Standout Papers
Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Loss of conformational entropy in protein folding calculated using realistic ensembles and its implications for NMR-based calculations
2014 StandoutNobel
Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
2006
A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery
2019
Restriction of PD-1 function by cis -PD-L1/CD80 interactions is required for optimal T cell responses
2019 Science
A non‐RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis
2005
PD-L1 Binds to B7-1 Only In Cis on the Same Cell Surface
2018
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
2017 StandoutNature
TIMP-3 Binds to Sulfated Glycosaminoglycans of the Extracellular Matrix
2000
Electroreduction of carbon monoxide to liquid fuel on oxide-derived nanocrystalline copper
2014 StandoutNature
mTOR Signaling in Growth Control and Disease
2012 Standout
Free R value: a novel statistical quantity for assessing the accuracy of crystal structures
1992 StandoutNature
Chemical shifts in denatured proteins: Resonance assignments for denatured ubiquitin and comparisons with other denatured proteins
2001
Crystal structure of globular domain of histone H5 and its implications for nucleosome binding
1993 StandoutNatureNobel
Fast Association and Slow Transitions in the Interaction between Two Intrinsically Disordered Protein Domains
2012
The structure of Escherichia coli cytosine deaminase 1 1Edited by I. A. Wilson
2002
Tissue inhibitors of metalloproteinases: evolution, structure and function
2000 Standout
The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA
1997 StandoutNobel
Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells
2009
New structure — novel fold?
1997
Dali: a network tool for protein structure comparison
1995
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
2019
Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
2012 StandoutNobel
Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus Dystrophy Mutation
1998
Assignment of the backbone 1H and 15N NMR resonances and secondary structure characterization of barstar
1993
[30] Tissue inhibitors of matrix metalloendopeptidases
1995
Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Binds to the Catalytic Domain of the Cell Surface Receptor, Membrane Type 1-Matrix Metalloproteinase 1 (MT1-MMP)
1998
Mutational analysis of the putative nucleic acid‐binding surface of the cold‐shock domain, CspB, revealed an essential role of aromatic and basic residues in binding of single‐stranded DNA containing the Y‐box motif
1995
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1
2015
Type VII secretion — mycobacteria show the way
2007
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Coevolution of metal availability and nitrogen assimilation in cyanobacteria and algae
2009
Mutational Study of the Amino-terminal Domain of Human Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) Locates an Inhibitory Region for Matrix Metalloproteinases
1997
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor
1998
Structural properties of matrix metalloproteinases
1999
A case of convergent evolution of nucleic acid binding modules
1996
Biochemical Characterization of the Catalytic Domain of Human Matrix Metalloproteinase 19
2000
TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)
2001
What is newsworthy?
1996
The Solution Structure of the S1 RNA Binding Domain: A Member of an Ancient Nucleic Acid–Binding Fold
1997
Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6
2011
The rise of oxygen in Earth’s early ocean and atmosphere
2014 StandoutNature
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies
2007 Standout
Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)
2001
A residue-specific NMR view of the non-cooperative unfolding of a molten globule
1997
EspA Acts as a Critical Mediator of ESX1-Dependent Virulence in Mycobacterium tuberculosis by Affecting Bacterial Cell Wall Integrity
2010
Comparative analysis of the noncollagenous NC1 domain of type IV collagen: Identification of structural features important for assembly, function, and pathogenesis
1998
Transverse relaxation optimized 3D and 4D 15N/15N separated NOESY experiments of 15N labeled proteins
2000
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 Å resolution
1998
Nucleases: diversity of structure, function and mechanism
2010
Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways
2010
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Matrix Metalloproteinases
1999 Standout
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Polarization transfer by cross-correlated relaxation in solution NMR with very large molecules
1999 StandoutNobel
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains.
1991
TROSY-type Triple-Resonance Experiments for Sequential NMR Assignments of Large Proteins
1999 StandoutNobel
PROTEIN FOLDS IN THE ALL-β AND ALL-α CLASSES
1997
A segment of cold shock protein directs the folding of a combinatorial protein
2005 StandoutNobel
Zinc: biological functions and coordination motifs
1993
Visualization of protein S1 within the 30S ribosomal subunit and its interaction with messenger RNA
2001 StandoutNobel
Structures of Larger Proteins in Solution: Three- and Four-Dimensional Heteronuclear NMR Spectroscopy
1991 Science
Novel folded protein domains generated by combinatorial shuffling of polypeptide segments
2000 StandoutNobel
On the Mechanism of Hydrolysis of Phosphate Monoesters Dianions in Solutions and Proteins
2006 StandoutNobel
Asymmetric Two‐Center Catalysis—Learning from Nature
1996
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
2002
Structural and Functional Aspects of Metal Sites in Biology
1996 Standout
TROSY in triple-resonance experiments: New perspectives for sequential NMR assignment of large proteins
1998 StandoutNobel
The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain.
1991 StandoutNobel
Reticular Electronic Tuning of Porphyrin Active Sites in Covalent Organic Frameworks for Electrocatalytic Carbon Dioxide Reduction
2017 StandoutNobel
Crystal Structure of an Initiation Factor Bound to the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
Degrees of Difficulty of Water-Consuming Reactions in the Absence of Enzymes
2006
Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin
2008
Asymmetrische Zweizentren‐Katalyse – von der Natur lernen
1996
Sclerostin: A gem from the genome leads to bone-building antibodies
2010
Covalent organic frameworks comprising cobalt porphyrins for catalytic CO 2 reduction in water
2015 StandoutScienceNobel
Mutually dependent secretion of proteins required for mycobacterial virulence
2005
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging
2015
Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones
2010
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Isotope labeling in solution protein assignment and structural analysis
1994
Coordinatively Unsaturated Metal Centers in the Extended Porous Framework of Zn3(BDC)3·6CH3OH (BDC = 1,4-Benzenedicarboxylate)
1998 StandoutNobel
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
DNA origami protection and molecular interfacing through engineered sequence-defined peptoids
2020 StandoutNobel
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1
1997 NatureNobel
Protein Structure Prediction and Structural Genomics
2001 StandoutScienceNobel
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO2 Fixation
2013 Standout
Reversal of DNA alkylation damage by two human dioxygenases
2002 StandoutNobel
Divergent Evolution of Enzymatic Function: Mechanistically Diverse Superfamilies and Functionally Distinct Suprafamilies
2001
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
How Matrix Metalloproteinases Regulate Cell Behavior
2001 Standout
The Microbial Engines That Drive Earth's Biogeochemical Cycles
2008 StandoutScience
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
2003 Standout
Mechanistic Studies on Synthetic Fe−S-Based Clusters and Their Relevance to the Action of Nitrogenases
2005 StandoutNobel
Metal–Organic Frameworks for Electrocatalytic Reduction of Carbon Dioxide
2015 StandoutNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis
1997
Computational design of a red fluorophore ligase for site-specific protein labeling in living cells
2014 StandoutNobel
Clustering of low-energy conformations near the native structures of small proteins
1998 StandoutNobel
Works of Mark D. Carr being referenced
Structure and Interactions of the Human Programmed Cell Death 1 Receptor
2013
Characterization of the Structural Features and Interactions of Sclerostin
2009
Structure and function of the complex formed by the tuberculosis virulence factors CFP‐10 and ESAT‐6
2005
Structural Diversity in p160/CREB-binding Protein Coactivator Complexes
2006
Stereospecific assignments of the leucine methyl resonances in the 1H NMR spectrum of Lactobacillus casei dihydrofolate reductase
1993
Chemically and Conformationally Authentic Active Domain of Human Tissue Inhibitor of Metalloproteinases‐2 Refolded from Bacterial Inclusion Bodies
1996
Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family
1994
Conclusive Evidence That the Major T-cell Antigens of theMycobacterium tuberculosis Complex ESAT-6 and CFP-10 Form a Tight, 1:1 Complex and Characterization of the Structural Properties of ESAT-6, CFP-10, and the ESAT-6·CFP-10 Complex
2002
A novel method of preparing totally α‐deuterated amino acids for selective incorporation into proteins
1990
Dihydrofolate reductase; sequential resonance assignments using 2D and 3D NMR and secondary structure determination in solution
1991
The 1H‐NMR assignments of the aromatic resonances in complexes of Lactobacillus casei dihydrofolate reductase and the origins of their chemical shifts
1990
High Resolution Structure of the N-terminal Domain of Tissue Inhibitor of Metalloproteinases-2 and Characterization of Its Interaction Site with Matrix Metalloproteinase-3
1998
NMR and molecular dynamics studies of the mKr2‘zinc finger’
1990
Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR
2007
The crystal structure of urease from Klebsiella aerogenes
1995 StandoutScience
HMQC-NOESY-HMQC, a three-dimensional NMR experiment which allows detection of nuclear overhauser effects between protons with overlapping signals
1990
Mapping the Binding Site for Matrix Metalloproteinase on the N-Terminal Domain of the Tissue Inhibitor of Metalloproteinases-2 by NMR Chemical Shift Perturbation
1997