Mark E. Arnold

Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation

A new anti-human Fc method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in serum from pre-clinical species

Multi-input chemical control of protein dimerization for programming graded cellular responses

Design, analysis, and presentation of crossover trials

The metabolic syndrome

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

Clinical Pharmacokinetics of Metformin

CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity

The mechanisms of action of metformin

A simple LC/MRM–MS-based method to quantify free linker-payload in antibody-drug conjugate preparations

Tunable and reversible drug control of protein production via a self-excising degron

The metabolic syndrome

Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis

Metformin hydrochloride in the treatment of type 2 diabetes mellitus: A clinical review with a focus on dual therapy

Analysis of anticancer drugs: A review

Glycemic control in patients with type 2 diabetes mellitus switched from twice-daily immediate-release metformin to a once-daily extended-release formulation

PROTAC targeted protein degraders: the past is prologue

5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods

Strategies and challenges for the next generation of antibody–drug conjugates

Dapagliflozin: A Review of Its Use in Patients with Type 2 Diabetes

Prodrugs of BMS-183920: Metabolism and Permeability Considerations

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

Peptidic degron for IMiD-induced degradation of heterologous proteins

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

Interventions for enhancing medication adherence

Atmospheric-pressure-ionization mass spectrometry

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Interventions for enhancing medication adherence

Plasma Proteome Association and Catalytic Activity of Stealth Polymer‐Grafted Iron Oxide Nanoparticles

ETCM: an encyclopaedia of traditional Chinese medicine

Dinuclear Palladium, Nickel, and Rhodium Complexes Based on 1,3-Bis[(2-(diphenylphosphino)benzylidene)amino]propan-2-ol

The effect ofin vitrogastrointestinal digestion on the anti-inflammatory activity ofVitis viniferaL. leaves

Natural Products as Sources of New Drugs from 1981 to 2014

Polyphenols and Human Health: The Role of Bioavailability

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

Biocatalytic Synthesis of Chiral Alcohols and Amino Acids for Development of Pharmaceuticals

5‐Substituted 1H‐Tetrazoles as Carboxylic Acid Isosteres: Medicinal Chemistry and Synthetic Methods

Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC–MS/MS approach: Assay development, validation, and a case study

A rugged and accurate liquid chromatography–tandem mass spectrometry method for the determination of asunaprevir, an NS3 protease inhibitor, in plasma

Sites of First-Pass Bioactivation (Hydrolysis) of Orally Administered Zofenopril Calcium in Dogs

Workshop Report: Crystal City V—Quantitative Bioanalytical Method Validation and Implementation: The 2013 Revised FDA Guidance

Liquid chromatography and tandem mass spectrometry for the quantitative determination of ixabepilone (BMS-247550, Ixempra™) in human plasma: Method validation, overcoming curve splitting issues and eliminating chromatographic interferences from degradants

Practical and Efficient Strategy for Evaluating Oral Absolute Bioavailability with an Intravenous Microdose of a Stable Isotopically-Labeled Drug Using a Selected Reaction Monitoring Mass Spectrometry Assay

Determination of SQ 33,600, a phosphinic acid containing HMG CoA reductase inhibitor, in human serum by high-performance liquid chromatography combined with ionspray mass spectrometry

Simultaneous oral therapeutic and intravenous ¹⁴C‐microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin

A Novel and Cost Effective Method of Removing Excess Albumin from Plasma/Serum Samples and Its Impacts on LC-MS/MS Bioanalysis of Therapeutic Proteins

Pharmacokinetics and Bioavailability of a Metformin/Glyburide Tablet Administered Alone and with Food