Citation Impact
Citing Papers
Chiral Aziridines—Their Synthesis and Use in Stereoselective Transformations
1994
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte Function-associated Antigen-1-dependent Adhesion
2005 StandoutNobel
Glucosamine‐6‐sulfamate Analogues of Heparan Sulfate as Inhibitors of Endosulfatases
2010
Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation
2008 StandoutNobel
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
2011
Ionotropic and metabotropic glutamate receptor structure and pharmacology
2005
Catalytic Asymmetric Three‐Component Synthesis of Homoallylic Amines
2013 StandoutNobel
Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA
2005 StandoutNobel
mTOR Signaling in Growth Control and Disease
2012 Standout
A view on drug resistance in cancer
2019 StandoutNature
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth
2014
Drug discovery approaches targeting the PI3K/Akt pathway in cancer
2008
Imaging the Glycosylation State of Cell Surface Glycoproteins by Two‐Photon Fluorescence Lifetime Imaging Microscopy
2013 StandoutNobel
Akt-regulated pathways in prostate cancer
2005
The αvintegrin antagonists as novel anticancer agents: an update
2002
Direct Catalytic Asymmetric Three‐Component Kabachnik–Fields Reaction
2008 StandoutNobel
Targeted covalent drugs of the kinase family
2010
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
2009
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Targeting cancer with small molecule kinase inhibitors
2008 Standout
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
2008
Drug discovery for a new generation of covalent drugs
2012
The Catalytic Asymmetric Abramov Reaction
2014 StandoutNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Methods in Mammalian Autophagy Research
2010 Standout
Catalytic Asymmetric Synthesis of Phosphine Boronates
2015 StandoutNobel
Therapeutic antagonists and conformational regulation of integrin function
2003
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
2015
Integrins
2002 Standout
Microparticle Matrix Encoding of Beads
2010 StandoutNobel
Bisphosphonate conjugation for bone specific drug targeting
2018
An Efficient Synthesis of an αvβ3 Antagonist
2004
Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry
2011
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Synthesis of β-Aminophosphonates and -Phosphinates
2005
Binding strength and activation state of single fibrinogen-integrin pairs on living cells
2002
Targeted Covalent Inhibitors for Drug Design
2016
Proline Editing: A General and Practical Approach to the Synthesis of Functionally and Structurally Diverse Peptides. Analysis of Steric versus Stereoelectronic Effects of 4-Substituted Prolines on Conformation within Peptides
2013
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding
2006
SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates
2018 StandoutNobel
Asymmetric catalysis as a method for the synthesis of chiral organophosphorus compounds
2014
Physiological roles of PKB/Akt isoforms in development and disease
2007
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Targeting RGD Recognizing Integrins: Drug Development, Biomaterial Research, Tumor Imaging and Targeting
2006
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
A revolution in optical manipulation
2003 StandoutNature
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Chirale Aziridine — Herstellung und stereoselektive Transformationen
1994
Novel Platelet Inhibitors
2001
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Catalytic Asymmetric Conjugate Addition and Allylic Alkylation with Grignard Reagents
2008 StandoutNobel
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
The resurgence of covalent drugs
2011
Bromine-Catalyzed Aziridination of Olefins. A Rare Example of Atom-Transfer Redox Catalysis by a Main Group Element
1998 StandoutNobel
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Handicapping the Race to Develop Inhibitors of the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway
2006
Application of Combinatorial Chemistry Science on Modern Drug Discovery
2008
Palladium‐Catalyzed Fluorosulfonylvinylation of Organic Iodides
2017 StandoutNobel
A Fluorogenic Trehalose Probe for Tracking Phagocytosed Mycobacterium tuberculosis
2020 StandoutNobel
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Quinine‐Catalyzed Enantioselective Michael Addition of Diphenyl Phosphite to Nitroolefins: Synthesis of Chiral Precursors of α‐Substituted β‐Aminophosphonates
2007
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
High throughput glutathione and Nrf2 assays to assess chemical and biological reactivity of cysteine-reactive compounds
2013
Platelet Glycoprotein IIb-IIIa Antagonists as Prototypical Integrin Blockers: Novel Parenteral and Potential Oral Antithrombotic Agents
2000
Regiospecific ring-opening reactions of β-aziridinyl α,β-enoates with acids: application to the stereoselective synthesis of a couple of diastereoisomeric (E )-alkene dipeptide isosteres from a single β-aziridinyl α,β-enoate and to the convenient preparation of amino alcohols bearing α,β-unsaturated ester groups
1999
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Biocatalytic Synthesis of Chiral Alcohols and Amino Acids for Development of Pharmaceuticals
2013
Works of Mark E. Duggan being referenced
A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
2005
Non-Peptide αvβ3 Antagonists. Part 4: Potent and Orally Bioavailable Chain-Shortened RGD Mimetics
2002
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
2005
Nonpeptide αvβ3 antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide
2002
Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA
2006
Design, Synthesis, and In Vivo Efficacy of Glycine Transporter‐1 (GlyT1) Inhibitors Derived from a Series of [4‐Phenyl‐1‐(propylsulfonyl)piperidin‐4‐yl]methyl Benzamides
2006
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
2007
Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist
1995
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines
1988
Non-peptide αvβ3 antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl β-amino acids as aspartic acid replacements
2002
Pharmacokinetics and Pharmacodynamics of L-703,014, a Potent Fibrinogen Receptor Antagonist, After Intravenous and Oral Administration in the Dog
1994
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
2004
Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors
1999
Ligands to the integrin receptor αvβ3
2000
A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain
2004
Covalent Modifiers: An Orthogonal Approach to Drug Design
2009
Binding Model for Nonpeptide Antagonists of αvβ3 Integrin
2002
Preparation of optically active 2-aminoalkylphosphinic and phosphonic acids
1983
Nonpeptide αvβ3 Antagonists. 1. Transformation of a Potent, Integrin-Selective αIIbβ3 Antagonist into a Potent αvβ3 Antagonist
2000
Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo
2004
Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members
2005
Tirofiban (Aggrastat®)
1999
Nonpeptide αvβ3 Antagonists. Part 11: Discovery and Preclinical Evaluation of Potent αvβ3 Antagonists for the Prevention and Treatment of Osteoporosis
2004