Citation Impact
Citing Papers
Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation
2013 Science
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
2014
The PINK1/Parkin pathway regulates mitochondrial morphology
2008
2014
PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
2013 Science
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
2008
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
2009 Standout
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
2013
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures
2006
Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
2013
Molecular interaction between parkin and PINK1 in mammalian neuronal cells
2009
DJ-1, a novel regulator of the tumor suppressor PTEN
2005
The Role of Innate and Adaptive Immunity in Parkinson's Disease
2013
Colonic bacterial composition in Parkinson's disease
2015 Standout
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
2009
Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission
2009
Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy
2014
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
2014
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster
2012
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
2012
Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy
2012
HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism
2014
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
Mammalian conserved ADAR targets comprise only a small fragment of the human editosome
2014
A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment
2013
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
2013
A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
2013
Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction
2012
HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease
2015
Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition
2011
Parkin Facilitates the Elimination of Expanded Polyglutamine Proteins and Leads to Preservation of Proteasome Function
2003
Transcriptomic profiling of microglia and astrocytes throughout aging
2020
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria
2012
PINK1 is degraded through the N-end rule pathway
2013
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
2010
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Proteasomal Inhibition by α-Synuclein Filaments and Oligomers
2004
Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation
2011
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
2008
Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease
2018
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
2010 Standout
Overlap of expression Quantitative Trait Loci (eQTL) in human brain and blood
2014
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
The genetics of Parkinson disease: implications for neurological care
2006
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism
2013
Ca2+-dependent regulation of mitochondrial dynamics by the Miro–Milton complex
2009
Autophagy and the Integrated Stress Response
2010 Standout
The link between the GBA gene and parkinsonism
2012
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Cerebrospinal fluid biomarkers in Parkinson disease
2013
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression
2003
Dopamine covalently modifies and functionally inactivates parkin
2005
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
2006
The role of autophagy in neurodegenerative disease
2013 Standout
ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression
2013
The Scaffold Protein Atg11 Recruits Fission Machinery to Drive Selective Mitochondria Degradation by Autophagy
2013
Ubiquitin is phosphorylated by PINK1 to activate parkin
2014 Nature
Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
2008
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
2008
Autophagy in mammalian development and differentiation
2010 Standout
ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy
2012
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
2016 Nature
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
2015 Standout
Parkin and PINK1: much more than mitophagy
2014
Select E2 enzymes differentially regulate parkin activation and mitophagy
2014
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
2014
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling
2009
Parkin and mitochondrial quality control: toward assembling the puzzle
2014
Inclusion Body Formation and Neurodegeneration Are Parkin Independent in a Mouse Model of α-Synucleinopathy
2006
Signaling the mitochondrial unfolded protein response
2012
Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice
2011
The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria
2013
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1
2007
Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
2014 Standout
TRAP1 rescues PINK1 loss-of-function phenotypes
2013
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
2007
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
2011
RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk
2013
Epidemiology of Parkinson's disease
2006 Standout
The genetics and neuropathology of Parkinson’s disease
2012
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Parkin Suppresses Dopaminergic Neuron-Selective Neurotoxicity Induced by Pael-R in Drosophila
2003
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
2010
Deciphering the role of heterozygous mutations in genes associated with parkinsonism
2007
Part II: α-synuclein and its molecular pathophysiological role in neurodegenerative disease
2003
Mitochondrial fusion and fission in cell life and death
2010 Standout
Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of γ‐synuclein, α‐synuclein and double α/γ‐synuclein null mutant mice
2004
PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix
2014
Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane
2011
Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome
2015
Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage
2007
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria
2009
A gene-based association method for mapping traits using reference transcriptome data
2015
Autophagy: Renovation of Cells and Tissues
2011 Standout
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
2005
100 years of Lewy pathology
2012
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
2012
Mitochondria: In Sickness and in Health
2012 Standout
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
2014 Nature
What causes cell death in Parkinson's disease?
2009
RNA-binding proteins in neurodegeneration: Seq and you shall receive
2015
Parkin Disease
2013
Mitochondrial dynamics in cell death and neurodegeneration
2010
The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases
2018
Complex relationship between Parkin mutations and Parkinson disease
2002
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
2012
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
2016 Standout
Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin–protein ligase with monoubiquitylation capacity
2006
Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
2011
HDAC6 and Microtubules Are Required for Autophagic Degradation of Aggregated Huntingtin
2005
PINK1 cleavage at position A103 by the mitochondrial protease PARL
2010
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress
2004
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
2011
Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation
2009
Selective autophagy mediated by autophagic adapter proteins
2011 Standout
Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin
2007
Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1
2005
Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering
2014
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis
2005
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
2010
Annotation of functional variation in personal genomes using RegulomeDB
2012 Standout
Ubiquitination and selective autophagy
2012
Parkin Interacts with Ambra1 to Induce Mitophagy
2011
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Parkinson's disease
2015 Standout
Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner
2012
Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases
2015
Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 – 2011)
2012
The axonal transport of mitochondria
2012
DJ‐1 is present in a large molecular complex in human brain tissue and interacts with α‐synuclein
2005
PINK1-linked parkinsonism is associated with Lewy body pathology
2010
Bit-by-bit autophagic removal of parkin-labelled mitochondria
2013
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
Deciphering the Molecular Signals of PINK1/Parkin Mitophagy
2016
RNF185, a Novel Mitochondrial Ubiquitin E3 Ligase, Regulates Autophagy through Interaction with BNIP1
2011
The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants
2012
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
2013 Nature
Loss-of-Function Analysis Suggests ThatOmi/HtrA2Is Not an Essential Component of thepink1/parkinPathwayIn Vivo
2008
Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease
2013
Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23
2016
Peptide‐Based Inhibitors of Amyloid Assembly
2006
α-Synuclein: Normal Function and Role in Neurodegenerative Diseases
2004
Dynamics of DNA Methylation in Recent Human and Great Ape Evolution
2013
Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy
2013
Mechanisms of mitophagy
2010 Standout
Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease
2014
PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1
2007
Advances in the genetics of Parkinson disease
2013
α-Synuclein Is Degraded by Both Autophagy and the Proteasome
2003
Part I: Parkin-associated proteins and Parkinson's disease
2003
Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism
2012 Nobel
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
2010
Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine
2010
Mitochondrial metabolism of reactive oxygen species
2005
Parkinson's disease and α‐synuclein expression
2011
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
2004
Neurodegeneration and Inflammation in Parkinson's disease
2011
Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts
2011
Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth
2009
PINK1 Triggers Autocatalytic Activation of Parkin to Specify Cell Fate Decisions
2014
Lewy body Parkinson's disease in a large pedigree with 77Parkin mutation carriers
2005
Functional mapping and annotation of genetic associations with FUMA
2017 Standout
Role of the Ubiquitin Conjugation System in the Maintenance of Mitochondrial Homeostasis
2008
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
2010
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
2010
Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons
2003
Distinct RolesIn Vivofor the Ubiquitin–Proteasome System and the Autophagy–Lysosomal Pathway in the Degradation of α-Synuclein
2011
Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
2014
Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance
2014
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
2009
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
The Impact of Pathogenic Mitochondrial DNA Mutations on Substantia Nigra Neurons
2013
Diverse Effects of Pathogenic Mutations of Parkin That Catalyze Multiple Monoubiquitylation in Vitro
2005
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
2010
Chromosome conformation elucidates regulatory relationships in developing human brain
2016 Nature
Are Ubiquitination Pathways Central to Parkinson's Disease?
2003
Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
2012
Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells
2011
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
2011
Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice
2014
Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy
2011
UBE2N, UBE2L3 and UBE2D2/3 ubiquitin-conjugating enzymes are essential for parkin-dependent mitophagy
2014
HITS‐CLIP: panoramic views of protein–RNA regulation in living cells
2010
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity
2003
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
2016 Standout
Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
2014
Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons
2012
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1
2006
Perturbations in Mitochondrial Dynamics Induced by Human Mutant PINK1 Can Be Rescued by the Mitochondrial Division Inhibitor mdivi-1
2010
Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1
2011
Beyond GWASs: Illuminating the Dark Road from Association to Function
2013
Mitochondria: The Next (Neurode)Generation
2011
Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy
2011
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Interplay of LRRK2 with chaperone-mediated autophagy
2013
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Expanding insights of mitochondrial dysfunction in Parkinson's disease
2006
The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway
2010
VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations
2013
Neurodegenerative diseases and oxidative stress
2004 Standout
Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease
2007
PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila
2014
Autophagy and Neuronal Cell Death in Neurological Disorders
2012
Autoregulation of Parkin activity through its ubiquitin‐like domain
2011
The role of parkin in familial and sporadic Parkinson's disease
2010
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
2012
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
2009
Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
2010
Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy
2013
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors
2018
Characterization of PINK1 processing, stability, and subcellular localization
2008
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Regulation of mitochondrial permeability transition pore by PINK1
2012
Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming
2010
Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease
2010
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
Parkinson's Disease
2003 Standout
Structure of the human Parkin ligase domain in an autoinhibited state
2013
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking
2011
Autophagy Protects the Retina from Light-induced Degeneration
2013
Pathogenic Lysosomal Depletion in Parkinson's Disease
2010
Ubiquitin–proteasome system dysfunction in Parkinson’s disease: current evidence and controversies
2007
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents
2018
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
2014
The Interplay Between Mitochondrial Dynamics and Mitophagy
2010
Neurochemistry of Parkinson's disease
2007
Nitric oxide neurotoxicity in neurodegenerative diseases
2004
Metabolic regulation of mitochondrial dynamics
2016
The genetics of P arkinson's disease: Progress and therapeutic implications
2013
Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions
2000 Science
Role of Nrf2 in Oxidative Stress and Toxicity
2013 Standout
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
2010
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
2011
γ‐Synuclein and the progression of cancer
2007
MYC regulates the non-coding transcriptome
2014
Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants
2012
Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
2014
Neurons Expressing the Highest Levels of γ-Synuclein Are Unaffected by Targeted Inactivation of the Gene
2003
How Mitochondrial Dynamism Orchestrates Mitophagy
2015
Alterations in the common fragile site gene Parkin in ovarian and other cancers
2003
Organellophagy: Eliminating cellular building blocks via selective autophagy
2014
Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
2011
Does Impairment of the Ubiquitin-Proteasome System or the Autophagy-Lysosome Pathway Predispose Individuals to Neurodegenerative Disorders such as Parkinson's Disease?
2010
What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease
2011
Misfolded CuZnSOD and amyotrophic lateral sclerosis
2003
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
2010
Mussel-Inspired Surface Chemistry for Multifunctional Coatings
2007 StandoutScience
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
2005
Mitochondrial Disorders in the Nervous System
2008
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
2010
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
2011
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and Parkin
2008
Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches
2009
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
2014
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
2006
MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
2014
Mitochondrial Contagion Induced by Parkin Deficiency in Drosophila Hearts and Its Containment by Suppressing Mitofusin
2013
Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
2011
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
2013
The kinase domain of mitochondrial PINK1 faces the cytoplasm
2008
Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locusSREBF1as a regulator of mitophagy
2014
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
2013
Phosphorylated ubiquitin chain is the genuine Parkin receptor
2015
MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5
2015
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
2008
Ischemic Cell Death in Brain Neurons
1999 Standout
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
2012
Loss of locus coeruleus neurons and reduced startle in parkin null mice
2004
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
2010
Mechanism of Toxicity in Rotenone Models of Parkinson's Disease
2003
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
2014
The synaptic function of LRRK2
2012
Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice
2004
Drosophila Histone Deacetylase 6 Protects Dopaminergic Neurons against α-Synuclein Toxicity by Promoting Inclusion Formation
2010
Increased glutathione S -transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
2005
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
2014
MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE
2005
The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
2018
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
The mitochondrial UPR – protecting organelle protein homeostasis
2010
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy
2014
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
2014
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy
2016
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
2010
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
2010 Standout
Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging
2006
The Sac1 Domain of SYNJ 1 Identified Mutated in a Family with Early‐Onset Progressive P arkinsonism with Generalized Seizures
2013
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
2011
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
The PINK1–Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
2013
PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy
2016
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
2005
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
2008 Standout
α‐Synuclein oligomers and clinical implications for Parkinson disease
2012
Works of Mark Cookson being referenced
Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease
2007
Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1
2009
Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain
2012
Evidence for natural antisense transcript-mediated inhibition of microRNA function
2010
Evolutionary and functional relationships within the DJ1 superfamily
2004
Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?
2012
Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
2017
The Metalloprotease Inhibitor TIMP-3 Regulates Amyloid Precursor Protein and Apolipoprotein E Receptor Proteolysis
2007
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling
2009
Cell systems and the toxic mechanism(s) of α-synuclein
2007
Genetic comorbidities in Parkinson's disease
2013
DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA
2008
DJ-1 regulation of mitochondrial function and autophagy through oxidative stress
2011
RING finger 1 mutations in Parkin produce altered localization of the protein
2003
Parkin‐mediated ubiquitination regulates phospholipase C‐γ1
2008
α-Synuclein and neuronal cell death
2009
Amyotrophic Lateral Sclerosis 2-Deficiency Leads to Neuronal Degeneration in Amyotrophic Lateral Sclerosis through Altered AMPA Receptor Trafficking
2006
Genes and parkinsonism
2003
The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2
2008
Role of LRRK2 kinase dysfunction in Parkinson disease
2011
Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain
2010
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
2010 Standout
Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in α-synuclein expression
2002
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
2006
Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies
2013
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
2010
Hexokinase activity is required for recruitment of parkin to depolarized mitochondria
2013
Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein
2009
Analysis of the Cytosolic Proteome in a Cell Culture Model of Familial Amyotrophic Lateral Sclerosis Reveals Alterations to the Proteasome, Antioxidant Defenses, and Nitric Oxide Synthetic Pathways
2003
mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex
2013
Mitochondrial Alterations in PINK1 Deficient Cells Are Influenced by Calcineurin-Dependent Dephosphorylation of Dynamin-Related Protein 1
2009
Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease
2009
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease
2008
Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system
2006
Unaltered α-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion
2004
Parkinson's disease: insights from pathways
2010
Identification and characterization of the human parkin gene promoter
2001
Co‐ordinate transcriptional regulation of dopamine synthesis genes by α‐synuclein in human neuroblastoma cell lines
2003
Parkin Protects against the Toxicity Associated with Mutant α-Synuclein
2002
The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation
2008
Pathways to Parkinsonism
2003
Mitochondrial function and morphology are impaired in parkin‐mutant fibroblasts
2008
Genetic variability in the regulation of gene expression in ten regions of the human brain
2014
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
2010
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
2007
Parkin's Substrates and the Pathways Leading to Neuronal Damage
2003
The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation
2010
Peroxynitrite and Hydrogen Peroxide Induced Cell Death in the NSC34 Neuroblastoma × Spinal Cord Cell Line: Role of Poly(ADP‐Ribose) Polymerase
1998
Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations
2011
Mitochondria and Dopamine
2004
L166P Mutant DJ-1, Causative for Recessive Parkinson's Disease, Is Degraded through the Ubiquitin-Proteasome System
2003
Oxidative Stress and Motor Neurone Disease
1999
The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics
2009
Genetics of Parkinson's disease and parkinsonism
2006
LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans
2009
Mitochondrial Quality Control and Dynamics in Parkinson's Disease
2011
α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication
2004
AnIn VitroModel of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage
2002
α‐Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
2003
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways
2008
Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions
2009
A soluble α-synuclein construct forms a dynamic tetramer
2011
Cellular effects of LRRK2 mutations
2012
THE BIOCHEMISTRY OF PARKINSON'S DISEASE
2005
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP
2008
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
2005
Genetic neuropathology of Parkinson's disease.
2008
7. Mitochondrial function and morphology are impaired in parkin mutant fibroblasts
2009
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
2008
Membrane-associated farnesylated UCH-L1 promotes α-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease
2009
A strategy for designing inhibitors of α ‐synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders
2004
Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking
2009
Genes associated with Parkinson's disease: regulation of autophagy and beyond
2015
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
2004