Citation Impact
Citing Papers
PKA phosphorylation couples hepatic inositol-requiring enzyme 1α to glucagon signaling in glucose metabolism
2011
Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption
2018
XBP1s Is an Anti-lipogenic Protein
2016
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Thematic Review Series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
2008
Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance
2017
Hepatic triacylglycerol accumulation and insulin resistance
2008
Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways
2010
A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis
2014
Genetic determinants of hepatic steatosis in man
2011
Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice
2013
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Skin-specific Deletion of Stearoyl-CoA Desaturase-1 Alters Skin Lipid Composition and Protects Mice from High Fat Diet-induced Obesity
2009
ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content
2014
Mitochondrial Dynamics and Metabolic Regulation
2016
Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance
2012
Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease
2007
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
2013
Inflammatory links between obesity and metabolic disease
2011 Standout
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
2018
Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2
2011
Brown and beige fat: development, function and therapeutic potential
2013 Standout
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
New insights into ER stress-induced insulin resistance
2012
Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance
2013
Chronic inflammation in the etiology of disease across the life span
2019 Standout
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
2016
The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
2012
Sphingolipids and their metabolism in physiology and disease
2017 Standout
Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
2016
Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans
2017
FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
2016
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
2008 Standout
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
2011 Standout
Regulation of hepatic glucose metabolism in health and disease
2017
The Role of Cholesterol in the Pathogenesis of NASH
2015
Hallmarks of aging: An expanding universe
2023 Standout
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
2010
The Human Intestinal Microbiome in Health and Disease
2016 Standout
Fatty liver, insulin resistance, and dyslipidemia
2008
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
2014 Nature
Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation
2018
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
2012
Benefits of lifestyle modification in NAFLD
2007
Dissociating fatty liver and diabetes
2012
Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice
2015
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
2015
Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance
2007
Mechanisms and disease consequences of nonalcoholic fatty liver disease
2021
Uncoupling protein-3 as a molecular determinant of the action of 3,5,3′-triiodothyronine on energy metabolism
2009
Hormonal Regulation of Hepatic Glucose Production in Health and Disease
2011
Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle
2013
NAFLD and diabetes mellitus
2016
What causes the insulin resistance underlying obesity?
2012
Metabolic Implications of Dietary Trans‐fatty Acids
2009
Type 2 diabetes as an inflammatory disease
2011 Standout
Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
2010
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia
2010
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice
2014
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
2014 StandoutNature
Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance
2010
Non-alcoholic fatty liver disease
2021 Standout
Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association
2021 Standout
Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
2008
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Insulin Receptor Signaling in Normal and Insulin-Resistant States
2014
Biochemical and cellular properties of insulin receptor signalling
2017
Dynamics and functions of lipid droplets
2018 Standout
The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance
2012
Fructose induced lipogenesis: from sugar to fat to insulin resistance
2010
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective
2010
Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance
2017
Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance
2011
The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
2016
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
2009 Standout
Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice
2012
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance
2018
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
2013
Risk of type 2 diabetes in patients with non-alcoholic fatty liver disease: Causal association or epiphenomenon?
2016
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
2011
Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance
2007
Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease
2020
Membrane lipids: where they are and how they behave
2008 Standout
Fructose consumption: recent results and their potential implications
2010
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
2012
Therapeutic Landscape for NAFLD in 2020
2020
Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?
2017
Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
2010 Standout
The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function
2017 Standout
The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance
2009
GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice
2009
What We Talk About When We Talk About Fat
2014 Standout
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans
2011
Lipid-induced insulin resistance: unravelling the mechanism
2010
Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects
2012
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
2015 Standout
Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler
2013
Type 2 diabetes mellitus
2015 Standout
Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes
2017
The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling
2012
The Hallmarks of Aging
2013 Standout
Ceramides – Lipotoxic Inducers of Metabolic Disorders
2015
Energy Metabolism in the Liver
2014 Standout
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
2011 Nature
Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression
2008
Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
2011
Ectopic fat, insulin resistance and non-alcoholic fatty liver disease
2013
Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease
2016
Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents
2018
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Increased risk of cardiovascular disease and chronic kidney disease in NAFLD
2012
Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease
2010
NAFLD: A multisystem disease
2015 Standout
Fibroblast Growth Factor Signaling in Metabolic Regulation
2016
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
2012
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
2016 StandoutNobel
Inhibition of PKCɛ Improves Glucose-Stimulated Insulin Secretion and Reduces Insulin Clearance
2007
DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling
2015
Dietary carbohydrates and fats in nonalcoholic fatty liver disease
2021
Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis
2010
Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
2017
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents
2009
Insulin signaling to hepatic lipid metabolism in health and disease
2011
Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis
2014
Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans
2012
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
2014
TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1
2009
AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease
2023 Standout
Pathophysiology of Human Visceral Obesity: An Update
2013 Standout
Nonalcoholic Fatty Liver: A Possible New Target for Type 2 Diabetes Prevention and Treatment
2013
Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice
2022
Postprandial Lipemia Associates with Liver Fat Content
2007
Causes and Metabolic Consequences of Fatty Liver
2008
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation
2012
Ectopic Fat, Insulin Resistance, and Nonalcoholic Fatty Liver Disease
2014
Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice
2008
Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity
2007
Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis
2008
Myocardial Fatty Acid Metabolism in Health and Disease
2010 Standout
Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity
2014
Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance
2011
Increased Bioactive Lipids Content in Human Subcutaneous and Epicardial Fat Tissue Correlates with Insulin Resistance
2012
Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum
2016
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
2007
Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
2009
Diabetic Cardiomyopathy
2018 Standout
Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion
2014 StandoutNobel
Overproduction of Very Low–Density Lipoproteins Is the Hallmark of the Dyslipidemia in the Metabolic Syndrome
2008
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
2017 Standout
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain
2010
Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
2017
Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
2008
Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet
2011
Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome
2018
Uncoupling proteins and the control of mitochondrial reactive oxygen species production
2011
Deletion of diacylglycerol kinase ε confers susceptibility to obesity via reduced lipolytic activity in murine adipocytes
2018
Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver
2017
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
2011
Thyroid Hormone Regulation of Metabolism
2014 Standout
The rs2294918 E434K variant modulates patatin‐like phospholipase domain‐containing 3 expression and liver damage
2015
Early Hepatic Insulin Resistance in Mice: A Metabolomics Analysis
2010
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
2011
Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG
2016
Inflammatory Mechanisms in Obesity
2011 Standout
Role of exercise-induced hepatokines in metabolic disorders
2019
31P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism
2012
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta‐analysis
2015
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
2014
Development of insulin resistance in mice lacking PGC-1α in adipose tissues
2012
Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance
2014
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans
2013
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
2011 StandoutNobel
Understanding the Physiology of FGF21
2015
Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways
2013
Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet
2009
Targeting fatty acid metabolism to improve glucose metabolism
2015
Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice
2014
Review article: the emerging role of genetics in precision medicine for patients with non‐alcoholic steatohepatitis
2020
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats
2015 Science
The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men
2017
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
2009
A longitudinal study of whole body, tissue, and cellular physiology in a mouse model of fibrosing NASH with high fidelity to the human condition
2017
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes
2015
A controlled‐release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice
2017
Mechanism by which arylamine N -acetyltransferase 1 ablation causes insulin resistance in mice
2017
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
2007
Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?
2015
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
2016
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
2016
Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice
2015
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance
2007
Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
2014
Works of Mario Kahn being referenced
Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice
2020
Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
2011
Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance
2007
Influence of the Hepatic Eukaryotic Initiation Factor 2α (eIF2α) Endoplasmic Reticulum (ER) Stress Response Pathway on Insulin-mediated ER Stress and Hepatic and Peripheral Glucose Metabolism
2011
Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein
2009
Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21
2015
Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance
2007
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats
2012
Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance
2011
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance
2020
Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease
2007
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo
2013
The Role of the Carbohydrate Response Element-Binding Protein in Male Fructose-Fed Rats
2012
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
2013
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
2011
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism
2012
Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice From High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance
2013
Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice
2013
Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression
2009