Citation Impact
Citing Papers
Involvement of multiple proteases during Fas‐mediated apoptosis in T lymphocytes
1995
Probing mucin-type O-linked glycosylation in living animals
2006 StandoutNobel
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK
2006
Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose
2005 StandoutNobel
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Site-Specific Insertion of 3-Aminotyrosine into Subunit α2 of E. coli Ribonucleotide Reductase: Direct Evidence for Involvement of Y 730 and Y 731 in Radical Propagation
2007
Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease
2002
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors
1996
Preparation of modified peptides: direct conversion of α-amino acids into β-amino aldehydes
2012
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
Ribonucleotide reductases: radical enzymes with suicidal tendencies
1995
Natural engineering principles of electron tunnelling in biological oxidation–reduction
1999 StandoutNature
Microbial tryptophan catabolites in health and disease
2018 Standout
Proteasome inhibitors: from research tools to drug candidates
2001
Caspases: pharmacological manipulation of cell death
2005 Standout
Cryopyrin activates the inflammasome in response to toxins and ATP
2006 StandoutNature
Autophagy regulates lipid metabolism
2009 StandoutNature
Radicals in biological catalysis
1988
In situ assembly of enzyme inhibitors using extended tethering
2003
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
2007 StandoutNature
Proteasome Inhibitors: Complex Tools for a Complex Enzyme
2002
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
An enzymatic colorimetric method for measuring naringin using 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) in the presence of peroxidase
1990
A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones
1999
The biochemistry of apoptosis
2000 StandoutNature
In vitro selection of RNA molecules that bind specific ligands
1990 StandoutNatureNobel
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
3 The Medicinal Chemistry of the Azido Group
1994
Peptidyl β-homo-aspartals: Specific inhibitors of interleukin-1β converting enzyme and its homologues (caspases)
1998
Altered Cytokine Production in Mice Lacking P2X7Receptors
2001
A Cellular Mechanism That Reversibly Inactivates Pancaspase Inhibitor zAsp-CH2-DCB: A Potential Pitfall Causing Discrepancy between in Vitro and in Vivo Caspase Assays
2002
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group
2004
A radical approach to enzyme catalysis
1995
Caspase Substrates and Inhibitors
2013
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding
1997
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
2017
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
In vitro evolution of a self-alkylatlng ribozyme
1995 StandoutNatureNobel
Activation of the Native 45-kDa Precursor Form of Interleukin-1-converting Enzyme
1996
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
An RNA motif that binds ATP
1993 StandoutNatureNobel
Template-directed synthesis of a genetic polymer in a model protocell
2008 StandoutNatureNobel
Chapter 11 Proteinase families and their inhibitors
2001
Caspases: key mediators of apoptosis
1998
A decade of caspases
2003
Antioxidant activity applying an improved ABTS radical cation decolorization assay
1999 Standout
Initiation of DNA Fragmentation during Apoptosis Induces Phosphorylation of H2AX Histone at Serine 139
2000
Interleukin‐1βconverting enzyme: A novel cysteine protease required for IL‐1β production and implicated in programmed cell death
1995
Bimodal Inhibition of Caspase-1 by Aryloxymethyl and Acyloxymethyl Ketones
1998
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
pH Rate Profiles of FnY356−R2s (n = 2, 3, 4) in Escherichia coli Ribonucleotide Reductase: Evidence that Y356 Is a Redox-Active Amino Acid along the Radical Propagation Pathway
2006
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Defining the Inside and Outside of a Catalytic RNA Molecule
1989 StandoutScienceNobel
Studies on the Mechanism of Ribonucleotide Reductases
1997
Stereochemistry of RNA Cleavage by the Tetrahymena Ribozyme and Evidence that the Chemical Step Is Not Rate-Limiting
1989 StandoutScienceNobel
Peroxidase Activity of Myoglobin Is Enhanced by Chemical Mutation of Heme-Propionates
1999 StandoutNobel
Oligosaccharide Mimetics Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded Glycopeptide Libraries
1998 StandoutNobel
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
Cysteine Proteases and Their Inhibitors
1997
Palladium-Catalyzed Anti-Markovnikov Oxidation of Allylic Amides to Protected β-Amino Aldehydes
2014 StandoutNobel
Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase
1990 StandoutScience
Probing Structure-Function Relations in Heme-Containing Oxygenases and Peroxidases
1988 Science
Why Nature Chose Phosphates
1987 StandoutScience
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
1997 Science
Combinatorial Synthesis of Small Organic Molecules
1996
Peptide Microarrays for the Determination of Protease Substrate Specificity
2002
Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis
1997
Small synthetic inhibitors of cysteine proteases
1996
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Synthesis of peptide aldehydes
2006
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Design, Synthesis and Evaluation of d-Homophenylalanyl Epoxysuccinate Inhibitors of the Trypanosomal Cysteine Protease Cruzain
2000
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas
2005
Modern metabolism as a palimpsest of the RNA world.
1989
Protease Inhibitors: Current Status and Future Prospects
2000
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery
2000
Mechanism of Assembly of the Tyrosyl Radical-Dinuclear Iron Cluster Cofactor of Ribonucleotide Reductase
1991 Science
Electron Tunneling Pathways and Role of Adenine in Repair of Cyclobutane Pyrimidine Dimer by DNA Photolyase
2012 StandoutNobel
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
DNA cleavage in immunoglobulin somatic hypermutation depends onde novoprotein synthesis but not on uracil DNA glycosylase
2005 StandoutNobel
Investigation into the P3 Binding Domain of m-Calpain Using Photoswitchable Diazo- and Triazene-dipeptide Aldehydes: New Anticataract Agents
2007
Fluorine in medicinal chemistry: A review of anti-cancer agents
2006
Protein Radicals in Enzyme Catalysis
1998 Standout
A Fundamental Assumption about OH- Attack in Phosphate Ester Hydrolysis Is Not Fully Justified
1997 StandoutNobel
Selective oxidations catalyzed by peroxidases
1997
Design and Therapeutic Application of Matrix Metalloproteinase Inhibitors
1999
Small substrates and cytochrome c are oxidized at different sites of cytochrome c peroxidase.
1991
Mechanism of bleomycin: evidence for a rate-determining 4'-hydrogen abstraction from poly(dA-dU) associated with the formation of both free base and base propenal
1985
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Probing Glycosyltransferase Activities with the Staudinger Ligation
2003 StandoutNobel
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
High-Throughput Screening in Drug Metabolism and Pharmacokinetic Support of Drug Discovery
2000
SPOCC: A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase
1999 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Azapeptides as Inhibitors and Active Site Titrants for Cysteine Proteinases
1998
Recent advances in matrix metalloproteinase inhibitor research
1996
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Mark A. Ator being referenced
Mechanism-based inactivation of horseradish peroxidase by sodium azide. Formation of meso-azidoprotoporphyrin IX
1988
Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine 5'-diphosphate
1993
P2-proline-derived inhibitors of calpain I
1998
A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis
2011
P2-achiral, P'-extended α-ketoamide inhibitors of calpain I
1999
P′-extended α-ketoamide inhibitors of proteasome
1999
Products of the inactivation of ribonucleoside diphosphate reductase from Escherichia coli with 2'-azido-2'-deoxyuridine 5'-diphosphate
1987
Aspartyl .alpha.-((1-Phenyl-3-(trifluoromethyl)- pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1.beta. Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme-Peptide Inhibitor Binding
1994
Calpain inhibitors based on the quiescent affinity label concept: high rates of calpain inactivation with leaving groups derived from N-hydroxy peptide coupling reagents
2000
Lead development: Validation and application of high throughput screening for determination of pharmacokinetic parameters for enzyme inhibitors
1996
Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin‐l β converting enzyme (ICE)
1994
P1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting Enzyme
1994
Validation of Screening Immobilized Peptide Libraries for Discovery of Protease Substrates
1995
Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme
1995
Subsite requirements for peptide aldehyde inhibitors of human calpain I
1997
Synthesis and evaluation of diacylhydrazines as inhibitors of the interleukin-1β converting enzyme (ICE)
1995
Mechanism of inactivation of Escherichia coli ribonucleotide reductase by 2'-chloro-2'-deoxyuridine 5'-diphosphate: evidence for generation of a 2'-deoxy-3'-ketonucleotide via a net 1,2 hydrogen shift
1985
Pre-Steady-State and Steady-State Kinetic Analysis of E. coli Class I Ribonucleotide Reductase
2003
Mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Evidence for 3'-C--H bond cleavage.
1983
Application of Genetic Algorithms to Combinatorial Synthesis: A Computational Approach to Lead Identification and Lead Optimization,
1996
First Examples of Peptidomimetic Inhibitors of Interleukin-1β Converting Enzyme
1996
Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells
2005
Synthesis and evaluation of azapeptide-derived inhibitors of serine and cysteine proteases
1992
Production of active human interleukin-1β-converting enzyme in a baculovirus expression system
1994
1998
2'-Azido-2'-deoxynucleotide interaction with E. coli ribonucleotide reductase: generation of a new radical species
1984
α-((Tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone inhibitors of the interleukin-1β converting enzyme (ICE)
1997
Potent fluoromethyl ketone inhibitors of recombinant human calpain I
1996
Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme.
1995
A New Class of Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Structure−Activity Relationships for a Series of 9-Alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the Identification of CEP-5214 and Its Dimethylglycine Ester Prodrug Clinical Candidate CEP-7055
2003
Synthesis and Biological Activity of a Series of Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain I
1997
Protein control of prosthetic heme reactivity. Reaction of substrates with the heme edge of horseradish peroxidase.
1987
Pyridazinodiazepines as a High-Affinity, P2−P3Peptidomimetic Class of Interleukin-1β-Converting Enzyme Inhibitor
1997
Mechanism of ribonucleotide reductase from herpes simplex virus type 1. Evidence for 3' carbon-hydrogen bond cleavage and inactivation by nucleotide analogs.
1986
Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor
2016
Structure and catalytic mechanism of horseradish peroxidase. Regiospecific meso alkylation of the prosthetic heme group by alkylhydrazines.
1987
Mechanism of inactivation of Escherichia coli and Lactobacillus leichmannii ribonucleotide reductases by 2'-chloro-2'-deoxynucleotides: evidence for generation of 2-methylene-3(2H)-furanone
1984