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Citing Papers
Small GTP-Binding Proteins
1992
PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
1990
NALPs: a novel protein family involved in inflammation
2003
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
1994
An Olfactory Sensory Map in the Fly Brain
2000 StandoutNobel
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes
1988 StandoutNature
Commentary Signal transduction by the receptors for platelet-derived growth factor
1990
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
PDGF induction of tyrosine phosphorylation of GTPase activating protein
1989 Nature
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
1994
The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product
1988 Nature
The drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure
1994
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
1993 Nature
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.
1992
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
1992
Mammalian Ras interacts directly with the serine/threonine kinase raf
1993 Standout
Ras - a versatile cellular switch
1998
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
1991
Regulators and Effectors of ras Proteins
1991
The Hallmarks of Cancer
2000 Standout
Molecular Events Mediating T Cell Activation
1990
Activation of the MAP kinase pathway by the protein kinase raf
1992
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Identification of effector-activating residues of Gsα
1992
Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells
1987
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Suppression of c-ras transformation by GTPase-activating protein
1990 Nature
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
Raf functions downstream of Rasl in the Sevenless signal transduction pathway
1992 Nature
let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein
1990
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
1994 Standout
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
The potential of nucleic acid repair in functional genomics
2001
Cooperation between oncogenes
1991
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
A ras-related gene with transformation suppressor activity
1989
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
1993 Nature
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
1992 Standout
Regulation of Phosphoinositide-specific Phospholipase C Isozymes
1997
Raf-1: A kinase currently without a cause but not lacking in effects
1991
Oncogenes and signal transduction
1991 Standout
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
1998 StandoutNatureNobel
Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF
1993
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
2004 StandoutNature
Molecular themes in oncogenesis
1991 StandoutNobel
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
1990 Nature
Inositol trisphosphate and calcium signalling
1993 StandoutNature
The mos proto‐oncogene product: Its role in oocyte maturation, metaphase arrest, and neoplastic transformation
1992
Raf-1 protein kinase is required for growth of induced NIH/3T3 cells
1991 Nature
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs
1994 StandoutNatureNobel
Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1
1991
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
1990 Nature
Human colony stimulating factor-1 receptor activates the C-raf-1 proto-oncogene kinase
1990
Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs
1991 StandoutNatureNobel
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
Cellular ras activity and phospholipid metabolism
1988
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21
1988 Science
Differential regulation of the p72-74 RAF-1 kinase in 3T3 fibroblasts expressing ras or src oncogenes.
1991
Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases
1992
Small GTP-Binding Proteins
2001 Standout
Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.
1990
Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP.
1991
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
1994
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
1990
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation
2003
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.
1992
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.
1993
Characterization of murine A-raf, a new oncogene related to the v-raf oncogene.
1986
Functional inactivation of genes by dominant negative mutations
1987 Nature
Characterization of Murine A-raf, a New Oncogene Related to the v-raf Oncogene
1986
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Carbon−Carbon Bond Forming Reactions Mediated by Silicon Lewis Acids
2003 Standout
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Function of Ras as a molecular switch in signal transduction.
1992
Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors
1992
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C.
1989
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP
1988
Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2.
1993 StandoutNobel
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.
1988
Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells
1993 ScienceNobel
p21H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C.
1989
The ras oncogene--an important regulatory element in lower eucaryotic organisms
1989
The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.
1989
Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.
1990
Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins
1986 Science
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
Biodegradation of polycyclic aromatic hydrocarbons
1992 Standout
ras-induced c-fos expression and proliferation in living rat fibroblasts involves C-kinase activation and the serum response element pathway.
1990
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.
1991
Mitogenic pathways regulated by G protein oncogenes.
1992
Induction of transformation and DNA synthesis after microinjection of raf proteins.
1990
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.
1991
Mutational analysis of a ras catalytic domain.
1986
Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila.
1993
Normal and activated ras oncogenes and their encoded products
1986
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
The Cellular Functions of Small GTP-Binding Proteins
1990 Science
Salmonella Exploits Caspase-1 to Colonize Peyer's Patches in a Murine Typhoid Model
2000
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Salmonella-Induced Caspase-2 Activation in Macrophages
2000
Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.
1991
Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence
1990
Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies.
1992
Cell cycle arrest and c-mos
1992 StandoutNatureNobel
Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.
1992
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade.
1990
Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.
1986
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Mutational activation of c-raf-1 and definition of the minimal transforming sequence.
1990
Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product.
1990
Microinjection of Transforming ras protein induces c-fos Expression
1987
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Ha-rasVal-12,Thr-59 activates S6 kinase and p34cdc2 kinase in Xenopus oocytes: evidence for c-mosxe-dependent and -independent pathways.
1990
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.
1994
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.
1989
RAS proteins can induce meiosis in xenopus oocytes
1985
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts
1990 Science
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.
1993
Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase
1993 Science
Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C.
1991
Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.
1991
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
1987
Binding of GAP to Activated PDGF Receptors
1990 Science
Microinjection of transforming ras protein induces c-fos expression.
1987
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.
1992
Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation
1985
Works of Mark R. Smith being referenced
The biodegradation of aromatic hydrocarbons by bacteria
1990
Biological actions of oncogenes
1993
PLCγ1 Src Homology Domain Induces Mitogenesis in Quiescent NIH 3T3 Fibroblasts
1996
Glass needle–mediated microinjection of macromolecules and transgenes into primary human blood stem/progenitor cells
2000
TheSalmonellainvasin SipB induces macrophage apoptosis by binding to caspase-1
1999
Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
1985 Nature
Cellular ras activity and tumor cell proliferation
1987
2,4,6-Tri-tert-butylpyrimidine (TTBP): A Cost Effective, Readily Available Alternative to the Hindered Base 2,6-Di-tert-butylpyridine and its 4-Substituted Derivatives in Glycosylation and Other Reactions
2001
Requirement for c-ras proteins during viral oncogene transformation
1986 Nature
Inhibition of Serum- and Ras-Stimulated DNA Synthesis by Antibodies to Phospholipase C
1990 Science
Structure-Function Analysis of the Shigella Virulence Factor IpaB
2001
Induction of Transformation and DNA Synthesis after Microinjection of raf Proteins
1990
Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins
1986