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Citing Papers
Cooperativity in ATP hydrolysis by GroEL is increased by GroES
1991
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
2012 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Dissection of USPcatalytic domains reveals five common insertion points
2009
Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14
2005
UAF1 Is a Subunit of Multiple Deubiquitinating Enzyme Complexes
2008
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Immunoproteasomes Shape Immunodominance Hierarchies of Antiviral Cd8+ T Cells at the Levels of T Cell Repertoire and Presentation of Viral Antigens
2001
Physiological functions of the HECT family of ubiquitin ligases
2009
Fluorescence Detection of Symmetric GroEL14(GroES7)2 Heterooligomers Involved in Protein Release during the Chaperonin Cycle
1996
Negative staining and image classification — powerful tools in modern electron microscopy
2004
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Multiple cycles of global unfolding of GroEL-bound cyclophilin A evidenced by NMR
1997 StandoutNobel
GroE prevents the accumulation of early folding intermediates of pre-.beta.-lactamase without changing the folding pathway
1992
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
1994 StandoutNatureNobel
Residues in chaperonin GroEL required for polypeptide binding and release
1994 Nature
Calnexin Discriminates between Protein Conformational States and Functions as a Molecular Chaperone In Vitro
1999
Review: A Structural View of the GroE Chaperone Cycle
2001
The ubiquitin‐proteasome pathway
2004
Prions and molecular chaperones
1993
The Origins and Consequences of Asymmetry in the Chaperonin Reaction Cycle
1995
Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding
1992 Nature
Renaturation of citrate synthase: Influence of denaturant and folding assistants
1992
Hsp90 chaperones protein folding in vitro
1992 Nature
Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome
2001
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
The 26S proteasome: assembly and function of a destructive machine
2010
Multiple States of a Nucleotide-Bound Group 2 Chaperonin
2008
MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function
2002
The crystal structure of the asymmetric GroEL–GroES–(ADP)7 chaperonin complex
1997 Nature
Structure and function of the GroE chaperone
2002
Protein thermostability in extremophiles
1998
The base of the proteasome regulatory particle exhibits chaperone-like activity
1999
Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97
2014
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate
2003
Uch2/Uch37 is the Major Deubiquitinating Enzyme Associated with the 26 S Proteasome in Fission Yeast
2004
GroEL/GroES: Structure and Function of a Two-Stroke Folding Machine
1998
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
2001 Nature
A Ubiquitin Stress Response Induces Altered Proteasome Composition
2007
The crystal structure of the GroES co-chaperonin at 2.8 Å resolution
1996 NatureNobel
Distinct Modes of Regulation of the Uch37 Deubiquitinating Enzyme in the Proteasome and in the Ino80 Chromatin-Remodeling Complex
2008
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
2006 StandoutNobel
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate
1991 Nature
Complex interactions between the chaperonin 60 molecular chaperone and dihydrofolate reductase
1991
K63‐specific deubiquitination by two JAMM/MPN+ complexes: BRISC‐associated Brcc36 and proteasomal Poh1
2009
The formation of symmetrical GroEL‐GroES complexes in the presence of ATP
1994
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1
2006
The Proteasome: Paradigm of a Self-Compartmentalizing Protease
1998
High incidence of ubiquitin‐like domains in human ubiquitin‐specific proteases
2007
Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells
2010
Location of a folding protein and shape changes in GroEL–GroES complexes imaged by cryo-electron microscopy
1994 Nature
Thermodynamic Partitioning Model for Hydrophobic Binding of Polypeptides by GroEL
1994
Antigen processing by the proteasome
2001
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Protein folding in the cell
1992 StandoutNature
Screen for ISG15-crossreactive Deubiquitinases
2007
Breaking the chains: structure and function of the deubiquitinases
2009 Standout
GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms
1994
Complete subunit architecture of the proteasome regulatory particle
2012 Nature
The reaction cycle of GroEL and GroES in chaperonin-assisted protein folding
1993 Nature
GroEL-Mediated Protein Folding: Making the Impossible, Possible
2006
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase
2013
Multiubiquitin Chain Receptors Define a Layer of Substrate Selectivity in the Ubiquitin-Proteasome System
2004
NMR analysis of a 900K GroEL–GroES complex
2002 StandoutNatureNobel
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
The protein translocation channel binds proteasomes to the endoplasmic reticulum membrane
2005
The chaperonin GroEL binds a polypeptide in an .alpha.-helical conformation
1991
Conformational Changes in the GroEL Oligomer during the Functional Cycle
1997
Revisiting the Anfinsen cage
1996
Protein folding: local structures, domains, subunits, and assemblies
1991
The Logic of the 26S Proteasome
2017
The crystal structure of the bacterial chaperonln GroEL at 2.8 Å
1994 Nature
Molten Globule and Protein Folding
1995
Binding of a chaperonin to the folding intermediates of lactate dehydrogenase
1991
Pyroptosis: host cell death and inflammation
2009 Standout
Molecular chaperones in cellular protein folding
1996 StandoutNature
Antigen presentation by MHC class I and its regulation by interferon γ
1999
Binding and hydrolysis of nucleotides in the chaperonin catalytic cycle: Implications for the mechanism of assisted protein folding
1993
Refolding of Bovine Mitochondrial Rhodanese by Chaperonins GroEL and GroES
2003
Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT
1998
ATP induces large quaternary rearrangements in a cage-like chaperonin structure
1993
Rad23 and Rpn10: perennial wallflowers join the m�l�e
2004
Regulation of proteasome assembly and activity in health and disease
2018
Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation
2009
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Targeting ubiquitin specific proteases for drug discovery
2007
Mechanism of folding chamber closure in a group II chaperonin
2010 StandoutNatureNobel
Two-dimensional Crystals of the Molecular Chaperone GroEL Reveal Structural Plasticity
1993
Mechanism of GroEL action: Productive release of polypeptide from a sequestered position under groes
1995
Proteasome Activators
2011
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
2014
The Hallmarks of Aging
2013 Standout
Stability and stabilization of globular proteins in solution
2000
Structural Basis for GroEL-assisted Protein Folding from the Crystal Structure of (GroEL-KMgATP)14 at 2.0Å Resolution
2003
Molecular Mechanism of Protein Folding in the Cell
2011 StandoutNobel
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Structure and Stability of Hyperstable Proteins: Glycolytic Enzymes From Hyperthermophilic Bacterium Thermotoga Maritima
1996
Purified chaperonin 60 (groEL) interacts with the nonnative states of a multitude of Escherichia coli proteins
1992
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
A cryptic protease couples deubiquitination and degradation by the proteasome
2002 Nature
Deubiquitinating Enzyme Ubp6 Functions Noncatalytically to Delay Proteasomal Degradation
2006
Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins
1999
Enhancement of proteasome activity by a small-molecule inhibitor of USP14
2010 Nature
Caspase Activation Inhibits Proteasome Function during Apoptosis
2004 StandoutNobel
A UAF1-Containing Multisubunit Protein Complex Regulates the Fanconi Anemia Pathway
2007
Folding in vivo of bacterial cytoplasmic proteins: Role of GroEL
1993
Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein.
1996 StandoutNobel
Coping with Protein Quality Control Failure
2017
Positive cooperativity in the functioning of molecular chaperone GroEL.
1992 StandoutNobel
Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C
2005 StandoutNobel
USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1
2008
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
Relative Structural and Functional Roles of Multiple Deubiquitylating Proteins Associated with Mammalian 26S Proteasome
2007
Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70
2000 StandoutNobel
Protein partners of deubiquitinating enzymes
2008
Prevention of Protein Denaturation Under Heat Stress by the Chaperonin Hsp60
1992 Science
A polypeptide bound by the chaperonin groEL is localized within a central cavity.
1993
Asymmetrical Interaction of GroEL and GroES in the ATPase Cycle of Assisted Protein Folding
1995 Science
Interaction of GroE with an all-beta-protein.
1992
Probing the Sequence of Conformationally Induced Polarity Changes in the Molecular Chaperonin GroEL with Fluorescence Spectroscopy
2005 StandoutNobel
Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.
1992
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
2000 StandoutScienceNobel
Small heat shock proteins are molecular chaperones.
1993 Standout
Catalysis of Amide Proton Exchange by the Molecular Chaperones GroEL and SecB
1996 Science
Significant hydrogen exchange protection in GroEL‐bound DHFR is maintained during iterative rounds of substrate cycling
1996
Directed evolution of a thermostable esterase
1998 StandoutNobel
Three-dimensional superresolution colocalization of intracellular protein superstructures and the cell surface in live Caulobacter crescentus
2011 StandoutNobel
Mechanism of chaperonin action: GroES binding and release can drive GroEL-mediated protein folding in the absence of ATP hydrolysis.
1996
BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum.
1995 StandoutNobel
Molecular Matchmakers
1993 StandoutScienceNobel
Reconstitution of a heat shock effect in vitro: influence of GroE on the thermal aggregation of .alpha.-glucosidase from yeast
1991
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity.
1992
The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.
1996
Toward a mechanism for GroEL.GroES chaperone activity: an ATPase-gated and -pulsed folding and annealing cage.
1996
Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling
2012 StandoutNobel
Characterization of a Functional GroEL 14 (GroES 7 ) 2 Chaperonin Hetero-Oligomer
1994 Science
Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors
2001
Role of accessory proteins in protein folding
1993
Alpha-crystallin can function as a molecular chaperone.
1992 Standout
Escherichia coli chaperonins cpn60 (groEL) and cpn10 (groES) do not catalyse the refolding of mitochondrial malate dehydrogenase
1993
Dynamics of the Chaperonin ATPase Cycle: Implications for Facilitated Protein Folding
1994 Science
STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING
1998
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells.
2002
The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks
2009
NMR structure determination of the Escherichia coli DnaJ molecular chaperone: secondary structure and backbone fold of the N-terminal region (residues 2-108) containing the highly conserved J domain.
1994 StandoutNobel
Functional Significance of Symmetrical Versus Asymmetrical GroEL-GroES Chaperonin Complexes
1995 Science
Structure of the Heat Shock Protein Chaperonin-10 of Mycobacterium leprae
1996 Science
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Conformational specificity of the chaperonin GroEL for the compact folding intermediates of alpha-lactalbumin.
1994
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Immunoproteasomes Largely Replace Constitutive Proteasomes During an Antiviral and Antibacterial Immune Response in the Liver
2001
NMR structure of the calreticulin P-domain
2001 StandoutNobel
The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release
2001
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Works of Marion Schmidt being referenced
Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism
2011
Characterization of the Proteasome Using Native Gel Electrophoresis
2005
Structure and mechanism of ATP-dependent proteases
1999
Proteasome-associated proteins: regulation of a proteolytic machine
2005
Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae
2011
GroE facilitates refolding of citrate synthase by suppressing aggregation
1991
Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(β5i) incorporation into 20 S proteasomes 1 1Edited by R. Huber
2000
Sequence information within proteasomal prosequences mediates efficient integration of β-subunits into the 20 s proteasome complex
1999
Multiple Associated Proteins Regulate Proteasome Structure and Function
2002
Maturation of mammalian 20 S proteasome: purification and characterization of 13 S and 16 S proteasome precursor complexes
1997
Ubiquitin Chains Are Remodeled at the Proteasome by Opposing Ubiquitin Ligase and Deubiquitinating Activities
2006
Regulation of proteasome activity in health and disease
2013
Hexameric assembly of the proteasomal ATPases is templated through their C termini
2009 Nature
Glycosylation inhibits the interaction of invertase with the chaperone GroEL
1992
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle
2005
Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes
2000
Biogenesis of eukaryotic 20S proteasomes: the complex maturation pathway of a complex enzyme
1997
Symmetric Complexes of GroE Chaperonins as Part of the Functional Cycle
1994 Science