Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Identification of functional similarities between proteins using directed evolution
2003 StandoutNobel
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
Architecture of the Photosynthetic Oxygen-Evolving Center
2004 StandoutScience
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Visualization of the movement of single histidine kinase molecules in live Caulobacter cells
2004 StandoutNobel
Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code
2010
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
Allosteric Communication in Dihydrofolate Reductase: Signaling Network and Pathways for Closed to Occluded Transition and Back
2007
Focusing Mutations into the P. fluorescens Esterase Binding Site Increases Enantioselectivity More Effectively than Distant Mutations
2005
Single-molecule detection of efflux pump machinery in Pseudomonas aeruginosa
2003
Identification, classification, and analysis of beta‐bulges in proteins
1993
Amino Acid Residues That Influence the Binding of Manganese or Calcium to Photosystem II. 1. The Lumenal Interhelical Domains of the D1 Polypeptide
1995
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Hydrophobic interactions via mutants of Escherichia coli dihydrofolate reductase: separation of binding and catalysis
1989
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
1988 StandoutNatureNobel
Insights into Enzyme Function from Studies on Mutants of Dihydrofolate Reductase
1988 Science
Solvation, Reorganization Energy, and Biological Catalysis
1998
Intrinsic antibiotic resistance: Mechanisms, origins, challenges and solutions
2013
Mutations in Distant Residues Moderately Increase the Enantioselectivity of Pseudomonas fluorescens Esterase towards Methyl 3Bromo‐2‐methylpropanoate and Ethyl 3Phenylbutyrate
2003
Amino Acid Residues That Influence the Binding of Manganese or Calcium to Photosystem II. 2. The Carboxy-Terminal Domain of the D1 Polypeptide
1995
Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions
2010
Dynamics of the Dihydrofolate Reductase-Folate Complex: Catalytic Sites and Regions Known To Undergo Conformational Change Exhibit Diverse Dynamical Features
1995
Flavin dynamics in reduced flavodoxins
1993
Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features
1999
Amino acid residues that modulate the properties of tyrosine YZ and the manganese cluster in the water oxidizing complex of photosystem II
2001
A combinatorial approach to hybrid enzymes independent of DNA homology
1999
High resolution functional analysis of antibody-antigen interactions
1992
In situ click chemistry: probing the binding landscapes of biological molecules
2010
Tandem inverse-electron-demand hetero-/retro-Diels–Alder reactions for aromatic nitrogen heterocycle synthesis
2012
Expanding the Range of Substrate Acceptance of Enzymes: Combinatorial Active‐Site Saturation Test
2005
Fluoroquinolones: Action and Resistance
2003
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Structural consequences of mutation
1992
Towards complete cofactor arrangement in the 3.0 Å resolution structure of photosystem II
2005 StandoutNature
Enhanced protein thermostability from designed mutations that interact with α-helix dipoles
1988 Nature
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
2019
Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å
2011 StandoutNature
Constructing and Analyzing the Fitness Landscape of an Experimental Evolutionary Process
2008
Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry
2009 StandoutNobel
Antibacterial drug discovery in the resistance era
2016 StandoutNature
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
2004 StandoutNobel
Evolution of protein function by Domain swapping
2001
Engineering the third wave of biocatalysis
2012 StandoutNature
Reshaping Human Antibodies: Grafting an Antilysozyme Activity
1988 StandoutScienceNobel
Dipoles localized at helix termini of proteins stabilize charges.
1991 StandoutNobel
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Probing the Role of an Active Site Aspartic Acid in Dihydrofolate Reductase
1997
Circular permutation and receptor insertion within green fluorescent proteins
1999 StandoutNobel
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase
2016 StandoutNobel
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
Import of an incompletely folded precursor protein into isolated mitochondria requires an energized inner membrane, but no added ATP.
1987
Novel folded protein domains generated by combinatorial shuffling of polypeptide segments
2000 StandoutNobel
Solute Solvent Dynamics and Energetics in Enzyme Catalysis: The SN2 Reaction of Dehalogenase as a General Benchmark
2004 StandoutNobel
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments
1998
Synthesis and Photophysical Properties of Iridium(III) Bisterpyridine and Its Homologues: a Family of Complexes with a Long-Lived Excited State
1999 StandoutNobel
Creation of Enantioselective Biocatalysts for Organic Chemistry by In Vitro Evolution
1997
Apparent NAC Effect in Chorismate Mutase Reflects Electrostatic Transition State Stabilization
2003 StandoutNobel
Cooperative Reactivity in an Extended-Viologen-Based Cyclophane
2016 StandoutNobel
Computer Simulation of the Chemical Catalysis of DNA Polymerases: Discriminating between Alternative Nucleotide Insertion Mechanisms for T7 DNA Polymerase
2003 StandoutNobel
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template
2012 StandoutNobel
Catalytic Mechanism of Dihydrofolate Reductase Enzyme. A Combined Quantum-Mechanical/Molecular-Mechanical Characterization of Transition State Structure for the Hydride Transfer Step
1999
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
Mechanisms of Antibody Binding to a Protein
1987 Science
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
How Much Do Enzymes Really Gain by Restraining Their Reacting Fragments?
2002 StandoutNobel
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids
2006 StandoutNobel
Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex
1992 StandoutScience
Protein Dynamics in Enzymatic Catalysis: Exploration of Dihydrofolate Reductase
1999
High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis
1989 Science
The Amidinium–Carboxylate Salt Bridge as a Proton‐Coupled Interface to Electron Transfer Pathways
1997
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Ultrafast Dynamics of Flavins in Five Redox States
2008 StandoutNobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
On the conservative nature of intragenic recombination
2005 StandoutNobel
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
Catalytic Reduction of Dinitrogen to Ammonia at a Single Molybdenum Center
2003 StandoutScienceNobel
Probing the salt bridge in the dihydrofolate reductase-methotrexate complex by using the coordinate-coupled free-energy perturbation method.
1988
Combinatorial protein engineering by incremental truncation
1999
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
Enzyme millisecond conformational dynamics do not catalyze the chemical step
2009 StandoutNobel
Simulation of enzyme reactions using valence bond force fields and other hybrid quantum/classical approaches
1993 StandoutNobel
Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides
2005 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
PROTON-COUPLED ELECTRON TRANSFER
1998
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Synthesis of Proteins by Native Chemical Ligation
1994 StandoutScience
Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase
2004
In Situ Formation of an Oxygen-Evolving Catalyst in Neutral Water Containing Phosphate and Co 2+
2008 StandoutScience
Works of Mark S. Warren being referenced
A structure—function study of dihydrofolate reductase by protein engineering
1986
Towards Structure-based Drug Design: Crystal Structure of a Multisubstrate Adduct Complex of Glycinamide Ribonucleotide Transformylase at 1.96 Å Resolution
1995
Analysis of hydride transfer and cofactor fluorescence decay in mutants of dihydrofolate reductase: possible evidence for participation of enzyme molecular motions in catalysis
1991
Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis
1991
Combinatorial manipulation of three key active site residues in glycinamide ribonucleotide transformylase
1997
Construction of an altered proton donation mechanism in Escherichia coli dihydrofolate reductase
1987
Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors
1998
10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): A potent inhibitor of glycinamide ribonucleotide transformylase
1997
A second-site mutation at phenylalanine-137 that increases catalytic efficiency in the mutant aspartate-27 .fwdarw. serine Escherichia coli dihydrofolate reductase
1990
Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance
2000
Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa
1999
Nuclear magnetic resonance study of the state of protonation of inhibitors bound to mutant dihydrofolate reductase lacking the active-site carboxyl
1986
Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination Therapy
2001
Functional Role of Aspartic Acid-27 in Dihydrofolate Reductase Revealed by Mutagenesis
1986 Science
A Rapid Screen of Active Site Mutants in Glycinamide Ribonucleotide Transformylase
1996
Assembly of an active enzyme by the linkage of two protein modules
1997