Standout Papers
Citation Impact
Citing Papers
Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs
2018 StandoutNobel
Differential dynamics of the mammalian mRNA and protein expression response to misfolding stress
2016
Identification of factors required for m 6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI
2017
Gene essentiality and synthetic lethality in haploid human cells
2015 Science
Identification and characterization of essential genes in the human genome
2015 Science
CRISPR/Cas9 in Genome Editing and Beyond
2016
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose
2016
Next-generation analysis of gene expression regulation – comparing the roles of synthesis and degradation
2015
The emerging biology of RNA post-transcriptional modifications
2016
Global signatures of protein and mRNA expression levels
2009
Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA
2014
Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution
2019
Conservation of mRNA and Protein Expression during Development of C. elegans
2014
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
2017
The m6A pathway facilitates sex determination in Drosophila
2017
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
2015
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets
2018
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal
2018
Deep Proteome Analysis Identifies Age-Related Processes in C. elegans
2016
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
2017
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1
2017
Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells
2015
Reproducible and Consistent Quantification of the Saccharomyces cerevisiae Proteome by SWATH-mass spectrometry *
2015
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
2017
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Negative feedback buffers effects of regulatory variants
2015
Pairing beyond the Seed Supports MicroRNA Targeting Specificity
2016
The Mtb Proteome Library: A Resource of Assays to Quantify the Complete Proteome of Mycobacterium tuberculosis
2013
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
2015
Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis
2017
Gene expression regulation mediated through reversible m6A RNA methylation
2014
The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′–3′ exoribonuclease XRN1
2018
N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
2016
The reverse transcription signature ofN-1-methyladenosine in RNA-Seq is sequence dependent
2015
nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs
2016
Distinguishing RNA modifications from noise in epitranscriptome maps
2018
N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
2017
N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
2016
Posttranscriptional m6A Editing of HIV-1 mRNAs Enhances Viral Gene Expression
2016
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis
2005
Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins
2015
m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells
2014 Standout
Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming
2015
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
2016 Standout
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
2007
YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
2016
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
2015 Standout
Protein abundances are more conserved than mRNA abundances across diverse taxa
2010
Reading RNA methylation codes through methyl-specific binding proteins
2014
Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding
2008
N6-Methylated Adenosine in RNA: From Bacteria to Humans
2015
Ribosome Footprint Profiling of Translation throughout the Genome
2016
Evolution of transcript modification by N6-methyladenosine in primates
2017
Post-transcriptional gene regulation by mRNA modifications
2016 Standout
Cracking the epitranscriptome
2016
N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection
2016
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
2016
m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition
2017 Nature
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
High‐Resolution N6‐Methyladenosine (m6A) Map Using Photo‐Crosslinking‐Assisted m6A Sequencing
2014
Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions
2012
A CRISPR toolbox to study virus–host interactions
2017
The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
2016
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
2016
Dynamics of Human and Viral RNA Methylation during Zika Virus Infection
2016
m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome
2016
Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA
2014
Structural imprints in vivo decode RNA regulatory mechanisms
2015 Nature
Interactions, localization, and phosphorylation of the m6A generating METTL3–METTL14–WTAP complex
2018
Structural Basis for Translation Termination on a Pseudouridylated Stop Codon
2016
Comprehensive proteomics
2010
mRNA structure determines modification by pseudouridine synthase 1
2019
Dynamic RNA Modifications in Gene Expression Regulation
2017 Standout
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation
2015
Contributions of mRNA abundance, ribosome loading, and post- or peri-translational effects to temporal repression of C. elegans heterochronic miRNA targets
2012 Nobel
N6-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding
2015
Shotgun proteomics data from multiple organisms reveals remarkable quantitative conservation of the eukaryotic core proteome
2010
m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
2016 Nature
TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code
2017
The coding capacity of SARS-CoV-2
2020 Nature
Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA
2019
Transcriptome-Wide Mapping of Pseudouridines: Pseudouridine Synthases Modify Specific mRNAs in S. cerevisiae
2014
Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling
2019
miRNAs cooperate in apoptosis regulation during C. elegans development
2017
Widespread occurrence ofN6-methyladenosine in bacterial mRNA
2015
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
2020 StandoutNobel
Base-pairing interactions between substrate RNA and H/ACA guide RNA modulate the kinetics of pseudouridylation, but not the affinity of substrate binding by H/ACA small nucleolar ribonucleoproteins
2019
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
RNA sequencing shows no dosage compensation of the active X-chromosome
2010
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d
2018
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
2015 Standout
N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
2017
Ribosome profiling reveals post-transcriptional buffering of divergent gene expression in yeast
2013
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
2012 Standout
5′ UTR m6A Promotes Cap-Independent Translation
2015 Standout
Dynamic m6A mRNA methylation directs translational control of heat shock response
2015 Nature
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
2017
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
N-Glycoprotein SRMAtlas
2013
sta-1is repressed bymir-58family inCaenorhabditis elegans
2016
The next generation of CRISPR–Cas technologies and applications
2019
Illumina-based RiboMethSeq approach for mapping of 2′-O-Me residues in RNA
2016
A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation
2015
Pseudouridylation meets next-generation sequencing
2016
An updated human snoRNAome
2016
Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
2017
Functional relevance of “seed” and “non-seed” sequences in microRNA-mediated promotion of C. elegans developmental progression
2015 Nobel
Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code
2015
The dynamic epitranscriptome: N6-methyladenosine and gene expression control
2014
Homing in: Mechanisms of Substrate Targeting by Protein Kinases
2018
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Reversible methylation of m6Am in the 5′ cap controls mRNA stability
2016 Nature
Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system
2013
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
2012 Standout
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
2006
Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome
2015
The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA
2016 Nature
Absolute Proteome Composition and Dynamics during Dormancy and Resuscitation of Mycobacterium tuberculosis
2015
Regulation of m6A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline
2017
Reading, writing and erasing mRNA methylation
2019 Standout
Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans
2015
Optical Pooled Screens in Human Cells
2019
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues
2015
Unique features of the m6A methylome in Arabidopsis thaliana
2014
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency
2018 Nature
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome
2016
Global quantification of mammalian gene expression control
2011 StandoutNature
The Mechanism of Human Nonhomologous DNA End Joining
2007
N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
2015
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Probing RNA Modification Status at Single-Nucleotide Resolution in Total RNA
2015
Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
2016 Nature
m6A RNA methylation promotes XIST-mediated transcriptional repression
2016 Nature
Dynamic RNA Modifications in Posttranscriptional Regulation
2014
Chapter 2 DNA-PK
2008
Pseudouridine: Still mysterious, but never a fake (uridine)!
2014
The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention
2017
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Reading m6A in the Transcriptome: m6A-Binding Proteins
2017
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
2014
PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles
2015 StandoutNobel
‘View From A Bridge’: A New Perspective on Eukaryotic rRNA Base Modification
2015
Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency
2018
Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells
2016
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
The evolution of gene expression levels in mammalian organs
2011 StandoutNatureNobel
N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
2015 StandoutNature
Functional Genomic Analysis of the let-7 Regulatory Network in Caenorhabditis elegans
2013
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Human METTL16 is a N 6 ‐methyladenosine (m 6 A) methyltransferase that targets pre‐mRNAs and various non‐coding RNAs
2017
In vivo 3′-to-5′ exoribonuclease targetomes of Streptococcus pyogenes
2018 StandoutNobel
Pseudouridinylation of mRNA coding sequences alters translation
2019
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
2016 Nature
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
HydraPsiSeq: a method for systematic and quantitative mapping of pseudouridines in RNA
2020
Rethinking m6A Readers, Writers, and Erasers
2017
Primate Transcript and Protein Expression Levels Evolve Under Compensatory Selection Pressures
2013 Science
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Cotranslational microRNA mediated messenger RNA destabilization
2016
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
The quantitative proteome of a human cell line
2011
RNA Pseudouridylation in Physiology and Medicine: For Better and for Worse
2017
Protein Analysis by Shotgun/Bottom-up Proteomics
2013
Version 4.0 of PaxDb: Protein abundance data, integrated across model organisms, tissues, and cell‐lines
2015
The Epitranscriptome of Noncoding RNAs in Cancer
2017
Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain
2014
Proteomics and the Analysis of Proteomic Data: 2013 Overview of Current Protein‐Profiling Technologies
2013
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
2018
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
2022 StandoutScienceNobel
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
Proteomics and the Analysis of Proteomic Data: An Overview of Current Protein‐Profiling Technologies
2005
Membrane-dependent relief of translation elongation arrest on pseudouridine- and N1-methyl-pseudouridine-modified mRNAs
2021
Selectable One-Step PCR-Mediated Integration of a Degron for Rapid Depletion of Endogenous Human Proteins
2016
Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function
2016
Emerging Roles of RNA Modification: m6A and U-Tail
2014
Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression?
2017
ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2
2018
Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification
2015
Absolute quantification of microbial proteomes at different states by directed mass spectrometry
2011
A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA
2022 StandoutNobel
m6A modulates neuronal functions and sex determination in Drosophila
2016 Nature
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
2017
Functional Mapping of the Zebrafish Early Embryo Proteome and Transcriptome
2014
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
Regulation of mRNA translation during mitosis
2015
Impact of regulatory variation from RNA to protein
2014 Science
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
2023 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease
2014
Proteomic cell surface phenotyping of differentiating acute myeloid leukemia cells
2010
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Structural insights into the molecular mechanism of the m6A writer complex
2016
Precise Antibody-Independent m6A Identification via 4SedTTP-Involved and FTO-Assisted Strategy at Single-Nucleotide Resolution
2018
Tunable protein synthesis by transcript isoforms in human cells
2016 StandoutNobel
RNA modification in Cajal bodies
2016
Next‐Generation Sequencing‐Based RiboMethSeq Protocol for Analysis of tRNA 2′‐O‐Methylation
2017
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline
2017
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Chemical Glycoproteomics
2016 StandoutNobel
Detecting RNA modifications in the epitranscriptome: predict and validate
2017
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
The ERI-6/7 Helicase Acts at the First Stage of an siRNA Amplification Pathway That Targets Recent Gene Duplications
2011 StandoutNobel
Works of Marko Jovanović being referenced
Dynamic profiling of the protein life cycle in response to pathogens
2015 Science
Protein Significance Analysis in Selected Reaction Monitoring (SRM) Measurements
2011
Protein Identification False Discovery Rates for Very Large Proteomics Data Sets Generated by Tandem Mass Spectrometry
2009
Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
2014
Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system
2003
Comparative Functional Analysis of the Caenorhabditis elegans and Drosophila melanogaster Proteomes
2009
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
2013 StandoutNobel
A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans
2010
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks
2015
High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies
2014
RIP-chip-SRM—a new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans
2012
A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation
2015
Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis
2006
Pervasive, Coordinated Protein-Level Changes Driven by Transcript Isoform Switching during Meiosis
2018
miRNAs and apoptosis: RNAs to die for
2006
Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans
2015
Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
2014
Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases
2009