Citation Impact
Citing Papers
The monovalent cation leak in overhydrated stomatocytic red blood cells results from amino acid substitutions in the Rh-associated glycoprotein
2008
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion
2007
The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells
2009
P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1β in Mouse Macrophage
2008
P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder
2006
P2X7 nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons
2005
The P2X1 receptor and platelet function
2011
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis
2013
Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP
2005
Reading the glyco-code: New approaches to studying protein–carbohydrate interactions
2022 StandoutNobel
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
2009 Standout
Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia
2009
Possible Involvement of P2X7 Receptor Activation in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats
2008
Associations of protein 4.2 with band 3 and ankyrin
2006
New structure enlivens interest in P2X receptors
2010
Presence of diverse functional P2X receptors in rat cerebellar synaptic terminals
2005
Molecular Determinants of Potent P2X2 Antagonism Identified by Functional Analysis, Mutagenesis, and Homology Docking
2010
Contribution of the intracellular C terminal domain to regulation of human P2X1 receptors for ATP by phorbol ester and Gq coupled mGlu1α receptors
2010
Purinoceptors in microglia and neuropathic pain
2006
Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat
2010
Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation
2012
Involvement of P2 receptors in the growth and survival of neurons in the CNS
2005
P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases
2010
Sjögren's syndrome
2005 Standout
Nucleotide signalling during inflammation
2014 StandoutNature
Descending control of pain
2002 Standout
Extracellular adenosine triphosphate and adenosine in cancer
2010
Mechanism and Regulation of NLRP3 Inflammasome Activation
2016 Standout
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
2019 Standout
Decrease of current responses at human recombinant P2X3 receptors after substitution by Asp of Ser/Thr residues in protein kinase C phosphorylation sites of their ecto-domains
2005
Orthosteric and allosteric binding sites of P2X receptors
2008
P2X7Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca2+Signaling
2006
Modulation of Glycan Recognition by Clustered Saccharide Patches
2014
Purinergic Signaling in the Airways
2012
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia
2005
Hereditary stomatocytosis and cation leaky red cells — Recent developments
2009
Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells
2006
Interaction of P2 purinergic receptors with cellular macromolecules
2007
Activation and regulation of the inflammasomes
2013 Standout
Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice
2018
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors
2009
Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression
2006
Clemastine Potentiates the Human P2X7 Receptor by Sensitizing It to Lower ATP Concentrations
2011
Lipid Raft Association and Cholesterol Sensitivity of P2X1-4 Receptors for ATP
2010
Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
2015
Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons
2006
Molecular structure of purinergic P2X receptors and their expression in hypothalamus and pituitary
2008
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
2008 Standout
[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors
2008
C-terminal Calmodulin-binding Motif Differentially Controls Human and Rat P2X7 Receptor Current Facilitation
2010
P2X7 receptors in the nervous system
2006
Cellular localization of P2X7 receptor mRNA in the rat brain
2008
ATP-gated P2X cation-channels
2008
Homotrimeric complexes are the dominant assembly state of native P2X7 subunits
2008
The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
2014
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
2013 StandoutNobel
Identification of Key Residues Coordinating Functional Inhibition of P2X7 Receptors by Zinc and Copper
2007
Identification of regions of the P2X7receptor that contribute to human and rat species differences in antagonist effects
2008
Interleukin-1β and Signaling of Interleukin-1 in Vascular Wall and Circulating Cells Modulates the Extent of Neointima Formation in Mice
2006
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Kinetics of P2X7 Receptor-Operated Single Channels Currents
2006
Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder
2006
Evolutionary origins of the purinergic signalling system
2009
P2X receptors and synaptic plasticity
2008
The P2X7 Receptor in Infection and Inflammation
2017
Principles and properties of ion flow in P2X receptors
2014
Electron microscopic localisation of P2X4 receptor subunit immunoreactivity to pre- and post-synaptic neuronal elements and glial processes in the dorsal vagal complex of the rat
2004
Direct Observation of ATP-Induced Conformational Changes in Single P2X4 Receptors
2009
Developmental downregulation of P2X3 receptors in motoneurons of the compact formation of the nucleus ambiguus
2005
P2X Receptors in Health and Disease
2011
Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells
2008
Residues 155 and 348 Contribute to the Determination of P2X7 Receptor Function via Distinct Mechanisms Revealed by Single-nucleotide Polymorphisms
2011
Facilitation of P2X7 Receptor Currents and Membrane Blebbing via Constitutive and Dynamic Calmodulin Binding
2008
Up-Regulation of P2X4Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain
2008
Regions of the amino terminus of the P2X1receptor required for modification by phorbol ester and mGluR1α receptors
2008
Many ways to dilate the P2X7 receptor pore
2011
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
2009 Standout
Rapidly inducible, genetically targeted inactivation of neural and synaptic activity in vivo
2007
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
2006 Standout
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
2013 Standout
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
2010 Standout
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
2010 StandoutNature
Molecular properties of P2X receptors
2006
Neuromodulation by Extracellular ATP and P2X Receptors in the CNS
2012
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
2012 Standout
Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death
2010
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers
2011
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Properties of presynaptic P2X7-like receptors at the neuromuscular junction
2005
A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
2006
P2X4 receptors mediate PGE2 release by tissue‐resident macrophages and initiate inflammatory pain
2010
Pharmacology of P2X channels
2006
Direct Excitation of Inhibitory Interneurons by Extracellular ATP Mediated by P2Y1Receptors in the Hippocampal Slice
2004
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
P2 receptors and neuronal injury
2006
ATP induces long‐term potentiation of C‐fiber‐evoked field potentials in spinal dorsal horn: The roles of P2X4 receptors and p38 MAPK in microglia
2008
Activation and Regulation of Purinergic P2X Receptor Channels
2011
P2X7 Nucleotide Receptors Mediate Blebbing in Osteoblasts through a Pathway Involving Lysophosphatidic Acid
2006
Regulation of immune responses by extracellular vesicles
2014 Standout
The birth and postnatal development of purinergic signalling
2010
Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors
2008
Dual Presynaptic Control by ATP of Glutamate Release via Facilitatory P2X1, P2X2/3, and P2X3and Inhibitory P2Y1, P2Y2, and/or P2Y4Receptors in the Rat Hippocampus
2005
Pyroptosis: host cell death and inflammation
2009 Standout
Sterile inflammation: sensing and reacting to damage
2010 Standout
Connexins, pannexins, innexins: novel roles of “hemi-channels”
2008
Characterization of a selective and potent antagonist of human P2X7receptors, AZ11645373
2006
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
2013 Standout
P2X2 and P2X5 Subunits Define a New Heteromeric Receptor with P2X7-Like Properties
2012
C terminus of the P2X7 receptor: treasure hunting
2011
Role of sodium in mitochondrial membrane depolarization induced by P2X7 receptor activation in submandibular glands
2005
Negative and positive allosteric modulators of the P2X7receptor
2007
MCC950 closes the active conformation of NLRP3 to an inactive state
2019
Regulation of Human Recombinant P2X3Receptors by Ecto-Protein Kinase C
2005
Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
2010 StandoutNobel
P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways
2009
Characterization of a functional P2X7‐like receptor in cerebellar granule neurons from P2X7 knockout mice
2005
Cloning and pharmacological characterization of the dog P2X7 receptor
2009
Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT
2008
Purinergic signalling in the nervous system: an overview
2008
2‐Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling
2002 StandoutNobel
Sensors and regulators of intracellular pH
2009 Standout
Dissecting the Facilitator and Inhibitor Allosteric Metal Sites of the P2X4 Receptor Channel
2007
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
2010 Standout
Pathophysiology of astroglial purinergic signalling
2012
The Role of the P2X7 Receptor in Infectious Diseases
2011
P2X1and P2X4receptor currents in mouse macrophages
2007
Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in vitro ischemia
2005
Astrocyte Control of Synaptic Transmission and Neurovascular Coupling
2006
Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain
2015
Biophysics of P2X receptors
2006
P2X7 receptors: Properties and relevance to CNS function
2006
P2X Receptors as Drug Targets
2012
Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7
2009
Crystal structure of the ATP-gated P2X4 ion channel in the closed state
2009 Nature
Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor−/− mice
2004
ATP‐induced apoptotic cell death in porcine ovarian theca cells through P2X7 receptor activation
2006
Site-Specific Biomolecule Labeling with Gold Clusters
2010
Reconstruction of the P2X2 Receptor Reveals a Vase-Shaped Structure with Lateral Tunnels above the Membrane
2009
Renal Tubular Acidosis, Sjögren Syndrome, and Bone Disease
2004
Neuroprotective effects of inhibiting N-methyl-d-aspartate receptors, P2X receptors and the mitogen-activated protein kinase cascade: A quantitative analysis in organotypical hippocampal slice cultures subjected to oxygen and glucose deprivation
2005
P2 receptors: intracellular signaling
2006
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
2005
Immunogenic cell death and DAMPs in cancer therapy
2012 Standout
P2X7 receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice
2005
The Role and Regulation of Adenosine in the Central Nervous System
2001 Standout
A Novel Recombinant Plasma Membrane-targeted Luciferase Reveals a New Pathway for ATP Secretion
2005
Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition
2012
Stimulation of P2X7Receptors Elevates Ca2+and Kills Retinal Ganglion Cells
2005
The P2X 7 purinergic receptor: from physiology to neurological disorders
2009
Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis
2007
Molecular Physiology of P2X Receptors
2002 Standout
Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor
2010
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
2019 Standout
Basal Activation of the P2X7 ATP Receptor Elevates Mitochondrial Calcium and Potential, Increases Cellular ATP Levels, and Promotes Serum-independent Growth
2005
Pain regulation by non-neuronal cells and inflammation
2016 StandoutScience
Protein kinase C regulation of P2X3 receptors is unlikely to involvedirect receptor phosphorylation
2006
Immunological and Inflammatory Functions of the Interleukin-1 Family
2009 Standout
Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes
2010
Place Cells, Grid Cells, and the Brain's Spatial Representation System
2008 StandoutNobel
Molecular physiology and genetics of Na+-independent SLC4 anion exchangers
2009
Purinergic control of neuropathic pain
2006
Extracellular nucleotides: Ancient signaling molecules
2009
Neuropathic Pain: From Mechanisms to Treatment
2020 Standout
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
2019 Standout
Signaling at Purinergic P2X Receptors
2008
P2X7 receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators
2007
Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
2020 Standout
Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole–cilium interface and facilitates proper cilium formation and function
2014 StandoutNobel
Prostaglandin E2 Potentiation of P2X3 Receptor Mediated Currents in Dorsal Root Ganglion Neurons
2007
Antagonists of the P2X7Receptor. From Lead Identification to Drug Development
2009
Increased susceptibility to ATP via alteration of P2X receptor function in dystrophic mdx mouse muscle cells
2006
Interaction and interrelation of P2X7 and P2X4 receptor complexes in mouse lung epithelial cells
2010
Receptors for Purines and Pyrimidines
2012 Standout
Emerging Targets in Photopharmacology
2016 StandoutNobel
P2X Receptors and Their Roles in Astroglia in the Central and Peripheral Nervous System
2011
Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages
2007
ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages
2008
G-protein-coupled receptor regulation of P2X1 receptors does not involve direct channel phosphorylation
2004
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Purinoceptors on Neuroglia
2009
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Physiology of Microglia
2011 Standout
Immunogenic Cell Death in Cancer Therapy
2012 Standout
Atomically Precise Clusters of Noble Metals: Emerging Link between Atoms and Nanoparticles
2017 Standout
Works of Mark T. Young being referenced
Distinct Regions of Human Glycophorin A Enhance Human Red Cell Anion Exchanger (Band 3; AE1) Transport Function and Surface Trafficking
2003
Molecular Shape, Architecture, and Size of P2X4 Receptors Determined Using Fluorescence Resonance Energy Transfer and Electron Microscopy
2008
Thr339-to-Serine Substitution in Rat P2X2Receptor Second Transmembrane Domain Causes Constitutive Opening and Indicates a Gating Role for Lys308
2007
Reanalysis of P2X7Receptor Expression in Rodent Brain
2004
Tyrosine Phosphorylation of HSP90 within the P2X7 Receptor Complex Negatively Regulates P2X7 Receptors
2003
Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1β
2006
Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP
2006
Permeation Properties of a P2X Receptor in the Green Algae Ostreococcus tauri
2008
Pseudoapoptosis Induced by Brief Activation of ATP-gated P2X7 Receptors
2005
Altered Hippocampal Synaptic Potentiation in P2X4Knock-Out Mice
2006
An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum
2007 Nature
Polar Residues in the Second Transmembrane Domain of the Rat P2X2 Receptor That Affect Spontaneous Gating, Unitary Conductance, and Rectification
2009
Caveolin‐1 influences P2X7 receptor expression and localization in mouse lung alveolar epithelial cells
2007
Identification of Thr283 as a key determinant of P2X7 receptor function
2006
P2X receptors: dawn of the post-structure era
2009
Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel
2012
Role of the domain encompassing Arg304–Ile328 in rat P2X2 receptor conformation revealed by alterations in complex glycosylation at Asn298
2008
Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia
2005
Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells
2000
Red-cell glycophorin A–band 3 interactions associated with the movement of band 3 to the cell surface
2000
Red-cell glycophorin A‒band 3 interactions associated with the movement of band 3 to the cell surface
2000
Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells
2000