Citation Impact
Citing Papers
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
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Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
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Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
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Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
2006
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
2003
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
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Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
2009 Standout
Psoriasis induced by topical imiquimod
2004
MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses
2009
Engineered receptors for soluble cellular communication and disease sensing
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IRF-7 is the master regulator of type-I interferon-dependent immune responses
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X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells
2010 StandoutNobel
Dendritic Cells: Translating Innate to Adaptive Immunity
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Psoriasis
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mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
Rewiring human cellular input–output using modular extracellular sensors
2016
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
2007 StandoutNobel
Adjuvants for cancer vaccines
2010
Rheumatogenic streptococci and autoimmunity
1991
TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway
2003
Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9
2007
The Small Antitumoral Immune Response Modifier Imiquimod Interacts with Adenosine Receptor Signaling in a TLR7- and TLR8-Independent Fashion
2006
RNA: The new revolution in nucleic acid vaccines
2013
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
1993 StandoutNature
Rheumatic heart disease
2012
Activation of the mammalian immune system by siRNAs
2005
The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily
2003
An insight into the epitope-based peptide vaccine design strategy and studies against COVID-19
2020
Innate immunity and antimicrobial defense systems in psoriasis
2007
Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system
1998
Streptococcus pyogenes type 5 M protein is an antigen, not a superantigen, for human T cells
1997
Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
2010 StandoutNobel
Psoriasis Triggered by Toll-like Receptor 7 Agonist Imiquimod in the Presence of Dermal Plasmacytoid Dendritic Cell Precursors
2004
A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C.
1993
Understanding the mechanism of action of bacterial superantigens from a decade of research
1999
Vaccine Adjuvants: Putting Innate Immunity to Work
2010
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Application potential of toll-like receptors in cancer immunotherapy
2016
Staphylococcal and Streptococcal Pyrogenic Toxins Involved in Toxic Shock Syndrome and Related Illnesses
1990
Cutaneous dendritic cells
2005
Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses
2010
University of California/Davis Interdepartmental Conference on Gram-Negative Septicemia
1991 StandoutNobel
Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor- viral RNA interactions
2005
Imiquimod: mode of action
2007
Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response
2017
New horizons in adjuvants for vaccine development
2008
A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T‐cell immunity in vivo
2011 StandoutNobel
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Clonal basis for resurgence of serious Streptococcus pyogenes disease in the 1980s
1992
Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses
1991
The challenge of emerging and re-emerging infectious diseases
2004 StandoutNature
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
2020 Standout
Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
2012
Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages
2007 StandoutNobel
Toll-like receptors and innate antiviral responses
2003
Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
2005 StandoutNobel
Imiquimod, a Topical Immune Response Modifier, Induces Migration of Langerhans Cells11The authors have declared a conflict of interest.
2000
Role of adjuvants in modeling the immune response
2010
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2
2007 StandoutNobel
Modulation of TH1 and TH2 Cytokine Production with the Immune Response Modifiers, R-848 and Imiquimod
1999
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Synthesis and Microcontact Printing of Dual End‐Functionalized Mucin‐like Glycopolymers for Microarray Applications
2009 StandoutNobel
The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells
2008 StandoutNobel
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
2002 Standout
Cross-Talk between Human Dendritic Cell Subsets Influences Expression of RNA Sensors and Inhibits Picornavirus Infection
2010
Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant
2011
Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
2002 StandoutNobel
Superantigens and Their Potential Role in Human Disease
1993
Cloning, characterization and overexpression of a Streptococcus pyogenes gene encoding a new type of mitogenic factor
1993
Recent advances in the discovery and delivery of vaccine adjuvants
2003
Monophosphoryl Lipid A (MPL) Formulations for the Next Generation of Vaccines
1999
Imiquimod 5% cream for the treatment of actinic keratosis: Results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology
2004
TLR-based immune adjuvants
2010
Staphylococcus aureusInfections
1998 Standout
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Autophagy in immunity and inflammation
2011 StandoutNature
Pathogen Recognition and Innate Immunity
2006 Standout
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
2009 StandoutNature
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
2′-O-methyl-modified RNAs Act as TLR7 Antagonists
2007
The immunopathogenesis of sepsis
2002 StandoutNature
Role of Superantigens in Human Disease
1993
DNA Vaccines: Recent Developments and Future Possibilities
2006
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
2009 StandoutNobel
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
2003
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
2006
Mapping T-cell epitopes in group A streptococcal type 5 M protein
1991
Streptococci and Rheumatic Fever
1996
Pathogenesis of Group A Streptococcal Infections
2000 Standout
Evidence for the Effects of a Superantigen in Rheumatoid Arthritis
1991 Science
Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN
2004
Superantigenic properties of the group A streptococcal exotoxin SpeF (MF)
1994
Toll-Like Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus- and HIV-1-Specific T Cell Responses
2003
TLR7 Is Involved in Sequence-Specific Sensing of Single-Stranded RNAs in Human Macrophages
2008
HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+T cell responses in nonhuman primates
2005
Molecular analysis of pyrogenic exotoxins from Streptococcus pyogenes isolates associated with toxic shock-like syndrome
1991
Immunologically Active Autoantigens: The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease
2007
Structure and Function of Toll Receptors and Their Ligands
2007
Mitogenicity of M5 protein extracted from Streptococcus pyogenes cells is due to streptococcal pyrogenic exotoxin C and mitogenic factor MF
1995
Preferential recognition of human myocardial antigens by T lymphocytes from rheumatic heart disease patients
1997
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
Characterization of a conserved helper-T-cell epitope from group A Streptococcal M proteins
1993
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
2011 StandoutNobel
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
2011 StandoutNobel
Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
2011 StandoutNobel
Activation and differentiation requirements of primary T cells in vitro.
1993 StandoutNobel
Generation of Th1-Polarizing Dendritic Cells Using the TLR7/8 Agonist CL075
2010
Pyrogenicity and Cytokine-Inducing Properties ofStreptococcus pyogenesSuperantigens: Comparative Study of Streptococcal Mitogenic Exotoxin Z and Pyrogenic Exotoxin A
2001
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
2005 StandoutScience
Immunization with HIV-1 Gag Protein Conjugated to a TLR7/8 Agonist Results in the Generation of HIV-1 Gag-Specific Th1 and CD8+ T Cell Responses
2005
Interferon-α and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets
2002
Plasmacytoid Dendritic Cells Control TLR7 Sensitivity of Naive B Cells via Type I IFN
2005
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis
2006 StandoutNobel
Analysis of the superantigenic activity of mutant and allelic forms of streptococcal pyrogenic exotoxin A
1996
Human Heart–Infiltrating T-Cell Clones From Rheumatic Heart Disease Patients Recognize Both Streptococcal and Cardiac Proteins
1995
Regulation of Adaptive Immunity by the Innate Immune System
2010 StandoutScience
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Molecular analysis of human cardiac myosin-cross-reactive B- and T-cell epitopes of the group A streptococcal M5 protein
1997
Frequency of the erythrogenic toxin B and C genes (speB and speC) among clinical isolates of group A streptococci
1991
Bacteriophage association of streptococcal pyrogenic exotoxin type C
1989
Identification and Characterization of pDC-Like Cells in Normal Mouse Skin and Melanomas Treated with Imiquimod
2004
Polyvalente Wechselwirkungen in biologischen Systemen: Auswirkungen auf das Design und die Verwendung multivalenter Liganden und Inhibitoren
1998
The Bacterial Superantigen Streptococcal Mitogenic Exotoxin Z Is the Major Immunoactive Agent ofStreptococcus pyogenes
2002
Streptococcal mitogenic exotoxin Z, a novel acidic superantigenic toxin produced by a T1 strain of Streptococcus pyogenes
1997
Vaccines: the Fourth Century
2009
Separation of T-cell-stimulating activity from streptococcal M protein
1992
Bacterial pyrogenic exotoxins as superantigens
1995
Virus-induced Interferon α Production by a Dendritic Cell Subset in the Absence of Feedback Signaling In Vivo
2002
Role of Natural Interferon-α Producing Cells (Plasmacytoid Dendritic Cells) in Autoimmunity
2003
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
N‐Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen‐Presenting Cells through Dectin‐1 and Dectin‐2
2018 StandoutNobel
Changing Streptococci and Prospects For The Global Eradication of Rheumatic Fever
1997
Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression.
1991
Works of Mark A. Tomai being referenced
TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN
2008
Review Article Imiquimod applied topically: a novel immune response modifier and new class of drug
1999
The Immune Response Modifier Resiquimod Mimics CD40-Induced B Cell Activation
2001
A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod
1998
Adjuvant Activities of Immune Response Modifier R-848: Comparison with CpG ODN
2000
The Imidazoquinolines, Imiquimod and R-848, Induce Functional, but Not Phenotypic, Maturation of Human Epidermal Langerhans' Cells
2000
Daily or Weekly Therapy with Resiquimod (R‐848) Reduces Genital Recurrences in Herpes Simplex Virus–Infected Guinea Pigs during and after Treatment
2001
New horizons in adjuvants for vaccine development
2020
Topically Applied Imiquimod Inhibits Vascular Tumor Growth In Vivo
2003
In Vivo and In Vitro Interferon Induction in Chickens by S-28828, an Imidazoquinolinamine Immunoenhancer
1996
Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists
2006
Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands
2007
Cellular Requirements for Cytokine Production in Response to the Immunomodulators Imiquimod and S-27609
1995
Dendritic Cell Maturation and Subsequent Enhanced T-Cell Stimulation Induced with the Novel Synthetic Immune Response Modifier R-848
1999
The Immune Response Modifiers Imiquimod and R-848 Are Potent Activators of B Lymphocytes
2000
Characterization of a Nontoxic Monophosphoryl Lipid A
1987
Effect of a Novel Topical Immunomodulator, S-28463, on Keratinocyte Cytokine Gene Expression and Production
1996
Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways
2012
Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8
2005
Role of antigen-presenting cells in activation of human T cells by the streptococcal M protein superantigen: requirement for secreted and membrane-associated costimulatory factors
1993
T cell receptor V gene usage by human T cells stimulated with the superantigen streptococcal M protein.
1991
Differential signal requirements in T-cell activation by mitogen and superantigen
1990
The Immune Response Modifier Imiquimod Requires STAT-1 for induction of Interferon, Interferon-Stimulated Genes, and Interleukin-6
1999
Glycolipid Induced Proliferation of Lipopolysaccharide Hyporesponsive C3H/HeJ Splenocytes
1988
Cytokine induction in mice by the immunomodulator imiquimod
1994
Bacteriophage involvement in group A streptococcal pyrogenic exotoxin A production
1986
Distinct T-cell receptor V beta gene usage by human T lymphocytes stimulated with the streptococcal pyrogenic exotoxins and pep M5 protein
1992
The adjuvant properties of a nontoxic monophosphoryl lipid A in hyporesponsive and aging mice.
1987
Cytokine induction by the immunomodulators imiquimod and S-27609
1995
Involvement of gamma interferon in antibody enhancement by adjuvants
1990
Molecular Mechanisms of B Lymphocyte Activation by the Immune Response Modifier R-848
2000
Characterization of unique human TCR V beta specificities for a family of streptococcal superantigens represented by rheumatogenic serotypes of M protein.
1994
Stimulation of Interferon and Cytokine Gene Expression by Imiquimod and Stimulation by Sendai Virus Utilize Similar Signal Transduction Pathways
1995
Superantigenicity of streptococcal M protein.
1990
Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod
2002
Accessory cell-independent stimulation of human T cells by streptococcal M protein superantigen.
1990