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Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
2010 StandoutScience
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu 5 ) X-ray Structures
2018
Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors
2007
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Ionotropic and metabotropic glutamate receptor structure and pharmacology
2005
Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics
2014
Pharmacology of AMPA/Kainate Receptor Ligands and Their Therapeutic Potential in Neurological and Psychiatric Disorders
2000
Pharmacological Properties of the Potent Epileptogenic Amino Acid Dysiherbaine, a Novel Glutamate Receptor Agonist Isolated from the Marine Sponge Dysidea herbacea
2001
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
2011 Standout
Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors1The first two authors contributed equally to this work.1
2001
Glutamate receptor ion channels
2005 Standout
Characteristics and function of Ca2+ — and inositol 1,4,5-trisphosphate-releasable stores of Ca2+ in neurons
1992
N-Methyl-d-aspartate (NMDA) Receptor Subunit NR1 Forms the Substrate for Oligomeric Assembly of the NMDA Receptor
2007
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Structural Basis for Gating and Activation of RyR1
2016 StandoutNobel
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice
2006
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Activation of recombinant NR1/NR2C NMDA receptors
2008
Glutamate and Schizophrenia: Phencyclidine, N‐Methyl‐d‐Aspartate Receptors, and Dopamine–Glutamate Interactions
2007
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Expression and immunolocalization of the oxytocin receptor in human lactating and non-lactating mammary glands
1998
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
2011 StandoutNature
Preterm labour: a pharmacological challenge
1995
Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus
2004
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
2008
Competitive AMPA receptor antagonists
2006
NOD1 and NOD2 signalling links ER stress with inflammation
2016 StandoutNature
Glial and neuronal control of brain blood flow
2010 StandoutNature
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Identification of Molecular Determinants That Are Important in the Assembly of N-Methyl-d-aspartate Receptors
2001
Distinct Neuronal Coding Schemes in Memory Revealed by Selective Erasure of Fast Synchronous Synaptic Transmission
2012 StandoutNobel
Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2
2005
Functional biology of the α2δ subunits of voltage-gated calcium channels
2007
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
2002
Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells
1995
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Nucleotide Sequence, Genomic Organization, and Chromosomal Localization of Genes Encoding the Human NMDA Receptor Subunits NR3A and NR3B
2001
Novel Therapies for the Treatment of Central Sleep Apnea
2016
Inositol trisphosphate and calcium signalling
1993 StandoutNature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Contributes to the Development of Nigro-Striatal Damage Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice
2004
Equilibrium Constants for (R)-[(S)-1-(4-Bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic Acid (NVP-AAM077) Acting at Recombinant NR1/NR2A and NR1/NR2B N-Methyl-d-aspartate Receptors: Implications for Studies of Synaptic Transmission
2006
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
Glutamate Receptor Gating
2004
The molecular neurobiology of depression
2008 StandoutNature
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Calcium signaling
1995 Standout
Functional NR2B‐ and NR2D‐containing NMDA receptor channels in rat substantia nigra dopaminergic neurones
2005
PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)
2000 Standout
Asymmetric Functioning of Dimeric Metabotropic Glutamate Receptors Disclosed by Positive Allosteric Modulators
2005
Structure and function of inositol triphosphate receptors
1991
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Sequential and domino Sonogashira coupling: Efficient tools for the synthesis of diarylalkynes
2005
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
The nickel-catalyzed Sonogashira–Hagihara reaction
2003
Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction
1997
Cross‐Coupling Reactions on Azoles with Two and More Heteroatoms
2006
Block of Ca 2+ Wave and Ca 2+ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs
1992 StandoutScienceNobel
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
1995 Standout
New Palladium‐Catalyzed Domino Reaction with Intramolecular Ring Closure of an N‐(2‐Chloro‐3‐heteroaryl)arylamide: First Synthesis of Oxazolo[4,5‐b]pyrazines
2014
Characterization of a rapidly dissociating inositol 1,4,5-trisphosphate-binding site in liver membranes.
1992
Applications of Deuterium in Medicinal Chemistry
2019
Phospholipase C-δ1 and oxytocin receptor signalling: evidence of its role as an effector
1998
The Oxytocin Receptor
1999
Facile Synthesis of 2-Alkynyl Buta-1,3-dienes via Sonogashira Cross-Coupling Methodology
2005
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Regioselective synthesis of cytotoxic 4-(1-alkynyl)-substituted 2-(5H)-furanones
2003
N-Heterocyclic Carbenes in Late Transition Metal Catalysis
2009 Standout
The Catalytic Asymmetric Intermolecular Prins Reaction
2021 StandoutNobel
Evidence for Inhibition by Protein Kinase A of Receptor/Gαq/Phospholipase C (PLC) Coupling by a Mechanism Not Involving PLCβ2*
1998
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
2011 Standout
Aryl−Aryl Bond Formation by Transition-Metal-Catalyzed Direct Arylation
2007 Standout
Multiple tachykinins are produced and secreted upon post-translational processing of the three substance P precursor proteins, α-, β-, and γ-preprotachykinin
1989 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
The Glutamate Receptor Ion Channels
1999 Standout
Copper-free palladium-catalyzed sonogashira-type coupling of aryl halides and 1-aryl-2-(trimethylsilyl)acetylenes
2005
Complementary roles of gasotransmitters CO and H2S in sleep apnea
2017 StandoutNobel
Activation of Protein Kinase C by Oxytocin Inhibits the Biological Activity of the Human Myometrial Corticotropin-Releasing Hormone Receptor at Term*
1999
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum
1991 StandoutNature
Regioselective cross-coupling reactions of multiple halogenated nitrogen-, oxygen-, and sulfur-containing heterocycles
2004
NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex
2004
Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling
1998 StandoutNobel
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
The glutamate receptor ion channels.
1999
The Oxytocin Receptor System: Structure, Function, and Regulation
2001 Standout
The polyprotein nature of substance P precursors
1989
Rufinamide Attenuates Mechanical Allodynia in a Model of Neuropathic Pain in the Mouse and Stabilizes Voltage-gated Sodium Channel Inactivated State
2012
Application of recoverable nanosized palladium(0) catalyst in Sonogashira reaction
2005
Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling
1998 StandoutNobel
Oxytocin receptor couples to the 80 kDa Gh alpha family protein in human myometrium.
1996
An Amine‐, Copper‐ and Phosphine‐Free Sonogashira Coupling Reaction Catalyzed by Immobilization of Palladium in Organic–Inorganic Hybrid Materials
2006
Mechanism of Ca2+ inhibition of inositol 1,4,5-trisphosphate (InsP3) binding to the cerebellar InsP3 receptor.
1992 StandoutNobel
Synthesis and Structure−Activity Relationships of 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine Analogues as Potent, Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists; Search for Cocaine Medications
2006
PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS
1997 Standout
Design, Synthesis, and Structure−Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5
2010
Silver-Catalyzed Csp−H and Csp−Si Bond Transformations and Related Processes
2008
Works of Mark A. Varney being referenced
Stable expression and characterization of recombinant human heteromeric N-methyl-D-aspartate receptor subtypes NMDAR1A/2A and NMDAR1A/2B in mammalian cells.
1996
(R, S)-4-Phosphonophenylglycine, a Potent and Selective Group III Metabotropic Glutamate Receptor Agonist, Is Anticonvulsive and Neuroprotective In Vivo
1999
Pharmacological Characterization of the Human Ionotropic Glutamate Receptor Subtype GluR3 Stably Expressed in Mammalian Cells
1998
Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2
2003
Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5
1995
In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine)
2003
Effects of ketamine and n-methyl-d-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268
2003
Anxiolytic-like activity of the mGluR5 antagonist MPEPA comparison with diazepam and buspirone
2002
Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function
2001
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
1999
Derivatives of tramadol for increased duration of effect
2005
Selective Antagonism of Opioid-Induced Ventilatory Depression by an Ampakine Molecule in Humans Without Loss of Opioid Analgesia
2009
Differential distribution of voltage‐gated calcium channel alpha‐2 delta (α2δ) subunit mRNA‐containing cells in the rat central nervous system and the dorsal root ganglia
2005
Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin-sensitive and -insensitive G-proteins
1993
Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor
2010
[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor
2003
Group II mGlu Receptor Activation Suppresses Norepinephrine Release in the Ventral Hippocampus and Locomotor Responses to Acute Ketamine Challenge
2003
The Human N‐Methyl‐d ‐Aspartate Receptor 2C Subunit: Genomic Analysis, Distribution in Human Brain, and Functional Expression
1998
Inositol 1,4,5-Trisphosphate and Oxytocin Binding in Human Myometrium*
1990
Influence of Mg2+ and pH on n.m.r. spectra and radioligand binding of inositol 1,4,5-trisphosphate
1991
Characterisation of tachykinin receptors using selectivity of agonists and antagonists: Evidence for an NK-4 type
1988
SIB-1757 and SIB-1893: Selective, Noncompetitive Antagonists of Metabotropic Glutamate Receptor Type 5
1999
Discovery of subtype-selective metabotropic glutamate receptor ligands using functional HTS assays
2000
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity
2002
Are there subtypes of the inositol 1,4,5-trisphosphate receptor?
1990