Standout Papers
Citation Impact
Citing Papers
Conserved ATPase and luciferase refolding activities between bacteria and yeast Hsp70 chaperones and modulators
1995
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
2007 StandoutScienceNobel
Chloroquine enhances human CD8 + T cell responses against soluble antigens in vivo
2005
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 + T lymphocytes are prognostic factors of human ovarian cancer
2007 StandoutNobel
Bacterial CpG-DNA activates dendritic cellsin vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins
2000
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies
2016
Multiple cycles of global unfolding of GroEL-bound cyclophilin A evidenced by NMR
1997 StandoutNobel
Inflammation and cancer
2002 StandoutNature
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL
1997 Nature
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
2010
The Origins and Consequences of Asymmetry in the Chaperonin Reaction Cycle
1995
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Successive action of Escherichia coli chaperones in vivo
1994
Active immunization against cancer with dendritic cells: The near future
2001 StandoutNobel
MHC-I–restricted presentation of HIV-1 virion antigens without viral replication
2001
The crystal structure of the asymmetric GroEL–GroES–(ADP)7 chaperonin complex
1997 Nature
The 2.4 Å crystal structure of the bacterial chaperonin GroEL complexed with ATPγS
1996
Release of both native and non-native proteins from a cis-only GroEL ternary complex
1996 Nature
Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
1993 StandoutNature
Purification of the Cytosolic Chaperonin TRiC from Bovine Testis
2003
How GroES Regulates Binding of Nonnative Protein to GroEL
1997
In vitro folding of phage P22 coat protein with amino acid substitutions that confer in vivo temperature sensitivity
1995
Chaperonin releases the substrate protein in a form with tendency to aggregate and ability to rebind to chaperonin
1995
GroEL/GroES: Structure and Function of a Two-Stroke Folding Machine
1998
Circular permutation of polypeptide chains: Implications for protein folding and stability
1995
The cell biology of antigen presentation in dendritic cells
2001
Protein Translocation
1999 StandoutNobel
The crystal structure of the GroES co-chaperonin at 2.8 Å resolution
1996 NatureNobel
The Hsp70 and Hsp60 Chaperone Machines
1998 Standout
Extracellular Proteins Needed for C. elegans Mechanosensation
1996 StandoutNobel
Binding of defined regions of a polypeptide to GroEL and its implications for chaperonin-mediated protein folding
1995
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
1990
Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila
1991 StandoutNobel
A role for the Drosophila neurogenic genes in mesoderm differentiation
1991 StandoutNobel
The formation of symmetrical GroEL‐GroES complexes in the presence of ATP
1994
Involvement of LOX-1 in Dendritic Cell-Mediated Antigen Cross-Presentation
2002
Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor
1991
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
2010 StandoutNobel
Nested cooperativity and salt dependence of the ATPase activity of the archaeal chaperonin Mm‐cpn
2003
Recombination of protein domains facilitated by co-translational folding in eukaryotes
1997 Nature
In Vivo Observation of Polypeptide Flux through the Bacterial Chaperonin System
1997
Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question
1992 StandoutNobel
DANCE, a Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-injured Arteries
1999 StandoutNobel
Location of a folding protein and shape changes in GroEL–GroES complexes imaged by cryo-electron microscopy
1994 Nature
The Crystal Structure of a GroEL/Peptide Complex
1999
The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1
1991
GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms
1994
GroEL-Mediated Protein Folding: Making the Impossible, Possible
2006
Efficiency of cross presentation of vaccinia virus-derived antigens by human dendritic cells
2001
Mechanisms and uses of hydrogen exchange
1996
Binding, encapsulation and ejection: substrate dynamics during a chaperonin-assisted folding reaction
1997
GroEL‐Mediated protein folding
1997
Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis
1993 StandoutNobel
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules
1997
NMR analysis of a 900K GroEL–GroES complex
2002 StandoutNatureNobel
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
1997 StandoutNobel
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing
2006
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin
1999
Domain rotations between open, closed and bullet-shaped forms of the thermosome, an archaeal chaperonin 1 1Edited by A. R. Fersht
2000
Fibulin-5/DANCE is essential for elastogenesis in vivo
2002 StandoutNatureNobel
Structure of the Molecular Chaperone Prefoldin
2000
Revisiting the Anfinsen cage
1996
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
The crystal structure of the bacterial chaperonln GroEL at 2.8 Å
1994 Nature
Molecular chaperones in cellular protein folding
1996 StandoutNature
Chaperones get in touch: the Hip-Hop connection
1997
Spinning molecular immunology into successful immunotherapy
2002
Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT
1998
Structural Adaptations in the Specialized Bacteriophage T4 Co-Chaperonin Gp31 Expand the Size of the Anfinsen Cage
1997 Nobel
Mechanism of folding chamber closure in a group II chaperonin
2010 StandoutNatureNobel
Mechanism of GroEL action: Productive release of polypeptide from a sequestered position under groes
1995
Folding of malate dehydrogenase inside the GroEL-GroES cavity.
2001
Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin
1998
How an Epidermal Growth Factor (EGF)-Like Domain Binds Calcium-High Resolution NMR Structure of the Calcium Form of the NH2-Terminal EGF-Like Domain in Coagulation Factor X
1993
A surprising simplicity to protein folding
2000 StandoutNatureNobel
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
Molecular Mechanism of Protein Folding in the Cell
2011 StandoutNobel
The Chaperonin ATPase Cycle: Mechanism of Allosteric Switching and Movements of Substrate-Binding Domains in GroEL
1996
Molecular Chaperones: Opening and closing the Anfinsen cage
1994
Characterization of the Active Intermediate of a GroEL–GroES-Mediated Protein Folding Reaction
1996
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Dual Function of Protein Confinement in Chaperonin-Assisted Protein Folding
2001
beta-Lactamase binds to GroEL in a conformation highly protected against hydrogen/deuterium exchange.
1996
An Overexpressed Gene Transcript in Senescent and Quiescent Human Fibroblasts Encoding a Novel Protein in the Epidermal Growth Factor-Like Repeat Family Stimulates DNA Synthesis
1995
Selective in vivo rescue by GroEL/ES of thermolabile folding intermediates to phage P22 structural proteins.
1994
Circular permutation and receptor insertion within green fluorescent proteins
1999 StandoutNobel
Principles of Chaperone-Assisted Protein Folding: Differences Between in Vitro and in Vivo Mechanisms
1996 Science
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25−T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo
2002 StandoutNobel
Chaperonin-facilitated protein folding: optimization of rate and yield by an iterative annealing mechanism.
1996
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 + T cells in a spectrum of human MHC I haplotypes
2007 StandoutNobel
Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.
1993 StandoutNobel
A structural model for GroEL–polypeptide recognition
1997
Structural Features of the GroEL-GroES Nano-Cage Required for Rapid Folding of Encapsulated Protein
2006
Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage ofMycobacterium tuberculosisHeat Shock Protein 70 Gene to an Antigen Gene
2001 StandoutNobel
Protein folding in the cell: competing models of chaperonin function
1996
Asymmetrical Interaction of GroEL and GroES in the ATPase Cycle of Assisted Protein Folding
1995 Science
Chaperonin Function: Folding by Forced Unfolding
1999 Science
Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria.
1994
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
2000 StandoutScienceNobel
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
2011 StandoutNobel
Compartmentation of G Protein-Coupled Signaling Pathways in Cardiac Myocytes
2001
Catalysis of Amide Proton Exchange by the Molecular Chaperones GroEL and SecB
1996 Science
Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
1992
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
2002 StandoutScience
Interplay of structure and disorder in cochaperonin mobile loops.
1996
The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.
1996
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
2006 StandoutNobel
Transforming growth factor-alpha. A model for membrane-anchored growth factors.
1990
Nucleotide-dependent protein folding in the type II chaperonin from the mesophilic archaeon Methanococcus maripaludis
2003
Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling
2012 StandoutNobel
Characterization of a Functional GroEL 14 (GroES 7 ) 2 Chaperonin Hetero-Oligomer
1994 Science
A thermodynamic coupling mechanism for GroEL-mediated unfolding.
1996
How chaperones tell wrong from right
1994
Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus
2011 StandoutNobel
Dynamics of the Chaperonin ATPase Cycle: Implications for Facilitated Protein Folding
1994 Science
Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding.
1993
Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL
1997
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING
1998
Folding of Newly Translated Proteins In Vivo: The Role of Molecular Chaperones
2001
Chaperone rings in protein folding and degradation
1999
Symmetric Complexes of GroE Chaperonins as Part of the Functional Cycle
1994 Science
The effect of macromolecular crowding on chaperonin-mediated protein folding
1997
Structure of the Heat Shock Protein Chaperonin-10 of Mycobacterium leprae
1996 Science
Conformational specificity of the chaperonin GroEL for the compact folding intermediates of alpha-lactalbumin.
1994
Antigen Presentation and T Cell Stimulation by Dendritic Cells
2002
Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin
1992 StandoutScienceNobel
Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo
2000
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
Antibody to Langerin/CD207 localizes large numbers of CD8α + dendritic cells to the marginal zone of mouse spleen
2009 StandoutNobel
slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.
1990
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.
1992
Works of Mark Mayhew being referenced
The three‐dimensional structure of the first EGF‐like module of human factor IX: Comparison with EGF and TGF‐α
1992
The structure of a Ca2+-binding epidermal growth factor-like domain: Its role in protein-protein interactions
1995
Key residues involved in calcium-binding motifs in EGF-like domains
1991 Nature
Ligand requirements for Ca2+ binding to EGF-like domains
1992
The reaction cycle of GroEL and GroES in chaperonin-assisted protein folding
1993 Nature
Characterization of a Receptor for Heat Shock Protein 70 on Macrophages and Monocytes
2000
Protein folding in the central cavity of the GroEL–GroES chaperonin complex
1996 Nature
The first EGF-like domain from human factor IX contains a high-affinity calcium binding site.
1990
Significant hydrogen exchange protection in GroEL‐bound DHFR is maintained during iterative rounds of substrate cycling
1996
The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X.
1993
Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways
1999 StandoutNobel
Conformation of GroEL-bound α-lactalbumin probed by mass spectrometry
1994 Nature
Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function.
1996