Citation Impact
Citing Papers
A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA2 as a Mitogen in Glioblastoma
2006
Integrated Array-Comparative Genomic Hybridization and Expression Array Profiles Identify Clinically Relevant Molecular Subtypes of Glioblastoma
2005
Tissue-specific p19 Arf regulation dictates the response to oncogenic K-ras
2010
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
Marked Genomic Differences Characterize Primary and Secondary Glioblastoma Subtypes and Identify Two Distinct Molecular and Clinical Secondary Glioblastoma Entities
2006
Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth
2010
Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse.
2002
The regulation of cellular metabolism by tumor suppressor p53
2013
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3 -mutant neoplasia
2015
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Expression of Oligodendroglial and Astrocytic Lineage Markers in Diffuse Gliomas
2006
Hallmarks of Cancer: The Next Generation
2011 Standout
The Oligodendroglial Lineage Marker OLIG2 Is Universally Expressed in Diffuse Gliomas
2004
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
2013
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog
2004
Recessive mutations in the gene encoding the tubby-like protein TULP1 in patients with Retinitis pigmentosa
1998
Ubiquitinylation and Ubiquitin-dependent Proteolysis in Vertebrate Photoreceptors (Rod Outer Segments)
1996
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1
1998
Can we safely target the WNT pathway?
2014
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Fission yeast Cut2 required for anaphase has two destruction boxes
1997 StandoutNobel
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Oncogene addiction: setting the stage for molecularly targeted cancer therapy
2007
The Molecular Biology of Cyclic Nucleotide Phosphodiesterases
1999
Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma
2007
Cellular senescence: when bad things happen to good cells
2007 Standout
Encapsidated adenovirus mini-chromosome-mediated delivery of genes to the retina: application to the rescue of photoreceptor degeneration
1998
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Role of cellular senescence in hepatic wound healing and carcinogenesis
2012
Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
2002
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
2012
Pro-senescence therapy for cancer treatment
2011
A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
2010 Standout
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
2006 Standout
p53 — a Jack of all trades but master of none
2009
Imaging in the era of molecular oncology
2008 StandoutNature
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis
1998
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
2005
Cellular Senescence in Cancer and Aging
2007 Standout
Living on a break: cellular senescence as a DNA-damage response
2008
Telomeres and telomerase in cancer
2009
Roles of ubiquitin-mediated proteolysis in cell cycle control
1997 StandoutNobel
Cancer stem cells revisited
2017 Standout
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
Gene Ontology: tool for the unification of biology
2000 Standout
Brain tumors: molecular biology and targeted therapies
2006
Mdm2-mediated ubiquitylation: p53 and beyond
2009
Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC
2001
Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence
2007 StandoutNobel
p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa
2013
Molecular Mechanisms of Glioma Cell Migration and Invasion
2004
<i>TP53</i> Status and Response to Chemotherapy in Breast Cancer
2008
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy
1996
Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
1991 StandoutNatureNobel
Senescent mesenchymal cells accumulate in human fibrosis by a telomere‐independent mechanism and ameliorate fibrosis through matrix metalloproteinases
2010
p21 in cancer: intricate networks and multiple activities
2009 Standout
Retinitis pigmentosa
2006 Standout
Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status
2010
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Tissue-specific and reversible RNA interference in transgenic mice
2007
Telomere dysfunction and tumour suppression: the senescence connection
2008
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Metabolic Regulation by p53 Family Members
2013
The essence of senescence: Figure 1.
2010 Standout
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
2010 Nature
Malignant Gliomas in Adults
2008 Standout
Comparative biology of mouse versus human cells: modelling human cancer in mice
2003
Identification and characterization of rod-derived cone viability factor
2004
Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence
2009
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake
2013
Modelling the molecular circuitry of cancer
2002
Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
2016
Deconstructing p53 transcriptional networks in tumor suppression
2011
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
2007
Oncogene-induced senescence: the bright and dark side of the response
2010
The anaphase-promoting complex: it's not just for mitosis any more
2002
The Anaphase-Promoting Complex
2002
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
2015 Nature
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
2009 Nature
Homozygous tandem duplication within the gene encoding the β-subunit of rod phosphodiesterase as a cause for autosomal recessive retinitis pigmentosa
1995
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
2009 StandoutNobel
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
2007
A novel family of genes encoding putative pheromone receptors in mammals
1995 StandoutNobel
Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse
1999
Crystallographic refinement of human serum retinol binding protein at 2Å resolution
1990
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior
2000 StandoutNobel
Retinal Ganglion Cells Survive and Maintain Normal Dendritic Morphology in a Mouse Model of Inherited Photoreceptor Degeneration
2008
Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions
2011
Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression
2008
Perspectives on Oxygen Sensing
1999 StandoutNobel
Retinopathy induced in mice by targeted disruption of the rhodopsin gene
1997 StandoutNobel
Actions of human telomerase beyond telomeres
2008
Fatty acylation of Wnt proteins
2016
The genetics of the p53 pathway, apoptosis and cancer therapy
2008
Astrocyte-specific expression of CDK4 is not sufficient for tumor formation, but cooperates with p53 heterozygosity to provide a growth advantage for astrocytes in vivo
2002
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Radial glia cells are candidate stem cells of ependymoma
2005
Senescence in tumours: evidence from mice and humans
2009
Cellular senescence: from physiology to pathology
2014 Standout
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
The mutant p53 mouse as a pre-clinical model
2013
Feedback between p21 and reactive oxygen production is necessary for cell senescence
2010
Rescue from Photoreceptor Degeneration in the rd Mouse by Human Immunodeficiency Virus Vector-Mediated Gene Transfer
1999
Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy
2008
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis
2008
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
2007
Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response
2008 Nobel
Digenic Retinitis Pigmentosa Due to Mutations at the Unlinked Peripherin/ RDS and ROM1 Loci
1994 Science
The effect of calcium channel blocker diltiazem on photoreceptor degeneration in the rhodopsin Pro213His rat.
2000
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
Mutations in a Conserved Region of RNA Polymerase II Influence the Accuracy of mRNA Start Site Selection
1991
Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of retinitis pigmentosa.
2001
PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
1999
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1
2000
Neural Science
2000 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.
1995
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
2015 Science
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
2005
Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.
2001
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
2008 Standout
The primary structure of aphrodisin.
1988
Mutations in a conserved region of RNA polymerase II influence the accuracy of mRNA start site selection.
1991
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
A genetically tractable model of human glioma formation.
2001
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Whose end is destruction: cell division and the anaphase-promoting complex
1999
Protection of mouse photoreceptors by survival factors in retinal degenerations.
1998
Myb-Related Schizosaccharomyces pombecdc5p Is Structurally and Functionally Conserved in Eukaryotes
1998
Works of Margaret E. McLaughlin being referenced
ROS Fusion Tyrosine Kinase Activates a SH2 Domain–Containing Phosphatase-2/Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Signaling Axis to Form Glioblastoma in Mice
2006
Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression
2011
Recessive mutations in the gene encoding the β–subunit of rod phosphodiesterase in patients with retinitis pigmentosa
1993
Telomerase modulates Wnt signalling by association with target gene chromatin
2009 Nature
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
2000
Restoration of p53 function leads to tumour regression in vivo
2007 Nature
Cell type-specific effects of Rb deletion in the murine retina
2004
TATA-dependent and TATA-independent transcription at the HIS4 gene of yeast
1990 Nature
APC-Mediated Proteolysis of Ase1 and the Morphogenesis of the Mitotic Spindle
1997 Science
The structure and expression of very closely related members of the alpha 2u globulin gene family.
1982
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
2013
Mouse Models of Tumor Development in Neurofibromatosis Type 1
1999 Science
Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa.
1995
Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.
2003
Maintenance of adenomatous polyposis coli ( APC )-mutant colorectal cancer is dependent on Wnt/β-catenin signaling
2011