Citation Impact
Citing Papers
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
Metagenomic Analysis of the Human Distal Gut Microbiome
2006 StandoutScience
Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action
2019 StandoutNobel
SCHEMA Recombination of a Fungal Cellulase Uncovers a Single Mutation That Contributes Markedly to Stability
2009 StandoutNobel
Mitigating risk in academic preclinical drug discovery
2015
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Mechanistic insights into glycosidase chemistry
2008
Europium Tetracycline as a Luminescent Probe for Nucleoside Phosphates and Its Application to the Determination of Kinase Activity
2007
Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidasesElectronic supplementary information (ESI) available: details of data and structure quality for complex of cel6A with 1. See http://www.rsc.org/suppdata/cc/b3/b301592k/
2003
The application of in silico drug-likeness predictions in pharmaceutical research
2015
Catalytic Three‐Component Ugi Reaction
2008 StandoutNobel
Paraneoplastic Syndromes Involving the Nervous System
2003 Standout
Structure-Based Drug Design Strategies in Medicinal Chemistry
2009
A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates
2004 StandoutNobel
Biology-inspired synthesis of compound libraries
2008
Trapping Covalent Intermediates on β-Glycosidases
2002
Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases
2007
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Stiff-Person Syndrome
2004
Engineering of a thioglycoligase: randomized mutagenesis of the acid-base residue leads to the identification of improved catalysts
2005
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Lessons from the Drug Discovery of Lapatinib, a Dual ErbB1/2 Tyrosine Kinase Inhibitor
2006
Intracellular Toll-like Receptors
2010 StandoutNobel
NALP Inflammasomes: a central role in innate immunity
2007
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
The carbohydrate-active enzymes database (CAZy) in 2013
2013 Standout
Luminescent Lanthanide Complexes as Probes for the Determination of Enzyme Activities
2008
Nanoscale synthesis and affinity ranking
2018 Nature
Pyroptosis: mechanisms and diseases
2021 Standout
Lanthanide luminescence for functional materials and bio-sciences
2009 Standout
Inhibition Profiling of Human Carbonic Anhydrase II by High-Throughput Screening of Structurally Diverse, Biologically Active Compounds
2006
Structural and sequence-based classification of glycoside hydrolases
1997 Standout
Caspase Substrates and Inhibitors
2013
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Drug discovery from medicinal plants
2005 Standout
Diversity-oriented synthesis: exploring the intersections between chemistry and biology
2005
AKT/PKB Signaling: Navigating the Network
2017 Standout
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Exploring protein fitness landscapes by directed evolution
2009 StandoutNobel
Cell signalling in the cardiovascular system: an overview
2005
Outrunning the Bear
2004
A New Sialidase Mechanism
2009
The Acid/Base Catalyst in the Exoglucanase/Xylanase from Cellulomonas fimi Is Glutamic Acid 127: Evidence from Detailed Kinetic Studies of Mutants
1994
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Snapshots along an Enzymatic Reaction Coordinate: Analysis of a Retaining β-Glycoside Hydrolase,
1998
Mutations in Synaptojanin Disrupt Synaptic Vesicle Recycling
2000 StandoutNobel
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Chemistry of Polyvalent Iodine
2008 Standout
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Stability studies of hydrazide and hydroxylamine-based glycoconjugates in aqueous solution
2008
Regulation of G Protein and Mitogen-Activated Protein Kinase Signaling by Ubiquitination
2006
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
2015 Standout
Fundamental Challenges in Mechanistic Enzymology: Progress toward Understanding the Rate Enhancements of Enzymes
2013
Lanthanide Luminescence for Biomedical Analyses and Imaging
2010 Standout
Synthesis of Glycopolymers for Microarray Applications via Ligation of Reducing Sugars to a Poly(acryloyl hydrazide) Scaffold
2010 StandoutNobel
The Role of Natural Product Chemistry in Drug Discovery
2004
Rules for Identifying Potentially Reactive or Promiscuous Compounds
2012
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
2009 Standout
Akt/PKB: one kinase, many modifications
2015
Coordinated Transcriptional Regulation of theunc-25Glutamic Acid Decarboxylase and theunc-47GABA Vesicular Transporter by theCaenorhabditis elegansUNC-30 Homeodomain Protein
1999 StandoutNobel
Implicit Solvation Models: Equilibria, Structure, Spectra, and Dynamics
1999 Standout
Dynamic Combinatorial Chemistry
2006 Standout
An Oxidative Enzyme Boosting the Enzymatic Conversion of Recalcitrant Polysaccharides
2010 StandoutScience
Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution
2005 StandoutNobel
A Specific Mechanism of Nonspecific Inhibition
2003 Standout
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
2006
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
A family of thermostable fungal cellulases created by structure-guided recombination
2009 StandoutNobel
The Essential Roles of Chemistry in High-Throughput Screening Triage
2014
DAST-Mediated Regioselective Anomeric Group Migration in Saccharides
2009
SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening
2016
Access to Oxetane-Containing psico-Nucleosides from 2-Methyleneoxetanes: A Role for Neighboring Group Participation?
2011
Organic Reactions in Aqueous Media with a Focus on Carbon−Carbon Bond Formations: A Decade Update
2005 Standout
Synthesis of 4,4-difluoroglycosides using ring-closing metathesis
2004
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
A Model Study of the Enzyme-Catalyzed Cytosine Methylation Using ab Initio Quantum Mechanical and Density Functional Theory Calculations: pKa of the Cytosine N3 in the Intermediates and Transition States of the Reaction
1998
X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the α-amylase family
1999
Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions
2017 StandoutNobel
A High-Throughput Screen for Aggregation-Based Inhibition in a Large Compound Library
2007
Increasing the Robustness and Validity of RNAi Screens
2007
Stereoselective C-Glycosylation Reactions of Ribose Derivatives: Electronic Effects of Five-Membered Ring Oxocarbenium Ions
2005
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Fragmentation of Carbohydrate Anomeric Alkoxyl Radicals: A New Synthesis of 1,1-Difluoro-1-iodo Alditols
2003
High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: Mimicry of carbohydrate substrate
2002 StandoutNobel
Trypanosoma cruzi Trans-sialidase Operates through a Covalent Sialyl−Enzyme Intermediate: Tyrosine Is the Catalytic Nucleophile
2003
Intracoronary KAI-9803 as an Adjunct to Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction
2008
TheCaenorhabditis elegansGeneunc-25Encodes Glutamic Acid Decarboxylase and Is Required for Synaptic Transmission But Not Synaptic Development
1999 StandoutNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of Mark Namchuk being referenced
c-Jun N-Terminal Kinases Mediate Reactivation of Akt and Cardiomyocyte Survival After Hypoxic Injury In Vitro and In Vivo
2005
Designing screens: how to make your hits a hit
2003
Phosphorylation of Serine Residues 3, 6, 10, and 13 Distinguishes Membrane Anchored from Soluble Glutamic Acid Decarboxylase 65 and Is Restricted to Glutamic Acid Decarboxylase 65α
1997
Syntheses of 2-deoxy-2-fluoro mono- and oligo-saccharide glycosides from glycals and evaluation as glycosidase inhibitors
1993
Mechanism of Agrobacterium .beta.-glucosidase: kinetic analysis of the role of noncovalent enzyme/substrate interactions
1995
(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R,3 S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18
2007
Substrate-induced inactivation of a crippled .beta.-glucosidase mutant: identification of the labeled amino acid and mutagenic analysis of its role
1995
The Role of Sugar Substituents in Glycoside Hydrolysis
2000
Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.
1994
Inhibitors of Protein Kinase Signaling Pathways
2004
Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors
2007