break repair with 53BP1.
2006
The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage
2009
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
2004
Vascular niche for adult hippocampal neurogenesis
2000 Standout
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
2007 Nature
Regulation of CHK2 by DNA-dependent Protein Kinase
2005
Functional neurogenesis in the adult hippocampus
2002 StandoutNature
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
2009 Standout
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
2006
ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks
2010
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation
2010
DNA repair is limiting for haematopoietic stem cells during ageing
2007 Nature
The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining
2008
Regulation of DNA double-strand break repair pathway choice
2007
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis
2006
DNA repair in terminally differentiated cells
2002
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Regulation of Chromatin Architecture by the PWWP Domain-Containing DNA Damage-Responsive Factor EXPAND1/MUM1
2010
A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining
2008
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
2009
The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art
2012
Suppressor mutations in Mecp2 -null mice implicate the DNA damage response in Rett syndrome pathology
2020
Checkpoint control and cancer
2011
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Predictable and precise template-free CRISPR editing of pathogenic variants
2018 Nature
Human DNA damage response and repair deficiency syndromes: Linking genomic instability and cell cycle checkpoint proficiency
2009
MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings
2008
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
2015
Immunity, Inflammation, and Cancer
2010 Standout
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
2005
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
2006
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
2007
Primary immunodeficiency syndromes associated with defective DNA double-strand break repair
2006
γH2AX and cancer
2008
Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities
2017
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
Imaging strategies to reduce the risk of radiation in CT studies, including selective substitution with MRI
2007
The cellular response to general and programmed DNA double strand breaks
2004
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation
2008
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle
2008
Crosstalk between histone modifications during the DNA damage response
2009
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences
2005
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder
1999
Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break
2004
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
2005 StandoutNature
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
2006
The role of senescent cells in ageing
2014 StandoutNature
Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase
2008
An improved zinc-finger nuclease architecture for highly specific genome editing
2007
TRIM28 prevents autoinflammatory T cell development in vivo
2012 StandoutNobel
The Hallmarks of Aging
2013 Standout
DNA repair pathways and hereditary cancer susceptibility syndromes
2007
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
2005
Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks
2006
Analysis of DNA double-strand break repair pathways in mice
2006
Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response
2010
The combined status of ATM and p53 link tumor development with therapeutic response
2009
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
2010 Nature
The Mechanism of Human Nonhomologous DNA End Joining
2007
Visualization of Altered Replication Dynamics after DNA Damage in Human Cells
2004
Chapter 2 DNA-PK
2008
Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth
2008
In vivo base editing of post-mitotic sensory cells
2018
Processing of 3′-Phosphoglycolate-terminated DNA Double Strand Breaks by Artemis Nuclease
2006
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
2006 Nature
Histone H2A.X Tyr142 phosphorylation: A novel sWItCH for apoptosis?
2009
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Multiple roles of ATM in monitoring and maintaining DNA integrity
2010
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Non-random distribution of DNA double-strand breaks induced by particle irradiation
1996
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions
2004
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
53BP1: function and mechanisms of focal recruitment
2009
Lysosome-mediated processing of chromatin in senescence
2013
Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells
2012
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
2003 StandoutScience
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
2011
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
Double-Strand Break End Resection and Repair Pathway Choice
2011
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
The DNA-damage response: new molecular insights and new approaches to cancer therapy
2009
ATM Mediates Cytotoxicity of a Mutant Telomerase RNA in Human Cancer Cells
2008 StandoutNobel
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks
2000
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
The role of the DNA damage response pathways in brain development and microcephaly: Insight from human disorders
2008
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
The ATM-mediated DNA-damage response: taking shape
2006
DNA Double-Strand Breaks
2002 StandoutNobel
Chromatin organization is a major influence on regional mutation rates in human cancer cells
2012 Nature
BAF180: Its Roles in DNA Repair and Consequences in Cancer
2017
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells
2007
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination
2013
Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM
2004
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
2011
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Evidence for Cardiomyocyte Renewal in Humans
2009 StandoutScience
Works of Markus Löbrich being referenced
ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
2004
Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin
2014
A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci
2004
Harmonising the response to DSBs: a new string in the ATM bow
2005
DNA Double-strand Break Measurement in Mammalian Cells by Pulsed-field Gel Electrophoresis: An Approach Using Restriction Enzymes and Gene Probing
1994
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax
2010
Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection
2014
Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability
2006
Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break
2006
DNA Double-strand Break Induction in Yeast by X-rays and α-particles Measured by Pulsed-field Gel Electrophoresis
1993
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
2009
X-irradiation of cells on glass slides has a dose doubling impact
2007
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction
2007
Formation and repair of DNA double-strand breaks in γ-irradiated K562 cells undergoing erythroid differentiation
2000
DNA double-strand breaks: their cellular and clinical impact?
2007
Factors determining DNA double‐strand break repair pathway choice in G2 phase
2011
Artemis links ATM to Double Strand Break Rejoining
2005
An Imperfect G2M Checkpoint Contributes to Chromosome Instability Following Irradiation of S and G2Phase Cells
2007
Analysis of the Inversion Effect in Pulsed Field Gel Electrophoresis by a Two-Dimensional Contour-Clamped Homogeneous Electric Field System
1993
ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin
2008
Radiation-induced DNA damage responses
2006
γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization
2010
CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
2010
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
2010
DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination
2017
Hyperthermia Activates a Subset of Ataxia-Telangiectasia Mutated Effectors Independent of DNA Strand Breaks and Heat Shock Protein 70 Status
2007
In vivo formation and repair of DNA double-strand breaks after computed tomography examinations
2005
A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity
2004
Chromosome breakage after G2 checkpoint release
2007
DNA Double-Strand Breaks Induced by High-Energy Neon and Iron Ions in Human Fibroblasts. I. Pulsed-Field Gel Electrophoresis Method
1994
Measurement of DNA Double-Strand Breaks in Mammalian Cells by Pulsed-Field Gel Electrophoresis: A New Approach Using Rarely Cutting Restriction Enzymes
1994
Role of ATM and the Damage Response Mediator Proteins 53BP1 and MDC1 in the Maintenance of G2/M Checkpoint Arrest
2010
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
2003
Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends.
1995