Citation Impact
Citing Papers
Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone Metastasis
2007
Bone Morphogenetic Protein 7 in the Development and Treatment of Bone Metastases from Breast Cancer
2007
Matrix Metalloproteinase (MMP)-13 Regulates Mammary Tumor–Induced Osteolysis by Activating MMP9 and Transforming Growth Factor-β Signaling at the Tumor-Bone Interface
2010
PDGFR Signaling Blockade in Marrow Stroma Impairs Lung Cancer Bone Metastasis
2010
Metastasis: from dissemination to organ-specific colonization
2009 Standout
Osteoclast Differentiation Factor Acts as a Multifunctional Regulator in Murine Osteoclast Differentiation and Function
1999
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
2017 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer.
2002
Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
2010
Breast Cancer Metastasis to Bone: Mechanisms of Osteolysis and Implications for Therapy
2005
Cellular and molecular basis of preferential metastasis of breast cancer to bone
2000
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
A view on drug resistance in cancer
2019 StandoutNature
Invasion and metastasis of a mammary tumor involves TGF-? signaling
2000
Cancer to bone: a fatal attraction
2011 Standout
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis
2017
Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
2012
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Breast cancer cells induce osteoclast formation by stimulating host IL‐11 production and downregulating granulocyte/macrophage colony‐stimulating factor
2004
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
2006
Role of endothelin-1 in osteoblastic bone metastases
2003
Contextual determinants of TGFβ action in development, immunity and cancer
2018
The tumor microenvironment is a dominant force in multidrug resistance
2012
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
TGF-β signalling-related markers in cancer patients with bone metastasis
2008
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
Cancer Metastasis: Building a Framework
2006 Standout
The Loss of TGF-β Signaling Promotes Prostate Cancer Metastasis
2003
PTH-related protein modulates PC-3 prostate cancer cell adhesion and integrin subunit profile
2003
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
Surviving at a Distance: Organ-Specific Metastasis
2015
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
2010 StandoutNature
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
The biology and function of fibroblasts in cancer
2016 Standout
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis
2009
Decorin Suppresses Bone Metastasis in a Breast Cancer Cell Line
2009
Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma
2002
Isolation of rare circulating tumour cells in cancer patients by microchip technology
2007 StandoutNature
A multigenic program mediating breast cancer metastasis to bone
2003 Standout
Integrins and bone metastasis: Integrating tumor cell and stromal cell interactions
2010
Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals
2009
Environment-mediated drug resistance: a major contributor to minimal residual disease
2009
TGFβ signalling: a complex web in cancer progression
2010
Receptor activator of NF-?B ligand, macrophage inflammatory protein-1?, and the proteasome
2003
KLF4, p21 and context-dependent opposing forces in cancer
2005
Growth Regulatory Factors and Bone
2001
TGF- β signaling in cancer – a double-edged sword
2001
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Targeting the transforming growth factor-β signalling pathway in metastatic cancer
2010
Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment
2009
A timeline of tumour-associated macrophage biology
2023
Immunity, Inflammation, and Cancer
2010 Standout
TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
2008
BMP7, a Putative Regulator of Epithelial Homeostasis in the Human Prostate, Is a Potent Inhibitor of Prostate Cancer Bone Metastasis in Vivo
2007
Cell biology of the osteoclast
1999
C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells
2006
Osteoclast differentiation and activation
2003 StandoutNature
Transforming growth factor-beta facilitates breast carcinoma metastasis by promoting tumor cell survival
2004
TGFβ in Cancer
2008 Standout
Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells
2011
Transfection of MDA-MB-231 human breast carcinoma cells with bone sialoprotein (BSP) stimulates migration and invasion in vitro and growth of primary and secondary tumors in nude mice
2004
Hypoxia: Signaling the Metastatic Cascade
2016
Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations
2007
Metastasis to bone: causes, consequences and therapeutic opportunities
2002 Standout
Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells
2000
Tumor metastasis: mechanistic insights and clinical challenges
2006 Standout
Future directions of bone-targeted therapy for metastatic breast cancer
2010
Bone metastasis: the importance of the neighbourhood
2016
A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras
1999
Mechanisms of Bone Metastasis
2004 Standout
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body
2012
Parathyroid hormone related peptide and receptor expression in paired primary prostate cancer and bone metastases
2002
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Genes that mediate breast cancer metastasis to lung
2005 StandoutNature
AMPK: a nutrient and energy sensor that maintains energy homeostasis
2012 Standout
The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts
2009
Bisphosphonate conjugation for bone specific drug targeting
2018
Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation
2004
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation
2001
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
2011 Standout
Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs
2011
Factors regulating the growth of metastatic cancer in bone.
1999
Parathyroid Hormone-Related Protein Production by Breast Cancers, Improved Survival, and Reduced Bone Metastases
2001
Role of stromal-derived cytokines and growth factors in bone metastasis
2003
Adenosine Monophosphate-Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection
2011
Controlling TGF-β signaling
2000
Multilineage Potential of Adult Human Mesenchymal Stem Cells
1999 StandoutScience
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
From transforming growth factor-β signaling to androgen action: Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells
2001
General mechanisms of metastasis
1997
Monitoring Metastatic Behavior of Human Tumor Cells in Mice with Species-Specific Polymerase Chain Reaction: Elevated Expression of Angiogenesis and Bone Resorption Stimulators by Breast Cancer in Bone Metastases
2001
Loss of responsiveness to transforming growth factor beta induces malignant transformation of nontumorigenic rat prostate epithelial cells.
1999
Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis
2010
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
2005
Bone Resorption by Osteoclasts
2000 StandoutScience
Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
2003
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.
2002
The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance
2008
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program
2001
Biology of Osteoclast Activation in Cancer
2001
The Hedgehog Signaling Molecule Gli2 Induces Parathyroid Hormone-Related Peptide Expression and Osteolysis in Metastatic Human Breast Cancer Cells
2006
Parathyroid Hormone–Related Protein Localization in Breast Cancers Predict Improved Prognosis
2006
Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively
2018 StandoutNobel
Total Synthesis of (+)-Madindoline A and (−)-Madindoline B, Potent, Selective Inhibitors of Interleukin 6. Determination of the Relative and Absolute Configurations
2000 StandoutNobel
Bone Turnover Mediates Preferential Localization of Prostate Cancer in the Skeleton
2005
Extracellular Calcium-Sensing Receptor Expression and Its Potential Role in Regulating Parathyroid Hormone-Related Peptide Secretion in Human Breast Cancer Cell Lines*
2000
Complementary roles of gasotransmitters CO and H2S in sleep apnea
2017 StandoutNobel
Macrophage inflammatory protein-1α is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor κB ligand
2001
HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition
2005
Platelet and osteoclast β 3 integrins are critical for bone metastasis
2003
Single-Colony Derived Strains of Human Marrow Stromal Fibroblasts Form Bone After Transplantation In Vivo
1997
A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases
2003
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
NF-κB p50 and p52 Expression Is Not Required for RANK-Expressing Osteoclast Progenitor Formation but Is Essential for RANK- and Cytokine-Mediated Osteoclastogenesis
2002
IL-6 as a drug discovery target
1998
The amazing osteocyte
2010 Standout
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Polysialic acid governs T-cell development by regulating progenitor access to the thymus
2009 StandoutNobel
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Molecular Biology of Bone Metastasis
2007
TGF-β Promotes the Establishment of Renal Cell Carcinoma Bone Metastasis
2006
Controlling TGF-beta signaling.
2000 Standout
Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner
2006
Therapeutic Approaches to Bone Diseases
2000 Science
The two faces of transforming growth factor β in carcinogenesis
2003 Standout
Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma
2018
Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases
2006
Works of Mark Dallas being referenced
Ibandronate decreases bone disease development and osteoclast stimulatory activity in an in vivo model of human myeloma
2001
TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
1999
Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice.
1998
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.
1996
Chromosome 18 suppresses prostate cancer metastases
2003
Ion Channel Regulation by AMPK
2009
Hypoxia suppresses astrocyte glutamate transport independently of amyloid formation
2007
Oxygen-dependent hydroxylation by Factor Inhibiting HIF (FIH) regulates the TRPV3 ion channel
2014
Parathyroid hormone-related protein (PTHrP)-(1-139) isoform is efficiently secreted in vitro and enhances breast cancer metastasis to bone in vivo
2002
Transforming Growth Factor-β Stimulates Parathyroid Hormone-related Protein and Osteolytic Metastases via Smad and Mitogen-activated Protein Kinase Signaling Pathways
2002
AMP-activated Protein Kinase Mediates Carotid Body Excitation by Hypoxia
2006
Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability
2011
Development and characterization of a human marrow stromal cell line that enhances osteoclast-like cell formation.
1995
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase
2010
Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage
1995
E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation
2006
Interleukin-6 antisense deoxyoligonucleotides inhibit bone resorption by giant cells from human giant cell tumors of bone
1994
Anti-α4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis
2004