Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Identification and characterization of essential genes in the human genome
2015 Science
Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis
2015
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
2017
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia
2012
The molecular hallmarks of epigenetic control
2016 Standout
Transcriptional Regulation and Its Misregulation in Disease
2013
Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses
2018 StandoutNobel
JAK2 Inhibitors: A Reality? A Hope?
2009
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
2013
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform
2013
JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis
2012 Standout
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Chromatin Connections to Pluripotency and Cellular Reprogramming
2011
Interleukin-6 signaling pathway in targeted therapy for cancer
2012
Lessons from the Cancer Genome
2013
Regulation of chromatin by histone modifications
2011 Standout
The emerging role of lncRNAs in cancer
2015 Standout
Hallmarks of aging: An expanding universe
2023 Standout
Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation
2013
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
The mini-driver model of polygenic cancer evolution
2015 StandoutNobel
A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks
2016
The Human Transcription Factors
2018 Standout
Regulatory Enhancer–Core-Promoter Communication via Transcription Factors and Cofactors
2016
Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets
2014
Antiviral resistance of stem cells
2018 StandoutNobel
Unravelling the genomic targets of small molecules using high-throughput sequencing
2014
PRC2 mediated H3K27 methylations in cellular identity and cancer
2015
Mitochondria: In Sickness and in Health
2012 Standout
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Functional Role of G9a Histone Methyltransferase in Cancer
2015
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain
2012
Targeting apoptosis in cancer therapy
2020 Standout
Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus
2010
Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
2014
ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency
2010
An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists
2014
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
2013 Standout
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Emerging Biological Principles of Metastasis
2017 Standout
Clinical Effect of Point Mutations in Myelodysplastic Syndromes
2011 Standout
Driver mutations of cancer epigenomes
2014
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Benefits of Metformin in Attenuating the Hallmarks of Aging
2020
Mechanisms and Functions of Inflammasomes
2014 Standout
Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers
2010
Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins
2015
Recent developments in epigenetics of acute and chronic kidney diseases
2015
5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy
2015
A Bioorthogonal Reaction of N‐Oxide and Boron Reagents
2015 StandoutNobel
Epigenetic modifications and human disease
2010 Standout
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
2014 Standout
Epigenetic Determinants of Cancer
2016
Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming
2013
Discovery and saturation analysis of cancer genes across 21 tumour types
2014 StandoutNature
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
2014 Standout
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
2012
Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
2014
Chronic Kidney Disease
2016 Standout
Comprehensive Catalog of Currently Documented Histone Modifications
2015
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
Emerging targeted agents in metastatic breast cancer
2013
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
2013 Standout
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Revised Dose Ramp-Up to Mitigate the Risk of Tumor Lysis Syndrome When Initiating Venetoclax in Patients With Mantle Cell Lymphoma
2018
Histone Deacetylase Inhibitors as Anticancer Drugs
2017
Chromatin features and the epigenetic regulation of pluripotency states in ESCs
2014
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Acute Myeloid Leukemia
2015 Standout
Identification and transcriptome analysis of erythroblastic island macrophages
2019 StandoutNobel
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
2015
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
2014 Standout
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL −/− clear cell renal carcinoma
2017 StandoutNobel
Epigenetic Regulation by Histone Demethylases in Hypoxia
2015
Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction
2009
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
2017 Standout
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance
2016
JAK2V617F activates Lu/BCAM-mediated red cell adhesion in polycythemia vera through an EpoR-independent Rap1/Akt pathway
2012
Epigenetic Reprogramming in Cancer
2013 Science
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax
2017
New mutations and pathogenesis of myeloproliferative neoplasms
2011
Cancer Genome Landscapes
2013 StandoutScience
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Emerging Droplet Microfluidics
2017 Standout
Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
2010
Works of Mark A. Dawson being referenced
Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
2015 Science
The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development
2009
Phosphorylation of Histone H3 Thr-45 Is Linked to Apoptosis
2009
Linezolid‐induced dyserythropoiesis: chloramphenicol toxicity revisited
2005
Targeting Epigenetic Readers in Cancer
2012
The roles of DNA, RNA and histone methylation in ageing and cancer
2019
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disorders
2010
JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
2009 Nature
LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease
2010
RS‐127445: a selective, high affinity, orally bioavailable 5‐HT2B receptor antagonist
1999
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
2013
AT9283, a Potent Inhibitor of JAK2, Is Active in JAK2 V617F Myeloproliferative Disease Models.
2007
COMBINATION IBRUTINIB (IBR) AND VENETOCLAX (VEN) FOR THE TREATMENT OF MANTLE CELL LYMPHOMA (MCL): PRIMARY ENDPOINT ASSESSMENT OF THE PHASE 2 AIM STUDY
2017
Two routes to leukemic transformation after a JAK2 mutation–positive myeloproliferative neoplasm
2009
The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia
2007
Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma
2018