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Transition-state stabilization as a measure of the efficiency of antibody catalysis
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Thrombin receptor (PAR-1) antagonists. Solid-Phase synthesis of indole-Based peptide mimetics by anchoring to a secondary amide
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Topological Analysis of the Functional Mimicry between a Peptide and a Carbohydrate Moiety
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Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates
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1999
An M13 phage library displaying random 38-amino-acid peptides as a source of novel sequences with affinity to selected targets
1993
[26] Synthesis and evaluation of 1,4-benzodiazepine libraries
1996
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
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2006
Building Antibodies from their Genes
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Evolution of peptides that modulate the spectral qualities of bound, small-molecule fluorophores
1998
The design and synthesis of substituted biphenyl libraries
1996
Optical barcoding of colloidal suspensions: applications in genomics, proteomics and drug discovery
2002
Use of a Perfluoroalkylsulfonyl (PFS) Linker in a “Traceless” Synthesis of Biaryls through Suzuki Cleavage
2001
In vitro evolution of a self-alkylatlng ribozyme
1995 StandoutNatureNobel
Solid-supported syntheses of 3-thio-1,2,4-triazoles
1997
In vitro evolution of new ribozymes with polynucleotide kinase activity
1994 StandoutNatureNobel
Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers
1998
Solid-supported reagents in organic synthesis
1999
Structure–activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry
2001
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997
1997
Structurally Complex and Highly Active RNA Ligases Derived from Random RNA Sequences
1995 StandoutScienceNobel
The search for orally active medications through combinatorial chemistry
1998
Detection of Benzodiazepine Receptor Ligands in Small Libraries of Flavone Derivatives Synthesized by Solution Phase Combinatorial Chemistry
1998
Identification of a potent and selective oxytocin antagonist, from screening a fully encoded differential release combinatorial chemical library
2001
Microparticle Matrix Encoding of Beads
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Spanning binding sites on allosteric proteins with polymer-linked ligand dimers
1998 Nature
Parallel-compound synthesis: Methodology for accelerating drug discovery
1996
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
2000 StandoutNature
Organic Azides: An Exploding Diversity of a Unique Class of Compounds
2005 Standout
Combinatorial approaches to carbohydrates
1997
Silicon directed ipso-substitution of polymer bound arylsilanes: Preparation of biaryls via the Suzuki cross-coupling reaction
1996
Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides
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Approaches to Combinatorial Synthesis of Heterocycles: A Solid-Phase Synthesis of 1,4-Dihydropyridines
1996
Transverse relaxation-optimized NMR spectroscopy with the outer membrane protein OmpX in dihexanoyl phosphatidylcholine micelles
2001 StandoutNobel
Radiofrequenz‐verschlüsselte kombinatorische Chemie
1995
Development of a Novel Silyl Ether Linker for Solid-Phase Organic Synthesis1
1996
Solid phase sequential 1,3-dipolar cycloaddition–Pictet–Spengler reactions
2000
Titanium mediated reductive amination on solid support: Extending the utility of the 4-hydroxy-thiophenol linker
1998
A Strategy for the Chemoselective Synthesis of O-Linked Glycopeptides with Native Sugar−Peptide Linkages
1997 StandoutNobel
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry
1995
Applications of solid supported azide anion: a one-pot, two-step preparation of functionalized 1,2,3-triazoles
2003
Solvent‐free synthesis of heterocyclic compounds using microwaves
1999
Application of the Pictet-Spengler reaction in combinatorial chemistry
1996
A three-hybrid system for detecting small ligand–protein receptor interactions
1996
Traceless Solid-Phase Organic Synthesis
2002
MECHANISTIC ASPECTS OF ENZYMATIC CATALYSIS: Lessons from Comparison of RNA and Protein Enzymes
1997
Nucleic Acid Selection and the Challenge of Combinatorial Chemistry
1997
An in vitro polysome display system for identifying ligands from very large peptide libraries.
1994
Oligosaccharide Mimetics Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded Glycopeptide Libraries
1998 StandoutNobel
Solid-Phase Synthesis of 1,4-Benzodiazepine-2,5-diones. Library Preparation and Demonstration of Synthesis Generality
1997
RNA-peptide fusions for the in vitro selection of peptides and proteins
1997 StandoutNobel
Solid phase parallel synthesis of highly substituted thiophene derivatives and identification of novel phosphodiesterase-4 (PDE-4) inhibitors
1999
Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives
1999
Solid phase cross-coupling reaction of aryl(halo)silanes with 4-iodobenzoic acid
2001
Germanium and Silicon Linking Strategies for Traceless Solid-Phase Synthesis
1997
The Suzuki, the Heck, and the Stille reaction - three versatile methods for the introduction of new C-C bonds on solid support
2000
Solid-Phase Suzuki Coupling for C−C Bond Formation
1996
Solid Phase Combinatorial Library of Phosphinic Peptides for Discovery of Matrix Metalloproteinase Inhibitors
2000 StandoutNobel
Preparation of 5-substituted 2-carboxyindoles on solid support
2000
Biaryl synthesis via suzuki coupling on a solid support
1994
Chemical Glycobiology
2001 StandoutScienceNobel
Synthesis of functionalized γ-and δ-lactones via polymer-bound epoxides
1997
Solid-Phase Synthesis of 3,4,5-Substituted 1,5-Benzodiazepin-2-ones
1999
Metal-Catalyzed Release of Supported Boronic Acids for C−C Bond Formation
2001
Polyvalent binding to carbohydrates immobilized on an insoluble resin
1997
Synthesis of Glycopeptides Containing Carbohydrate and Peptide Recognition Motifs
2000
The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.
1994
Solid-phase synthesis of substituted benzimidazoles
1999
A Combinatorial Approach to Recognition of Chirality: Preparation of Highly Enantioselective Aryl-Dihydropyrimidine Selectors for Chiral HPLC
1998
Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition
1998 Standout
Combinatorial Synthesis of Small Organic Molecules
1996
Traceless, Self-Cleaving Solid- and Solution-Phase Parallel Synthesis of 3,4,7-Trisubstituted 3,4-Dihydroquinoxalin-2-ones
2001
Recent Advances in the Preparation of Heterocycles on Solid Support: A Review of the Literature
2000
Solution-Phase Synthesis of a 1,5-Dialkylamino-2,4-dinitrobenzene Library and the Identification of Novel Antibacterial Compounds from This Library
2000
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
The Current Status of Heterocyclic Combinatorial Libraries
1997
Synthetic Cyclic Oligosaccharides
1998 StandoutNobel
Solid phase synthesis of benzimidazoles
1996
Hydrogen Sorption in Functionalized Metal−Organic Frameworks
2004 StandoutNobel
Solid-phase cross-coupling reaction of aryl(fluoro)silanes with 4-iodobenzoic acid
2000
Homogeneous Catalysis in Supercritical Fluids
1999 StandoutNobel
Folding of a donor–acceptor polyrotaxane by using noncovalent bonding interactions
2008 StandoutNobel
Carbon−Carbon Bond Forming Solid-Phase Reactions
1999
Solid Phase Heterocyclic Chemistry
2001
Fluorous Synthesis: A Fluorous-Phase Strategy for Improving Separation Efficiency in Organic Synthesis
1997 Science
A solid phase synthesis of miconazole analogs via an iodoetherification reaction
1996
In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy
2001
A Nitroxyl Synthase Catalytic Antibody
1996
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Novel avidin and streptavidin binding sequences found in synthetic peptide libraries
1995
An efficient solid phase synthetic route to 1,3-disubstituted 2,4(1H,3H)-Quinazolinediones suitable for combinatorial synthesis
1996
The Stille cross coupling reactions on solid support. Link to solution phase directed ortho metalation. An ester linker approach to styryl, biaryl and heterobiaryl car☐ylic acids
1998
Comprehensive Survey of Combinatorial Library Synthesis: 1999
2000
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
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Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Recursive deconvolution of combinatorial chemical libraries.
1994 StandoutNobel
Combinatorial Liquid-Phase Synthesis of Structurally Diverse Benzimidazole Libraries
2000
New Biarsenical Ligands and Tetracysteine Motifs for Protein Labeling in Vitro and in Vivo: Synthesis and Biological Applications
2002 StandoutNobel
Organic Chemistry on Solid Supports
1996
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
2001 StandoutNobel
Discovery of Sequence-Selective Peptide Binding by Synthetic Receptors Using Encoded Combinatorial Libraries
1996
Solid phase synthesis of 1-alkyl-2-alkylthio-5-carbamoylbenzimidazoles
1998
Solid-phase organic reactions II: A review of the literature Nov 95–Nov 96
1997
Artificial Organic Host Molecules for Anions
1997 Standout
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Organische Chemie an fester Phase
1996
"Diabodies": small bivalent and bispecific antibody fragments.
1993 StandoutNobel
Efficient reduction of aromatic nitro/azido groups on solid support employing indium: synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones
2001
[11] Cell-free synthesis of peptide libraries displayed on polysomes
1996
The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes
1998
Solid Phase Synthesis of 3,4-Disubstituted-7-carbamoyl-1,2,3,4-tetrahydroquinoxalin-2-ones
1997
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Expanding the Scope of RNA Catalysis
1994 Science
Phage Display
1997
Solid-phase synthesis of substituted 1-phenyl-2-aminomethyl-benzimidazoles and 1-phenyl-2-thiomethyl-benzimidazoles
1998
Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies
1997
Aminooxy-, Hydrazide-, and Thiosemicarbazide-Functionalized Saccharides: Versatile Reagents for Glycoconjugate Synthesis
1998 StandoutNobel
From Molecular Diversity to Catalysis: Lessons from the Immune System
1995 Science
Combinatorial Synthesis of Heterocycles: Solid-Phase Synthesis of 2-Amino-4(1H)-quinazolinone Derivatives
2000
Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones
1996
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Platinum group metals in the formation of metal–carbon multiple bonds
1986
A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage.
1996 StandoutNobel
Solid-phase organic reactions: A review of the recent literature
1996
Crystal Engineering and Organometallic Architecture
1998
Solid-Supported Benzotriazoles: Synthetic Auxiliaries and Traceless Linkers for the Combinatorial Synthesis of Amine Libraries
1999
Synthesis of Tetrasubstituted Ethylenes on Solid Support via Resin Capture
1996
Solution- and Solid-Phase Strategies for the Design, Synthesis, and Screening of Libraries Based on Natural Product Templates: A Comprehensive Survey
2001
Solid-phase synthesis of substituted 2-aminomethylbenzimidazoles
2000
Glycals in Organic Synthesis: The Evolution of Comprehensive Strategies for the Assembly of Oligosaccharides and Glycoconjugates of Biological Consequence
1996
Rapid deconvolution of combinatorial libraries using HPLC fractionation
1998
Synthesis and Applications of Small Molecule Libraries
1996
A general and efficient solid phase synthesis of quinazoline-2,4-diones
1997
Discovering High-Affinity Ligands for Proteins: SAR by NMR
1996 StandoutScience
Polystyrene-Supported Benzenesulfonyl Azide: A Diazo Transfer Reagent That Is Both Efficient and Safe
2001
Vilsmeier Formylation of 2-Carboxyindoles and Preparation of O-Benzylhydroxyureas on Solid Phase
2001
Polymer-supported silyl cyanide and silyl azide: Useful reagents for solid-phase applications
2000
The “One-Bead-One-Compound” Combinatorial Library Method
1997
Synthesis of a 10 000 Member 1,5-Benzodiazepine-2-one Library by the Directed Sorting Method
2000
Comprehensive Survey of Combinatorial Library Synthesis: 1998
1999
Solid phase synthesis of biphenyltetrazole derivatives
1997
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library
1996 Science
Rapid microscale synthesis: Solution phase parallel synthesis of a library of piperazines and piperidines using a water soluble base
1998
Design and synthesis of fluconazole/bile acid conjugate using click reaction
2006
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
Stereochemische Eigenschaften als Diversitätselement: Festphasensynthese cyclischer RGD-Peptidderivate via asymmetrische Katalyse
1998
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
2014 StandoutNobel
Solid-phase synthesis of functionalized 1,2,3-triazoles
2002
A new vinyl ether type linker for solid-phase synthesis
2000
Filamentous Phage Display in the New Millennium
2005
Synthesis and Applications of RuCl2(CHR‘)(PR3)2: The Influence of the Alkylidene Moiety on Metathesis Activity
1996 StandoutNobel
Revolutionizing Resin Handling for Combinatorial Synthesis
2001
Rapid microwave-assisted Suzuki coupling on solid-phase
1996
Partially Modified Retro-Inverso Peptides: Development, Synthesis, and Conformational Behavior
1998
Animal Lectins
1997
Radiofrequency Encoded Combinatorial Chemistry
1995
The solid phase synthesis of oligoureas
1996
Works of Mark A. Gallop being referenced
Recognition of an octapeptide sequence by multiple Galα(1,3)Gal‐binding proteins
1996
Exploring structure-activity relationships around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis
1998
Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions
1994
Strategies for the Synthesis and Screening of Glycoconjugates. 2. Covalent Immobilization for Flow Cytometry
1995
Synthesis and biological evaluation of novel steroidal pyrazoles as substrates for bile acid transporters
2004
[16] Encoded combinatorial chemistry: Binary coding using chemically robust secondary amine tags
1996
Strategies for the Synthesis and Screening of Glycoconjugates. 1. A Library of Glycosylamines
1995
Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries
1994
Synthetic Compound Libraries Displayed on the Surface of Encoded Bacteriophage
2003
Encoded combinatorial chemistry: Synthesis and screening of a library of highly functionalized pyrrolidines
1997
Generation and screening of an oligonucleotide-encoded synthetic peptide library.
1993
Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery
1996
An α-diazoalkylosmium complex as carbyne-complex precursor. Synthesis and X-ray crystal structure of [OsCl(I)(NO)(PPh2C6H4CHCO2Et)(PPh3)], the product of an intramolecular carbyne insertion reaction
1984
Solid-Phase Synthesis of 3,5-Disubstituted 2,3-Dihydro-1,5-benzothiazepin-4(5H)-ones
1999
A Versatile Solid‐Phase Synthesis of N‐Linked Glycopeptides
1995
Strategies for Combinatorial Organic Synthesis: Solution and Polymer-Supported Synthesis of 4-Thiazolidinones and 4-Metathiazanones Derived from Amino Acids
1995
Auf dem Weg zu Antikörper‐Glycosidasen
1994
Peptide ligands for a sugar-binding protein isolated from a random peptide library.
1992
Solid-Phase Synthesis of 4-Arylazetidin-2-ones via Suzuki and Heck Cross-Coupling Reactions
1997
Antibody-Catalyzed Prodrug Activation
1994
Trimethylorthoformate: A mild and effective dehydrating reagent for solution and solid phase imine formation
1995
Kinetic analysis of the stereochemical nonrigidity of the triosmium .mu.3-arene/alkene complex Os3(CO)8(.eta.2-CH2CH2)(.mu.3:.eta.2:.eta.2:.eta.2-C6H6) in the solid state by carbon-13 CP/MAS NMR spectroscopy
1991
Solid-Supported Combinatorial Synthesis of Structurally Diverse β-Lactams
1996
Solid-Phase Synthesis of Highly Functionalized 2,2‘-Bipyridines
1999
Stereoselective Solid-Phase Synthesis of a Triaza Tricyclic Ring System: A New Chemotype for Lead Discovery
1999
Combinatorial Organic Synthesis of Highly Functionalized Pyrrolidines: Identification of a Potent Angiotensin Converting Enzyme Inhibitor from a Mercaptoacyl Proline Library
1995
Versatile Approach To Encoding Combinatorial Organic Syntheses Using Chemically Robust Secondary Amine Tags
1996
Methods for Combinatorial Organic Synthesis: The Use of Fast 13C NMR Analysis for Gel Phase Reaction Monitoring
1994
“Traceless” solid-phase synthesis of furans via 1,3-dipolar cycloaddition reactions of isomünchnones
1997
Solid-phase synthesis of 1,5-benzodiazepin-2-ones
1998
Eine vielseitige Festphasensynthese von N‐verknüpften Glycopeptiden
1995
Progress toward an Antibody Glycosidase
1994
The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries
1996