Citation Impact
Citing Papers
Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
2009 Science
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data
2020 StandoutNobel
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
To Interfere and to Anti-interfere: The Interplay Between Hepatitis C Virus and Interferon
2002
Emerging therapies for the treatment of hepatitis C
2013 StandoutNobel
A randomised phase II/III trial of 3-weekly cisplatin-based sequential transarterial chemoembolisation vs embolisation alone for hepatocellular carcinoma
2013
The global burden of hepatitis C
2009
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
1996 Standout
Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report
2011
Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?
1993
Mechanisms of type-I- and type-II-interferon-mediated signalling
2005 Standout
Inflammation and cancer
2002 StandoutNature
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Nonstructural protein 3‐4A: the Swiss army knife of hepatitis C virus
2011
Murine models of hepatitis C: What can we look forward to?
2014
Cellular and molecular mechanisms of fibrosis
2007 Standout
Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling
1995
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
1996
Reconstitution of a High Affinity Binding Site for Type I Interferons
1995
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
A Central Role for mTOR in Lipid Homeostasis
2013
Treatment triumphs
2014 StandoutNatureNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Surveying the global virome: Identification and characterization of HCV-related animal hepaciviruses
2014
Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures
2010 StandoutNobel
Regulation of hepatic innate immunity by hepatitis C virus
2013
Evasion of intracellular host defence by hepatitis C virus
2005 Nature
Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor
1995 Nobel
Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
1997
Hypoxia and Inflammation
2011 Standout
Components of a stat recognition code: Evidence for two layers of molecular selectivity
1995
Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice
1996
IL28B and the Control of Hepatitis C Virus Infection
2010
Three-dimensional structure of the Stat3β homodimer bound to DNA
1998 Nature
Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma
2016
IFNs, ISGylation and cancer: Cui prodest?
2012
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
1997 Standout
Human acetyltransferase polymorphisms
1997
Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1
2001
Perspectives and challenges of interferon-free therapy for chronic hepatitis C
2012
An Amino-terminal Amphipathic α-Helix Mediates Membrane Association of the Hepatitis C Virus Nonstructural Protein 5A
2002
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Structure of the NCoA-1/SRC-1 PAS-B Domain Bound to the LXXLL Motif of the STAT6 Transactivation Domain
2004 StandoutNobel
Nonlinear material behaviour of spider silk yields robust webs
2012 StandoutNature
Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase
2001 StandoutNobel
Immune Responses to HCV and Other Hepatitis Viruses
2014
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
2009
Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: The SPACE trial
2016
p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6
1999
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Structure and function of a new STAT-induced STAT inhibitor
1997 Nature
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
The Humoral Immune Response to HCV: Understanding is Key to Vaccine Development
2014
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1
2002
The ins and outs of hepatitis C virus entry and assembly
2013 StandoutNobel
Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells
2013
N-acetyltransferases: Pharmacogenetics and clinical consequences of polymorphic drug metabolism
1996
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
1998 StandoutNature
IL-4 Function Can Be Transferred to the IL-2 Receptor by Tyrosine Containing Sequences Found in the IL-4 Receptor α Chain
1996
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
2013 StandoutNobel
Hepatic Gene Expression Discriminates Responders and Nonresponders in Treatment of Chronic Hepatitis C Viral Infection
2005
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
2009 StandoutNature
Adipogenesis and Obesity: Rounding Out the Big Picture
1996
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ
1996
Stat1 Depends on Transcriptional Synergy with Sp1
1995
Virion Assembly and Release
2013
USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response
2011
Treatment of intermediate-stage hepatocellular carcinoma
2014
The biology of leptin: a review.
1998
Immunomodulatory functions of type I interferons
2012
Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding
1997
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process
1995
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
2014 Standout
Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription
2001
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled, double-blind, phase 3 trial
2017
Intracellular signalling: Putting JAKs on the kinase MAP
1996
How do persistent infections with hepatitis C virus cause liver cancer?
2015
Neuro-Immune Interactions at Barrier Surfaces
2016
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Leptin and the regulation of body weight in mammals
1998 StandoutNature
IL28B Genotype Is Associated With Differential Expression of Intrahepatic Interferon-Stimulated Genes in Patients With Chronic Hepatitis C
2010
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Innate immune responses in hepatitis C virus infection
2012
Innate Immune Responses to Hepatitis C Virus
2013 StandoutNobel
Complex Modulation of Cell Type-Specific Signaling in Response to Type I Interferons
2006
Molecular basis of interferon resistance in hepatitis C virus
2014
A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
2015
STATs: Signal Transducers and Activators of Transcription
1996
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Cytokine receptor signalling
1995 Nature
Leptin Inhibits Bone Formation through a Hypothalamic Relay
2000 Standout
Treatment of HCV Infection by Targeting MicroRNA
2013 Standout
Interferon-γ: an overview of signals, mechanisms and functions
2003 Standout
Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes
1997
Functional Subdomains of STAT2 Required for Preassociation with the Alpha Interferon Receptor and for Signaling
1997
Role of STAT2 in the Alpha Interferon Signaling Pathway
1995
Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications
2019 Standout
Function of Stat2 Protein in Transcriptional Activation by Alpha Interferon
1996
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
1998
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
1997
Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA
2011
Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice
2015 StandoutNobel
STATs and Gene Regulation
1997 StandoutScience
Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.
1996
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
MOLECULAR MECHANISMS OF GENETIC POLYMORPHISMS OF DRUG METABOLISM
1997
Interactions between STAT and Non-STAT Proteins in the Interferon-Stimulated Gene Factor 3 Transcription Complex
1996
The Strange, Expanding World of Animal Hepaciviruses
2016
Reflections on STAT3, STAT5, and STAT6 as fat STATs.
1996
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor
1998
Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.
1996
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors
1995 Science
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
2002
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.
1995
Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain
1996 Science
CELLULAR RESPONSES TO INTERFERON-γ
1997 Standout
p300/CREB-Binding Protein Enhances the Prolactin-Mediated Transcriptional Induction through Direct Interaction with the Transactivation Domain of Stat5, but Does Not Participate in the Stat5-Mediated Suppression of the Glucocorticoid Response
1998
On the History of Hepatitis C Virus Cell Culture Systems
2013
Hepatitis C virus NS5A: tales of a promiscuous protein
2004
Increased Replicative Fitness Can Lead to Decreased Drug Sensitivity of Hepatitis C Virus
2014 StandoutNobel
Viral persistence, liver disease, and host response in a hepatitis C–like virus rat model
2017 StandoutNobel
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
2018 Standout
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype
1996
Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases
1997 Science
Fine Structure of the Murine Leptin Receptor Gene: Splice Site Suppression Is Required to Form Two Alternatively Spliced Transcripts
1997
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.
1996
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
1998
In vivo models of hepatitis B and C virus infection
2016
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
1997
THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling
1997
Naturally Occurring Dominant Negative Variants of Stat5
1996
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Markus H. Heim being referenced
Interferon signaling and treatment outcome in chronic hepatitis C
2008
Faldaprevir (Bi 201335), Deleobuvir (Bi 207127) and Ribavirin Oral Therapy for Treatment-Naive HCV Genotype 1: Sound-C1 Final Results
2013
Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver
2013
Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C
2010
Expression of hepatitis c virus proteins inhibits interferon α signaling in the liver of transgenic mice
2003
Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
2012
Human Arylamine N -Acetyltransferase Genes: Isolation, Chromosomal Localization, and Functional Expression
1990
Debrisoquine/Sparteine Hydroxylation Genotype and Phenotype: Analysis of Common Mutations and Alleles of CYP2D6 in a European Population
1991
Activation of endoplasmic reticulum stress response by hepatitis viruses up‐regulates protein phosphatase 2A†
2007
Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification
1990
Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6
1992
Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells
2013
S‐adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro†
2006
Is tumor biopsy necessary?
2011
Comparative genetic analyses point to HCP5 as susceptibility locus for HCV-associated hepatocellular carcinoma
2013
Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway
1995 Science
Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo
2011
Interferons and hepatitis C virus
2012
Hepatitis C: an update
2001
Spider Silk: From Soluble Protein to Extraordinary Fiber
2009
Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy
2011
Efficacy of the Protease Inhibitor BI 201335, Polymerase Inhibitor BI 207127, and Ribavirin in Patients With Chronic HCV Infection
2011
Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
2009
Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha
2013
Innate and adaptive immune responses in HCV infections
2014
Interferon‐α activates signal transducers and activators of transcription 5 and 6 in Daudi cells
1998
Hepatitis C Virus–Induced Up-Regulation of Protein Phosphatase 2A Inhibits Histone Modification and Dna Damage Repair
2009
Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system†
2009
Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A
2003
25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
2013
Transcriptional response to hepatitis C virus infection and interferon‐alpha treatment in the human liver
2017
Upregulation of Protein Phosphatase 2Ac by Hepatitis C Virus Modulates NS3 Helicase Activity through Inhibition of Protein Arginine Methyltransferase 1
2005
Comparison of the Transactivation Domains of Stat5 and Stat6 in Lymphoid Cells and Mammary Epithelial Cells
1997
Host- rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection
2008
The interleukin-4/interleukin-13 receptor of human synovial fibroblasts: overexpression of the nonsignaling interleukin-13 receptor alpha2.
1998
Defective STAT signaling by the leptin receptor in diabetic mice.
1996
Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43
2009
Hepatitis C Virus (HCV) Induces Formation of Stress Granules Whose Proteins Regulate HCV RNA Replication and Virus Assembly and Egress
2012
Continuous Administration of Sorafenib in Combination with Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma: Results of a Phase I Study
2010
Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.
1990
Clinical course of infection and viral tissue tropism of hepatitis C virus–like nonprimate hepaciviruses in horses
2014
Expression of Hepatitis C Virus Proteins Inhibits Signal Transduction through the Jak-STAT Pathway
1999
Molecular mechanism of slow acetylation of drugs and carcinogens in humans.
1991
The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota
2014
Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1α-Mediated Glycolytic Adaptation
2009