Mark Ozeck

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling

The 2.6 Angstrom Crystal Structure of a Human A _2A Adenosine Receptor Bound to an Antagonist

Therapeutic targets in triple negative breast cancer

Breast cancer

Clinical implications of molecular heterogeneity in triple negative breast cancer

A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma

G Protein-Coupled Receptor Allosterism and Complexing

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

Lung Cancer Biomarkers

A₁adenosine receptor agonists and their potential therapeutic applications

Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of A1-adenosine receptor

Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma

Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone (PD81,723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor11Abbreviations: CCPA, 2-chloro-N6-cyclopentyladenosine; DPCPX, 1,3-dipropyl-8-cyclopentylxanthine; CPA, N6-cyclopentyladenosine, R-PIA, N6-[-(R)-1-methyl-2-phenylethyl]adenosine; NECA, 5′-(N-ethyl)-carboxamidoadenosine; N-0840, N6-cyclopentyl-9-methyladenine; theophylline, 1,3-dimethylxanthine; PD81,723, (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone; BCA, bicinchoninic acid; BCS, bovine calf serum; cAMP, adenosine 3′,5′-cyclic monophosphate; DMEM, Dulbecco’s modified Eagle’s medium; CHO, Chinese hamster ovary; and wt, wild-type.

Lipolysis and lipid mobilization in human adipose tissue

Cell cycle proteins as promising targets in cancer therapy

Allosteric Modulation of the Adenosine Family of Receptors

The biology and management of non-small cell lung cancer

[3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors

The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis

Molecular action of methotrexate in inflammatory diseases.

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Adenosine Promotes Wound Healing and Mediates Angiogenesis in Response to Tissue Injury Via Occupancy of A2A Receptors

Adenosine receptors as therapeutic targets

Understanding and targeting resistance mechanisms in NSCLC

Identification of an Allosteric Binding Site for Zn2+on the β2 Adrenergic Receptor

Allosteric Modulation of Family C G-Protein-Coupled Receptors: from Molecular Insights to Therapeutic Perspectives

Diagnostic procedures for non-small-cell lung cancer (NSCLC): recommendations of the European Expert Group

Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO‐dependent mechanism

Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2

Cell Biology of Ischemia/Reperfusion Injury

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

2-Phenylimidazo[2,1-i]purin-5-ones Structure–Activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

Caffeinated and decaffeinated coffee and tea intakes and risk of colorectal cancer in a large prospective study

Agonist Actions of “β-Blockers” Provide Evidence for Two Agonist Activation Sites or Conformations of the Human β1-Adrenoceptor

Allosteric Modulation of β2-Adrenergic Receptor by Zn2+

Lung cancer: current therapies and new targeted treatments

GTP differentially affects antagonist radioligand binding to adenosine A1 and A2A receptors in human brain

The hypoxic tumor microenvironment: A driving force for breast cancer progression

Nanoparticles functionalised with reversible molecular and supramolecular switches

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

The inflammatory response in myocardial infarction

Pyroptosis: mechanisms and diseases

Targeting apoptosis in cancer therapy

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

Autologous platelets as a source of proteins for healing and tissue regeneration

Physiology and Pathophysiology of Purinergic Neurotransmission

Allosteric modulation, thermodynamics and binding to wild‐type and mutant (T277A) adenosine A₁receptors of LUF5831, a novel nonadenosine‐like agonist

Tumor-promoting functions of adenosine

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

CD39 and CD73 in immunity and inflammation

Structure of a β1-adrenergic G-protein-coupled receptor

A “locked-on,” constitutively active mutant of the adenosine A1 receptor

Molecular alterations in triple-negative breast cancer—the road to new treatment strategies

Improving Potency, Selectivity, and Water Solubility of Adenosine A₁ Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3‐cd]purinediones

Nanoparticle and targeted systems for cancer therapy

Oncogene addiction in non-small cell lung cancer: Focus on ROS1 inhibition

Purinergic regulation of vascular tone and remodelling

Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

Activation of G Protein–Coupled Receptors

Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells

Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue — Interactions with insulin

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

Targeting Tumor Angiogenesis with Gene Therapy

Immunogenic cell death and DAMPs in cancer therapy

Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma

Mechanisms of Insulin Action and Insulin Resistance

Differential Expression of Adenosine Receptors in Human Endothelial Cells

Myocardial Fatty Acid Metabolism in Health and Disease

The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs

Structure−Activity Relationships at Human and Rat A_2B Adenosine Receptors of Xanthine Derivatives Substituted at the 1-, 3-, 7-, and 8-Positions

Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[N-(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A₁Adenosine Receptor

Hybrid Ortho/Allosteric Ligands for the Adenosine A₁Receptor

Purinergic Signaling and Vascular Cell Proliferation and Death

Molecular Docking and Structure-Based Drug Design Strategies

Chromone: A Valid Scaffold in Medicinal Chemistry

Methylxanthines and Human Health: Epidemiological and Experimental Evidence

Breast Cancer Treatment

Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo

Small Cell Lung Cancer: Will Recent Progress Lead to Improved Outcomes?

Allosteric Modulators of the Adenosine A₁Receptor: Synthesis and Pharmacological Evaluation of 4-Substituted 2-Amino-3-benzoylthiophenes

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

Small molecule modulation of Smoothened activity

Adenosine A1 Receptor-Dependent and -Independent Effects of the Allosteric Enhancer PD 81,723

Fractalkine, a CX3C Chemokine, as a Mediator of Ocular Angiogenesis

Hypoxia Modulates Adenosine Receptors in Human Endothelial and Smooth Muscle Cells Toward an A _2B Angiogenic Phenotype

Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells

Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists

Mechanisms of Diabetic Complications

Sudden cardiac death: the lost fatty acid hypothesis

Receptors for Purines and Pyrimidines

International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors

A_2BReceptors Mediate Antimitogenesis in Vascular Smooth Muscle Cells

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

The A2b adenosine receptor protects against vascular injury

The Continuing Challenges of Leprosy

Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy

Complement Gene Expression by Rabbit Heart

Adenosine Receptor Activation Induces Vascular Endothelial Growth Factor in Human Retinal Endothelial Cells

An Integrated Genomic Approach to Identify Predictive Biomarkers of Response to the Aurora Kinase Inhibitor PF-03814735

Biomarker and Pharmacologic Evaluation of the γ-Secretase Inhibitor PF-03084014 in Breast Cancer Models

PEST Domain Mutations in Notch Receptors Comprise an Oncogenic Driver Segment in Triple-Negative Breast Cancer Sensitive to a γ-Secretase Inhibitor

HIP1–ALK, A Novel ALK Fusion Variant that Responds to Crizotinib

N-[3-(R)-Tetrahydrofuranyl]-6-aminopurine Riboside, an A1 Adenosine Receptor Agonist, Antagonizes Catecholamine-Induced Lipolysis without Cardiovascular Effects in Awake Rats

A Single-Tube Multiplexed Assay for Detecting ALK, ROS1, and RET Fusions in Lung Cancer

Tonic activity of the rat adipocyte A₁‐adenosine receptor

Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways

Agonist-Independent Effect of an Allosteric Enhancer of the A1 Adenosine Receptor in CHO Cells Stably Expressing the Recombinant Human A1 Receptor

Inverse Agonists and Neutral Antagonists of Recombinant Human A1 Adenosine Receptors Stably Expressed in Chinese Hamster Ovary Cells

LU 51198, a Highly Sulfated, Low-Molecular-Weight Heparin Derivative, Prevents Complement-Mediated Myocardial Injury in the Perfused Rabbit Heart