Citation Impact
Citing Papers
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
2013 StandoutScience
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
2007 StandoutScience
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
2005 StandoutNobel
Tyrosine Phosphorylation Mapping of the Epidermal Growth Factor Receptor Signaling Pathway
2002
In vivo maturation and migration of dendritic cells
2001
cbl-3: a new mammalian cbl family protein
1999
Small molecule LFA-1 antagonists compete with an anti-LFA-1 monoclonal antibody for binding to the CD11a I domain: development of a flow-cytometry-based receptor occupancy assay
2003
The F-box protein TIR1 is an auxin receptor
2005 StandoutNature
Costimulation in antiviral immunity: differential requirements for CD4+ and CD8+ T cell responses
2000
Integrin avidity regulation: are changes in affinity and conformation underemphasized?
2003
Systems Biology of Growth Factor‐Induced Receptor Endocytosis
2008
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys
2004 StandoutNature
The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation
1999
Oncogenic kinase signalling
2001 StandoutNature
Mutation of the c-Cbl TKB Domain Binding Site on the Met Receptor Tyrosine Kinase Converts It into a Transforming Protein
2001
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Tyrosine Phosphorylation of Tub and Its Association with Src Homology 2 Domain-containing Proteins Implicate Tub in Intracellular Signaling by Insulin
1999
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012 StandoutNature
Effector and memory T-cell differentiation: implications for vaccine development
2002 Standout
Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation
2003
CSF-1 signaling mediates recovery from acute kidney injury
2012
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State
2001
Monoubiquitin carries a novel internalization signal that is appended to activated receptors
2000
Macrophages: Master Regulators of Inflammation and Fibrosis
2010 Standout
The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy
2013
Tissue-resident macrophages
2013 Standout
Modulation of Protein–Protein Interactions with Small Organic Molecules
2003
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
Conversion between Three Conformational States of Integrin I Domains with a C-Terminal Pull Spring Studied with Molecular Dynamics
2004
Regulated portals of entry into the cell
2003 StandoutNature
The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor
1999
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis
2015
T cell antigen receptor signal transduction
1997
Epithelial–mesenchymal transitions in tumour progression
2002 Standout
Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity
2009
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
2001
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
Macrophages in Tissue Repair, Regeneration, and Fibrosis
2016 Standout
Central nervous system control of food intake
2000 StandoutNature
Small Molecule Inhibitors Induce Conformational Changes in the I Domain and the I-like Domain of Lymphocyte Function-associated Antigen-1
2002
Gettin’ down with ubiquitin: turning off cell-surface receptors, transporters and channels
1999
Distinct mRNA microarray profiles of tolerogenic dendritic cells
2001
TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P
2010
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
2004 Standout
Remodelling the extracellular matrix in development and disease
2014 Standout
Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving β 2 integrins and selectin ligands
2002
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
2012 Standout
Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7
1999
Th1 and Th2 cells
2001
Integrin Activation Involves a Conformational Change in the α1 Helix of the β Subunit A-domain
2002
Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair
2012
Structure of a c-Cbl–UbcH7 Complex
2000
cbl-b inhibits epidermal growth factor receptor signaling
1999
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Endocytosis and Degradation of the Growth Hormone Receptor Are Proteasome-dependent
2000
Therapeutic antagonists and conformational regulation of integrin function
2003
Three-dimensional segregation of supramolecular activation clusters in T cells
1998 StandoutNature
Points of control in inflammation
2002 StandoutNature
When cell biology meets development: endocytic regulation of signaling pathways
2002
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Small Molecule Integrin Antagonists that Bind to the β2 Subunit I-like Domain and Activate Signals in One Direction and Block Them in the Other
2003
Binding Stoichiometry and Kinetics of the Interaction of a Human Anthrax Toxin Receptor, CMG2, with Protective Antigen
2004
Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1
1999 StandoutNobel
1,4-Diazepane-2-ones as novel inhibitors of LFA-1
2003
RING domains: master builders of molecular scaffolds?
2000
Cbl-mediated Negative Regulation of Platelet-derived Growth Factor Receptor-dependent Cell Proliferation
1999
Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells
2001
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
1998
Integrins
2002 Standout
Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis
2014
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
2007 StandoutNature
Metchnikoff's policemen: macrophages in development, homeostasis and regeneration
2011
An Isoleucine-based Allosteric Switch Controls Affinity and Shape Shifting in Integrin CD11b A-domain
2000
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
2004 StandoutNature
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
1999 Nature
The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses
2000
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase
1999 Science
Small molecule antagonists of the LFA-1/ICAM-1 interaction as potential therapeutic agents
2001
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity
2009
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Macrophage activation and skeletal muscle healing following traumatic injury
2013
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
2012
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
2005 StandoutScience
Inhibitors of protein-protein interactions
2002
c‐Cbl: A regulator of T cell receptor‐mediated signalling
1998
Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo
2003
Integrin activation takes shape
2002
Network of dendritic cells within the muscular layer of the mouse intestine
2005 StandoutNobel
Mass spectrometry-based proteomics
2003 StandoutNature
A model of anthrax toxin lethal factor bound to protective antigen
2005 StandoutNobel
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
1999
An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond
2001
A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.
2003
Mechanisms Underlying Ubiquitination
2001 Standout
A Tale of Two Cbls: Interplay of c-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation
2008
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease
1998
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Cancer Genome Landscapes
2013 StandoutScience
T Cell Accumulation in B Cell Follicles Is Regulated by Dendritic Cells and Is Independent of B Cell Activation
2003
The Ubiquitin-Proteasome Pathway and Its Role in Cancer
2005
Diverse functions of matrix metalloproteinases during fibrosis
2014
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
Conformational Regulation of Integrin Structure and Function
2002
Negative Regulation of Cytokine Signaling Pathways
2000 Standout
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
1999
Interactions of Drosophila Cbl with Epidermal Growth Factor Receptors and Role of Cbl in R7 Photoreceptor Cell Development
1997
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
The ubiquitin-proteasome system and endocytosis
1999
Macrophage plasticity and polarization in tissue repair and remodelling
2012 Standout
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activityin vivo
2001
Works of Mark Lupher being referenced
Bone Marrow Ly6Chigh Monocytes Are Selectively Recruited to Injured Kidney and Differentiate into Functionally Distinct Populations
2009
A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells
1996
PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis
2010
Cbl-mediated Negative Regulation of the Syk Tyrosine Kinase
1998
The Cbl Protooncogene Product: From an Enigmatic Oncogene to Center Stage of Signal Transduction
1997
The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase
2000
The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70
1997
The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor
2000
Ox40-Ligand Has a Critical Costimulatory Role in Dendritic Cell:T Cell Interactions
1999
The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction
1999
Molecules in focus: The c-Cbl oncoprotein
1998
Host Responses in Tissue Repair and Fibrosis
2012
The Linker Phosphorylation Site Tyr292 Mediates the Negative Regulatory Effect of Cbl on ZAP-70 in T Cells
2000
The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α
1998
Cellular Activation of Leukocyte Function-Associated Antigen-1 and Its Affinity Are Regulated at the I Domain Allosteric Site
2001
Serum Amyloid P Inhibits Fibrosis Through FcγR-Dependent Monocyte-Macrophage Regulation in Vivo
2009
Cbl-transforming Variants Trigger a Cascade of Molecular Alterations That Lead to Epithelial Mesenchymal Conversion
2000
NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding
2000
Phosphotyrosine Binding Domain-Dependent Upregulation of the Platelet-Derived Growth Factor Receptor α Signaling Cascade by Transforming Mutants of Cbl: Implications for Cbl’s Function and Oncogenicity
1997