Standout Papers
Citation Impact
Citing Papers
Crystal Structure of a Lipid G Protein–Coupled Receptor
2012 Science
Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-Dependent Wasting Disease and Intestinal Inflammation in Gimap5-Deficient Mice
2010 StandoutNobel
Developmental and pathological lymphangiogenesis: from models to human disease
2008
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
2005
New insights into T cell biology and T cell‐directed therapy for autoimmunity, inflammation, and immunosuppression
2010
The Discovery of Enfumafungin, a Novel Antifungal Compound Produced by an Endophytic Hormonema Species Biological Activity and Taxonomy of the Producing Organisms
2000
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis
2010 Standout
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
2009 StandoutNobel
A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
2010 Standout
Artificial lymph nodes induce potent secondary immune responses in naive and immunodeficient mice
2007
Gi-Coupled GPCR Signaling Controls the Formation and Organization of Human Pluripotent Colonies
2009 StandoutNobel
Finding a way out: lymphocyte egress from lymphoid organs
2007
Homing and cellular traffic in lymph nodes
2003
Pathogenesis and therapy of psoriasis
2007 StandoutNature
The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR
2009
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
2002
G protein-independent cell-based assays for drug discovery on seven-transmembrane receptors
2008
The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
2002
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
2007
Systematic identification of regulatory proteins critical for T-cell activation
2003
Lymphangiogenesis: Molecular Mechanisms and Future Promise
2010 Standout
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
2004 StandoutNature
FTY720 modulates human oligodendrocyte progenitor process extension and survival
2007
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4
2005 StandoutNobel
Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors
2010
Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice
2004
The Role of Sphingosine 1‐Phosphate Receptors in the Trafficking of Hematopoietic Progenitor Cells
2005
Immunosurveillance by Hematopoietic Progenitor Cells Trafficking through Blood, Lymph, and Peripheral Tissues
2007
A Self‐Sufficient Peroxide‐Driven Hydroxylation Biocatalyst
2003 StandoutNobel
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
2017 Standout
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
2002
Regulation of lymphocyte development by Notch signaling
2007 StandoutNobel
The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors
2007
Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
2008 Nature
Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo
2018
Multiple sclerosis
2008 Standout
Lymphangiogenesis in development and human disease
2005 StandoutNature
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
2012
Microbial natural products as a source of antifungals
2003
Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
2005
Natural products to drugs: natural product-derived compounds in clinical trials
2008 Standout
T cell–directed therapies: lessons learned and future prospects
2006
FTY720: Sphingosine 1-Phosphate Receptor-1 in the Control of Lymphocyte Egress and Endothelial Barrier Function
2004
Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases
2003
Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment
2003
Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
2012
Echinocandin antifungal drugs
2003 Standout
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
2009
FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
2009
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
2004
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
2010 StandoutNobel
Chemokine regulation of naıve T cell traffic in health and disease
2003
Type 1 diabetes
2013 Standout
Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study
2003
Teaching old receptors new tricks: biasing seven-transmembrane receptors
2010 StandoutNobel
Ulcerative colitis
2016 Standout
Membrane lipids: where they are and how they behave
2008 Standout
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
2010
Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism
2006
Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis
2006
Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology
2007
Death-defying immunity: do apoptotic cells influence antigen processing and presentation?
2004
N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
2012 StandoutNobel
Endothelial Functions of Sphingosine-1-phosphate
2010
Basic and Therapeutic Aspects of Angiogenesis
2011 Standout
Imaging the choreography of lymphocyte trafficking and the immune response
2006
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
2009
Natural products to drugs: natural product derived compounds in clinical trials
2005
Lymphoid organ development and cell migration
2003
Infection in Solid-Organ Transplant Recipients
2007 Standout
Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases
2020 StandoutNobel
Immunosuppressive Drugs for Kidney Transplantation
2004 Standout
What's in the Pipeline? New Immunosuppressive Drugs in Transplantation
2002
Sphingosine-1-phosphate: an enigmatic signalling lipid
2003 Standout
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate
2004
Development and Maintenance of Regulatory T cells
2013 StandoutNobel
Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis
2016
Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis
2007
Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
2007
Oxidative biotransformations using oxygenases
2002
The Many Roles of Chemokines and Chemokine Receptors in Inflammation
2006 Standout
Iron-Catalyzed Reactions in Organic Synthesis
2004 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
Kruppel-Like Factor 2 Controls T Cell Trafficking by Activating L-Selectin (CD62L) and Sphingosine-1-Phosphate Receptor 1 Transcription
2007
Development of Monocytes, Macrophages, and Dendritic Cells
2010 StandoutScience
Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist
2003
Antifungal Activities of Antineoplastic Agents:Saccharomyces cerevisiaeas a Model System To Study Drug Action
1999
Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues
2005
Oral fingolimod (FTY720) in multiple sclerosis
2009
Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation
2019 StandoutNobel
Advances in Transition Metal (Pd,Ni,Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners
2011 Standout
Strength of TCR–Peptide/MHC Interactions and In Vivo T Cell Responses
2011 StandoutNobel
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Iron-Catalyzed Cross-Coupling Reactions. A Scalable Synthesis of the Immunosuppressive Agent FTY720
2004
Cutting Edge: Priming of NK Cells by IL-18
2008 StandoutNobel
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Emerging novel antifungal agents
2000
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling
2005
CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS
2004
Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase
2002
Multiphoton Absorbing Materials: Molecular Designs, Characterizations, and Applications
2008 Standout
In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination
2004 StandoutNobel
Activation‐regulated expression and chemotactic function of sphingosine 1‐phosphate receptors in mouse splenic T cells
2002
The Sphingosine 1-Phosphate Receptor Agonist FTY720 Differentially Affects the Sequestration of CD4+/CD25+ T-Regulatory Cells and Enhances Their Functional Activity
2005
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis
2007
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
2002
A novel modifier of regulatory T cells
2009 StandoutNobel
Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator
2013
CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium
2004
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors
2006
Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate
2002
Works of Mark Rosenbach being referenced
Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720
2004
Inhibition of Fungal Sphingolipid Biosynthesis by Rustmicin, Galbonolide B and Their New 21-Hydroxy Analogs.
1998
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720
2004
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists
2004
Khafrefungin, a Novel Inhibitor of Sphingolipid Synthesis
1997
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720
2004
Rustmicin, a Potent Antifungal Agent, Inhibits Sphingolipid Synthesis at Inositol Phosphoceramide Synthase
1998
Antimicrobial activity of ergokonin A from Trichoderma longibrachiatum
2001
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
2002 StandoutScience
Microbial hydroxylation of rustmicin (galbonolide A) and galbonolide B, two antifungal products produced by Micromonospora sp.
2001