Standout Papers
Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Modulation of non‐NMDA receptor gating by auxiliary subunits
2014
Two Regions in the N-terminal Domain of Ionotropic Glutamate Receptor 3 Form the Subunit Oligomerization Interfaces That Control Subtype-specific Receptor Assembly
2005
Radial symmetry in a chimeric glutamate receptor pore
2014
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Properties of the kainate channel in rat brain mRNA injected Xenopus oocytes: ionic selectivity and blockage
1989
Block of Kainate Receptor Desensitization Uncovers a Key Trafficking Checkpoint
2006
Ionotropic glutamate receptors
1996
Functional Assembly of AMPA and Kainate Receptors Is Mediated by Several Discrete Protein-Protein Interactions
2001
Evidence that excitatory amino acids not only activate the receptor channel complex but also lead to use-dependent block
1986
Concentration-dependent substate behavior of native AMPA receptors
2000
Mapping the Interaction Sites between AMPA Receptors and TARPs Reveals a Role for the Receptor N-Terminal Domain in Channel Gating
2014
The Tetrameric Structure of a Glutamate Receptor Channel
1998 Science
Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles
2013
Ca2+–Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration
2000
Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
1990
A Point Mutation in the Glutamate Binding Site Blocks Desensitization of AMPA Receptors
1998
Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord
1999 Nature
Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP
1989 Science
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
1991
Blockade of Ca2+-Permeable AMPA/Kainate Channels Decreases Oxygen–Glucose Deprivation-Induced Zn2+Accumulation and Neuronal Loss in Hippocampal Pyramidal Neurons
2002
Ionotropic Glutamate Receptors & CNS Disorders
2008
A Nondesensitizing Kainate Receptor Point Mutant
2009
Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
2001
Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?
1990
The open pore conformation of potassium channels
2002 StandoutNatureNobel
Role of excitatory amino acid receptors in synaptic transmission in area CA1 of rat hippocampus
1989
Are unconventional NMDA receptors involved in slowly adapting type I mechanoreceptor responses?
2005
Homodimeric architecture of a CIC-type chloride ion channel
1996 Nature
Quisqualate‐ and kainate‐activated channels in mouse central neurones in culture.
1988
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors
2005
Quinolinate neurotoxicity in cortical cell culture
1987
Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses
2018 StandoutNobel
Molecular Neurobiology of Glutamate Receptors
1992
Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents
1990 Nature
Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices.
1992 Nobel
Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95
1995 StandoutScience
The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat
1996
Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs
1992 Nature
Expression and properties of hyperpolarization‐activated current in rat dorsal root ganglion neurons with known sensory function
2012
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Interactions between AMPA receptors and intracellular proteins
2000
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Historical Overview
1988
Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor
2006
Ion conduction pore is conserved among potassium channels
2001 Nature
Apparent desensitization of NMDA responses in xenopus oocytes involves calcium-dependent chloride current
1990
The Stoichiometry of AMPA Receptors and TARPs Varies by Neuronal Cell Type
2009
Antagonism of responses to excitatory amino acids on rat cortical neurones by the spider toxin, argiotoxin636
1989
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors
1994
X-ray structure of a voltage-dependent K+ channel
2003 StandoutNatureNobel
Models of neuronal injury in AIDS: another role for the NMDA receptor?
1992
Effect of Noncompetitive Blockade of N‐Methyl‐d‐Aspartate Receptors on the Neurochemical Sequelae of Experimental Brain Injury
1990
Separating dual effects of zinc at recombinant N-methyl-d-aspartate receptors
1996
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
AMPA Receptor Trafficking at Excitatory Synapses
2003
Interaction of the M4 Segment with Other Transmembrane Segments Is Required for Surface Expression of Mammalian α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
2011
NMDA application potentiates synaptic transmission in the hippocampus
1988 Nature
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
AMPA Receptor Binding Cleft Mutations That Alter Affinity, Efficacy, and Recovery from Desensitization
2005
The Transmembrane Domain Mediates Tetramerization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
2016
Suppression of long-term potentiation in hippocampal slices by copper
1997
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
The current excitement in long term potentiation
1988
Molecular diversity of the NMDA receptor channel
1992 Nature
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptor
2011
An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation
1989 Nature
Regulation of synaptic transmission in the central nervous system: Long-term potentiation
1989
Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms
1994
Evidence that the Loss of the Voltage‐Dependent Mg2+ Block at the N‐Methyl‐D‐Aspartate Receptor Underlies Receptor Activation During Inhibition of Neuronal Metabolism
1992
Regulation of AMPA receptors during synaptic plasticity
2002
Assembly and Stoichiometry of the AMPA Receptor and Transmembrane AMPA Receptor Regulatory Protein Complex
2010
Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor
2000
Inhibitors of calmodulin and protein kinase C block different phases of hippocampal long-term potentiation
1988
The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits
2011
TARPs differentially decorate AMPA receptors to specify neuropharmacology
2010
Postsynaptic NMDA receptor-mediated calcium accumulation in hippocampal CAl pyramidal cell dendrites
1990 Nature
The neurobiology of zinc in health and disease
2005 Standout
Potentiation of NMDA receptor currents by arachidonic acid
1992 Nature
Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
1995 StandoutNatureNobel
GABAB autoreceptors regulate the induction of LTP
1991 Nature
Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors
2016
Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures
1999
Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents
2014
Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2
1990
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation
1992 Nature
Two Families of TARP Isoforms that Have Distinct Effects on the Kinetic Properties of AMPA Receptors and Synaptic Currents
2007
The Role of Ionotropic Glutamate Receptors in Childhood Neurodevelopmental Disorders: Autism Spectrum Disorders and Fragile X Syndrome
2014
Regulation of calcium influx by second messengers in rat mast cells
1988 StandoutNatureNobel
Differential Sensitivity of RecombinantN-Methyl-d-Aspartate Receptor Subtypes to Zinc Inhibition
1997
The protease inhibitor leupeptin interferes with the development of LTP in hippocampal slices
1989
Gating Modes in AMPA Receptors
2010
Block of AMPA Receptor Desensitization by a Point Mutation outside the Ligand-Binding Domain
2004
Delayed neurotoxicity of excitatory amino acids In vitro
1987
GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses
1993
Coupled Control of Desensitization and Gating by the Ligand Binding Domain of Glutamate Receptors
2012
Allosteric control of an ionotropic glutamate receptor with an optical switch
2005
A synaptic model of memory: long-term potentiation in the hippocampus
1993 StandoutNature
Crystal structure and association behaviour of the GluR2 amino‐terminal domain
2009
Structural landscape of isolated agonist-binding domains from single AMPA receptors
2011
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses
1991 Nature
Differential effect of zinc on the vertebrate GABAA‐receptor complex
1990
Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex.
1992 Nobel
NMDA receptors activate the arachidonic acid cascade system in striatal neurons
1988 Nature
Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons
1998
A specific quisqualate agonist inhibits kainate responses induced in Xenopus oocytes injected with rat brain RNA
1989
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+
1990 StandoutNobel
Biochemical Responses Mediated by N‐Methyl‐d ‐Aspartate Receptors in Rat Cortical Slices Are Differentially Sensitive to Magnesium
1992
Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors
2005
Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function
2015
Superactivation of AMPA receptors by auxiliary proteins
2016
Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture
1991
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
The role of immediate early genes in the stabilization of long-term potentiation
1991
Dextromethorphan and dextrorphan as calcium channel antagonists
1988
The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System
1989 Standout
L-glutamate and acetylcholine mobilise Ca2+ from the same intracellular pool in cerebellar granule cells using transduction mechanisms with different Ca2+ sensitivities
1992
Mechanisms of Modal Activation of GluA3 Receptors
2011
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain
1998 StandoutNobel
Cloning, expression and modulation of a mouse NMDA receptor subunit
1992
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity
1992
Structure of a glutamate-receptor ligand-binding core in complex with kainate
1998 Nature
Zinc has opposite effects on NMDA and Non-NMDA receptors expressed in xenopus oocytes
1990
Membrane-permeant chelators can attenuate Zn2+-induced cortical neuronal death
2003
Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating
2017
Structure and different conformational states of native AMPA receptor complexes
2005 Nature
Stargazin modulates AMPA receptor gating and trafficking by distinct domains
2005 Nature
Appropriate NR1-NR1 Disulfide-linked Homodimer Formation Is Requisite for Efficient Expression of Functional, Cell Surface N-Methyl-D-aspartate NR1/NR2 Receptors
2004
A biological role for prokaryotic ClC chloride channels
2002 Nature
l-Homocysteate is a potent neurotoxin on cultured cortical neurons
1987
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Autoinactivation of Neuronal AMPA Receptors via Glutamate-Regulated TARP Interaction
2009
Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States
2014
Novel form of long-term potentiation produced by a K+channel blocker in the hippocampus
1991 Nature
Long‐term Potentiation of NMDA Receptor‐mediated EPSP in Guinea‐pig Hippocampal Slices
1991
Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons
1992 Nature
Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit
1992 Nobel
Excitatory amino acid receptors in the brain: membrane binding and receptor autoradiographic approaches
1990
The Micromolar Zinc-Binding Domain on the NMDA Receptor Subunit NR2B
2005
Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor
1999
Glutamate receptor desensitization and its role in synaptic transmission
1989
Activity‐Dependent Changes in Rat Ventral Horn Neurons in vitro; Summation of Prolonged Afferent Evoked Postsynaptic Depolarizations Produce a D‐2‐Amino‐5‐Phosphonovaleric Acid Sensitive Windup
1990
Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA
1991 Nature
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
1988 StandoutNature
Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus
1991 Nature
Regulation of N-methyl-d-aspartate (NMDA) receptor function during the rearrangement of developing neuronal connections
1994
Src, N-methyl-d-aspartate (NMDA) receptors, and synaptic plasticity
1998
Neurobiology of Zinc and Zinc-Containing Neurons
1989
Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression
1998
Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor
1993
The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked
1991
The Outer Pore of the Glutamate Receptor Channel Has 2-Fold Rotational Symmetry
2004
Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation
1992 Nature
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
The ontogeny of excitatory amino acid receptors in rat forebrain—I.N-methyl-d-aspartate and quisqualate receptors
1990
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
1994 StandoutNobel
Oxidative stress: Free radical production in neural degeneration
1994
A potential role for excitotoxins in the pathophysiology of spinal cord injury
1988
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
1994 Standout
Mutation of a glutamate receptor motif reveals its role in gating and δ2 receptor channel properties
2000
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
2002 StandoutNatureNobel
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
2009 Nature
Antagonists of the Platelet‐activating Factor Receptor Block Long‐term Potentiation in Hippocampal Slices
1992
A benzodiazepine recognition site associated with the non-NMDA glutamate receptor
1993
Stargazin Modulation of AMPA Receptors
2016
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
A persistent postsynaptic modification mediates long-term potentiation in the hippocampus
1988
The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses
2000
Endogenous Zinc Inhibits GABAAReceptors in a Hippocampal Pathway
2004
Primary structure and expression of the γ2 subunit of the glutamate receptor channel selective for kainate
1992
Differential expression of immediate early genes in the hippocampus and spinal cord
1990
The Relationship between Agonist Potency and AMPA Receptor Kinetics
2006
Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiation
1992
Stimulus-induced coordinate changes in mRNA abundance in single postsynaptic hippocampal CA1 neurons
1992
Synaptic AMPA receptor composition in development, plasticity and disease
2016
The role of divalent cations in the N‐methyl‐D‐aspartate responses of mouse central neurones in culture.
1988
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
2004 StandoutNobel
Identification of the platelet ADP receptor targeted by antithrombotic drugs
2001 StandoutNatureNobel
A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors
2016
Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes
2016
A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties
1990 StandoutNobel
Glutamate neurotoxicity in spinal cord cell culture
1991
The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro
1987
Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons
1992
NMDA receptors - their role in long-term potentiation
1987
Stargazin promotes closure of the AMPA receptor ligand-binding domain
2014
Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity
1987
Activation of NMDA receptors elecits fictive locomotion and bistable membrane properties in the lamprey spinal cord
1985
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Long-term potentiation differentially affects two components of synaptic responses in hippocampus.
1988
Dual‐component amino‐acid‐mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos.
1985
Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition
1992 Science
Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury
1987
Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture
1992
Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.
1987
Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.
1988
Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity
2001
Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor
1992 ScienceNobel
Voltage‐dependent block by zinc of single calcium channels in mouse myotubes.
1990
Synaptic activation of N‐methyl‐D‐aspartate receptors in the Schaffer collateral‐commissural pathway of rat hippocampus.
1988
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
2007
High Probability Opening of NMDA Receptor Channels by L-Glutamate
1992 Science
Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons
1987 Science
Multiple-conductance channels activated by excitatory amino acids in cerebellar neurons
1987 Nature
Anatomic correlation of NMDA and 3H-TCP-labeled receptors in rat brain
1988
The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro
1987
Neurotransmitter regulation of neuronal outgrowth, plasticity and survival
1989
Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain
2017
Differential Dependence on GluR2 Expression of Three Characteristic Features of AMPA Receptors
1997
The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia
1996 Science
Glycine potentiates the NMDA response in cultured mouse brain neurons
1987 StandoutNature
The inositol 1,4,5‐trisphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA.
1992
Effects of new non‐N‐methyl‐D‐aspartate antagonists on synaptic transmission in the in vitro rat hippocampus.
1989
Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
1993
The Time Course of Glutamate in the Synaptic Cleft
1992 Science
Structure and organization of heteromeric AMPA-type glutamate receptors
2016 Science
Structure of an agonist-bound ionotropic glutamate receptor
2014 Science
Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III
1987
Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes
1990 Science
Highly Zinc-Selective Fluorescent Sensor Molecules Suitable for Biological Applications
2000
Auxiliary proteins promote modal gating ofAMPA ‐ and kainate‐type glutamate receptors
2014
Engineering Light-Gated Ion Channels
2006
Properties of excitatory postsynaptic currents recorded in vitro from rat hippocampal interneurones.
1990
Divalent cations reduce depolarization of primary afferent terminations by GABA
1987
Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury
1991
Sustained Dendritic Gradients of Ca 2+ Induced by Excitatory Amino Acids in CA1 Hippocampal Neurons
1988 Science
Glutamate receptor pores
2014
A Family of AMPA-Selective Glutamate Receptors
1990 StandoutScienceNobel
Mossy fiber Zn2+ spillover modulates heterosynapticN-methyl-d -aspartate receptor activity in hippocampal CA3 circuits
2002
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
l-Glutamate, excitatory amino acid receptors and brain function
1985
Molecular Structure and Physiological Function of Chloride Channels
2002
Vanilloid (Capsaicin) Receptors and Mechanisms
1999 Standout
Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels
1991 StandoutScienceNobel
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
1986 StandoutNature
Ca2 + Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition
1991 Science
Modulation of the Time Course of Fast EPSCs and Glutamate Channel Kinetics by Aniracetam
1991 Science
Low-frequency stimulation of afferent Adelta-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat.
1997
Electrophysiological studies of NMDA receptors
1987
Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.
1993
Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord
1990
Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA.
1988
Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.
1988
Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation
1991 Science
Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM
2016 Nature
Low-Frequency Stimulation of Afferent Aδ-Fibers Induces Long-Term Depression at Primary Afferent Synapses with Substantia Gelatinosa Neurons in the Rat
1997
Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors.
1992 StandoutNobel
Neural Science
2000 StandoutNobel
Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.
1988
Receptors, ion channels and synaptic potentials underlying the integrative actions of excitatory amino acids
1987
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists
1988
How AMPA Receptor Desensitization Depends on Receptor Occupancy
2003
Molecular machines integrate coincident synaptic signals
1993
Two components of long-term potentiation induced by different patterns of afferent activation
1990 Nature
Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones.
1990
Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability
1991 Science
X-ray structures of AMPA receptor–cone snail toxin complexes illuminate activation mechanism
2014 Science
Induction of Mossy Fiber→CA3 Long-Term Potentiation Requires Translocation of Synaptically Released Zn2+
2001
Glutamate and the pathophysiology of hypoxic–ischemic brain damage
1986 Standout
Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate
1993
NMDA channel behavior depends on agonist affinity
1992
Non-competitive antagonists of excitatory amino acid receptors
1987
Structure and gating of tetrameric glutamate receptors
2013
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity
1992
Neurons Containing NADPH-Diaphorase Are Selectively Resistant to Quinolinate Toxicity
1986 Science
Memories of NMDA receptors and LTP
1995
Measurement of Intracellular Free Zinc Concentrations Accompanying Zinc-Induced Neuronal Death
1999
Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors
1990
Glutamate activates multiple single channel conductances in hippocampal neurons
1987 Nature
Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey
1997
Zinc alters excitatory amino acid neurotoxicity on cortical neurons
1988
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
1990 StandoutScienceNobel
Frequency‐dependent N‐methyl‐D‐aspartate receptor‐mediated synaptic transmission in rat hippocampus.
1988
High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors
1997
Noise and single channels activated by excitatory amino acids in rat cerebellar granule neurones.
1988
Agonists and antagonists for excitatory amino acid receptors
1987
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus.
1991
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
1998
Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry
1997
Rapid Translocation of Zn2+From Presynaptic Terminals Into Postsynaptic Hippocampal Neurons After Physiological Stimulation
2001
Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord
1993
Single-Channel Properties of Recombinant AMPA Receptors Depend on RNA Editing, Splice Variation, and Subunit Composition
1997
Blocking effects of cobalt and related ions on the gamma‐aminobutyric acid‐induced current in turtle retinal cones.
1986
Pathways of Ca2+ influx at the plasma membrane: Voltage-, receptor-, and second messenger-operated channels
1987
A new type of glutamate receptor linked to inositol phospholipid metabolism
1987 Nature
A Eukaryotic Specific Transmembrane Segment is Required for Tetramerization in AMPA Receptors
2013
In vitro release and electrophysiological effects in situ of homocysteic acid, an endogenous N-methyl-(D)-aspartic acid agonist, in the mammalian striatum
1986
Neuronal Plasticity: Increasing the Gain in Pain
2000 StandoutScience
Control of Voltage-Independent Zinc Inhibition of NMDA Receptors by the NR1 Subunit
1998
Applications of quantitative measurements for assessing glutamate neurotoxicity.
1988
Bright Ion Channels and Lipid Bilayers
2013 StandoutNobel
Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission
1988 Science
Zinc and Copper Influence Excitability of Rat Olfactory Bulb Neurons by Multiple Mechanisms
2001
The impact of postsynaptic calcium on synaptic transmission — its role in long-term potentiation
1989
Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles
1994
N-methyl-D-aspartate receptor activation increases cAMP levels and voltage-gated Ca2+ channel activity in area CA1 of hippocampus.
1991
Quisqualate Activates a Rapidly Inactivating High Conductance Ionic Channel in Hippocampal Neurons
1989 Science
Ketamine and phencyclidine cause a voltage-dependent block of responses to l-aspartic acid
1985
ZnT-3, a putative transporter of zinc into synaptic vesicles
1996
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
ZINC AND BRAIN INJURY
1998
A role for Na + ‐dependent Ca 2+ extrusion in protection against neuronal excitotoxicity
1989
A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation
1991 Science
Role of dimer interface in activation and desensitization in AMPA receptors
2010
Protein kinase C‐mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes.
1992
Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes
1992 StandoutScienceNobel
Currents through single glutamate receptor channels in outside‐out patches from rat cerebellar granule cells.
1991
Works of Mark L. Mayer being referenced
Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A
1993
Structure and Mechanism of Kainate Receptor Modulation by Anions
2007
The N-terminal domain of GluR6-subtype glutamate receptor ion channels
2009
ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function
2008
Modulation of excitatory synaptic transmission by drugs that reduce desensitization at AMPA/kainate receptors
1991
Structure‐activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational restriction
1991
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors.
1993
Domain organization and function in GluK2 subtype kainate receptors
2010
Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors
2008
Crystal Structures of the Glutamate Receptor Ion Channel GluK3 and GluK5 Amino-Terminal Domains
2010
Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain
2013
Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions
2009
Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface
2012
Molecular Basis of Kainate Receptor Modulation by Sodium
2008
Crystal Structures of the Kainate Receptor GluR5 Ligand Binding Core Dimer with Novel GluR5-Selective Antagonists
2006
Crystal Structures of the GluR5 and GluR6 Ligand Binding Cores: Molecular Mechanisms Underlying Kainate Receptor Selectivity
2005
Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines
1999
Structural basis of kainate subtype glutamate receptor desensitization
2016 Nature
Structural mechanism of glutamate receptor activation and desensitization
2014 Nature
Cellular mechanisms underlying excitotoxicity
1987
Glutamate receptor ion channels
2005 Standout
Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state
2001
Glutamate receptors at atomic resolution
2006 Nature
Emerging Models of Glutamate Receptor Ion Channel Structure and Function
2011
Structural biology of glutamate receptor ion channel complexes
2016
Regulation of AMPA Receptor Gating by Ligand Binding Core Dimers
2004
Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine
1989 Nature
Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
2002
Characterization of a Soluble Ligand Binding Domain of the NMDA Receptor Regulatory Subunit NR3A
2006
Structural determinants of allosteric regulation in alternatively spliced AMPA receptors
1995
Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors
2008
Mechanism of glutamate receptor desensitization
2002 Nature
AMPA Receptor Ligand Binding Domain Mobility Revealed by Functional Cross Linking
2009
Interdomain Interactions in AMPA and Kainate Receptors Regulate Affinity for Glutamate
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Stability of ligand‐binding domain dimer assembly controls kainate receptor desensitization
2009
Open channel block of NMDA receptor responses evoked by tricyclic antidepressants
1989
Conformational restriction blocks glutamate receptor desensitization
2006
Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor
1994
Functional characterization of a potassium-selective prokaryotic glutamate receptor
1999 Nature
Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine
1991
Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation
2011
Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus
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Structural basis for partial agonist action at ionotropic glutamate receptors
2003
Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons
1990
Mechanism of Activation and Selectivity in a Ligand-Gated Ion Channel: Structural and Functional Studies of GluR2 and Quisqualate,
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Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique
1988
The action of zinc on synaptic transmission and neuronal excitability in cultures of mouse hippocampus.
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1987 Nature
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NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
1986 Nature
The action of N‐methyl‐D‐aspartic acid on mouse spinal neurones in culture.
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AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate
1996
Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors.
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Functional Insights from Glutamate Receptor Ion Channel Structures
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1984
Structure and Function of Glutamate Receptor Ion Channels
2004
A Novel Allosteric Potentiator of AMPA Receptors: 4-[2-(Phenylsulfonylamino)ethylthio]-2,6-Difluoro-Phenoxyacetamide
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Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
1984 StandoutNature
Growth Factor-Induced Transcription of GluR1 Increases Functional AMPA Receptor Density in Glial Progenitor Cells
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The physiology of excitatory amino acids in the vertebrate central nervous system
1987 Standout
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes
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Glutamate currents in mammalian spinal neurons: resolution of a paradox
1984
Modulation of N‐methyl‐D‐aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.
1990
Mg2+ dependence of membrane resistance increases evoked by NMDA in hippocampal neurones
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Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones.
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A physiologist's view of the N‐methyl‐D‐Aspartate receptor: An allosteric ion channel with multiple regulatory sites
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Structural Similarities between Glutamate Receptor Channels and K+ Channels Examined by Scanning Mutagenesis
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1994