Citation Impact
Citing Papers
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
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Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
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Trained immunity: A program of innate immune memory in health and disease
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The microbiota regulates type 2 immunity through RORγt + T cells
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An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
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Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
2003 StandoutScience
Effective expansion of alloantigen-specific Foxp3 + CD25 + CD4 + regulatory T cells by dendritic cells during the mixed leukocyte reaction
2006 StandoutNobel
Oligodeoxynucleotides Containing Palindrome Sequences with Internal 5′-CpG-3′ Act Directly on Human NK and Activated T Cells to Induce IFN-γ Production In Vitro
1999
Immunostimulatory CpG-Oligodeoxynucleotides Cause Extramedullary Murine Hemopoiesis
1999
Oligodeoxynucleotides containing palindrome sequences with internal 5'-CpG-3' act directly on human NK and activated T cells to induce IFN-gamma production in vitro.
1999
The Influence of Lipofectin on the In Vitro Stimulation of Murine Spleen Cells by Bacterial DNA and Plasmid DNA Vectors
1999
CpG ODN-mediated regulation of IL-12 p40 transcription
2000
CpG Motifs in Bacterial DNA Activate Leukocytes Through the pH-Dependent Generation of Reactive Oxygen Species
1998
Bacterial DNA Containing CpG Motifs Stimulates Lymphocyte-Dependent Protection of Mice Against Lethal Infection with Intracellular Bacteria
1999
Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection
2014
IRF-7 is the master regulator of type-I interferon-dependent immune responses
2005 StandoutNature
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Whole blood cultures to assess the immunostimulatory activities of CpG oligodeoxynucleotides
2001
Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis
1999
Modulating gene expression using DNA vaccines with different 3′-UTRs influences antibody titer, seroconversion and cytokine profiles
2003
Strategies to overcome immune ignorance and tolerance
2002
Immune responses after immunization with plasmid DNA encoding Bet v 1, the major allergen of birch pollen
1999
mRNA Is an Endogenous Ligand for Toll-like Receptor 3
2004 StandoutNobel
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
2015 StandoutNature
Immunotherapeutic uses of CpG oligodeoxynucleotides
2004
Toll-like receptor 9–induced type I IFN protects mice from experimental colitis
2005
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Toll-like Receptors and Innate Immunity
2001
Gene gun DNA vaccination with Rev-independent synthetic HIV-1 gp160 envelope gene using mammalian codons
1999
Immune responses to gene therapy vectors: influence on vector function and effector mechanisms
2004
A targeted DNA vaccine encoding Fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis
2000
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
2003 StandoutNature
Immunostimulatory bacterial DNA sequences activate dendritic cells and promote priming and differentiation of CD8+ T cells
2000
Redirecting Th2 Responses in Allergy
1999
Exacerbation of Viral and Autoimmune Animal Models for Multiple Sclerosis by Bacterial DNA
1999
Myoblasts in pattern formation and gene therapy
1993
CpG DNA rescues B cells from apoptosis by activating NFκB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway
1999
The discovery of immunostimulatory DNA sequence
2001
Response of human monocyte-derived dendritic cells to immunostimulatory DNA
2000
Bacterial DNA-Induced NK Cell IFN-γ Production Is Dependent on Macrophage Secretion of IL-12
1997
VEGF Gene Delivery to Muscle
1998
PRDM16 controls a brown fat/skeletal muscle switch
2008 StandoutNature
IL-12 in Autoimmunity
1998
CpG Oligodeoxynucleotides Enhance Monoclonal Antibody Therapy of a Murine Lymphoma
2000
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
The effects of DNA containing CpG motif on dendritic cells
2000
Allergic Rhinitis and Its Impact on Asthma
2001 Standout
Immunostimulatory properties of genomic DNA from different bacterial species
1999
The development of allergic inflammation
2008 StandoutNature
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
2001
Immunostimulatory DNA Prepriming: A Novel Approach for Prolonged Th1-Biased Immunity
1999
Direct Immunologic activities of CpG DNA and implications for gene therapy
1999
Retroviral Vector-Mediated Gene Transfer into Human Primary Myogenic Cells Leads to Expression in Muscle Fibers In Vivo
1993
Indoor allergens and asthma:Report of the Third International Workshop
1997
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic Cells In Vivo
2001
Vaccines against intracellular infections requiring cellular immunity
2000 Nature
CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract.
1997
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
1999 StandoutNature
The latex allergen Hev b 5 transcript is widely distributed after subcutaneous injection in BALB/c mice of its DNA vaccine
1998
Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesisin vitro
1999
Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides
2004
Mucin-type O-Glycosylation during Development
2013
Genetic adjuvants for DNA vaccines
2001
The role of CpG motifs in innate immunity
2000
Allergen immunotherapy: Therapeutic vaccines for allergic diseases A WHO position paper
1998 Standout
Factors controlling the turnover of T memory cells
1997
Vascular-specific growth factors and blood vessel formation
2000 StandoutNature
IFN-γ Primes Macrophage Responses to Bacterial DNA
1998
CpG‐containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
1997
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
2004
Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation?
2005
Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs
2001
CpG‐oligodeoxynucleotides enhance T‐cell receptor‐triggered interferon‐γ production and up‐regulation of CD69 via induction of antigen‐presenting cell‐derived interferon type I and interleukin‐12
2000
Bacterial CpG DNA Activates Immune Cells to Signal Infectious Danger
1999
Immunostimulatory DNA: Sequence‐dependent production of potentially harmful or useful cytokines
1997
Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus
1996
The influence of base sequence on the immunological properties of defined oligonucleotides
1998
Phagocytic antigen processing and effects of microbial products on antigen processing and T‐cell responses
1999
Pragmatic Randomized Trial Evaluating the Clinical and Economic Effectiveness of Acupuncture for Chronic Low Back Pain
2006
CpG DNA and LPS induce distinct patterns of activation in human monocytes
1999
T1 and T2 CD4+ cells in human allergic diseases
1997
CpG-oligodeoxynucleotides co-stimulate primary T cells in the absence of antigen-presenting cells
1999
CpG motifs induce Langerhans cell migration in vivo
2000
Oligodeoxynucleotides containing CpG motifs modulate the allergic TH2 response of BALB/c mice to Bet v 1, the major birch pollen allergen☆☆☆★
1999
Extracellular mRNA Induces Dendritic Cell Activation by Stimulating Tumor Necrosis Factor-α Secretion and Signaling through a Nucleotide Receptor
2002 StandoutNobel
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
2002 StandoutNature
Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor‐α‐mediated shock
1997
Immunological mechanisms of allergen-specific immunotherapy
2006
Activation of the innate immune system by CpG oligodeoxynucleotides: immunoprotective activity and safety
2000
Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA Complexes
1999
Bacterial DNA as immune cell activator
1998
Transient in vivo activation of rat brain macrophages/microglial cells and astrocytes by immunostimulatory multiple CpG oligonucleotides
2001
Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
2002
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
DNA and RNA-based vaccines: principles, progress and prospects
1999
DNA–Based Immunization for Asthma
1999
Pathogen Recognition and Innate Immunity
2006 Standout
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
2009 StandoutNature
Immune Recognition of Foreign DNA
1999
Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
1998
Synthetic Oligodeoxynucleotides Inhibit IgE Induction in Human Lymphocytes
2000
Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis
1998
Anti-Double-Stranded DNA Antibodies and Immunostimulatory Plasmid DNA in Combination Mimic the Endogenous IFN-α Inducer in Systemic Lupus Erythematosus
1999
Priming MHC-I-Restricted Cytotoxic T Lymphocyte Responses to Exogenous Hepatitis B Surface Antigen Is CD4+ T Cell Dependent
1999
Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients
2001
Cancer dormancy. VII. A regulatory role for CD8+ T cells and IFN-gamma in establishing and maintaining the tumor-dormant state.
1999
Cancer Dormancy. VII. A Regulatory Role for CD8+ T Cells and IFN-γ in Establishing and Maintaining the Tumor-Dormant State
1999
Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models.
2000
CpG Motifs inPorphyromonas gingivalisDNA Stimulate Interleukin-6 Expression in Human Gingival Fibroblasts
1999
Human Peripheral Blood Cells Differentially Recognize and Respond to Two Distinct CpG Motifs
2001
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
1999 StandoutScience
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Antimetastatic effect of CpG DNA mediated by type I IFN.
2001
Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice.
1999
Bacterial CpG-DNA Triggers Activation and Maturation of Human CD11c−, CD123+ Dendritic Cells
2001
CpG-DNA Activates In Vivo T Cell Epitope Presenting Dendritic Cells to Trigger Protective Antiviral Cytotoxic T Cell Responses
2000
Immunostimulatory DNA Sequences Influence the Course of Adjuvant Arthritis
2002
Mammalian granulocyte–macrophage colony‐stimulating factor and some CpG motifs have an effect on the immunogenicity of DNA and subunit vaccines in fish
1999
Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in Mice
2001
Immunostimulatory DNA Sequences Inhibit IL-5, Eosinophilic Inflammation, and Airway Hyperresponsiveness in Mice
1998
Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA.
1998
CpG Oligonucleotides Are Potent Adjuvants for the Activation of Autoreactive Encephalitogenic T Cells In Vivo
2000
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
2023 StandoutNobel
Vaccination with DNA Encoding an Immunodominant Myelin Basic Protein Peptide Targeted to Fc of Immunoglobulin G Suppresses Experimental Autoimmune Encephalomyelitis
1998
Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors
1999
CpG Oligodeoxynucleotides Down-Regulate Macrophage Class II MHC Antigen Processing
1999
A Targeted DNA Vaccine Augments the Natural Immune Response to Self TNF-α and Suppresses Ongoing Adjuvant Arthritis
2000
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
2004 StandoutScience
Phosphorothioate Backbone Modification Modulates Macrophage Activation by CpG DNA
2000
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Integrated NY-ESO-1 antibody and CD8+T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
2011 StandoutNobel
Safety and immunogenicity of a human and mouse gp100 DNA vaccine in a phase I trial of patients with melanoma.
2009
Cutting Edge: Rapid Induction of Mitogen-Activated Protein Kinases by Immune Stimulatory CpG DNA
1998
Divergent Therapeutic and Immunologic Effects of Oligodeoxynucleotides with Distinct CpG Motifs
2001
A Novel Function of Phosphorothioate Oligodeoxynucleotides as Chemoattractants for Primary Macrophages
2001
Nonpharmacologic Therapies for Acute and Chronic Low Back Pain: A Review of the Evidence for an American Pain Society/American College of Physicians Clinical Practice Guideline
2007 Standout
Oral Administration of Chitin Down-Regulates Serum IgE Levels and Lung Eosinophilia in the Allergic Mouse
2000
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Long-Lasting Protective Immunity to Experimental Autoimmune Encephalomyelitis Following Vaccination with Naked DNA Encoding C-C Chemokines
1998
DNA and a CpG Oligonucleotide Derived fromBabesia bovisAre Mitogenic for Bovine B Cells
1998
Lactoferrin Binds CpG-Containing Oligonucleotides and Inhibits Their Immunostimulatory Effects on Human B Cells
2001
CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.
1998
Repeated Administration of Synthetic Oligodeoxynucleotides Expressing CpG Motifs Provides Long-Term Protection against Bacterial Infection
1999
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
CpG Motifs in Bacterial DNA and Their Immune Effects
2002 Standout
Allergy and Allergic Diseases
2001
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
1998 StandoutScience
The discovery of immunostimulatory DNA sequence
2000
Extracellular DNA Required for Bacterial Biofilm Formation
2002 StandoutScience
Immunostimulatory DNA as an Adjuvant in Vaccination againstLeishmania major
1999
Successful treatment of intracranial gliomas in rat by oligodeoxynucleotides containing CpG motifs.
2000
Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy.
1994 Standout
The Basic Science of Gene Therapy
1993 Science
DNA Immunization against Herpes Simplex Virus: Enhanced Efficacy Using a Sindbis Virus-Based Vector
1998
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
1998
Bacterial DNA and Lipopolysaccharide Induce Synergistic Production of TNF-α Through a Post-Transcriptional Mechanism
2001
Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA
1998
Immunostimulatory CpG Oligodeoxynucleotides Enhance the Immune Response to Vaccine Strategies Involving Granulocyte-Macrophage Colony-Stimulating Factor
1998
Vaccination with Plasmid DNA Activates Dendritic Cells via Toll-Like Receptor 9 (TLR9) but Functions in TLR9-Deficient Mice
2003
Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance
2002 StandoutNobel
Bacterial/CpG DNA Down-Modulates Colony Stimulating Factor-1 Receptor Surface Expression on Murine Bone Marrow-Derived Macrophages with Concomitant Growth Arrest and Factor-Independent Survival
1999
CpG DNA Induces Sustained IL-12 Expression In Vivo and Resistance to Listeria monocytogenes Challenge
1998
Meta-Analysis: Acupuncture for Low Back Pain
2005
Bacterial DNA or Oligonucleotides Containing Unmethylated CpG Motifs Can Minimize Lipopolysaccharide-Induced Inflammation in the Lower Respiratory Tract Through an IL-12-Dependent Pathway
1999
A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells
2003
Enhancement of Innate Immunity againstMycobacterium aviumInfection by Immunostimulatory DNA Is Mediated by Indoleamine 2,3-Dioxygenase
2001
The Roles of MHC Class II, CD40, and B7 Costimulation in CTL Induction by Plasmid DNA
2001
DNA vaccines
1999
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus.
1999
Enhanced Dendritic Cell Maturation by TNF-α or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo
2000
CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens
2001
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
1999
Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8 + T cells
2010 StandoutNobel
Regulation of Hepatitis B Virus mRNA Expression in a Hepatitis B Surface Antigen Transgenic Mouse Model by IFN-γ-Secreting T Cells After DNA-Based Immunization
1998
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
1996 StandoutScience
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Evidence for Developmentally Programmed Transdifferentiation in Mouse Esophageal Muscle
1995 StandoutScienceNobel
Presence of CpG DNA and the Local Cytokine Milieu Determine the Efficacy of Suppressive DNA Vaccination in Experimental Autoimmune Encephalomyelitis
1999
Delivery of human factor IX in mice by encapsulated recombinant myoblasts: a novel approach towards allogeneic gene therapy of hemophilia B
1996
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
Regulation of gene expression in mouse macrophages stimulated with bacterial CpG-DNA and lipopolysaccharide
2002
Type I Interferon-mediated Stimulation of T Cells by CpG DNA
1998
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
1998
DNA Vaccination: Transfection and Activation of Dendritic Cells as Key Events for Immunity
1999
CpG Oligodeoxynucleotides with Hepatitis B Surface Antigen (HBsAg) for Vaccination in HBsAg-Transgenic Mice
2001
Noncytopathic Sindbis virus RNA vectors for heterologous gene expression
1998 StandoutNobel
Sterically Stabilized Cationic Liposomes Improve the Uptake and Immunostimulatory Activity of CpG Oligonucleotides
2001
From Allergen Genes to Allergy Vaccines
2010
CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity
1997
Cyclosporin A Enhances IL-12 Production by CpG Motifs in Bacterial DNA and Synthetic Oligodeoxynucleotides
1998
Immunostimulatory oligodeoxynucleotide induces TH1 immune response and inhibition of IgE antibody production to cedar pollen allergens in mice☆☆☆★
1999
Lipid-DNA Complexes Induce Potent Activation of Innate Immune Responses and Antitumor Activity When Administered Intravenously
1999
CpG Oligonucleotides Can Prophylactically Immunize Against Th2-Mediated Schistosome Egg-Induced Pathology by an IL-12-Independent Mechanism
2000
Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization.
1998
Effects of Bacterial DNA on Cytokine Production by (NZB/NZW)F1 Mice
1998
Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo
2000
Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms
1999
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
CpG-DNA-Mediated Transient Lymphadenopathy Is Associated with a State of Th1 Predisposition to Antigen-Driven Responses
2000
Works of Mark Roman being referenced
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
1997
Longer term clinical and economic benefits of offering acupuncture to patients with chronic low back pain assessed as suitable for primary care management
1999
Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle
1992
Gene vaccination: plasmid DNA is more than just a blueprint
1998
Inhibition of IgE Antibody Formation by Plasmid DNA Immunization Is Mediated by both CD4+ and CD8+ T Cells
1997
Systemic Administration of Immunostimulatory DNA Sequences Mediates Reversible Inhibition of Th2 Responses in a Mouse Model of Asthma
2001
Inhibition of IgE formation and allergic inflammation by allergen gene immunization
1998
Randomised controlled trial of a short course of traditional acupuncture compared with usual care for persistent non-specific low back pain
2006
Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment
2002
Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo.
1992
Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization
1996 Science
Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.
1996
Longer term clinical and economic benefits of offering acupuncture care to patients with chronic low back pain
2005