Citation Impact
Citing Papers
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
CRISPR/Cas9 in Genome Editing and Beyond
2016
RNA editing with CRISPR-Cas13
2017 Science
A CRISPR/Cas9-Based System for Reprogramming Cell Lineage Specification
2014
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Precision cancer mouse models through genome editing with CRISPR-Cas9
2015
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9
2017
Switchable Cas9
2017 StandoutNobel
CRISPR-Cas9-based Photoactivatable Transcription System
2015
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
A CRISPR-based approach for targeted DNA demethylation
2016
Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28
2017
An RNA-aptamer-based two-color CRISPR labeling system
2016
Hyaluronic Acid Hydrogels for Biomedical Applications
2011 Standout
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
2015
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
2015
Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system
2016
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
2015
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
2016
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation
2017
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
Hydrogels in Regenerative Medicine
2009 Standout
Rewiring human cellular input–output using modular extracellular sensors
2016
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
2015
Induced Pluripotent Stem Cells Meet Genome Editing
2016
RNA targeting with CRISPR–Cas13
2017 Nature
Chromatin regulation at the frontier of synthetic biology
2015
Development of an intein-mediated split–Cas9 system for gene therapy
2015
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
2017
A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology
2018
Comparison of Cas9 activators in multiple species
2016
The emerging role of lncRNAs in cancer
2015 Standout
Expanding the CRISPR imaging toolset withStaphylococcus aureusCas9 for simultaneous imaging of multiple genomic loci
2016
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
2016
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks
2015
Optogenetics: 10 years of microbial opsins in neuroscience
2015 Standout
Applications of the CRISPR–Cas9 system in cancer biology
2015
A CRISPR toolbox to study virus–host interactions
2017
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array
2016
Enabling functional genomics with genome engineering
2015
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
2015
Highly efficient Cas9-mediated transcriptional programming
2015
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system
2017
Functional annotation of native enhancers with a Cas9–histone demethylase fusion
2015
A split-Cas9 architecture for inducible genome editing and transcription modulation
2015
CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci
2016
In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target
2015
Applications of CRISPR–Cas systems in neuroscience
2015
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
CRISPR interference-based specific and efficient gene inactivation in the brain
2018
Genome-scale CRISPR pooled screens
2016
Crystal Structure of Staphylococcus aureus Cas9
2015
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
2015
CRISPR/Cas9-Based Engineering of the Epigenome
2017
Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
2015
CRISPR-Cas systems for editing, regulating and targeting genomes
2014 Standout
Editing DNA Methylation in the Mammalian Genome
2016
Locus-specific editing of histone modifications at endogenous enhancers
2013
Bacterial CRISPR: accomplishments and prospects
2015
High-throughput functional genomics using CRISPR–Cas9
2015
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
A thermostable Cas9 with increased lifetime in human plasma
2017 StandoutNobel
The next generation of CRISPR–Cas technologies and applications
2019
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
2014
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
2015
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
2013
Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions
2016
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
2016
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow
2016
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Photochemistry of flavoprotein light sensors
2014
Photoreceptor engineering
2015
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Repurposing the CRISPR-Cas9 system for targeted DNA methylation
2016
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
2016 Science
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
2015
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine
2017
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning
2015 StandoutScienceNobel
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering
2016 StandoutNobel
Imaging Specific Genomic DNA in Living Cells
2016
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference
2014 StandoutNobel
Development of Light‐Activated CRISPR Using Guide RNAs with Photocleavable Protectors
2016
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells
2013
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
2015
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins
2014
Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast
2016
De novo design of protein logic gates
2020 StandoutScienceNobel
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
2016
Works of Mark D. Brigham being referenced
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2016
Mechanically Robust and Bioadhesive Collagen and Photocrosslinkable Hyaluronic Acid Semi-Interpenetrating Networks
2008
Optical control of mammalian endogenous transcription and epigenetic states
2013 Nature
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
2017