Standout Papers
Citation Impact
Citing Papers
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes
1982 StandoutNobel
Plasma lipoproteins: apolipoprotein structure and function.
1984
Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)
1990
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
1997
Regulation of Glucocorticoid Receptor Expression: Evidence for Transcriptional and Posttranslational Mechanisms
1988
The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a β turn
1991
Linking cargo to vesicle formation: receptor tail interactions with coat proteins
1997
Three Different Rearrangements in a Single Intron Truncate Sterol Regulatory Element Binding Protein-2 and Produce Sterol-resistant Phenotype in Three Cell Lines
1995 Nobel
Structure of the Human Gene Encoding Sterol Regulatory Element Binding Protein 2 (SREBF2)
1997
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
1997 StandoutNobel
Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses
1994
Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis
1990
Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.
1994 Nobel
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
1995 StandoutNatureNobel
Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons
1994 Standout
Somatic cell genetic and biochemical characterization of cell lines resulting from human genomic DNA transfections of Chinese hamster ovary cell mutants defective in sterol-dependent activation of sterol synthesis and LDL receptor expression
1994
Molecular Cloning and Functional Analysis of the Promoter of the Human Squalene Synthase Gene
1995
Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.
1994
SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.
1996
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
1996
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
Genetic Analysis of Mint/X11 Proteins: Essential Presynaptic Functions of a Neuronal Adaptor Protein Family
2006 StandoutNobel
Somatic cell genetic analysis of two classes of CHO cell mutants expressing opposite phenotypes in sterol-depedent regulation of cholesterol metabolism
1994
Saturation of the Endocytic Pathway for the Transferrin Receptor Does Not Affect the Endocytosis of the Epidermal Growth Factor Receptor
1997 StandoutNobel
The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation
1991
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Oncogenes and signal transduction
1991 Standout
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
1994 Nobel
Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter
1996
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13
1995 Nobel
C1 Inhibitor-C 1 ¯ s
1997
Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction
2000
Synergistic Binding of Sterol Regulatory Element-binding Protein and NF-Y to the Farnesyl Diphosphate Synthase Promoter Is Critical for Sterol-regulated Expression of the Gene
1996
Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs
1998 StandoutNobel
Identification of Residues in α-Macroglobulins Important for Binding to the α2-Macroglobulin Receptor/Low Density Lipoprotein Receptor-related Protein
1996
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
1994 Standout
The YXXL Motif, but Not the Two NPXY Motifs, Serves as the Dominant Endocytosis Signal for Low Density Lipoprotein Receptor-related Protein
2000
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling
1994
Regulation of the Ligand Binding Activity of the Human Very Low Density Lipoprotein Receptor by Protein Kinase C-dependent Phosphorylation
2001
Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein
1996 Nobel
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection
1995 Nobel
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.
1982
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.
1994 StandoutNobel
Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites.
1981
The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
1985 StandoutScienceNobel
Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver.
1981 StandoutNobel
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
1992 StandoutNature
Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking.
1991
Characterization of the major apolipoproteins secreted by two human hepatoma cell lines
1981
Genetic Models of Human Vascular Disease
1995 StandoutNobel
Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.
1982 StandoutNobel
The basolateral targeting signal in the cytoplasmic domain of glycoprotein G from vesicular stomatitis virus resembles a variety of intracellular targeting motifs related by primary sequence but having diverse targeting activities.
1994
Serpin Structure, Mechanism, and Function
2002 Standout
An appraisal of the application of recombinant DNA techniques to chromosome defects
1985
Lipoprotein receptors and cholesterol homeostasis
1983
Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail.
1991
Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).
1994 Nobel
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.
1996
Loss of Transcriptional Activation of Three Sterol-Regulated Genes in Mutant Hamster Cells
1993
Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
1992
Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.
1996
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.
1986 StandoutNobel
Expression of the VLDL Receptor in Endothelial Cells
1996
The metabolism of very low density and intermediate density lipoproteins in patients with familial hypercholesterolaemia
1982
Regulation of Plasma Cholesterol by Lipoprotein Receptors
1981 StandoutScienceNobel
Apoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells.
1982
HLH106, a Drosophila transcription factor with similarity to the vertebrate sterol responsive element binding protein.
1996
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals
1996
A Receptor-Mediated Pathway for Cholesterol Homeostasis
1986 StandoutScienceNobel
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.
1988
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
1993 Nobel
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. II. Isolation of the gene and characterization of the 5' flanking region.
1986 Nobel
Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.
1982 StandoutNobel
Endocytosis and the recycling of plasma membrane.
1983 StandoutNobel
Isolation and characterization of the apolipoprotein E receptor from canine and human liver.
1986
Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.
1994
Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
1985 StandoutScienceNobel
Overexpression of Low Density Lipoprotein (LDL) Receptor Eliminates LDL from Plasma in Transgenic Mice
1988 ScienceNobel
Autoradiographic localization of the sites of uptake, cellular transport, and catabolism of low density lipoproteins in the liver of normal and estrogen-treated rats
1981
Receptor-mediated endocytosis of urokinase-type plasminogen activator is regulated by cAMP-dependent protein kinase
1997
Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.
1990
Antibody against low density lipoprotein receptor blocks uptake of low density lipoprotein (but not high density lipoprotein) by the adrenal gland of the mouse in vivo.
1981 StandoutNobel
Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.
1996
Purification and characterization of the mammalian .beta.2-adrenergic receptor
1983
Deletion in Cysteine-Rich Region of LDL Receptor Impedes Transport to Cell Surface in WHHL Rabbit
1986 ScienceNobel
The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments
2000 StandoutNobel
42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter
1987 StandoutNobel
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.
1981
Atherogenic Hyperlipoproteinemia: The Cellular and Molecular Biology of Plasma Lipoproteins Altered by Dietary Fat and Cholesterol
1982
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
1988 StandoutScience
Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.
1993
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.
1989 StandoutNobel
Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.
1983 StandoutNobel
Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia.
1986
Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.
1981
The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.
1983
Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
1981 StandoutNobel
An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface.
1995
Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia
1982 StandoutNobel
Molecular Bases for the Recognition of Tyrosine-based Sorting Signals
1999
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane coated vesicles.
1991
The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
1984 StandoutNobel
Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies.
1982 StandoutNobel
In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.
1994
The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.
1992
Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains
1985 StandoutScienceNobel
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
1993 Nobel
The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling
1985
Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.
1983
Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone.
1986
Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor
1984 StandoutNobel
Evidence for a second alpha 2-macroglobulin receptor.
1994
Molecular cloning of pancreatic group I phospholipase A2 receptor.
1994
Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.
1987 StandoutNobel
Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines
1996 Nobel
The LDL Receptor and HMG-CoA Reductase — Two Membrane Molecules That Regulate Cholesterol Homeostasis
1985 StandoutNobel
Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.
1981
Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.
1981 StandoutNobel
Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain.
1990
Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension.
1995 StandoutNobel
YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.
1993
Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.
1981 StandoutNobel
Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
1981 StandoutNobel
Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains.
1990
Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type repeats
1993
Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts.
1983 StandoutNobel
Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.
1990
Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia
1984 StandoutNobel
Rates of low density lipoprotein uptake and cholesterol synthesis are regulated independently in the liver.
1985
Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor.
1991
Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol
1984 StandoutNobel
Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia.
1982
Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.
1996
Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
1985 StandoutNobel
The tyrosine-containing internalization motif in the cytoplasmic domain of TGN38/41 lies within a nascent helix.
1994
Works of Mark S. Brown being referenced
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.
1993 Nobel
Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.
1990
Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver.
1990 Nobel
The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.
1980
NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.
1990
Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease.
1984
Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1991 Nobel
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence
1993 Nobel
cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.
1983 StandoutNobel
Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex.
1980