Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Requirement of Prorenin Receptor and Vacuolar H + -ATPase–Mediated Acidification for Wnt Signaling
2010 Science
The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia
2003
Wnt5a–Ror–Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis
2012
Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase
2000
Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled
2016
A genetic and developmental analysis of mutations in labial, a gene necessary for proper head formation in Drosophila melanogaster
1989
Genetic and biochemical analysis of TGFβ signal transduction
1997
Distal-less encodes a homoeodomain protein required for limb development in Drosophila
1989 Nature
MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling
1996
Control of cell cycle progression by c-Jun is p53 dependent
1999
Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
1999
MicroRNAs
2004 Standout
Jagged: A mammalian ligand that activates notch1
1995
The complex world of WNT receptor signalling
2012
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
1999
Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling
1997
Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases
2015
The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo
1989 StandoutNatureNobel
Dpp Gradient Formation in the Drosophila Wing Imaginal Disc
2000
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
Secreted and Transmembrane Wnt Inhibitors and Activators
2012
An essential complementary role of NF‐κB pathway to microbicidal oxidants in Drosophila gut immunity
2006
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Sequential Activation of Signaling Pathways during Innate Immune Responses in Drosophila
2002
Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres
1988 Nature
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
1998
The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD
2002 StandoutNobel
Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iε
2001
The Abdominal-B gene of Drosophila melanogaster : overlapping transcripts exhibit two different spatial distributions
1988
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
2012 Nature
Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses
2001
The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
2000
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
2001 StandoutNobel
Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor
1991
Cloning and analysis of three new homeobox genes from the nematodeCaenorhabditis elegans
1990
Control of Cell Polarity and Asymmetric Division in C. elegans
2012
Mechanism of TGFβ receptor inhibition by FKBP12
1997
The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family
1995
Characterization of Mouse Dishevelled (Dvl) Proteins in Wnt/Wingless Signaling Pathway
1999
Cellular and Genetic Analysis of Wound Healing in Drosophila Larvae
2004
Polarized Wnt Signaling Regulates Ectodermal Cell Fate in Xenopus
2014
Molecular and Genetic Organization of The Antennapedia Gene Complex of Drosophila melanogaster
1990
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
2002
Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening
2003
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
1997 Nature
The moleskin gene product is essential for Caudal‐mediated constitutive antifungal Drosomycin gene expression in Drosophila epithelia
2004
Rho GTPases and signaling networks
1997 Standout
Inducible Expression of Double-Stranded RNA Reveals a Role for dFADD in the Regulation of the Antibacterial Response in Drosophila Adults
2002
Wnt Signals Can Function as Positional Cues in Establishing Cell Polarity
2006
The C. elegans genome sequencing project: a beginning
1992 StandoutNatureNobel
Caenorhabditis elegans has scores of homoeobox-containing genes
1989 StandoutNatureNobel
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling
2001
Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals
2016
The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily
1990 StandoutNobel
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.
1996 Standout
The immune response of Drosophila
2003 StandoutNatureNobel
Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein
2006
A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction
1997
The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors
1988 StandoutNobel
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
PTEN: Life as a Tumor Suppressor
2001
Mapping candidate genes for Drosophila melanogaster resistance to the parasitoid wasp Leptopilina boulardi
2006
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli
2005
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development
1992 StandoutNobel
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6
1992 StandoutNatureNobel
Induction across germ layers in Drosophila mediated by a genetic cascade
1990
The murine and Drosophila homeobox gene complexes have common features of organization and expression
1989
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Homeobox genes and axial patterning
1992 Standout
Dishevelled Proteins Lead to Two Signaling Pathways
1999
The sequence specificity of homeodomain-DNA interaction
1988
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
2007 StandoutNobel
Function of torso in determining the terminal anlagen of the Drosophila embryo
1988 StandoutNatureNobel
Rescue of bicoid mutant Drosophila embryos by Bicoid fusion proteins containing heterologous activating sequences
1989 StandoutNatureNobel
SPXX, a frequent sequence motif in gene regulatory proteins
1989
Revealing the world of RNA interference
2004 StandoutNatureNobel
The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner
1988 StandoutNobel
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression
1991
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
2002
JNK Signaling Pathway Is Required for Efficient Wound Healing in Drosophila
2002
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma
1996
Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic
1994
The human HOX gene family
1989
Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients
2002
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease
2001
The specificities of sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain
1990
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
1995 StandoutNatureNobel
Coupled oscillators control morning and evening locomotor behaviour of Drosophila
2004 StandoutNatureNobel
TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling
1997
A synthetic multicellular system for programmed pattern formation
2005 StandoutNatureNobel
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
1996 StandoutNature
The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization
2007
A gradient of bicoid protein in Drosophila embryos
1988 StandoutNobel
What determines the specificity of action of Drosophila homeodomain proteins?
1990
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
2004
The functions of animal microRNAs
2004 StandoutNatureNobel
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos
1988
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
1997
Genetics and molecular biology of rhythms in Drosophila and other insects
2003 StandoutNobel
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates
1999
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
A Drosophila p38 orthologue is required for environmental stress responses
2004
Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development.
1989
Wnt Signaling in Neural Circuit Assembly
2008
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.
1996
Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes
1987 Nature
The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain.
1989 StandoutNobel
NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein.
1992 StandoutNobel
Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium
1997
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled
2012
The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles
2005
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Homeo Boxes in the Study of Development
1987 Science
A chicken caudal homologue, CHox-cad, is expressed in the epiblast with posterior localization and in the early endodermal lineage
1991
Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus
2000 Science
The correct activation of Antennapedia and bithorax complex genes requires the fushi tarazu gene
1986 Nature
Homeotic genes and the control of segment diversity
1988
Altering the Genome by Homologous Recombination
1989 StandoutScienceNobel
Dynamical Analysis of Regulatory Interactions in the Gap Gene System of Drosophila melanogaster
2004
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
1999
Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos.
1988
Graded requirement for the zygotic terminal gene,tailless, in the brain and tail region of theDrosophilaembryo
1988
Microarray Analysis of Drosophila Development During Metamorphosis
1999 Science
The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.
1996 StandoutNobel
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd
2001
Pathway Specificity by the Bifunctional Receptor Frizzled Is Determined by Affinity for Wingless
2000
DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability
1999
The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors
1998
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
Cellular Transformation and Malignancy Induced by ras Require c-jun
1996
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
1999 Standout
Towards an integrated view of Wnt signaling in development
2009
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Head and thoracic transformations caused by ectopic expression ofAntennapediaduringDrosophiladevelopment
1988
Rho GTPases and the Actin Cytoskeleton
1998 StandoutScience
DNA Repair in Drosophila
2000
Determination of Anteroposterior Polarity in Drosophila
1987 StandoutScienceNobel
Characterization and localization of the even-skipped protein of Drosophila.
1987
Expression and embryonic function of empty spiracles: a Drosophila homeo box gene with two patterning functions on the anterior-posterior axis of the embryo.
1989
The ubiquitin ligase Hyperplastic discs negatively regulateshedgehoganddecapentaplegicexpression by independent mechanisms
2002
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
1998 Standout
Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells
1996
A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.
1988
Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.
1991
The Drosophila Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial Infection
2006
Do multigene families regulate vertebrate development?
1988
The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.
1989
Mothers against dpp participates in a DPP/TGF-β responsive serine-threonine kinase signal transduction cascade
1997
A molecular gradient in early Drosophila embryos and its role in specifying the body pattern
1986 Nature
Developmental and spatial patterns of expression of the mouse homeobox gene,Hox2.1
1987
Differential and stage-related expression in embryonic tissues of a new human homoeobox gene
1986 Nature
Structure and expression of Hox-2.2, a murine homeobox-containing gene.
1988
Notch Signaling
1995 Science
The molecular genetics of head development in Drosophila melanogaster
1991
The Host Defense of Drosophila melanogaster
2007 StandoutNobel
Expression of the mouse labial-Alike homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain
1991
TGF-β signalling through the Smad pathway
1997
The bantam Gene Regulates Drosophila Growth
2002
Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex.
1987
Inhibition of the Wnt Signaling Pathway by Idax, a Novel Dvl-Binding Protein
2001
Notch Signaling: Cell Fate Control and Signal Integration in Development
1999 StandoutScience
Discrete Functions of TRAF1 and TRAF2 in Drosophila melanogaster Mediated by c-Jun N-Terminal Kinase and NF-κB-Dependent Signaling Pathways
2003
Regulatory elements of the bithorax complex that control expression along the anterior-posterior axis.
1990
Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster.
1988
Human DNA Repair Genes
2001 StandoutScienceNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
A yeast artificial chromosome containing the mouse homeobox cluster Hox-2.
1990
The molecular basis for metameric pattern in the Drosophila embryo
1987
Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network
1986
Structural complexity and evolutionary conservation of the Drosophila homeotic gene proboscipedia.
1992
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Morphogen gradient interpretation
2001 StandoutNatureNobel
Spatial regulation of the Antennapedia and Ultrabithorax homeotic genes during Drosophila early development.
1989
Analysis of Krüppel protein distribution during early Drosophila development reveals posttranscriptional regulation
1987
Works of Marek Mlodzik being referenced
The influence on the blastoderm fate map of maternal-effect genes that affect the antero-posterior pattern inDrosophila
1987
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development
2009
Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?
2002
A quest for the mechanism regulating global planar cell polarity of tissues
2009
Dishevelled: at the crossroads of divergent intracellular signaling pathways
1999
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
1999
The role of the Drosophila TAK homologue dTAK during development
2001
Isolation of caudal , a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage
1985
JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye
1995
Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling
1998
Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye
1999 Nature
The Apical Determinants aPKC and dPatj Regulate Frizzled-Dependent Planar Cell Polarity in the Drosophila Eye
2005
Drosophila Jun mediates Ras-dependent photoreceptor determination
1994
Planar polarity in the Drosophila eye: a multifaceted view of signaling specificity and cross-talk
1999
Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled
2003
The drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates
1990
Regulation of Lethal giant larvae by Dishevelled
2005 Nature
The role of RhoA in tissue polarity and Frizzled signalling
1997 Nature
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
2007
The Atypical Cadherin Flamingo Links Frizzled and Notch Signaling in Planar Polarity Establishment in the Drosophila Eye
2002
Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A
1995 Nature
The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development
2000
Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization
2009
Frizzled–Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila
2007
The deubiquitination enzyme Fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development
1997
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways
2005
Subcellular Localization of Frizzled Receptors, Mediated by Their Cytoplasmic Tails, Regulates Signaling Pathway Specificity
2004
Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila
2013
Cooperative control of Drosophila immune responses by the JNK and NF‐κB signaling pathways
2006
The regulation of hedgehog and decapentaplegic during Drosophila eye imaginal disc development
1996
ThemuscleblindGene Participates in the Organization of Z-Bands and Epidermal Attachments ofDrosophilaMuscles and Is Regulated byDmef2
1998
Effects of ectopic expression of caudal during Drosophila development
1990
Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development.
1997
Planar Cell Polarity Signaling: From Fly Development to Human Disease
2008
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
1996
Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye
2000
PLANAR CELL POLARIZATION: An Emerging Model Points in the Right Direction
2005
Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent
2000
Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila.
1990
Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways.
1997
Spacing Differentiation in the Developing Drosophila Eye: a Fibrinogen-related Lateral Inhibitor Encoded by scabrous
1990 Science
Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation.
1996
Hierarchy of the genetic interactions that specify the anteroposterior segmentation pattern of the Drosophila embryo as monitored by caudal protein expression
1987
The role of yan in mediating the choice between cell division and differentiation
1995
Expression of the caudal gene in the germ line of Drosophila: Formation of an RNA and protein gradient during early embryogenesis
1987
Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex.
1988
Signaling Specificity by Frizzled Receptors in Drosophila
2000 Science