Citation Impact
Citing Papers
Architecture of a Fungal Fatty Acid Synthase at 5 A Resolution
2006 Science
Localizing the Membrane Binding Region of Group VIA Ca2+-independent Phospholipase A2 Using Peptide Amide Hydrogen/Deuterium Exchange Mass Spectrometry
2009
Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A2α in Regulating Interfacial Kinetics and Binding and Cellular Function
2009
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase
2003
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Serine 727 Phosphorylation and Activation of Cytosolic Phospholipase A2 by MNK1-related Protein Kinases
2000
Growth factors in development, transformation, and tumorigenesis
1991
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
A Phospholipid Substrate Molecule Residing in the Membrane Surface Mediates Opening of the Lid Region in Group IVA Cytosolic Phospholipase A2
2008
Structure–activity relationships of indole cytosolic phospholipase A 2 α inhibitors: substrate mimetics
2003
Cation–π interactions in ligand recognition and catalysis
2002
Cloning and sequence of multiple forms of phospholipase C
1988
The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
1989
Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction
1989
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
Requirement for a functional Rb-1 gene in murine development
1992 Nature
Phosphoinositide metabolism and the control of cell proliferation
1989
Phospholipase A2 structure/function, mechanism, and signaling
2008
Cloning of bovine GAP and its interaction with oncogenic ras p21
1988 Nature
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
1991 Standout
Clonally Derived Human Embryonic Stem Cell Lines Maintain Pluripotency and Proliferative Potential for Prolonged Periods of Culture
2000
Identification of Essential Residues for the Catalytic Function of 85-kDa Cytosolic Phospholipase A2
1996
Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning
1993
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
1992 Standout
Refinement of severely incomplete structures with maximum likelihood inBUSTER–TNT
2004
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Crystal structure of a Src-homology 3 (SH3) domain
1992 Nature
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Primary structure of the brain alpha-spectrin [published erratum appears in J Cell Biol 1989 Mar;108(3):following 1175]
1989
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Phospholipase C Isozymes: Structural and Functional Similarities
2007
Studies of Inositol Phospholipid-Specific Phospholipase C
1989 Science
Mechanism of Regulation of Group IVA Phospholipase A2 Activity by Ser727 Phosphorylation
2007
Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition
2008
Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs
1993
Identification of Novel Cytosolic Phospholipase A2s, Murine cPLA2δ, ϵ, and ζ, Which Form a Gene Cluster with cPLA2β
2005
Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase
2003
2003
The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
1989 StandoutNature
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
1992 Nature
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
2000 Standout
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
Functional Interaction of Calcium-/Calmodulin-dependent Protein Kinase II and Cytosolic Phospholipase A2
2001
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
1991
Roles for cytosolic phospholipase A2α as revealed by gene-targeted mice
2002
Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory Pathway
1998
Inhibiting Bacterial Fatty Acid Synthesis
2006
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Similarity between phospholipase C and the regulatory domain of protein kinase C
1989
1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase
2009
Cytosolic Phospholipase A2α Is Targeted to the p47 -PX Domain of the Assembled NADPH Oxidase via a Novel Binding Site in Its C2 Domain
2008
The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization
1989 Nobel
Self Renewal of Embryonic Stem Cells in the Absence of Feeder Cells and Exogenous Leukaemia Inhibitory Factor
1997
Phospholipase A2 Biochemistry
2008
Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s
2006
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Inherited human cPLA2α deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction
2008
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
2008
The C. elegans genome sequencing project: a beginning
1992 StandoutNatureNobel
Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I
1990 Nature
Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells
1992
Synaptotagmin I functions as a calcium regulator of release probability
2001 StandoutNatureNobel
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
2005
Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture
1991 Nature
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
2003 Standout
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling
1989
1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors
2006
Essential Ca2+-independent Role of the Group IVA Cytosolic Phospholipase A2 C2 Domain for Interfacial Activity
2003
Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
1995 StandoutNatureNobel
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
1992 StandoutNature
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
1988 StandoutNature
Oncogenes and signal transduction
1991 Standout
Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells
1999
Male–female differences in fertility and blood pressure in ACE-deficient mice
1995 StandoutNatureNobel
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Clearance and fate of leukemia‐inhibitory factor (LIF) after injection into mice
1991
Properties of the Group IV phospholipase A2 family
2006
Cloning and Characterization of Ehox, a Novel Homeobox Gene Essential for Embryonic Stem Cell Differentiation
2002
Calcium Binding Rigidifies the C2 Domain and the Intradomain Interaction of GIVA Phospholipase A2 as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
2008
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
1994 Standout
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
Ca2+ bridges the C2 membrane-binding domain of protein kinase Cα directly to phosphatidylserine
1999
Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution
2000 StandoutNobel
B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
2004 StandoutNobel
A Novel Function for the Second C2 Domain of Synaptotagmin
1996
Roles of Catalytic Domain Residues in Interfacial Binding and Activation of Group IV Cytosolic Phospholipase A2
2002
The expanding superfamily of phospholipase A2 enzymes: classification and characterization
2000 Standout
Identification of the Expressed Form of Human Cytosolic Phospholipase A2β (cPLA2β)
2006
Phospholipase A2inhibitors as potential therapeutic agents for the treatment of inflammatory diseases
2009
Directed evolution converts subtilisin E into a functional equivalent of thermitase
1999 StandoutNobel
SH3 — an abundant protein domain in search of a function
1992
Signalling, cell cycle and pluripotency in embryonic stem cells
2002
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
1991
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
1995 StandoutNatureNobel
Structural Studies of Fatty Acyl-(Acyl Carrier Protein) Thioesters Reveal a Hydrophobic Binding Cavity that Can Expand to Fit Longer Substrates
2006
Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties
2009
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
1990 Nature
Localization and function of cytosolic phospholipase A2α at the Golgi
2010
Synthesis and activity of 2-oxoamides containing long chain β-amino acids
2004
Mechanism of Group IVA Cytosolic Phospholipase A2 Activation by Phosphorylation
2003
Phospholipase A2 enzymes
2002
LIF: lots of interesting functions
1992
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
2013 StandoutNobel
Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
1989
The B7–CD28 superfamily
2002
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
Synaptic Vesicles and Exocytosis
1994
Characterization and Function in Vivo of Two Novel Phospholipases B/Lysophospholipases fromSaccharomyces cerevisiae
1999
A novel viral oncogene with structural similarity to phospholipase C
1988 Nature
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
1999
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A 2 1 1Edited by J. Karn
1998
CRYSTAL STRUCTURE OF THE SH3 DOMAIN IN HUMAN FYN; COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SH3 DOMAINS IN TYROSINE KINASES AND SPECTRIN
1993
The patatin-like lipase family in Gallus gallus
2008
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
An Animal Model for Cystic Fibrosis Made by Gene Targeting
1992 StandoutScienceNobel
Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.
1990
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Cellular Regulation of Cytosolic Group IV Phospholipase A2 by Phosphatidylinositol Bisphosphate Levels
2000
Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one Skeleton
2002
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation
1990
Presence of an SH2 Domain in the Actin-Binding Protein Tensin
1991 Science
Inhibition of Group IVA Cytosolic Phospholipase A2by Novel 2-Oxoamides in Vitro, in Cells, and in Vivo
2004
Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.
1989
In vitro differentiation of embryonic stem cells into lymphocyte precursors able to generate T and B lymphocytes in vivo.
1992
N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.
1989 Nobel
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
1990
Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.
1989
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.
1991 Nobel
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.
1992
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
1992
Calcium-independent Phospholipases in the Heart: Mediators of Cellular Signaling, Bioenergetics, and Ischemia-induced Electrophysiologic Dysfunction
2009
Developmental expression of myeloid leukemia inhibitory factor gene in preimplantation blastocysts and in extraembryonic tissue of mouse embryos.
1990
Quality Control by DNA Repair
1999 StandoutScienceNobel
Novel 2-Oxoamide Inhibitors of Human Group IVA Phospholipase A2
2002
Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
1995
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.
1990
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
1992
S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C.
1989
Characterization of a novel inhibitor of cytosolic phospholipase A2α, pyrrophenone
2002
Characterization of the 47-Kilodalton Autosomal Chronic Granulomatous Disease Protein: Tissue-Specific Expression and Transcriptional Control by Retinoic Acid
1990
Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors
1990 Science
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4
2004
The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.
1989
Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway.
1992
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
2008 StandoutNobel
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.
1990
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.
1991
Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation.
1991
THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS
2005
Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes
1991
Calcium-independent phospholipases in the heart: mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction.
2009
Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines
2001
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.
1991
Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction
2003 StandoutNobel
Location of Inhibitors Bound to Group IVA Phospholipase A2 Determined by Molecular Dynamics and Deuterium Exchange Mass Spectrometry
2009
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.
1991 StandoutNobel
Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrix.
1991
Differential Inhibition of Group IVA and Group VIA Phospholipases A2by 2-Oxoamides
2006
Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.
1990
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells.
1990
Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.
1989
Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.
1994
Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability
1989
A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity
1989
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression
2005
Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.
1990
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.
1994
Chimeric analysis of T (Brachyury) gene function
1993
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.
1990
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
1990
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
2004 StandoutScience
Phospholipase A2 inhibitors in inflammation
2001
Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity
1990
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis.
1990
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
1998
Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins.
1989
Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A2α Inhibitors
2009
Hematopoietic commitment during embryonic stem cell differentiation in culture.
1993
Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein.
1989
Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells.
1988
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner
1989
Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines
1994
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Src homology region 2 domains direct protein-protein interactions in signal transduction.
1990
Structure−Activity Relationship of 2-Oxoamide Inhibition of Group IVA Cytosolic Phospholipase A2and Group V Secreted Phospholipase A2
2007
Transformation of Chicken Embryo Fibroblast Cells by Avian Retroviruses Containing the Human Fyn Gene and Its Mutated Genes
1990
Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants
1989
Stable Association of Activated pp60src with Two Tyrosine-Phosphorylated Cellular Proteins
1989
Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins
1990 Science
Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry
2014 StandoutNobel
Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain
1989
Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.
1994
Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 c-src
1990 Science
Works of Mark Stahl being referenced
Inactivation of a Cytosolic Phospholipase A2 by Thiol-Modifying Reagents: Cysteine Residues as Potential Targets of Phospholipase A2
1994
Sequence similarity of phospholipase C with the non-catalytic region of src
1988 Nature
Crystal Structure of Human Cytosolic Phospholipase A2 Reveals a Novel Topology and Catalytic Mechanism
1999
Complete 1H, 15N and 13C assignments, secondary structure, and topology of recombinant human interleukin-6
1996
Solution structure of recombinant human interleukin-6 1 1Edited by P. E. Wright
1997
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
1988 Nature
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
2001 Nature
Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites
2000
Phospholipase C-148: Chromosomal Location and Deletion Mapping of Functional Domains
1988
Replacement of the Bacillus subtilis subtilisin structural gene with an In vitro-derived deletion mutation
1984