Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
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2009 StandoutNobel
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2003 StandoutScienceNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Regulation of Ion Channels by ABC Transporters That Secrete ATP
1995 Science
Sputum Biomarkers of Inflammation in Cystic Fibrosis Lung Disease
2007
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
A1 Receptor Antagonist 8-Cyclopentyl-1,3-dipropylxanthine Selectively Activates Chloride Efflux from Human Epithelial and Mouse Fibroblast Cell Lines Expressing the Cystic Fibrosis Transmembrane Regulator .DELTA.F508 Mutation
1995
Inflammation and metabolic disorders
2006 StandoutNature
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line
1997
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Nucleotide signalling during inflammation
2014 StandoutNature
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
2001 StandoutNature
The genesis of cystic fibrosis lung disease
1999
Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila
2005
Partial Restoration of Mutant Enzyme Homeostasis in Three Distinct Lysosomal Storage Disease Cell Lines by Altering Calcium Homeostasis
2008
PLGA-based nanoparticles: An overview of biomedical applications
2012 Standout
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
2021 Standout
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
CFTR, Mucins, and Mucus Obstruction in Cystic Fibrosis
2012
Production of a severe cystic fibrosis mutation in mice by gene targeting
1993 StandoutNobel
Structural Basis of Inward Rectification
2002 StandoutNobel
Constitutive Release of ATP and Evidence for Major Contribution of Ecto-nucleotide Pyrophosphatase and Nucleoside Diphosphokinase to Extracellular Nucleotide Concentrations
2000
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
Management of Pulmonary Disease in Patients with Cystic Fibrosis
1996
Calcium-activated chloride conductance is not increased in pancreatic duct cells of CF mice
1995 StandoutNobel
Defective Trafficking of Nephrin Missense Mutants Rescued by a Chemical Chaperone
2004
Human airway ion transport. Part one.
1994
Chloride secretion in response to guanylin in colonic epithelia from normal and transgenic cystic fibrosis mice
1994 StandoutNobel
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
2010 StandoutNature
Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain
1998 StandoutNobel
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Chloride channels: a molecular perspective
1996
Control of Cardiac Development by an Evolutionarily Conserved Transcriptional Network
2002
Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0
2007
CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship
1993 Nature
Molecular pathogenesis of Bartter’s and Gitelman’s syndromes
1998
Expression and Regulation of the Na+‐K+‐2Cl− Cotransporter NKCC1 in the Normal and CFTR‐Deficient Murine Colon
2003 StandoutNobel
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Recombinant Adeno-Associated Virus Gene Therapy for Cystic Fibrosis and α1-Antitrypsin Deficiency
2002
PIEZO2 in sensory neurons and urothelial cells coordinates urination
2020 StandoutNatureNobel
Cystic fibrosis in the mouse by targeted insertional mutagenesis
1992 Nature
Folding of CFTR Is Predominantly Cotranslational
2005
Molecular physiology of anion channels
1994
ATP and purinergic receptor–dependent membrane traffic in bladder umbrella cells
2005
Cystic Fibrosis Transmembrane Conductance Regulator Mediates the Cyclic Adenosine Monophosphate–Induced Fluid Secretion But Not the Inhibition of Resorption in Mouse Gallbladder Epithelium
1997 StandoutNobel
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
2006
Regulation of the epithelial sodium channel (ENaC) by accessory proteins
2000
Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy
2015
Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs
1994 StandoutNatureNobel
Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation
1997
In Vivo Nasal Potential Difference: Techniques and Protocols for Assessing Efficacy of Gene Transfer in Cystic Fibrosis
1995
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
Amazing chloride channels: an overview
2003
ATP release from non-excitable cells
2009
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
2002 StandoutNature
A Pilot Clinical Trial of Oral Sodium 4-Phenylbutyrate (Buphenyl) in Δ F508-Homozygous Cystic Fibrosis Patients
1998
Evidence that Systemic Gentamicin Suppresses Premature Stop Mutations in Patients with Cystic Fibrosis
2001
Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis
2003 Standout
A Pilot Study of the Effect of Gentamicin on Nasal Potential Difference Measurements in Cystic Fibrosis Patients Carrying Stop Mutations
2000
Inflammatory Response in Airway Epithelial Cells Isolated from Patients with Cystic Fibrosis
2002
A Phase II, Double-Blind, Randomized, Placebo-Controlled Clinical Trial of tgAAVCF Using Maxillary Sinus Delivery in Patients with Cystic Fibrosis with Antrostomies
2002
Transport Protein Trafficking in Polarized Cells
2003
Anion Transport in Heart
2000
A Selective, Cell-Permeable Optical Probe for Hydrogen Peroxide in Living Cells
2004
P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.
1996
Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.
1996
Inflammation and its genesis in cystic fibrosis
2015
Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector.
1993
CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo
2002
Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists
2001
Inwardly rectifying K+ channels and volume-regulated anion channels in multidrug-resistant small cell lung cancer cells.
1993
Inwardly Rectifying K+ (Kir) Channels inDrosophila
2002
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
2006
In Vivo Airway Surface Liquid Cl− Analysis with Solid-State Electrodes
2001
Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells.
1995
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Multi-State Regulation of the Dihydrogen Phosphate Binding Affinity to a Light- and Heat-Responsive Bis-Urea Receptor
2014 StandoutNobel
INWARD RECTIFIER POTASSIUM CHANNELS
1997
CLONED POTASSIUM CHANNELS FROM EUKARYOTES AND PROKARYOTES
1997
Molecular Structure and Physiological Function of Chloride Channels
2002
Structure, Regulation, and Functional Diversity of Microvilli on the Apical Domain of Epithelial Cells
2015
Both CFTR and outwardly rectifying chloride channels contribute to cAMP-stimulated whole cell chloride currents
1994
Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation
1998
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
2005 Standout
The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.
1994
Extracellular ATP stimulates volume decrease inNecturusred blood cells
1999
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
Control of CFTR Channel Gating by Phosphorylation and Nucleotide Hydrolysis
1999
Bioluminescence detection of ATP release mechanisms in epithelia
1998
Basal chloride currents in murine airway epithelial cells: modulation by CFTR
1998 StandoutNobel
Molecular basis for defective glycosylation and Pseudomonas pathogenesis in cystic fibrosis lung
2001
METABOLIC ENGINEERING WITH RECOMBINANT ADENOVIRUSES
1999
The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung
2015
The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease.
1996
Chemical chaperones mediate increased secretion of mutant α1-antitrypsin (α1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in α1-AT deficiency
2000
ClC-2 Cl−channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole
2001
Volume‐activated chloride currents associated with the multidrug resistance P‐glycoprotein.
1995
The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis inDrosophila
2005
Spontaneous Cell Fusion in Macrophage Cultures Expressing High Levels of the P2Z/P2X7 Receptor
1997
Functional Significance of Cell Volume Regulatory Mechanisms
1998 Standout
Hyperabsorption of Na+ and raised Ca(2+)-mediated Cl- secretion in nasal epithelia of CF mice
1994
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Uncompensated polyuria in a mouse model of Bartter's syndrome
2000 StandoutNobel
Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing
2013
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
2006 StandoutScience
Lung Infections Associated with Cystic Fibrosis
2002 Standout
A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteins
1998 StandoutNobel
Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice.
1995 StandoutNobel
The ATP-sensitive potassium (K ATP ) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman
2006
ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor
2001 StandoutNobel
SIGNALING BY EXTRACELLULAR NUCLEOTIDES
1996 StandoutNobel
II. Regulation of CFTR by small molecules including HCO 3 −
1998
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Marie E. Egan being referenced
Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients
2007
Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR
1992 Nature
A Novel Sulfonylurea Receptor Family Member Expressed in the Embryonic Drosophila Dorsal Vessel and Tracheal System
1999
Identification of the Cystic Fibrosis Transmembrane Conductance Regulator Domains That Are Important for Interactions with ROMK2
2000
CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP
1995
Long-term treatment with oral N-acetylcysteine: Affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial
2014
Effects of the Serine/Threonine Kinase SGK1 on the Epithelial Na<sup>+</sup> Channel (ENaC) and CFTR: Implications for Cystic Fibrosis
2001
Calcium-pump inhibitors induce functional surface expression of ΔF508-CFTR protein in cystic fibrosis epithelial cells
2002
Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator −/− Mice
2008
In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR.
1997
Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator.
1996
Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects
2004 Science
Transmembrane Mutations Alter the Channel Characteristics of the Cystic Fibrosis Transmembrane Conductance Regulator Expressed in <i>Xenopus</i> Oocytes
1994
Continuous detection of extracellular ATP on living cells by using atomic force microscopy
1999
CFTR Is a Conductance Regulator as well as a Chloride Channel
1999
Partial Correction of Cystic Fibrosis Defects with PLGA Nanoparticles Encapsulating Curcumin
2009
Abnormal Trafficking and Degradation of TLR4 Underlie the Elevated Inflammatory Response in Cystic Fibrosis
2011
Myosin Ia is Required for CFTR Brush Border Membrane Trafficking and Ion Transport in the Mouse Small Intestine
2012
Reduced Caveolin-1 Promotes Hyperinflammation due to Abnormal Heme Oxygenase-1 Localization in Lipopolysaccharide-Challenged Macrophages with Dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator
2013
Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line.
1996