Citation Impact
Citing Papers
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
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DNA capture by a CRISPR-Cas9–guided adenine base editor
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Lipid Rafts As a Membrane-Organizing Principle
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The Genetic Basis for Bacterial Mercury Methylation
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De novo design of transmembrane β barrels
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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
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Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED
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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
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Structural and Kinetic Evidence for an Extended Hydrogen-bonding Network in Catalysis of Methyl Group Transfer
2006
Monte Carlo-MST: New strategy for representation of solvent configurational space in solution
1999
Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells
2015 StandoutNobel
Purine nucleoside phosphorylases: properties, functions, and clinical aspects
2000
Abiotic Stress Signaling and Responses in Plants
2016 Standout
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
2006
Purine nucleoside phosphorylase from Cellulomonas sp.: physicochemical properties and binding of substrates determined by ligand-dependent enhancement of enzyme intrinsic fluorescence, and by protective effects of ligands on thermal inactivation of the enzyme
2002
β-Arrestin Is Crucial for Ubiquitination and Down-regulation of the Insulin-like Growth Factor-1 Receptor by Acting as Adaptor for the MDM2 E3 Ligase
2005 StandoutNobel
Animal Models for the Study of Hepatitis C Virus Infection and Related Liver Disease
2012
GB/SA water model for the Merck molecular force field (MMFF)
2000
Crystal Structure of Calf Spleen Purine Nucleoside Phosphorylase with Two Full Trimers in the Asymmetric Unit: Important Implications for the Mechanism of Catalysis
2004 StandoutNobel
Nucleotide signalling during inflammation
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Extracellular adenosine triphosphate and adenosine in cancer
2010
A Fast Flexible Docking Method using an Incremental Construction Algorithm
1996 Standout
Enzymatic transition states: thermodynamics, dynamics and analogue design
2004
Purine nucleoside phosphorylase: A target for drug design
1993
Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation
2013
Hallmarks of aging: An expanding universe
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Insulin and Insulin-like Growth Factor I Receptors Utilize Different G Protein Signaling Components
2001
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine
1995
Calf spleen purine nucleoside phosphorylase: complex kinetic mechanism, hydrolysis of 7-methylguanosine, and oligomeric state in solution
2002
Calf spleen purine nucleoside phosphorylase: structure of its ternary complex with an N(7)-acycloguanosine inhibitor and a phosphate anion
2001
Calf spleen purine-nucleoside phosphorylase: crystal structure of the binary complex with a potent multisubstrate analogue inhibitor
2004
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS
2000 StandoutNature
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex
1992
Calf spleen purine nucleoside phosphorylase: purification, sequence and crystal structure of its complex with an N(7)‐acycloguanosine inhibitor
1995
New insights into copper monooxygenases and peptide amidation: structure, mechanism and function
2000
Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs
1999
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
2014 StandoutNature
[5] Peptidylglycine α-amidating monooxygenase: An ascorbate-requiring enzyme
1997
AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
2015
Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis
2012
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
2012 Standout
Thyroid Hormone Analogues for the Treatment of Metabolic Disorders: New Potential for Unmet Clinical Needs?
2012
Thyroid Hormone Regulates Hepatic Expression of Fibroblast Growth Factor 21 in a PPARα-dependent Manner
2010
β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis
2003 StandoutNobel
Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes
2009
Enantioselective Enzymes by Computational Design and In Silico Screening
2015 StandoutNobel
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 Å resolution
1997
Design and directed evolution of a dideoxy purine nucleoside phosphorylase
2010
Binding of phosphate and sulfate anions by purine nucleoside phosphorylase from E. coli: ligand-dependent quenching of enzyme intrinsic fluorescence
1997
Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists
2005
Memory of Extracellular Adenosine A2A Purinergic Receptor-mediated Signaling in Murine T Cells
1997 StandoutNobel
Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism
2002
Structure-based drug design
1994
Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity
2016
Topology of subunits of the mammalian cytochrome c oxidase: relationship to the assembly of the enzyme complex
1991
Nuclear Receptors Reverse McGarry's Vicious Cycle to Insulin Resistance
2012
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
1994 Standout
Immucillin‐H binding to purine nucleoside phosphorylase reduces dynamic solvent exchange
2000
β-Arrestin and Mdm2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression
2007 StandoutNobel
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
2000 StandoutNature
A Model Binding Site for Testing Scoring Functions in Molecular Docking
2002
Ligand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice
2011
Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation
2009
Principles determining the structure of β-sheet barrels in proteins II. The observed structures
1994
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Mechanisms of thyroid hormone action
2012
Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry
2011
Ab Initio Evaluation of the Potential Surface for General Base- Catalyzed Methanolysis of Formamide: A Reference Solution Reaction for Studies of Serine Proteases
2000 StandoutNobel
Atomic Dissection of the Hydrogen Bond Network for Transition-State Analogue Binding to Purine Nucleoside Phosphorylase
2002
Generalized Born Models of Macromolecular Solvation Effects
2000
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
A Model of the Interaction of Substrates and Inhibitors with Xanthine Oxidase
1997
Functions of the gene products of Escherichia coli
1993
Promoting Vibrations in Human Purine Nucleoside Phosphorylase. A Molecular Dynamics and Hybrid Quantum Mechanical/Molecular Mechanical Study
2004
Copper-Catalyzed P-Arylation via Direct Coupling of Diaryliodonium Salts with Phosphorus Nucleophiles at Room Temperature
2013
Thyroid Hormone-Related Regulation of Gene Expression in Human Fatty Liver
2009
Bioisosterism: A Rational Approach in Drug Design
1996
Substrate Analogues for an RNA-Editing Adenosine Deaminase: Mechanistic Investigation and Inhibitor Design
2003
Structure, dynamics and composition of the lipid-protein interface. Perspectives from spin-labelling
1998
A Transition State Analogue for an RNA-Editing Reaction
2004
Structure of Staphylococcal α-Hemolysin, a Heptameric Transmembrane Pore
1996 StandoutScience
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Implicit Solvation Models: Equilibria, Structure, Spectra, and Dynamics
1999 Standout
2-Benzyloxymethyl-5-(tributylstannyl)tetrazole. A reagent for the preparation of 5-aryl- and 5-heteroaryl-1H-tetrazoles via the Stille reaction
2000
In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue
2013
Protein NMR Structures Refined with Rosetta Have Higher Accuracy Relative to Corresponding X-ray Crystal Structures
2014 StandoutNobel
Catalytic Asymmetric Hydroalkoxylation of C–C Multiple Bonds
2021 StandoutNobel
Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates
2019
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Synthesis of 4-substituted phenylalanine derivatives by cross-coupling reaction of p-boronophenylalanines
1997
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å
1996 StandoutScience
Solvent dramatically affects protein structure refinement
2008 StandoutNobel
Thyroid Hormone Regulation of Metabolism
2014 Standout
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Structure-based discovery of β 2 -adrenergic receptor ligands
2009 StandoutNobel
Efficient Drug Lead Discovery and Optimization
2009
Medicinal Chemistry of Nucleoside Phosphonate Prodrugs for Antiviral Therapy
2011
Docking flexible molecules: A case study of three proteins
1995
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Review on Modern Advances of Chemical Methods for the Introduction of a Phosphonic Acid Group
2011
The Complete Genome Sequence of Escherichia coli K-12
1997 StandoutScience
Solvation Free Energy of Biomacromolecules: Parameters for a Modified Generalized Born Model Consistent with the AMBER Force Field
1998
Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways
2013
A good ligand is hard to find: Automated docking methods
1993
Quantum Mechanical Continuum Solvation Models
2005 Standout
A Genomic Perspective on Protein Families
1997 StandoutScience
Long-Term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats
2005
One-Third-the-Sites Transition-State Inhibitors for Purine Nucleoside Phosphorylase
1998
In Vivo Activity of the Thyroid Hormone Receptor β- and α-Selective Agonists GC-24 and CO23 on Rat Liver, Heart, and Brain
2011
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Calf Spleen Purine Nucleoside Phosphorylase Complexed with Substrates and Substrate Analogues,
1998
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
Equilibrium Constants for Dehydration of Water Adducts of Aromatic Carbon−Carbon Double Bonds
2002
Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions
2009 Standout
Works of Mark D. Erion being referenced
Purine nucleoside phosphorylase inhibitors: biochemical and pharmacological studies with 9-benzyl-9-deazaguanine and related compounds.
1993
Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist #
2008
1-Aminocyclopropanephosphonate: time-dependent inactivation of 1-aminocyclopropanecarboxylate deaminase and Bacillus stearothermophilus alanine racemase by slow dissociation behavior
1987
Chorismate aminations: partial purification of Escherichia coli PABA synthase and mechanistic comparison with anthranilate synthase
1987
Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanine
1993
Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 4. A Study of Phosphate Mimics
1994
Suppression of Substance P Biosynthesis in Sensory Neurons of Dorsal Root Ganglion by Prodrug Esters of Potent Peptidylglycine α-Amidating Monooxygenase Inhibitors
1997
Inhibition of Peptidylglycine .alpha.-Amidating Monooxygenase by N-Substituted Homocysteine Analogs
1994
A radioimmunoassay for measuring α-amidating enzyme activity
1990
N-Phosphonomethyl Dipeptides and Their Phosphonate Prodrugs, a New Generation of Neutral Endopeptidase (NEP, EC 3.4.24.11) Inhibitors
1994
The structure of human 5′-deoxy-5′-methylthioadenosine phosphorylase at 1.7 Å resolution provides insights into substrate binding and catalysis
1999
Hypoglycaemic effect of AICAriboside in mice
1996
Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine
1993
Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the arylmethyl group
1993
Purine Nucleoside Phosphorylase. 3. Reversal of Purine Base Specificity by Site-Directed Mutagenesis
1997
Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins.
1995
Discovery of Phosphonic Diamide Prodrugs and Their Use for the Oral Delivery of a Series of Fructose 1,6-Bisphosphatase Inhibitors
2008
Design, Synthesis, and Characterization of a Series of Cytochrome P4503A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver§
2004
Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism
1997
Calculation of Relative Hydration Free Energy Differences for Heteroaromatic Compounds: Use in the Design of Adenosine Deaminase and Cytidine Deaminase Inhibitors
1998
Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′- C -Methylcytidine to Hepatitis C Virus-Infected Chimpanzees
2011
Pharmacologic Profile of CGS 24128, a Potent, Long-Acting Inhibitor of Neutral Endopeptidase 24.11
1994
Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index
2007
Purine Nucleoside Phosphorylase. 1. Structure−Function Studies
1997
Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys
2017
A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis
2010
Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
1991
Identifying regions of membrane proteins in contact with phospholipid head groups: covalent attachment of a new class of aldehyde lipid labels to cytochrome c oxidase
1986
Relative Binding Affinities of Fructose-1,6-Bisphosphatase Inhibitors Calculated Using a Quantum Mechanics-Based Free Energy Perturbation Method
2007
Calculation of Relative Binding Free Energy Differences for Fructose 1,6-Bisphosphatase Inhibitors Using the Thermodynamic Cycle Perturbation Approach
2001
Prodrugs of Phosphates and Phosphonates
2008
Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B
2008
Structure-Guided Design of AMP Mimics That Inhibit Fructose-1,6-bisphosphatase with High Affinity and Specificity
2007 Nobel
Discovery of a Series of Phosphonic Acid-Containing Thiazoles and Orally Bioavailable Diamide Prodrugs That Lower Glucose in Diabetic Animals Through Inhibition of Fructose-1,6-Bisphosphatase
2010
Synthesis and Biological Evaluation of a Series of Liver-Selective Phosphonic Acid Thyroid Hormone Receptor Agonists and Their Prodrugs
2008
Probing the conformational space available to inhibitors in the thermolysin active site using Monte Carlo/energy minimization techniques
1992
Design of Purine Nucleoside Phosphorylase Inhibitors
2018
Solvation free energies calculated using the GB/SA model: Sensitivity of results on charge sets, protocols, and force fields
1998
The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure.
1994
AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series
2000
Fructose-1,6-bisphosphatase Inhibitors. 2. Design, Synthesis, and Structure−Activity Relationship of a Series of Phosphonic Acid Containing Benzimidazoles that Function as 5′-Adenosinemonophosphate (AMP) Mimics
2009