Citation Impact
Citing Papers
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
2010 Science
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
2010 StandoutScience
Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi–lysosome contact site
2017
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
2008 StandoutScience
TOR Signaling in Growth and Metabolism
2006 Standout
mTOR signaling: implications for cancer and anticancer therapy
2005
Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart
2002
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells
2019
The metabolic life and times of a T‐cell
2010
mTOR Signaling in Growth Control and Disease
2012 Standout
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
2011
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
2007
The tor pathway: a target for cancer therapy
2004 Standout
TOR signalling in bugs, brain and brawn
2003
The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs
2013
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
2004 StandoutNature
Growing roles for the mTOR pathway
2005
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
2005
Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo
1999
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
2004
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
2011
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
2009 Standout
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
The genetics of ageing
2010 StandoutNature
Regulation of translation initiation by FRAP/mTOR
2001
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
2004 StandoutNobel
Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia
2001
mTOR signaling: At the crossroads of plasticity, memory and disease
2009
Protein kinase cascades in the regulation of cardiac hypertrophy
2005
Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1
2007
mTOR, translational control and human disease
2005
The biology of incretin hormones
2006 Standout
Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5
2007
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
2013 StandoutNatureNobel
Rapamycin‐sensitive phase of 3T3‐L1 preadipocyte differentiation after clonal expansion
2001
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice
2017 Nature
The mechanism of eukaryotic translation initiation and principles of its regulation
2010 Standout
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Translational control in cancer
2010
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
PRDM16 controls a brown fat/skeletal muscle switch
2008 StandoutNature
The RSK factors of activating the Ras/MAPK signaling cascade
2008
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
2008
Upstream and downstream of mTOR
2004 Standout
A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility
2017
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
2007 Standout
Chapter 1 Physiological Roles of Ribosomal Protein S6: One of Its Kind
2008
Coordinate regulation of translation by the PI 3-kinase and mTOR pathways
2002
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
2009 StandoutNature
Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction
2010
Subtype determination of presynaptic ?2-autoreceptors in the rabbit pulmonary artery and human saphenous vein
1995
Interplay Between Lipid Metabolism and Autophagy
2020
Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice
2004
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
A unifying model for mTORC1-mediated regulation of mRNA translation
2012 Nature
Stress and mTORture signaling
2006
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
2005
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
2010
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB
1998
Cellular Fatty Acid Metabolism and Cancer
2013 Standout
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
2005
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
2009
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
2008
Presynaptic ?2-autoreceptors in brain cortex: ?2D in the rat and ?2A in the rabbit
1993
Pdx1 restores β cell function in Irs2 knockout mice
2002
The Physiology of Glucagon-like Peptide 1
2007 Standout
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
2004 Nature
Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E
2010
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
2006
SKAR Is a Specific Target of S6 Kinase 1 in Cell Growth Control
2004
Extracellular Regulated Kinases (ERK) 1 and ERK2 Are Authentic Substrates for the Dual-specificity Protein-tyrosine Phosphatase VHR
1999
A re-investigation of questionable subclassifications of presynaptic α2-autoreceptors: rat vena cava, rat atria, human kidney and guinea-pig urethra
1997
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
CREB: A Major Mediator of Neuronal Neurotrophin Responses
1997
PTEN function in mammalian cell size regulation
2002
AKT/PKB Signaling: Navigating the Network
2017 Standout
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
2007
mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events
2005
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
Investigation of the subtype of α2‐adrenoceptor mediating prejunctional inhibition of cardioacceleration in the pithed rat heart
1995
Biochemical mechanisms for translational regulation in synaptic plasticity
2004
A recollection of mTOR signaling in learning and memory
2013
The Hallmarks of Aging
2013 Standout
Temporal Control of Differentiation by the Insulin Receptor/Tor Pathway in Drosophila
2004
Regulation of cardiac hypertrophy by intracellular signalling pathways
2006 Standout
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
2008
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
Chronic rapamycin treatment or lack ofS6K1does not reduce ribosome activity in vivo
2013
Signaling pathways controlling skeletal muscle mass
2013
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
2004
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
2008
Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells
2005
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
2006
Molecular mechanisms of mTOR-mediated translational control
2009 Standout
The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation
2005
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
2004 Standout
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
Oncogenic PI3K deregulates transcription and translation
2005
Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking
2008
AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
2011
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
2010
mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells
2004 StandoutNobel
Regulatory circuits controlling white versus brown adipocyte differentiation
2006
The role of raptor in the mechanical load‐induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy
2018
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
mTOR coordinates protein synthesis, mitochondrial activity and proliferation
2015
Responding to Hypoxia: Lessons From a Model Cell Line
2002
The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner
2008
mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
2013
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis
2009
Minireview: Role of the Growth Hormone/Insulin-Like Growth Factor System in Mammalian Aging
2005
TOPs and their regulation
2006
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
2008
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
2001
Chemical Ablation of Gastric Inhibitory Polypeptide Receptor Action by Daily (Pro3)GIP Administration Improves Glucose Tolerance and Ameliorates Insulin Resistance and Abnormalities of Islet Structure in Obesity-Related Diabetes
2005
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Regulation and function of the RSK family of protein kinases
2011
Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia
2001
mTORC1 Directly Phosphorylates and Regulates Human MAF1
2010
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
2004 StandoutScience
Responding to Hypoxia: Lessons From a Model Cell Line
2002
Class IA Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy
2005
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development
2004
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
2009
CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
1999 Standout
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
2013 Science
mTOR Pathway as a Target in Tissue Hypertrophy
2006
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size
2005
mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3‐L1 Adipocytes
2010
Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload
2004
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases
2014
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Extending Healthy Life Span—From Yeast to Humans
2010 StandoutScience
When Translation Meets Metabolism: Multiple Links to Diabetes
2003
Cyclin-Dependent Kinase-9
2004
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Pdx1 restores β cell function in Irs2 knockout mice
2002
Works of Mario Pende being referenced
S6K1 −/− / S6K2 −/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
2004
S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy
2016
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
2000 Nature
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
2006
Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
2013
Rictor is a novel target of p70 S6 kinase-1
2009
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
2019
Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation
2008
Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
2009
Subclassification of release‐regulating α2‐autoreceptors in human brain cortex
1992
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors
2004
S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover
2007
S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
2011
Depdc5 knockout rat: A novel model of mTORopathy
2016
Atrophy of S6K1−/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
2005
S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase
2007
The Type 1 Insulin-Like Growth Factor Receptor (IGF-IR) Pathway Is Mandatory for the Follistatin-Induced Skeletal Muscle Hypertrophy
2011
Neurotransmitter- and Growth Factor-Induced cAMP Response Element Binding Protein Phosphorylation in Glial Cell Progenitors: Role of Calcium Ions, Protein Kinase C, and Mitogen-Activated Protein Kinase/Ribosomal S6 Kinase Pathway
1997
Glutamate regulates intracellular calcium and gene expression in oligodendrocyte progenitors through the activation of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
1994
Roles of the Lactogens and Somatogens in Perinatal and Postnatal Metabolism and Growth: Studies of a Novel Mouse Model Combining Lactogen Resistance and Growth Hormone Deficiency
2004
Regulation of the SREBP transcription factors by mTORC1
2011
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
2014
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors
2004
Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy
2004
Important role for AMPKαl in limiting skeletal muscle cell hypertrophy
2009