Standout Papers
Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
MYC Drives Pten/Trp53 -Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2
2015
Phthalimide conjugation as a strategy for in vivo target protein degradation
2015 Science
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Acute B lymphoblastic leukaemia‐propagating cells are present at high frequency in diverse lymphoblast populations
2012
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
Non-Cell-Autonomous Tumor Suppression by p53
2013
β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells
2010
RNAi screening comes of age: improved techniques and complementary approaches
2014
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
A view on drug resistance in cancer
2019 StandoutNature
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
2017
Cancer stem cells: never Wnt away from the niche
2008
Targeting Epigenetic Readers in Cancer
2012
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
p21/CDKN1A Mediates Negative Regulation of Transcription by p53
2003
The Human Transcription Factors
2018 Standout
Regulatory Enhancer–Core-Promoter Communication via Transcription Factors and Cofactors
2016
An Optimized microRNA Backbone for Effective Single-Copy RNAi
2013
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
Protecting adolescents from harm. Findings from the National Longitudinal Study on Adolescent Health
1997 Standout
Metazoan MicroRNAs
2018 Standout
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Wnt/β-Catenin Signaling and Disease
2012 Standout
An allelic series of miR-17∼92–mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron
2015
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
2013
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy
2015
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Emerging Biological Principles of Metastasis
2017 Standout
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
2015
CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
2015
EMT: 2016
2016 Standout
BET domain co-regulators in obesity, inflammation and cancer
2012
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
2013 Standout
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
TGF-β Tumor Suppression through a Lethal EMT
2016
Clonal evolution in cancer
2012 StandoutNature
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
2012
CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo
2017 StandoutNobel
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
The PI3K Pathway in Human Disease
2017 Standout
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer
2010
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting
2013
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
2011
Transcription control by the ENL YEATS domain in acute leukaemia
2017 Nature
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing
2017 Nature
CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy
2015
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Acute Myeloid Leukemia
2015 Standout
A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
2014 Science
Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma
2014
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy
2016
SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis
2018 Science
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
2012
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
2013
Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
2013
Epigenetic plasticity: A central regulator of epithelial-to-mesenchymal transition in cancer
2014
Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia
2018 Standout
Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34− fraction
2010
The prognostic and functional role of microRNAs in acute myeloid leukemia
2010
Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers
2014
Stem cell concepts renew cancer research
2008
Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs
2015
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
MLL leukemia induction by genome editing of human CD34+ hematopoietic cells
2015
Adolescence: a foundation for future health
2012 Standout
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia
2021 StandoutNobel
Genetics and biology of pancreatic ductal adenocarcinoma
2016
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment
2011
Works of Mark Wunderlich being referenced
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia
2008
Mdm2 inhibition of p53 induces E2F1 transactivation via p21
2002
Model Systems for Examining Effects of Leukemia Associated Oncogenes in Primary Human CD34+ Cells via Retroviral Transduction
2009
Don't ask, they won't tell: the quality of adolescent health screening in five practice settings.
1996
p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death
2007
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity
2013
Aberrant overexpression and function of the miR-17-92 cluster in MLL -rearranged acute leukemia
2010