Standout Papers
- A synaptic vesicle membrane protein is conserved from mammals to Drosophila (1989)
- Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes (1993)
- rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. (1990)
- Tetanus toxin action: Inhibition of neurotransmitter release linked to synaptobrevin proteolysis (1992)
Citation Impact
Citing Papers
SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
2001 StandoutScienceNobel
Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.
1991
The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae.
1996
Synaptoporin, a novel putative channel protein of synaptic vesicles
1990
The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations.
1989
Small GTP-binding proteins and their role in transport
1991
Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans
1995 StandoutNatureNobel
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
1993 StandoutNobel
Understanding Synapses: Past, Present, and Future
2008 StandoutNobel
Evidence That the Rab3a-binding Protein, Rabphilin3a, Enhances Regulated Secretion.
1995
Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
1993 StandoutNatureNobel
Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane.
1995
Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects
1995
Structural Basis of Rab Effector Specificity
1999
Structural Determinants of Synaptobrevin 2 Function in Synaptic Vesicle Fusion
2006 StandoutNobel
Torpedo synaptophysin: evolution of a synaptic vesicle protein
1990
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Differential expression of the p65 gene family
1991
Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae
1993
SNAREs and SNARE regulators in membrane fusion and exocytosis
1999
Cellugyrin, a Novel Ubiquitous Form of Synaptogyrin That Is Phosphorylated by pp60c-
1998 StandoutNobel
A targeting signal in VAMP regulating transport to synaptic vesicles
1995
Comparison of the Effects on Secretion in Chromaffin and PC12 Cells of Rab3 Family Members and Mutants
1999
Conserved α-Helical Segments on Yeast Homologs of the Synaptobrevin/VAMP Family of v-SNAREs Mediate Exocytic Function
1997
Vesicle fusion from yeast to man
1994 Nature
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
2009 StandoutNobel
Botulinum neurotoxin light chains inhibit both Ca2+‐induced and GTP analogue‐induced catecholamine release from permeabilised adrenal chromaffin cells
1996
ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein
1991
Rab proteins and the road maps for intracellular transport
1993
A small GTP-binding protein dissociates from synaptic vesicles during exocytosis
1991 Nature
Complexins: Cytosolic proteins that regulate SNAP receptor function
1995
A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles
1994 StandoutNobel
Distribution of synaptic markers in the retina: Implications for synaptic vesicle traffic in ribbon synapses
1994 StandoutNobel
Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release
1993
Exocytotic and endocytotic membrane traffic in neurons
1991
SNAREpins: Minimal Machinery for Membrane Fusion
1998 StandoutNobel
The sequence of events that underlie quantal transmission at central glutamatergic synapses
2007
Inhibition of RabSB expression attenuates Ca2+-dependent exocytosis in rat anterior pituitary cells
1993 Nature
Endocytosis in yeast: Evidence for the involvement of a small GTP-binding protein (Ypt7p)
1992
Rab proteins
1998
Characterization of the human synaptogyrin gene family
1998
Mechanism of action of tetanus and botulinum neurotoxins
1994
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
1993 StandoutNatureNobel
Synaptogyrins Regulate Ca2+-dependent Exocytosis in PC12 Cells
1999 StandoutNobel
Implications of the SNARE hypothesis for intracellular membrane topology and dynamics
1994 StandoutNobel
Clostridial neurotoxins: new tools for dissecting exocytosis
1994
Essential Roles in Synaptic Plasticity for Synaptogyrin I and Synaptophysin I
1999 StandoutNobel
Molecular Mass, Stoichiometry, and Assembly of 20 S Particles
2001 StandoutNobel
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
The N-Ethylmaleimide-sensitive Fusion Protein and α-SNAP Induce a Conformational Change in Syntaxin
1995
Neurotransmission: harnessing fusion machinery at the synapse
1994 StandoutNobel
Transmitter release from synapses: Does a preassembled fusion pore initiate exocytosis?
1990
Storage and release of neurotransmitters
1993
SNAREs — engines for membrane fusion
2006 Standout
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
1992 Nature
A stable interaction between syntaxin 1a and synaptobrevin 2 mediated by their transmembrane domains
1999
Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1
1995
A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.
1995 StandoutNobel
The C2 Domains of Rabphilin3A Specifically Bind Phosphatidylinositol 4,5-Bisphosphate Containing Vesicles in a Ca2+-dependent Manner
1998
Molecular dissection of the secretory pathway
1992 Nature
Structure and function of tetanus and botulinum neurotoxins
1995
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C
1990 Nature
Synaptic vesicles
1989 StandoutNobel
Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product
1992 StandoutNobel
PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis
2005
Double In Situ Hybridization Reveals Overlapping Neuronal Populations Expressing the Low Molecular Weight GTPases Rab3a and Rab3b in Rat Brain
1995
Evidence Against an Acute Inhibitory Role of nSec‐1 (Munc‐18) in Late Steps of Regulated Exocytosis in Chromaffin and PC12 Cells
1997
Hypervariable C-termmal domain of rab proteins acts as a targeting signal
1991 Nature
Role of Rab GTPases in Membrane Traffic
1997
Differential expression ofrab3 isoforms in oligodendrocytes and astrocytes
1996
rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence
1991 StandoutNobel
Real-time measurement of transmitter release from single synaptic vesicles
1995 Nature
Exocytotic fusion is activated by Rab3a peptides
1992 Nature
Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis
1994
The RIM/NIM Family of Neuronal C2 Domain Proteins
2000 StandoutNobel
The Length of the Flexible SNAREpin Juxtamembrane Region Is a Critical Determinant of SNARE-Dependent Fusion
1999 StandoutNobel
Arrangement of Subunits in 20 S Particles Consisting of NSF, SNAPs, and SNARE Complexes
1998 StandoutNobel
Proteins of synaptic vesicles involved in exocytosis and membrane recycling
1991
SNARE-mediated membrane fusion
2001
The syntaxin family of vesicular transport receptors
1993
Physical and Functional Interaction of Rabphilin-3A with α-Actinin
1996
Synaptic Vesicle Traffic: Rush Hour in the Nerve Terminal
1993
Spontaneous Neural Activity Is Required for the Establishment and Maintenance of the Olfactory Sensory Map
2004 StandoutNobel
Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein
1993 StandoutNatureNobel
rab5 controls early endosome fusion in vitro
1991
The C. elegans unc-18 gene encodes a protein expressed in motor neurons
1993
Similar effects of α‐ and β‐SNAP on Ca 2+‐regulated exocytosis
1996
Postsynaptic expression of tetanus toxin light chain blocks synaptogenesis in Drosophila
1999
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C
1994 StandoutNobel
v‐SNAREs control exocytosis of vesicles from priming to fusion
2005 StandoutNobel
Synaptic Vesicles and Exocytosis
1994
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Tissue-specific alternative RNA splicing of rat vesicle-associated membrane protein-1 (VAMP-1)
1997
Localization Versus Function of Rab3 Proteins
2002 StandoutNobel
Synaptic Core Complex of Synaptobrevin, Syntaxin, and SNAP25 Forms High Affinity -SNAP Binding Site
1995 StandoutNobel
Ultrastructural localization of SNAP‐25 within the rat spinal cord and peripheral nervous system
1995
Syntaxin 5 Is a Common Component of the NSF- and p97-Mediated Reassembly Pathways of Golgi Cisternae from Mitotic Golgi Fragments In Vitro
1998
Rab3D, a Small GTPase, Is Localized on Mast Cell Secretory Granules and Translocates to the Plasma Membrane upon Exocytosis
1999
Synaptic vesicle membrane proteins interact to form a multimeric complex.
1992
Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.
1991
Relative properties and localizations of synaptic vesicle protein isoforms: the case of the synaptophysins
1993
Nonneuronal expression of Rab3A: induction during adipogenesis and association with different intracellular membranes than Rab3D.
1995
Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants.
1998
Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae
1997 StandoutNobel
Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport.
1993
A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin.
1994
Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F.
1994 StandoutNobel
Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons
1992
Close Is Not Enough
2000 StandoutNobel
Distinct Requirements for Evoked and Spontaneous Release of Neurotransmitter Are Revealed by Mutations in theDrosophilaGeneneuronal-synaptobrevin
1998
Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesis.
1991
Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.
1994 StandoutNobel
The BOS1 gene encodes an essential 27-kD putative membrane protein that is required for vesicular transport from the ER to the Golgi complex in yeast.
1991
Membrane fusion machinery: Insights from synaptic proteins
1993 StandoutNobel
GS32, a Novel Golgi SNARE of 32 kDa, Interacts Preferentially with Syntaxin 6
1999
SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils.
1994
Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond.
1994
Involvement of Long Chain Fatty Acid Elongation in the Trafficking of Secretory Vesicles in Yeast
1998
The small GTP-binding protein rab4 is associated with early endosomes.
1991
Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains.
1993
Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin.
1994 StandoutNobel
Immunoisolation of GABA-Specific Synaptic Vesicles Defines a Functionally Distinct Subset of Synaptic Vesicles
2000
Bos1p, a membrane protein required for ER to Golgi transport in yeast, co-purifies with the carrier vesicles and with Bet1p and the ER membrane.
1992
Domain structure of synaptotagmin (p65)
1991 StandoutNobel
Differential expression and regulation of multiple dynamins.
1994 StandoutNobel
GENETICS OF SYNAPTIC VESICLE FUNCTION: Toward the Complete Functional Anatomy of an Organelle
1999 StandoutNobel
RECONSTITUTION OF REGULATED EXOCYTOSIS IN CELL-FREE SYSTEMS: A Critical Appraisal
1999
Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle
1992 Nobel
Purification and expression of gCap39. An intracellular and secreted Ca2(+)-dependent actin-binding protein enriched in mononuclear phagocytes.
1990 StandoutNobel
Structural features of the GTP-binding defective Rab5 mutants required for their inhibitory activity on endocytosis.
1994
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.
1993
A mammalian inhibitory GDP/GTP exchange protein (GDP dissociation inhibitor) for smg p25A is active on the yeast SEC4 protein.
1991
C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.
1991
Caenorhabditis elegans rab-3Mutant Synapses Exhibit Impaired Function and Are Partially Depleted of Vesicles
1997 StandoutNobel
SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.
1992
Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
1992 Science
Identification and Structure of Four Yeast Genes (SLY) That Are Able To Suppress the Functional Loss of YPT1, a Member of the RAS Superfamily
1991
Rabphilin-3A is associated with synaptic vesicles through a vesicle protein in a manner independent of Rab3A
1994
Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis
1994 StandoutNobel
Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin.
1993
Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis.
1993
TRANSPORT VESICLE DOCKING: SNAREs and Associates
1996
A rab protein regulates the localization of secretory granules in AtT-20 cells.
1993
The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling.
1995
Novel SCAMPs Lacking NPF Repeats: Ubiquitous and Synaptic Vesicle-Specific Forms Implicate SCAMPs in Multiple Membrane-Trafficking Functions
2000 StandoutNobel
Synaptic Transmission Deficits inCaenorhabditis elegansSynaptobrevin Mutants
1998
SVOP, an Evolutionarily Conserved Synaptic Vesicle Protein, Suggests Novel Transport Functions of Synaptic Vesicles
1998 StandoutNobel
Synapsin II. Mapping of a domain in the NH2-terminal region which binds to small synaptic vesicles.
1990 StandoutNobel
Membrane Fusion and Exocytosis
1999 StandoutNobel
n-Sec1: a neural-specific syntaxin-bindingprotein.
1994
Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.
1995
Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans.
1991 StandoutNobel
Rabphilin Knock-Out Mice Reveal That Rabphilin Is Not Required for Rab3 Function in Regulating Neurotransmitter Release
1999 StandoutNobel
The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport.
1991
In vitro exocytosis in sea urchin eggs requires a synaptobrevin-related protein
1997
The Cellular Functions of Small GTP-Binding Proteins
1990 Science
Rab3A and Rab3D Control the Total Granule Number and the Fraction of Granules Docked at the Plasma Membrane in PC12 Cells
2000
Insulin and okadaic acid induce Rab4 redistribution in adipocytes.
1993
Syntaxin 4, VAMP2, and/or VAMP3/Cellubrevin Are Functional Target Membrane and Vesicle SNAP Receptors for Insulin-Stimulated GLUT4 Translocation in Adipocytes
1997
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Removal of Rab GTP-binding proteins from Golgi membranes by GDP dissociation inhibitor inhibits inter-cisternal transport in the Golgi stacks.
1994 StandoutNobel
Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling.
1992
Distinct patterns of expression of two VAMP genes within the rat brain
1990
Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras.
1996 StandoutNobel
Differential expression of two novel Munc13 proteins in rat brain
1999
The Role of GTP-Binding Proteins in Transport Along the Exocytic Pathway
1993
Association of Rab3A with synaptic vesicles at late stages of the secretory pathway.
1991
Characterization of Rab3A, Rab3B and Rab3C: different biochemical properties and intracellular localization in bovine chromaffin cells
1997
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
1992
Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro.
1995
Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes.
1992
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles.
1996
Biogenesis of synaptic vesicle-like structures in a pheochromocytoma cell line PC-12.
1990
Structure and expression of the rat inositol 1,4,5-trisphosphate receptor.
1990 StandoutNobel
Endobrevin, a Novel Synaptobrevin/VAMP-Like Protein Preferentially Associated with the Early Endosome
1998
Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.
1992
Cloning of a Rab3 isotype predominantly expressed in adipocytes.
1992
Rabphilin-3A, a Putative Target Protein for smg p25A/rab3A p25 Small GTP-Binding Protein Related to Synaptotagmin
1993
Proteolysis of SNAP-25 by types E and A botulinal neurotoxins.
1994 StandoutNobel
The GTPase Rab3a negatively controls calcium-dependent exocytosis in neuroendocrine cells.
1994
Yeast Homotypic Vacuole Fusion: A Window on Organelle Trafficking Mechanisms
2000
ERS-24, a Mammalian v-SNARE Implicated in Vesicle Traffic between the ER and the Golgi
1997 StandoutNobel
Ca2+or Sr2+Partially Rescues Synaptic Transmission in Hippocampal Cultures Treated with Botulinum Toxin A and C, But Not Tetanus Toxin
1997
The multisubunit structure of synaptophysin. Relationship between disulfide bonding and homo-oligomerization.
1990 StandoutNobel
Protein-Protein Interactions Contributing to the Specificity of Intracellular Vesicular Trafficking
1994 Science
Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.
1993
Structure of synaptogyrin (p29) defines novel synaptic vesicle protein.
1995 StandoutNobel
Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function
1993 Science
Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2.
1990 StandoutNobel
Mediation of the Attachment or Fusion Step in Vesicular Transport by the GTP-Binding Ypt1 Protein
1991 Science
The molecular machinery for secretion is conserved from yeast to neurons.
1993
Rab3A GTPase-activating protein-inhibiting activity of Rabphilin-3A, a putative Rab3A target protein.
1993
A synthetic peptide of the rab3a effector domain stimulates amylase release from permeabilized pancreatic acini.
1992
Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes.
1993 StandoutNobel
Secretory carrier membrane proteins 31-35 define a common protein composition among secretory carrier membranes.
1991
Works of Marion Baumert being referenced
Tetanus toxin action: Inhibition of neurotransmitter release linked to synaptobrevin proteolysis
1992 StandoutNobel
Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate
1989
A synaptic vesicle membrane protein is conserved from mammals to Drosophila
1989 StandoutNobel
Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain.
1989
P29: a novel tyrosine-phosphorylated membrane protein present in small clear vesicles of neurons and endocrine cells.
1990
Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes
1993 StandoutNobel
rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.
1990 StandoutNobel