Citation Impact
Citing Papers
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
2009 StandoutScience
Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
2008 Standout
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
A 2.8 Å resolution structure of 6-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei : comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues 1 1Edited by R. Huber
1998
The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?
2018
On the allelic spectrum of human disease
2001
Proteins regulating Ras and its relatives
1993 StandoutNature
Clonality of cell populations in refractory anaemia using combined approach of gene loss and X‐linked restriction fragment length polymorphism‐methylation analyses
1991
A view on drug resistance in cancer
2019 StandoutNature
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Are myelodysplastic syndromes “cancer”?
2006
Leukemia and the disruption of normal hematopoiesis
1991
Oxidative stress, inflammation, and cancer: How are they linked?
2010 Standout
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
2014 Standout
Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia
2001
Nucleotide signalling during inflammation
2014 StandoutNature
Characterization of human bone marrow‐derived closed circular DNA clones
1993
Langerhans'-Cell Histiocytosis (Histiocytosis X) -- A Clonal Proliferative Disease
1994 Standout
Oxidative stress, antioxidants and stress tolerance
2002 Standout
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Chronic non-spherocytic haemolytic disorders associated with glucose-6-phosphate dehydrogenase variants
2000
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
1994 StandoutNature
Dissemination and growth of cancer cells in metastatic sites
2002 Standout
Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP + molecule and provides insights into enzyme deficiency
2000
Hematologically Important Mutations: Glucose-6-phosphate Dehydrogenase
1996
Triosephosphate isomerase deficiency: historical perspectives and molecular aspects
2000
Heterogeneity of lineage involvement by trisomy 8 in myelodysplastic syndrome
1995
Sickle-cell disease
1997
The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
2014
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
2007 Standout
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
2013 StandoutNobel
Cancer genes and the pathways they control
2004 Standout
The P2X7 Receptor in Infection and Inflammation
2017
CC Chemokine Receptors and Chronic Inflammation—Therapeutic Opportunities and Pharmacological Challenges
2013
Cardiomyopathy With Restrictive Physiology in Sickle Cell Disease
2016
Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies
2018
Glutathione S-Transferase Polymorphisms and Their Biological Consequences
2000
Respect, trust, and the management of sickle cell disease pain in hospital: comparative analysis of concern-raising behaviors, preliminary model, and agenda for international collaborative research to inform practice
2011
Clonal lymphocytes are detectable in only some cases of MDS
1992
Targeting RAS signalling pathways in cancer therapy
2003 Standout
Methemoglobinemia: Etiology, Pharmacology, and Clinical Management
1999 Standout
Sickle-cell disease
2010 Standout
Clinical Effect of Point Mutations in Myelodysplastic Syndromes
2011 Standout
X‐chromosome inactivation patterns using HPRT and PGK polymorphisms in haematologically normal and post‐chemotherapy females
1991
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Transcription of HERV-E and HERV-E-related sequences in malignant and non-malignant human haematopoietic cells
2008 StandoutNobel
Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives
2015
The ChEMBL database in 2017
2016 Standout
Glucose-6-phosphate dehydrogenase deficiency
2000
G6PD: Population genetics and clinical manifestations
1996
Mechanisms and Functions of Inflammasomes
2014 Standout
Global epidemiology of haemoglobin disorders and derived service indicators
2008 Standout
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
2012
Pyrimidine pathways in health and disease
2005
Common 4q24 deletion in four cases of hematopoietic malignancy: early stem cell involvement?
2005
Genome-wide association studies for common diseases and complex traits
2005 Standout
Somatic mutations in the neurofibromatosis 1 gene in human tumors
1992
Reactive oxygen species, cellular redox systems, and apoptosis
2010 Standout
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
1997 Standout
P2X Receptors as Drug Targets
2012
Missense mutations in the ABCB6 transporter cause dominant familialpseudohyperkalemia
2012
DNA methylation and human disease
2005 Standout
Combined immunophenotyping and DNA in situ hybridization to study lineage involvement in patients with myelodysplastic syndromes
1992
Cytogenetic clonality in myelodysplastic syndromes studied with fluorescence in situ hybridization: lineage, response to growth factor therapy, and clone expansion
1993
2016
Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia
2016
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection
2017 Standout
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations
2018
Mutations and Expression of the ras Family Genes in Leukemias
1996
Deficiencies in Mouse Myh and Ogg1 Result in Tumor Predisposition and G to T Mutations in Codon 12 of the K-Ras Oncogene in Lung Tumors
2004 StandoutNobel
Glucose-6-phosphate dehydrogenase deficiency
1994
Clonal studies in the myelodysplastic syndrome using X-linked restriction fragment length polymorphisms
1990
Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress.
1995
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
2019 Standout
Kit ligand improves in vitro erythropoiesis in myelodysplastic syndrome
1992
Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation
2017 StandoutNobel
GLUTATHIONE TRANSFERASES
2004 Standout
A Comprehensive Survey of Ras Mutations in Cancer
2012 Standout
Estimated pulmonary artery systolic pressure and sickle cell disease: a meta‐analysis and systematic review
2015
Clonal involvement of granulocytes and monocytes, but not of T and B lymphocytes and natural killer cells in patients with myelodysplasia: analysis by X-linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene
1992
The Biological Basis for Cardiac Repair After Myocardial Infarction
2016 Standout
Mechanisms of Diabetic Complications
2013 Standout
Growth Factors and Cancer
1991 StandoutScience
EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure
2017
Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes
1994 StandoutNobel
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
2015 Standout
Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction.
1991
Glucose-6-phosphate dehydrogenase deficiency
2008 Standout
ras oncogenes in human cancer: a review.
1989 Standout
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Molecular heterogeneity of glucose-6-phosphate dehydrogenase (G6PD) variants in Italy.
1997
N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome
1993
Applications of Fluorine in Medicinal Chemistry
2015 Standout
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
2014 Standout
Monoclonal nature of transient abnormal myelopoiesis in Down's syndrome
1991
Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+ subpopulations
1995
Reversal of Metabolic Block in Glycolysis by Enzyme Replacement in Triosephosphate Isomerase–Deficient Cells
1999
New glucose-6-phosphate dehydrogenase mutations associated with chronic anemia
1995
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
2006 Standout
Works of Mark Layton being referenced
Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
2012
Diagnosing and preventing inherited disease: Detection of sickle gene by coelocentesis in early pregnancy: a new approach to prenatal diagnosis of single gene disorders
1995
Erythrocyte Cdp-Choline Accumulation in Haemolytic Anaemia and Renal Failure (Rf)
1998
The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms
1999
Four pedigrees of the cation‐leaky hereditary stomatocytosis class presenting with pseudohyperkalaemia. Novel profile of temperature dependence of Na+–K+ leak in a xerocytic form
2004
Audit of prenatal diagnosis for haemoglobin disorders in the United Kingdom: the first 20 years
1997
Metabolic Correction of Triose Phosphate Isomerase Deficiencyin Vitroby Complementation
1997
Absence of Expression of the Wiskott–Aldrich Syndrome Protein in Peripheral Blood Cells of Wiskott–Aldrich Syndrome Patients
1998
Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate
2010
Mapping the prevalence of sickle cell and beta thalassaemia in England: estimating and validating ethnic‐specific rates
1999
Mutation of Ki-ras and N-ras oncogenes in myelodysplastic syndromes
1988
Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria
2013
Bone Marrow Failure in Children With Acute Liver Failure
2000
Clonal analysis of myelodysplastic syndromes: evidence of multipotent stem cell origin
1989
Glucose-6-phosphate dehydrogenase deficiency
1995
GBT440, a Potent Anti-Sickling Hemoglobin Modifier Reduces Hemolysis, Improves Anemia and Nearly Eliminates Sickle Cells in Peripheral Blood of Patients with Sickle Cell Disease
2015
The association between tricuspid regurgitation velocity and 5‐year survival in a N orth W est L ondon population of patients with sickle cell disease in the U nited K ingdom
2013