Citation Impact
Citing Papers
Genome Editing Using Cas9 Nickases
2014
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions
2013 StandoutNobel
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
CRISPR–Cas9 Structures and Mechanisms
2017 StandoutNobel
CRISPR/Cas9 in Genome Editing and Beyond
2016
Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
2012 Standout
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
The crystal structure of Cpf1 in complex with CRISPR RNA
2016 Nature
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Structures of the RNA-guided surveillance complex from a bacterial immune system
2011 StandoutNatureNobel
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
In Vivo Cleavage Map Illuminates the Central Role of RNase E in Coding and Non-coding RNA Pathways
2017
Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA
2012 StandoutNobel
Structure and Engineering of Francisella novicida Cas9
2016
Characterization of CRISPR RNA processing in Clostridium thermocellum and Methanococcus maripaludis
2012
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
The Population and Evolutionary Dynamics of Phage and Bacteria with CRISPR–Mediated Immunity
2013
A Ruler Protein in a Complex for Antiviral Defense Determines the Length of Small Interfering CRISPR RNAs
2013
Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems
2015
A genome-wide view of the expression and processing patterns of Thermus thermophilus HB8 CRISPR RNAs
2012
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
2013 Standout
Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
2015
Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2
2013
Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4
2014
DNA targeting specificity of RNA-guided Cas9 nucleases
2013 Standout
Cutting it close: CRISPR-associated endoribonuclease structure and function
2014 StandoutNobel
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
2015 Standout
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
2015
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease
2016
Comparative analysis of Cas6b processing and CRISPR RNA stability
2013
Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
2017 Nature
Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos
2013
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
2013
First indication for a functional CRISPR/Cas system in Francisella tularensis
2013
The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems
2013 StandoutNobel
Degradation of Phage Transcripts by CRISPR-Associated RNases Enables Type III CRISPR-Cas Immunity
2016
CRISPR RNAs trigger innate immune responses in human cells
2018
In Vitro Enzymology of Cas9
2014
Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9
2017
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
Classification and evolution of type II CRISPR-Cas systems
2014 StandoutNobel
CRISPR interference (CRISPRi) for sequence-specific control of gene expression
2013
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Structure of an RNA Silencing Complex of the CRISPR-Cas Immune System
2013
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
2016
Identification of endoribonuclease specific cleavage positions reveals novel targets of RNase III inStreptococcus pyogenes
2017 StandoutNobel
Phage-Induced Expression of CRISPR-Associated Proteins Is Revealed by Shotgun Proteomics in Streptococcus thermophilus
2012
Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity
2012
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
2017
crRNA and tracrRNA guide Cas9-mediated DNA interference inStreptococcus thermophilus
2013
CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3
2012
RNA-based recognition and targeting: sowing the seeds of specificity
2017 StandoutNobel
Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2
2013
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
2015
CRISPR–Cas systems: beyond adaptive immunity
2014
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
NmeCas9 is an intrinsically high-fidelity genome-editing platform
2018
CRISPR Interference Can Prevent Natural Transformation and Virulence Acquisition during In Vivo Bacterial Infection
2012
CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity
2014
CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration
2016
Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands
2013
DNA Targeting by a Minimal CRISPR RNA-Guided Cascade
2016 StandoutNobel
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
2014 Nature
Harnessing Type I and Type III CRISPR-Cas systems for genome editing
2015
Enabling functional genomics with genome engineering
2015
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes
2017 StandoutNobel
CRISPR adaptive immune systems of Archaea
2014
Highly efficient Cas9-mediated transcriptional programming
2015
Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases
2012
Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA
2011
Target RNA capture and cleavage by the Cmr type III-B CRISPR–Cas effector complex
2014
CRISPR-Cas
2013
To acquire or resist: the complex biological effects of CRISPR–Cas systems
2014
Diversity and evolution of class 2 CRISPR–Cas systems
2017
Exploiting CRISPR–Cas immune systems for genome editing in bacteria
2015
A decade of discovery: CRISPR functions and applications
2017
Foreign DNA capture during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
2016
Crystal structure and nucleic acid‐binding activity of the CRISPR‐associated protein Csx1 of Pyrococcus furiosus
2012
CRISPRTarget
2013
In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target
2015
High-Resolution Transcriptome Maps Reveal Strain-Specific Regulatory Features of Multiple Campylobacter jejuni Isolates
2013
Planting the seed: target recognition of short guide RNAs
2014
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
2013 Standout
Applications of CRISPR–Cas systems in neuroscience
2015
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
2016
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Inhibition of CRISPR-Cas systems by mobile genetic elements
2017
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
CRISPR-Cas immunity in prokaryotes
2015 Nature
Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome
2015
The structural biology of CRISPR-Cas systems
2015 StandoutNobel
Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials
2014
Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis
2013
Identification, structural, and biochemical characterization of a group of large Csn2 proteins involved in CRISPR‐mediated bacterial immunity
2012
High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes
2015
Cas9 specifies functional viral targets during CRISPR–Cas adaptation
2015 Nature
Cas9 as a versatile tool for engineering biology
2013
Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system
2014
Inhibition of CRISPR-Cas9 with Bacteriophage Proteins
2016
Essential Features and Rational Design of CRISPR RNAs that Function with the Cas RAMP Module Complex to Cleave RNAs
2012
Crystal Structure of Staphylococcus aureus Cas9
2015
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
2014
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
2013
DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes
2015 StandoutNobel
RNA-guided genome editing à la carte
2013
Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity
2014 StandoutNobel
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System
2012
Comparative genomics of defense systems in archaea and bacteria
2013
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac
2014
Crystal Structure of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated Csn2 Protein Revealed Ca2+-dependent Double-stranded DNA Binding Activity
2011
CRISPR-Cas systems for editing, regulating and targeting genomes
2014 Standout
Modulation of CRISPR locus transcription by the repeat-binding protein Cbp1 in Sulfolobus
2011
Genome engineering using the CRISPR-Cas9 system
2013 Standout
A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain–Barré syndrome
2012
Editing plant genomes with CRISPR/Cas9
2014
Evolution and classification of the CRISPR–Cas systems
2011 StandoutNobel
High-throughput functional genomics using CRISPR–Cas9
2015
CRISPR-based adaptive immune systems
2011
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
CRISPR–Cas systems exploit viral DNA injection to establish and maintain adaptive immunity
2017 Nature
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
2018
Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System
2012 StandoutNobel
Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system
2012 Nature
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
RNA sequencing uncovers antisense RNAs and novel small RNAs inStreptococcus pyogenes
2015 StandoutNobel
A thermostable Cas9 with increased lifetime in human plasma
2017 StandoutNobel
The next generation of CRISPR–Cas technologies and applications
2019
Annotation and Classification of CRISPR-Cas Systems
2015
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
2013 Standout
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
2014
Crystal Structure of Streptococcus pyogenes Cas1 and Its Interaction with Csn2 in the Type II CRISPR-Cas System
2015
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
2013 Nobel
RNA-activated DNA cleavage by the Type III-B CRISPR–Cas effector complex
2016
Mechanism of substrate selection by a highly specific CRISPR endoribonuclease
2012 StandoutNobel
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
I can see CRISPR now, even when phage are gone
2015
Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems
2017
In vitro reconstitution of Cascade‐mediated CRISPR immunity in Streptococcus thermophilus
2013
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity
2015 StandoutNobel
Protecting genome integrity during CRISPR immune adaptation
2016 StandoutNobel
Investigating CRISPR RNA Biogenesis and Function Using RNA-seq
2015
Arrangement and number of clustered regularly interspaced short palindromic repeat spacers are associated with erythromycin susceptibility in emm12, emm75 and emm 92 of group A streptococcus
2013
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
2016
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Global Regulatory Functions of the Staphylococcus aureus Endoribonuclease III in Gene Expression
2012
Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition
2016
Crystal Structure of Streptococcus pyogenes Csn2 Reveals Calcium-Dependent Conformational Changes in Its Tertiary and Quaternary Structure
2012
The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit
2017
Harnessing CRISPR–Cas systems for bacterial genome editing
2015
In vitro assembly and activity of an archaeal CRISPR-Cas type I-A Cascade interference complex
2014
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
2013
Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition
2013
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence
2013 Nature
Evaluation of sgRNA Target Sites for CRISPR-Mediated Repression of TP53
2014
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6
2016
DNase H Activity of Neisseria meningitidis Cas9
2015
Foreign DNA acquisition by the I-F CRISPR–Cas system requires all components of the interference machinery
2015
Diverse CRISPRs Evolving in Human Microbiomes
2012
Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality
2014
RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing?
2013
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
2015
Genome Editing B.C. (Before CRISPR): Lasting Lessons from the “Old Testament”
2018
The Bacterial Origins of the CRISPR Genome-Editing Revolution
2015
CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy
2015
RNA-programmed genome editing in human cells
2013 StandoutNobel
CRISPR-Cas Systems in Bacteria and Archaea: Versatile Small RNAs for Adaptive Defense and Regulation
2011
A New Group of Phage Anti-CRISPR Genes Inhibits the Type I-E CRISPR-Cas System of Pseudomonas aeruginosa
2014
Performance of the Cas9 Nickase System inDrosophila melanogaster
2014
Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site
2011
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
2016 Science
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing
2013
The CRISPR-Associated Genecas2of Legionella pneumophila Is Required for Intracellular Infection of Amoebae
2013
Concerning RNA-guided gene drives for the alteration of wild populations
2014
Cleavage of Phage DNA by the Streptococcus thermophilus CRISPR3-Cas System
2012
CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
2015
Crystal structure of a CRISPR RNA–guided surveillance complex bound to a ssDNA target
2014 Science
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
2013 Standout
Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies
2015
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering
2016 StandoutNobel
Evolution and Ecology of CRISPR
2016
CRISPR interference: a structural perspective
2013
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9
2018
CRISPR-Cas Systems
2012
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes
2015
Nature and Intensity of Selection Pressure on CRISPR-Associated Genes
2011
CRISPR: New Horizons in Phage Resistance and Strain Identification
2012
Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9
2015
Optical Control of CRISPR/Cas9 Gene Editing
2015
Adapting to new threats: the generation of memory by CRISPR‐Cas immune systems
2014
Active site plasticity enables metal-dependent tuning of Cas5d nuclease activity in CRISPR-Cas type I-C system
2013
The basic building blocks and evolution of CRISPR–Cas systems
2013
Cas9 function and host genome sampling in Type II-A CRISPR–Cas adaptation
2015
CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea
2013
Programmable RNA Cleavage and Recognition by a Natural CRISPR-Cas9 System from Neisseria meningitidis
2018
Viral Diversity Threshold for Adaptive Immunity in Prokaryotes
2012
The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae
2012
CRISPR-Cas Adaptive Immune Systems of the Sulfolobales: Unravelling Their Complexity and Diversity
2015
CRISPR-based screening of genomic island excision events in bacteria
2015
Cas9 Targeting and the CRISPR Revolution
2014 Science
Messenger RNA Degradation in Bacterial Cells
2014
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
The CRISPR/Cas9 system and its applications in crop genome editing
2019
Function and Regulation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) / CRISPR Associated (Cas) Systems
2012
Genome Editing: A New Approach to Human Therapeutics
2015
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
2013 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Rewriting a genome
2013 StandoutNatureNobel
RNase III: Genetics and Function; Structure and Mechanism
2013
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
2020 StandoutNobel
CRISPR‐Based Technologies and the Future of Food Science
2015
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
2013
Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3
2014
Works of Mária Eckert being referenced
Identification of the NAD+-Binding Fold of Glyceraldehyde-3-Phosphate Dehydrogenase as a Novel RNA-Binding Domain
2000
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel