Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance
2014 StandoutNobel
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State
2005
Deregulated NOTCH Signaling in Acute T-Cell Lymphoblastic Leukemia/Lymphoma: New Insights, Questions, and Opportunities
2005
Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression
2003
Calcium dynamics and buffering in oculomotor neurones from mouse that are particularly resistant during amyotrophic lateral sclerosis (ALS)‐related motoneurone disease
2000
Inactivation of human Cu,Zn superoxide dismutase by peroxynitrite and formation of histidinyl radical
2004
Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine
2003
Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour
2005 StandoutNatureNobel
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
2002
QUANTITATIVE ANALYSIS OF CARDIAC 3-L-NITROTYROSINE DURING ACUTE ALLOGRAFT REJECTION IN AN EXPERIMENTAL HEART TRANSPLANTATION1
1999
SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
1999
Glutamate, excitotoxicity and amyotrophic lateral sclerosis
1997
Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis
1998
The genetic and molecular mechanisms of motor neuron disease
1998
Superoxide dismutase and the death of motoneurons in ALS
2001
Regulation of Notch signalling by non-visual β-arrestin
2005
Calcium‐permeable α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptors: A molecular determinant of selective vulnerability in amyotrophic lateral sclerosis
1997
Inducible Nitric Oxide Synthase (iNOS) and Nitrotyrosine Immunoreactivity in the Spinal Cords of Transgenic Mice with a G93A MutantSOD1Gene
2001
Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction
2001
The C-terminal PDZ-Ligand of JAGGED1 Is Essential for Cellular Transformation
2003
Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2
2000 StandoutNobel
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain
2003
Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
1995 StandoutNobel
Up‐Regulation of Protein Chaperones Preserves Viability of Cells Expressing Toxic Cu/Zn‐Superoxide Dismutase Mutants Associated with Amyotrophic Lateral Sclerosis
1999
Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice
2001
Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis
1999
Notch signalling: a simple pathway becomes complex
2006 Standout
A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
2004
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
Protein Degradation: Four E3s For The Notch Pathway
2002
Structural Changes Accompanying Memory Storage
1993 StandoutNobel
Visualizing Sexual Dimorphism in the Brain
2004 StandoutNobel
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Effect of overexpression of wild‐type and mutant Cu/Zn‐superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis
2001
Chapter 19 Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture
1998
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase
1994 StandoutNobel
Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta
2003
[39] Immunohistochemical methods to detect nitrotyrosine
1999
Oncogenic aberrations of cullin-dependent ubiquitin ligases
2004
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
1996 StandoutNobel
Mutant SOD1 causes motor neuron disease independent of copper chaperone–mediated copper loading
2002
Relevance of protein nitration in brain injury: a key pathophysiological mechanism in neurodegenerative, autoimmune, or inflammatory CNS diseases and stroke
2003
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Twitter evolution: converging mechanisms in birdsong and human speech
2010
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
Alzheimer's Disease
2004 Standout
Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice
1999
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
2006
Epidemiology of mutations in superoxide dismutase in amyotrophic lateal sclerosis
1997 StandoutNobel
Are Complex Behaviors Specified by Dedicated Regulatory Genes? Reasoning from Drosophila
2001 StandoutNobel
Neurodegenerative diseases and oxidative stress
2003
Mutated Human SOD1 Causes Dysfunction of Oxidative Phosphorylation in Mitochondria of Transgenic Mice
2002
Variations on the Notch pathway in neural development
2002
Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1‐mediated motor neuron cell death and increase amyotrophic lateral sclerosis‐like transgenic mouse survival
2002
Motoneuron Death Triggered by a Specific Pathway Downstream of Fas
2002
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Six important themes in amyotrophic lateral sclerosis (ALS) research, 1999
2000
ALS-Linked Cu/Zn–SOD Mutation Increases Vulnerability of Motor Neurons to Excitotoxicity by a Mechanism Involving Increased Oxidative Stress and Perturbed Calcium Homeostasis
1999
Amyotrophic Lateral Sclerosis
2001 Standout
Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients
1998
Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress–induced death of motor neurons in amyotrophic lateral sclerosis
2002
Parkinson's Disease
2003 Standout
Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis
2001
A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis
1999 StandoutNobel
Motor unit number estimation, ALS and clinical trials
2000
Clinical Trials in Motor Neuron Diseases
1999
Neuronal Nitric Oxide Synthase Activation and Peroxynitrite Formation in Ischemic Stroke Linked to Neural Damage
1999
Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration
2003
Sexual dimorphism in the vertebrate nervous system
1992
Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis
1997 Science
Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1
2004
The ubiquitin ligaseDrosophilaMind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
2005
REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY
2005
Building a bird brain: Sculpting neural circuits for a learned behavior
1997
Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species
1998
Neuronal growth, atrophy and death in a sexually dimorphic song nucleus in the zebra finch brain
1985 Nature
Receptor regulation: β-arrestin moves up a notch
2005 StandoutNobel
Interaction between auditory and motor activities in an avian song control nucleus.
1981
Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity
2002
Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants
1998
Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model
2000 Science
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Genesis and death of vocal control neurons during sexual differentiation in the zebra finch
1989
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
1994 StandoutScienceNobel
Monomeric Cu,Zn-superoxide Dismutase Is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral Sclerosis
2004
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
In vivo genome editing improves motor function and extends survival in a mouse model of ALS
2017
Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses.
1993 StandoutNobel
Neural Science
2000 StandoutNobel
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
Effect of overexpression of wild‐type and mutant Cu/Zn‐superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide, 4‐hydroxynonenal or serum deprivation: potentiation of injury by ALS‐related mutant superoxide dismutases and protection by Bcl‐2
2001
From Charcot to SOD1
1999
Superoxide dismutase and the death of motoneurons in ALS
2001
Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein.
1996
Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals
2003
Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition
2003
Genetic elements of courtship inDrosophila: Mosaics and learning mutants
1984 StandoutNobel
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Notch: a membrane-bound transcription factor
2002
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling
2017
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Axonal Self-Destruction and Neurodegeneration
2002 Science
Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: Common links and potential therapeutic targets
2004
Receptor regulation: β-arrestin moves up a notch
2005 StandoutNobel
Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase
1998
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
1999
The Mating of a Fly
1994 StandoutScienceNobel
Toward a molecular definition of long-term memory storage
1996 StandoutNobel
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
2004
Forebrain Lesions Disrupt Development But Not Maintenance of Song in Passerine Birds
1984 StandoutScience
The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation
2010
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Sexual Differentiation of the Central Nervous System
1981 StandoutScience
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
The interplay between DSL proteins and ubiquitin ligases in Notch signaling
2005
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
Connections of vocal control nuclei in the canary telencephalon
1982
COPPER-ZINC SUPEROXIDE DISMUTASE AND AMYOTROPHIC LATERAL SCLEROSIS
2003
Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes
2015
Oxidative stress in neurodegeneration: cause or consequence?
2004 Standout
Expression of vasopressin receptors in hamster hypothalamus is sexually dimorphic and dependent upon photoperiod.
1991 StandoutNobel
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Regulation of Notch Signaling Activity
2004
Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis
1999
Works of Mark E. Gurney being referenced
Human apolipoprotein E4 accelerates β‐amyloid deposition in APPsw transgenic mouse brain
2001
Progressive motor neuron impairment in an animal model of familial amyotrophic lateral sclerosis
1997
Brain-derived neurotrophic factor transiently stabilizes silent synapses on developing neuromuscular junctions
1996
Increased 3‐nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation
1997
Leukemia inhibitory factor influences the timing of programmed synapse withdrawal from neonatal muscles
1995
The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog
2001
Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis
1999
Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis
1997
Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis
1996
The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies
1997
Protein Oxidative Damage in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis
1998
Metabolic Dysfunction in Familial, but Not Sporadic, Amyotrophic Lateral Sclerosis
1998
Mutant CuZn superoxide dismutase in motor neuron disease
1998
Behavioral correlates of sexual differentiation in the zebra finch song system
1982
Auditory responses in the zebra finch's motor system for song
1981
Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis
1998
Synthesis and Biological Evaluation of Novel 2,4-Diaminoquinazoline Derivatives as SMN2 Promoter Activators for the Potential Treatment of Spinal Muscular Atrophy
2008
Sexual differentiation of brain and behaviour
1982
SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation
2001
Hormone-Induced Sexual Differentiation of Brain and Behavior in Zebra Finches
1980 Science