Standout Papers
Citation Impact
Citing Papers
STIM1, an essential and conserved component of store-operated Ca2 + channel function
2005 Standout
CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry
2006 StandoutScience
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
A Store-operated Calcium Channel in Drosophila S2 Cells
2004
The trp ion channel family
2001
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1
2006
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
2003 StandoutNobel
The open pore conformation of potassium channels
2002 StandoutNatureNobel
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Cloning and Expression of a Novel Mammalian Homolog ofDrosophila Transient Receptor Potential (Trp) Involved in Calcium Entry Secondary to Activation of Receptors Coupled by the Gq Class of G Protein
1997
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Degradation of a Calcium Influx Factor (CIF) Can Be Blocked by Phosphatase Inhibitors or Chelation of Ca2+
1995 StandoutNobel
Functional analysis of an archaebacterial voltage-dependent K+ channel
2003 StandoutNatureNobel
From worm to man: three subfamilies of TRP channels
2000
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
1997 Nature
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
X-ray structure of a voltage-dependent K+ channel
2003 StandoutNatureNobel
The TRPC3 Channel Has a Large Internal Chamber Surrounded by Signal Sensing Antennas
2006
Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria
1999
Conductance and permeation of monovalent cations through depletion-activated Ca2+ channels (ICRAC) in Jurkat T cells
1996
Store-Operated Ca2+ Entry
1999
Ca2+ Oscillations in Non-Excitable Cells
1993
Use of transgenic mice to study voltage-dependent Ca2+ channels
2001
Calcium signalling in lymphocyte activation and disease
2007
Subcloning the RBL-2H3 mucosal mast cell line reduces Ca2+ response heterogeneity at the single-cell level
1996
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
Ion currents of Xenopus laevis oocytes: state of the art
1999
Outer Pore Architecture of a Ca2+-selective TRP Channel
2004
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Trends in GPCR drug discovery: new agents, targets and indications
2017 Standout
Monovalent cation permeability and Ca2+ block of the store-operated Ca2+ current I CRAC in rat basophilic leukemia cells
2002
Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion
1996
Molecular basis of ancestral vertebrate electroreception
2017 StandoutNatureNobel
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
2006 Nature
Ca2+ Modulation of Ca2+ Release-Activated Ca2+ Channels Is Responsible for the Inactivation of Its Monovalent Cation Current
2004
A non‐capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin
1999
Functional interaction between InsP3 receptors and store-operated Htrp3 channels
1998 Nature
The versatility and universality of calcium signalling
2000 Standout
Store-Operated Calcium Channels
2005 Standout
In Vivo Analysis of the Drosophila Light-Sensitive Channels, TRP and TRPL
1997
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Separation and Characterization of Currents through Store-operated CRAC Channels and Mg2+-inhibited Cation (MIC) Channels
2002
1 Intracellular calcium waves
1995
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
2006 StandoutNature
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
2005
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Receptor-activated Ca2+ Influx via Human Trp3 Stably Expressed in Human Embryonic Kidney (HEK)293 Cells
1998
Calcium channels activated by depletion of internal calcium stores in A431 cells
1994
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
Potentiation and inhibition of Ca2+ release‐activated Ca2+ channels by 2‐aminoethyldiphenyl borate (2‐APB) occurs independently of IP3 receptors
2001
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
1998 StandoutNatureNobel
Lymphocyte calcium signaling from membrane to nucleus
2005
Isolation of mutant T lymphocytes with defects in capacitative calcium entry
1995
Calcium release and influx colocalize to the endoplasmic reticulum
1997
Capacitative calcium entry is colocalised with calcium release in Xenopus oocytes: Evidence against a highly diffusible calcium influx factor
1996
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
1999 StandoutNature
TRPM2
2014
Capacitative calcium entry is inhibited in vascular endothelial cells by disruption of cytoskeletal microfilaments
1997
CRAC channels: activation, permeation, and the search for a molecular identity
2003
TRP Is Cracked but Is CRAC TRP?
1996
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
1996 Nature
trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry
1996
Calcium oscillations increase the efficiency and specificity of gene expression
1998 StandoutNature
Receptor-activated Ca2+ influx: how many mechanisms for how many channels?
1994
Capacitative calcium entry channels
1999
The principle of gating charge movement in a voltage-dependent K+ channel
2003 StandoutNatureNobel
Inositol trisphosphate and calcium signalling
1993 StandoutNature
Calcium signalling in lymphocytes
2003
Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization
2000
Mapping the Receptor Site for Hanatoxin, a Gating Modifier of Voltage-Dependent K+ Channels
1997
Calcium signalling and cell proliferation
1995
Phase-dependent contributions from Ca2+ entry and Ca2+ release to caffeine-induced [Ca2+]i oscillations in bullfrog sympathetic neurons
1992
Energetic and structural interactions between δ-dendrotoxin and a voltage-gated potassium channel 1 1Edited by G. von Heijne
2000 StandoutNobel
Store-operated Ca2+ influx: What is the message from the stores to the membrane?
1996
Hanatoxin Modifies the Gating of a Voltage-Dependent K+ Channel through Multiple Binding Sites
1997 StandoutNobel
New Light on TRP and TRPL
1997
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Orai1 is an essential pore subunit of the CRAC channel
2006 StandoutNature
Calcium Signaling
2007 Standout
Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death
1999
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels
2005 Standout
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
CaT1 and the Calcium Release-activated Calcium Channel Manifest Distinct Pore Properties
2001
CaT1 Contributes to the Stores-operated Calcium Current in Jurkat T-lymphocytes
2002
I ARC, a Novel Arachidonate-regulated, Noncapacitative Ca2+ Entry Channel
2000
Gene regulation mediated by calcium signals in T lymphocytes
2001
An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula
1995 StandoutNobel
Modulation of Mitochondrial Ca2+ Homeostasis by Bcl-2
1999
Dissociation of the store‐operated calcium current ICRAC and the Mg‐nucleotide‐regulated metal ion current MagNuM
2002
Cloning and expression localization of cDNA for rat homolog of TRP protein, a possible store-operated calcium (Ca2+) channel
1996
Calcium signaling
1995 Standout
Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit
1994 Nature
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Structure and function of inositol triphosphate receptors
1991
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Molecular Cloning and Functional Characterization of a Novel Receptor-activated TRP Ca2+ Channel from Mouse Brain
1998
Quantitation of Transcription and Clonal Selection of Single Living Cells with β-Lactamase as Reporter
1998 StandoutScienceNobel
Capacitative Calcium Entry
1998
Structural and functional features and significance of the physical linkage between ER and mitochondria
2006
Intracellular calcium dependence of gene expression in single T lymphocytes.
1994
Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.
1995
CaT1 manifests the pore properties of the calcium-release-activated calcium channel
2001 Nature
G-protein regulation of capacitative calcium entry may be mediated by protein kinases A and C in Xenopus oocytes
1995
Structure of the Cytoplasmic β Subunit--T1 Assembly of Voltage-Dependent K + Channels
2000 StandoutScienceNobel
The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.
1994
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
2006
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients
2005
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans
2000 StandoutNatureNobel
Primaquine, an inhibitor of vesicular transport, blocks the calcium-release-activated current in rat megakaryocytes
1995
Regulation of TRP Channels via Lipid Second Messengers
2003
Kinetics of empty store-activated Ca2+ influx in HeLa cells.
1994
The TRP Superfamily of Cation Channels
2005
Regulation of CRAC Channel Activity by Recruitment of Silent Channels to a High Open-probability Gating Mode
2006
Mg2+-dependent Gating and Strong Inward Rectification of the Cation Channel TRPV6
2003
Control of Ca2+ entry into HL60 and U937 human leukaemia cells by the filling state of the intracellular Ca2+ stores
1993
Capacitative Ca2+ Entry Is Closely Linked to the Filling State of Internal Ca2+ Stores: A Study Using Simultaneous Measurements of ICRAC and Intraluminal [Ca2+]
1998
[Ca2+]i oscillations in sympathetic neurons: an experimental test of a theoretical model
1995
IP 3 Receptor: Localization to Plasma Membrane of T Cells and Cocapping with the T Cell Receptor
1992 Science
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
2001
Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx.
1996
Membrane voltage initiates Ca 2+ waves and potentiates Ca 2+ increases with abscisic acid in stomatal guard cells
1998
Capacitative calcium entry
1995
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
2001
Control of plasma-membrane Ca2+ entry by the intracellular Ca2+ stores. Kinetic evidence for a short-lived mediator
1992
Depletion of intracellular Ca2+ stores activates a Ca(2+)-selective channel in vascular endothelium
1994
Acceleration of Intracellular Calcium Waves in Xenopus Oocytes by Calcium Influx
1993 Science
A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.
1996
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
1997 Standout
Transient Receptor Potential 1 Regulates Capacitative Ca2+ Entry and Ca2+ Release from Endoplasmic Reticulum in B Lymphocytes
2002
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
2006
Stimulus-Induced Oscillations in Guard Cell Cytosolic Free Calcium.
1995
Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca 2+ and K + channels
1998
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
Signaling Mechanisms Underlying the Vascular Myogenic Response
1999
On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trp proteins
1996
Intercellular Propagation of Calcium Waves Mediated by Inositol Trisphosphate
1992 Science
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.
1993
Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues
1995
Effect of Ca2+ influx on intracellular free Ca2+ responses in antigen-stimulated RBL-2H3 cells
1996
Alteration of Stimulus-Specific Guard Cell Calcium Oscillations and Stomatal Closing in Arabidopsis det3 Mutant
2000 StandoutScienceNobel
Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger
1993 Nature
A Current Activated on Depletion of Intracellular Ca2+Stores Can Regulate Exocytosis in Adrenal Chromaffin Cells
1999
Calcium Current Activated by Depletion of Calcium Stores in Xenopus Oocytes
1997 StandoutNobel
Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores
1999
Potassium and Calcium Channels in Lymphocytes
1995
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
Calcium Signaling Mechanisms in T Lymphocytes
2001
A primary T-cell immunodeficiency associated with defective transmembrane calcium influx
1995
Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes.
1996
Expression of TRPC3 in Chinese Hamster Ovary Cells Results in Calcium-activated Cation Currents Not Related to Store Depletion
1997
The molecular choreography of a store-operated calcium channel
2007 Nature
Store-activated Ca2+ inflow in Xenopus laevis oocytes: inhibition by primaquine and evaluation of the role of membrane fusion
1996
Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes.
1994
Works of Markus Hoth being referenced
TRPC3 Mediates T-cell Receptor-dependent Calcium Entry in Human T-lymphocytes
2003
Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide
2014
Absence of the γ Subunit of the Skeletal Muscle Dihydropyridine Receptor Increases L-type Ca2+ Currents and Alters Channel Inactivation Properties
2000
Calcium release‐activated calcium current in rat mast cells.
1993
Recognition of Bacterial Signal Peptides by Mammalian Formyl Peptide Receptors
2015
Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma‐membrane calcium‐ATPase in human T cells
2002
TRP4 (CCE1) Protein Is Part of Native Calcium Release-activated Ca2+-like Channels in Adrenal Cells
2000
Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells
2013
Non-specific effects of calcium entry antagonists in mast cells
1994
Depletion of intracellular calcium stores activates a calcium current in mast cells
1992 StandoutNature
Calcium and barium permeation through calcium release-activated calcium (CRAC) channels
1995
Depletion of intracellular calcium stores activates an outward potassium current in mast and RBL‐1 cells that is correlated with CRAC channel activation
1996
Multiple mechanisms of manganese-induced quenching of fura-2 fluorescence in rat mast cells
1993
Sustained Activity of Calcium Release-activated Calcium Channels Requires Translocation of Mitochondria to the Plasma Membrane
2006
TRP expression pattern and the functional importance of TRPC3 in primary human T-cells
2011
Ion Channels and Calcium Signaling in Mast Cellsa
1993
Swapping of functional domains in voltage-gated K + channels
1991
Calcium influx and its control by calcium release
1993
The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells
2002
A GTP-dependent step in the activation mechanism of capacitative calcium influx.
1993
Mitochondrial control of calcium-channel gating: A mechanism for sustained signaling and transcriptional activation in T lymphocytes
2000
Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.
1995
Ca2+ and Mn2+ influx through receptor-mediated activation of nonspecific cation channels in mast cells.
1993
Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes
1997