Standout Papers
Citation Impact
Citing Papers
Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding
2010 Science
Differential dynamics of the mammalian mRNA and protein expression response to misfolding stress
2016
Dynamic profiling of the protein life cycle in response to pathogens
2015 Science
Molecular Cloning of a Human Prion Protein cDNA
1986 StandoutNobel
Next-generation analysis of gene expression regulation – comparing the roles of synthesis and degradation
2015
The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms.
1994 StandoutNobel
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Distinct prion proteins in short and long scrapie incubation period mice
1987 StandoutNobel
Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase
1993 StandoutNobel
Concentration-dependent transcriptional activation or repression by Krüppel from a single binding site
1991 Nature
ESC, ESCL and their roles in Polycomb Group mechanisms
2008
Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction
1989
The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide
1992
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
2015
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
2008
Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning
1998 StandoutNobel
Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif
1988
Quantifying transcription factor kinetics: At work or at play?
2013
A mutant with a defect in telomere elongation leads to senescence in yeast
1989 StandoutNobel
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms
2008
O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation
1988
Transcriptional activation of Drosphila homeotic genes form distant regulatory elements
1993
Jarid2 and PRC2, partners in regulating gene expression
2010
Sturcture and expression of the humanXPBC/ERCC-3gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's syndrome
1991
The ‘heavy’ subunit of the photosynthetic reaction centre from Rhodopseudomonas viridis : isolation of the gene, nucleotide and amino acid sequence
1985
An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters
1988
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
Cloning and characterization of the mitochondrial phosphate transport protein gene from the yeast Saccharomyces cerevisiae
1991
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Two bovine genes for mitochondrial ADP/ATP translocase expressed differently in various tissues
1989 StandoutNobel
Telomeres shorten during ageing of human fibroblasts
1990 StandoutNatureNobel
Facultative Heterochromatin: Is There a Distinctive Molecular Signature?
2007
Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution
1985 StandoutNatureNobel
The Mammalian Epigenome
2007 Standout
Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos
2009
Role of the polycomb protein EED in the propagation of repressive histone marks
2009 Nature
Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles
1992 StandoutNobel
Fiji: an open-source platform for biological-image analysis
2012 Standout
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
Polycomb Group proteins: an evolutionary perspective
2007
ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency
2010
A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain
2009
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
2010 Standout
Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2
1988 Nature
Analysis of variation at transcription factor binding sites in Drosophila and humans
2012
Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier
1992 StandoutNobel
ATP synthase from bovine mitochondria: sequences of imported precursors of oligomycin sensitivity conferral protein, factor 6, and adenosine triphosphatase inhibitor protein
1987 StandoutNobel
Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro
2009
Sequences of 20 subunits of NADH: Ubiquinone oxidoreductase from bovine heart mitochondria
1992 StandoutNobel
Homeobox genes and axial patterning
1992 Standout
Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2
2010
Structure of the human DNA ligast I gene
1992 StandoutNobel
Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards
1987 StandoutNobel
Understanding transcriptional regulation by integrative analysis of transcription factor binding data
2012
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
2007
Kaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity–Based Lymphomas
1995 Standout
Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution
2011
Immunological responses to Epstein-barr virus infection and the pathogenesis of EBV-induced diseases
1989
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
2007
Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data
2010
Sequence of the bovine 2-oxoglutarate/malate carrier protein: structural relationship to other mitochondrial transport proteins
1990 StandoutNobel
A novel form of Epstein-Barr virus latency in normal B cells in vivo
1995 Standout
Whole-Genome Mapping of Histone H3 Lys4 and 27 Trimethylations Reveals Distinct Genomic Compartments in Human Embryonic Stem Cells
2007
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness
2010
Localization and nucleotide sequence of the gene for the membrane polypeptide D2 from pea chloroplast DNA
1984
The ε-subunit of ATP synthase from bovine heart mitochondria. Complementary DNA sequence, expression in bovine tissues and evidence of homologous sequences in man and rat
1990 StandoutNobel
Construction of heterodimer tyrosyl-tRNA synthetase shows tRNATyr interacts with both subunits.
1986 StandoutNobel
cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.
1986 StandoutNobel
Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila.
1995 StandoutNobel
Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein gene
1991
Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome.
1989
The level of c-fgr RNA is increased by EBNA-2, an Epstein-Barr virus gene required for B-cell immortalization
1990
Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma
1994 StandoutScience
NIH Image to ImageJ: 25 years of image analysis
2012 Standout
Bioimage informatics: a new area of engineering biology
2008
Synchronous and sequential activation of latently infected Epstein-Barr virus genomes
1989
Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila.
1991
Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.
1994 StandoutNobel
Organization of the human myoglobin gene.
1984
Sequence of the bovine mitochondrial phosphate carrier protein: structural relationship to ADP/ATP translocase and the brown fat mitochondria uncoupling protein.
1987 StandoutNobel
Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression
1991
Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice
2009
Nucleotide sequence of the human N-myc gene.
1986 StandoutNobel
Molecular cloning of a bovine cathepsin
1985 StandoutNobel
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)
1984 StandoutNobel
Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator.
1987
Abundant bacterial expression and reconstitution of an intrinsic membrane-transport protein from bovine mitochondria
1993 StandoutNobel
(CT)n (GA)n repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of the Drosophila hsp26 gene.
1993
Significant potential secondary structures in the Epstein-Barr virus genome.
1986
The yeast α-factor receptor: structural properties deduced from the sequence of theSTE2gene
1985 StandoutNobel
(CT)n (GA)n Repeats and Heat Shock Elements Have Distinct Roles in Chromatin Structure and Transcriptional Activation of the Drosophila hsp26 Gene
1993
The Drosophila zeste protein binds cooperatively to sites in many gene regulatory regions: implications for transvection and gene regulation.
1988
Autoregulation of a segmentation gene in Drosophila: combinatorial interaction of the even-skipped homeo box protein with a distal enhancer element.
1991
Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1.
1988
DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.
1987 Standout
Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.
1987
Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus
1989
The rDNA ofC. elegans: sequence and structure
1986 StandoutNobel
Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo
2008
Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen.
1990 StandoutNobel
Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6
1993
SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast Golgi apparatus.
1988 StandoutNobel
Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.
1988
Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.
1989
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
1988 StandoutNobel
Hypervariable ‘minisatellite’ regions in human DNA
1985 StandoutNature
Synthesis of a Site-Specific DNA-Binding Peptide
1987 StandoutScienceNobel
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Epstein-Barr virus-encoded nuclear antigen 2 activates the viral latent membrane protein promoter by modulating the activity of a negative regulatory element.
1990
Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II)
1985 StandoutNobel
CBP-mediated acetylation of histone H3 lysine 27 antagonizesDrosophilaPolycomb silencing
2009
Primary structure of the herpesvirus saimiri genome
1992
Two genes encoding the bovine mitochondrial ATP synthase proteolipid specify precursors with different import sequences and are expressed in a tissue-specific manner.
1985 StandoutNobel
Primary structure of the L subunit of the reaction center from Rhodopseudomonas sphaeroides.
1984
Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.
1984
The small subunit of ribonucleotide reductase is encoded by one of the most abundant translationally regulated maternal RNAs in clam and sea urchin eggs.
1985 StandoutNobel
MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos.
1989 StandoutNobel
High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene.
1991
Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23.
1987
Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain
1992
Rapid determination of 16S ribosomal RNA sequences for phylogenetic analyses.
1985 Standout
Nudeotide sequence of the BsuRI restriction-modification system
1985 StandoutNobel
Structure and function of telomeres
1991 StandoutNatureNobel
Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 ‘start’ gene.
1985 StandoutNobel
A large increase in enzyme–substrate affinity by protein engineering
1984 StandoutNatureNobel
Frequent c-myc oncogene activation and infrequent presence of Epstein- Barr virus genome in AIDS-associated lymphoma
1988
Mechanisms of Polycomb gene silencing: knowns and unknowns
2009
The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter.
1993
Detection and quantification of latently infected B lymphocytes in Epstein-Barr virus-seropositive, healthy individuals by polymerase chain reaction
1992
Works of Mark D. Biggin being referenced
A Quantitative Spatiotemporal Atlas of Gene Expression in the Drosophila Blastoderm
2008
The role of chromatin accessibility in directing the widespread, overlapping patterns of Drosophila transcription factor binding
2011
Binding Site Turnover Produces Pervasive Quantitative Changes in Transcription Factor Binding between Closely Related Drosophila Species
2010
Genome-wide analysis of Polycomb targets in Drosophila melanogaster
2006
Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
2009
Animal Transcription Networks as Highly Connected, Quantitative Continua
2011
A purified Drosophila homeodomain protein represses transcription in vitro
1989
Three-dimensional morphology and gene expression in the Drosophilablastoderm at cellular resolution I: data acquisition pipeline
2006
Large-Scale Turnover of Functional Transcription Factor Binding Sites in Drosophila
2006
Quantitative Models of the Mechanisms That Control Genome-Wide Patterns of Transcription Factor Binding during Early Drosophila Development
2011
Zeste encodes a sequence-specific transcription factor that activates the Ultrabithorax promoter in vitro
1988
Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts
1988
Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells
1987
Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.
1983 Standout
zeste, a nonessential gene, potently activates Ultrabithorax transcription in the Drosophila embryo.
1992
Coordinate action of a proximal homeoprotein binding site and a distal sequence confers the Ultrabithorax expression pattern in the visceral mesoderm.
1989
DNA binding specificity of two homeodomain proteins in vitro and in Drosophila embryos.
1996
Transcription and DNA sequence of the BamHI L fragment of B95-8 Epstein-Barr virus.
1984
DNA sequence and expression of the B95-8 Epstein—Barr virus genome
1984 StandoutNature
DNA regions bound at low occupancy by transcription factors do not drive patterned reporter gene expression in Drosophila
2012
System wide analyses have underestimated protein abundances and the importance of transcription in mammals
2014