Standout Papers
Citation Impact
Citing Papers
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
2005 StandoutNobel
Mouse Neutrophils Require JNK2 MAPK for Toxoplasma gondii -Induced IL-12p40 and CCL2/MCP-1 Release
2007
Matrix Survival Signaling
2000
Regulation of a DLK-1 and p38 MAP Kinase Pathway by the Ubiquitin Ligase RPM-1 Is Required for Presynaptic Development
2005
Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction
2004
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Impaired Synergistic Activation of Stress-activated Protein Kinase SAPK/JNK in Mouse Embryonic Stem Cells Lacking SEK1/MKK4
2001
LPS induction of gene expression in human monocytes
2001 Standout
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines
2001
Inflammation and metabolic disorders
2006 StandoutNature
Selectin-Mediated Interactions Regulate Cytokine Networks and Macrophage Heme Oxygenase-1 Induction in Cardiac Allograft Recipients
2002
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo
2004
MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous
1997
MKK3 Mitogen-Activated Protein Kinase Pathway Mediates Carbon Monoxide-Induced Protection Against Oxidant-Induced Lung Injury
2003
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Cobalt Induces Heme Oxygenase-1 Expression by a Hypoxia-inducible Factor-independent Mechanism in Chinese Hamster Ovary Cells
2001
Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
1999
Oxidative stress and gene regulation
2000
Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes
2004
Physiology of Cell Volume Regulation in Vertebrates
2009
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
1997 Nature
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
2003
Protection Against Ischemia/Reperfusion Injury in Cardiac and Renal Transplantation with Carbon Monoxide, Biliverdin and Both
2005
Transcriptional Regulation of Heme Oxygenase-1 Gene Expression by MAP Kinases of the JNK and p38 Pathways in Primary Cultures of Rat Hepatocytes
2003
Vasoactive properties of CORM‐3, a novel water‐soluble carbon monoxide‐releasing molecule
2004
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
Carbon Monoxide Suppresses Bleomycin-Induced Lung Fibrosis
2005
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
1998
Nitric Oxide-inducible Expression of Heme Oxygenase-1 in Human Cells
2000
Oxidized Phospholipids Induce Expression of Human Heme Oxygenase-1 Involving Activation of cAMP-responsive Element-binding Protein
2003
Mitogen activated protein kinase inhibitors: where are we now and where are we going?
2006
Increased expression of heme oxygenase-1 in human lung transplantation
2002
From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance
2005
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
1999
Induction of Heme Oxygenase-1 Expression in Murine Macrophages Is Essential for the Anti-inflammatory Effect of Low Dose 15-Deoxy-Δ12,14-prostaglandin J2
2003
Nonresolving Inflammation
2010 Standout
Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38
1997
JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection
1999
JNK is required for effector T-cell function but not for T-cell activation
2000 Nature
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
2006 Standout
Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats
2004
Analysis of pharmacologic inhibitors of Jun N-terminal kinases
2001
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Mapping of the Chick Heme Oxygenase-1 Proximal Promoter for Responsiveness to Metalloporphyrins
2002
Quantum imaging with undetected photons
2014 StandoutNatureNobel
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
Biliverdin Reductase, a Novel Regulator for Induction of Activating Transcription Factor-2 and Heme Oxygenase-1
2004
Expression of protective genes in human renal allografts: a regulatory response to injury associated with graft rejection1,2
2002
Differential Activation of Two JNK Activators, MKK7 and SEK1, by MKN28-derived Nonreceptor Serine/Threonine Kinase/Mixed Lineage Kinase 2
1998
Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats
2004
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
2001
The C. elegans genome sequencing project: a beginning
1992 StandoutNatureNobel
Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli
1998
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice
1999
SEK1/MKK4 Is Required for Maintenance of a Normal Peripheral Lymphoid Compartment but Not for Lymphocyte Development
1998
Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism is Associated with Restenosis after Percutaneous Transluminal Angioplasty
2001
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin
2000
Role of Ets-2 in the Regulation of Heme Oxygenase-1 by Endotoxin
2004
Osteoclast differentiation and activation
2003 StandoutNature
Dendritic cell regulation of TH1-TH2 development
2000
Glucose Deprivation Induces Heme Oxygenase-1 Gene Expression by a Pathway Independent of the Unfolded Protein Response
2002
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Heme oxygenase-1 protects against vascular constriction and proliferation
2001
Signals involved in thymocyte positive and negative selection
1999
Endoplasmic Reticulum Stress Stimulates Heme Oxygenase-1 Gene Expression in Vascular Smooth Muscle
2004
Carbon Monoxide Induces Cytoprotection in Rat Orthotopic Lung Transplantation via Anti-Inflammatory and Anti-Apoptotic Effects
2003
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
1999
Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway
2002
Th1 and Th2 cells
2001
Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells
2003 StandoutNobel
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Induction of Cellular Antioxidative Stress Genes through Heterodimeric Transcription Factor Nrf2/Small Maf by Antirheumatic Gold(I) Compounds
2001
Mammalian MAP kinase signalling cascades
2001 StandoutNature
T-cell regulation by CD28 and CTLA-4
2001
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
1999
Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts
2003
Carbon Monoxide Inhibition of Apoptosis during Ischemia-Reperfusion Lung Injury Is Dependent on the p38 Mitogen-activated Protein Kinase Pathway and Involves Caspase 3
2003
A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses
1997
Requirement for p38α in Erythropoietin Expression
2000
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
New Insights into the Control of MAP Kinase Pathways
1999
Cystathionine β‐synthase as a carbon monoxide–sensitive regulator of bile excretion†
2008
B7S1, a Novel B7 Family Member that Negatively Regulates T Cell Activation
2003
Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers
2002
Low‐light imaging technology in the life sciences
1994
Carbon monoxide in biology and medicine
2004
MAP-kinase signaling pathways in T cells
2001
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
2002 Standout
Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon‐γ‐induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV‐irradiation‐induced cell death
2002
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2
1998
Suppression of Inflammatory Cytokine Production by Carbon Monoxide Involves the JNK Pathway and AP-1
2003
Heme oxygenase-1 and carbon monoxide in pulmonary medicine
2003
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Small Interference RNA-mediated Gene Silencing of Human Biliverdin Reductase, but Not That of Heme Oxygenase-1, Attenuates Arsenite-mediated Induction of the Oxygenase and Increases Apoptosis in 293A Kidney Cells
2005
Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-κB to Protect Endothelial Cells from Tumor Necrosis Factor-α-mediated Apoptosis
2002
Carbon monoxide‐releasing molecules (CO‐RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages
2005
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
2006
JNK1 is not essential for TNF-mediated joint disease
2004
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons
1999
Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)
1997
Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription
1999
Adrenocorticotropin induces heme oxygenase-1 expression in adrenal cells
2004
Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis
2001
Jun N-Terminal Kinase in Rheumatoid Arthritis
1999
Caveolin-1 expression by means of p38β mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide
2005
Inhaled Carbon Monoxide Confers Antiinflammatory Effects against Ventilator-induced Lung Injury
2004
Carbon Monoxide Modulates Endotoxin-Induced Production of Granulocyte Macrophage Colony-Stimulating Factor in Macrophages
2002
Heme Oxygenase-1: Redox Regulation of a Stress Protein in Lung and Cell Culture Models
2004
Activation of the Mouse Heme Oxygenase-1 Gene by 15-Deoxy-Δ 12,14 -Prostaglandin J 2 Is Mediated by the Stress Response Elements and Transcription Factor Nrf2
2002
Adenovirus-Mediated Transfer and Overexpression of Heme Oxygenase 1 cDNA in Lung Prevents Bleomycin-Induced Pulmonary Fibrosis via a Fas–Fas Ligand-Independent Pathway
2002
The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes
1998
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
Heme oxygenase: colors of defense against cellular stress
2000
The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells
2001 StandoutNobel
Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis
2000
Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH2-Terminal Kinase-Specific Kinase
1997
Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury
2002
Caveolae compartmentalization of heme oxygenase‐1 in endothelial cells
2004
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH 2 -terminal kinase
1997
C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation
2001
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
2000 StandoutScience
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
2001 Standout
B7x: A widely expressed B7 family member that inhibits T cell activation
2003 StandoutNobel
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
1999
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
2002
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro
2005 StandoutNobel
Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3
2001 StandoutNobel
Cardiac-Specific Expression of Heme Oxygenase-1 Protects Against Ischemia and Reperfusion Injury in Transgenic Mice
2001
Carbon Monoxide Inhibits T Lymphocyte Proliferation via Caspase-Dependent Pathway
2004
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
2003
Absence of Heme Oxygenase-1 Exacerbates Myocardial Ischemia/Reperfusion Injury in Diabetic Mice
2005
Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain
2003
Absence of heme oxygenase‐1 exacerbates atherosclerotic lesion formation and vascular remodeling
2003
Hepatic maturation in differentiating embryonic stem cells in vitro
2001
Carbon Monoxide Protects against Liver Failure through Nitric Oxide–induced Heme Oxygenase 1
2003
Regulation of Inducible Nitric Oxide Synthase Expression in Advanced Glycation End Product–Stimulated RAW 264.7 Cells
2004 Nobel
c-Jun NH2-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1
2000
Methods for Measurements of Heme Oxygenase (HO) Isoforms-Mediated Synthesis of Carbon Monoxide and HO-1 and HO-2 Proteins
2003
Signaling by Gasotransmitters
2009
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
1999 Standout
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
2006
Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide
2004
Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus)
1996 StandoutNobel
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Carbon monoxide attenuates aeroallergen-induced inflammation in mice
2001
Disturbance of Tumor Necrosis Factor Alpha-Mediated Beta Interferon Signaling in Cervical Carcinoma Cells
2002 StandoutNobel
Heme Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout Mice
2001
The MKK7 Gene Encodes a Group of c-Jun NH2-Terminal Kinase Kinases
1999
Cardioprotective Actions by a Water-Soluble Carbon Monoxide–Releasing Molecule
2003
Bilirubin From Heme Oxygenase-1 Attenuates Vascular Endothelial Activation and Dysfunction
2004
Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF-β homologuedecapentaplegic
1997
Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation
2000
TGF-β1stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells
2002
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
2007 StandoutNobel
Complementary roles of gasotransmitters CO and H2S in sleep apnea
2017 StandoutNobel
Molecular Mechanisms RegulatinG Th1 Immune Responses
2003
B7h is required for T cell activation, differentiation, and effector function
2003
A cis -Acting Region Regulates Oxidized Lipid-Mediated Induction of the Human Heme Oxygenase-1 Gene in Endothelial Cells
2003
Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis
2004 Science
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
2006
The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury
2004
Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation
2004
Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders
2005 StandoutNobel
Large-Scale and Automated DNA Sequence Determination
1991 Science
Single dose of anti–CTLA-4 enhances CD8 + T-cell memory formation, function, and maintenance
2010 StandoutNobel
Transcriptional regulation of the HO-1 gene in cultured macrophages exposed to model airborne particulate matter
2003
MEKK1/JNK signaling stabilizes and activates p53
1998
Human Heme Oxygenase-1 Gene Transfer Lowers Blood Pressure and Promotes Growth in Spontaneously Hypertensive Rats
2001
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
2001
CORM‐A1: a new pharmacologically active carbon monoxide‐releasing molecule
2004
Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-κB and JNK
2005
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
2002
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase
2004
Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants
2001
Inhibition of c-Jun N-Terminal Kinase 2 Expression Suppresses Growth and Induces Apoptosis of Human Tumor Cells in a p53-Dependent Manner
2000
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
1998
The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins
1999
The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats
2004
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Heme Oxygenase-1 Induction in Islet Cells Results in Protection From Apoptosis and Improved In Vivo Function After Transplantation
2001
Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3
2000
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
Carbon Monoxide-Releasing Molecules
2002
Heme Oxygenase-1 Protects Pancreatic β Cells from Apoptosis Caused by Various Stimuli
2001
Works of Mark Wysk being referenced
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
2000 Standout
Molecular Basis of T-cell Differentiation
1999
Differential involvement of p38 mitogen‐activated protein kinase kinases MKK3 and MKK6 in T‐cell apoptosis
2002
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH 2 -terminal kinase activation, and defects in AP-1 transcriptional activity
1997
Imaging of DNA sequences with chemiluminescence.
1990
JNK1 Is Required for T Cell-Mediated Immunity AgainstLeishmania majorInfection
2000
Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE.
1996
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression
1999
Defective T Cell Differentiation in the Absence of Jnk1
1998 Science