Standout Papers
- Expression pattern of the von Hippel-Lindau protein in human tissues. (1996)
Citation Impact
Citing Papers
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
2002 StandoutScience
Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death
1999
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Antioxidant Therapy: A New Pharmacological Approach in Shock, Inflammation, and Ischemia/Reperfusion Injury
2001
The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death
1996
Avian encephalomyelitis virus nonstructural protein 2C induces apoptosis by activating cytochrome c/caspase-9 pathway
2003
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
Caspase Inhibition Selectively Reduces the Apoptotic Component of Oxygen-Glucose Deprivation-Induced Cortical Neuronal Cell Death
1997
Redox Regulation of NF-kappa B Activation
1997
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
2003
Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice
2001
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Mitochondrial control of apoptosis
1997
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
2000
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Mitochondrial Glutathione and Chemically Induced Stress Including Ethanol
2004
Poly(ADP-ribose) Polymerase-1 Signaling to Mitochondria in Necrotic Cell Death Requires RIP1/TRAF2-mediated JNK1 Activation
2006
The Role of c-FLIP in Modulation of CD95-induced Apoptosis
1999
Molecular basis of the VHL hereditary cancer syndrome
2002 StandoutNobel
Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB
1999
Apoptosis by Death Factor
1997 Standout
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Telomere states and cell fates
2000 StandoutNatureNobel
The von Hippel–Lindau tumor suppressor protein
2001 StandoutNobel
Shock, inflammation and PARP
2005
The Hallmarks of Cancer
2000 Standout
von Hippel-Lindau Disease
1997 StandoutNobel
The Bcl2 family: regulators of the cellular life-or-death switch
2002 Standout
NF-κB activation by reactive oxygen species: Fifteen years later
2006
The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
2002 Standout
Upregulation of bcl‐2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines
2001
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Betulinic acid: A new cytotoxic agent against malignant brain-tumor cells
1999
Necrotic death as a cell fate
2006
Lysosomes in cell death
2004
The von Hippel-Lindau Tumor Suppressor Protein Is Required for Proper Assembly of an Extracellular Fibronectin Matrix
1998 StandoutNobel
Transient Poly(ADP-ribosyl)ation of Nuclear Proteins and Role of Poly(ADP-ribose) Polymerase in the Early Stages of Apoptosis
1998
Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death
2001
Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo
2006
Death receptors in chemotherapy and cancer
2004
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks
2004
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
1996 Standout
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32
1996
Caspase Functions in Cell Death and Disease
2013 Standout
Protease activation during apoptosis: Death by a thousand cuts?
1995 Standout
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Molecular Ordering of the Cell Death Pathway
1996
Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis
1999
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
1999
A License to Kill
1996
Apoptosis
2002 Standout
Two CD95 (APO-1/Fas) signaling pathways
1998 Standout
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
1997
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Activation of Mitogen-activated Protein Kinase by H2O2
1996
Cell death in the regulation of immune responses
1997
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Free radicals and antioxidants in normal physiological functions and human disease
2006 Standout
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304
1997
Reactive Oxygen Species and Vascular Signal Transduction Mechanisms
1996
Oxidative stress and nuclear factor-κB activation
2000
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis
1996
Redox Regulation of Cellular Signalling
1999
Regulation of NF-κB Activation by MAP Kinase Cascades
1997
Programmed population control by cell–cell communication and regulated killing
2004 StandoutNatureNobel
Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
1997
Involvement of poly(ADP-ribose) polymerase in base excision repair
1999
Cellular Responses to DNA Damage in the Absence of Poly(ADP-ribose) Polymerase
1998
Two tumour necrosis factor receptors: structure and function
1995
On the origin, evolution, and nature of programmed cell death: a timeline of four billion years
2002
The cell-death machine
1996
Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid
1998
Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1
2000
ZAP-70-dependent and -independent Activation of Erk in Jurkat T Cells
1998
Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation
2001
Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling
2000
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
1996 Nature
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
2003
Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils
2005
Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO‐1/Fas) ligand expression in microglial cells
1998
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
1995
TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways
1996 Standout
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway
2004
Therapeutic peptides: Targeting the mitochondrion to modulate apoptosis
2006
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion
1998
CPP32 inhibition prevents Fas‐induced ceramide generation and apoptosis in human cells
1996
CrmA-inhibitable Cleavage of the 70-kDa Protein Component of the U1 Small Nuclear Ribonucleoprotein during Fas- and Tumor Necrosis Factor-induced Apoptosis
1995
Role of oxidants/antioxidants in smoking-induced lung diseases
1996
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis
2002 StandoutNobel
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis
1996
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis
2001
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
2006
Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase
2000
NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase
2000
Life, death, and the pursuit of apoptosis.
1996
Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death.
1998
rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation
1996
The Von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer
2004 StandoutNobel
The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore
2000
Apoptosis induction resulting from proteasome inhibition
1996
Mitochondrial permeability transition is a central coordinating event of apoptosis.
1996
Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes.
2000
P2X7 Receptor-Dependent Blebbing and the Activation of Rho-Effector Kinases, Caspases, and IL-1β Release
2003
Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.
1996
Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid
1997
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Inhibition of Poly(ADP-Ribose) Polymerase
1998
Quality Control by DNA Repair
1999 StandoutScienceNobel
Failure of Poly(ADP-Ribose) Polymerase Cleavage by Caspases Leads to Induction of Necrosis and Enhanced Apoptosis
1999
Myocardial Postischemic Injury Is Reduced by PolyADPribose Polymerase-1 Gene Disruption
2000
The Cysteine-Rich Regions of the Regulatory Domains of Raf and Protein Kinase C as Retinoid Receptors
2000
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
1995 Standout
Reactive Nitrogen Species-Induced Cell Death Requires Fas-Dependent Activation of c-Jun N-Terminal Kinase
2004
Adenine Nucleotide Translocase-1, a Component of the Permeability Transition Pore, Can Dominantly Induce Apoptosis
1999
Retinoids as ligands and coactivators of protein kinase C alpha
2000
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
The role of proteases during apoptosis
1996
Evidence for regulation of NF-κB by poly(ADP-ribose) polymerase
2000
Apoptosis Signaling
2000
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription
1997 StandoutNobel
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
1999 Standout
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species 1
1997
Caspases: the executioners of apoptosis
1997 Standout
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
2000
Ischemic Cell Death in Brain Neurons
1999 Standout
Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species
1996
PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase
1999
In Vitro Enzymatic Characterization of Near Full Length EGFR in Activated and Inhibited States
2009
Engineering allosteric regulation in protein kinases
2018
Purified Photoproducts of Merocyanine 540 Trigger Cytochrome C Release and Caspase 8-Dependent Apoptosis in Human Leukemia and Melanoma Cells
1999
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
Elevation of Mitochondrial Transmembrane Potential and Reactive Oxygen Intermediate Levels Are Early Events and Occur Independently from Activation of Caspases in Fas Signaling
1999
A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.
1996
Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex
2000
Antioxidant and redox regulation of gene transcription
1996 Standout
Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2
1998 StandoutNobel
REDOX REGULATION OF CELLULAR ACTIVATION
1997
A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection.
1996
Angiogenesis in Endocrine Tumors
2003
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
1996 Standout
Enhancement of T Cell Receptor Signaling by a Mild Oxidative Shift in the Intracellular Thiol Pool
2000
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
1996
Bcl-2 Expression in Neural Cells Blocks Activation of ICE/CED-3 Family Proteases during Apoptosis
1996
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Antibodies against Adhesion Molecules Reduce Apoptosis after Transient Middle Cerebral Artery Occlusion in Rat Brain
1996
An Inherited Disorder of Lymphocyte Apoptosis: The Autoimmune Lymphoproliferative Syndrome
1999
Free Radicals in the Physiological Control of Cell Function
2002 Standout
REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN
1999
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism
1999
Transient Global Forebrain Ischemia Induces a Prolonged Expression of the Caspase-3 mRNA in Rat Hippocampal CA1 Pyramidal Neurons
1998
Poly(ADP-Ribose) Synthetase Activation Mediates Mitochondrial Injury During Oxidant-Induced Cell Death
1998
The Molecular Basis of Von Hippel-Lindau Disease
1997 StandoutNobel
Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells
1999
A Matter of Life and Cell Death
1998 Science
Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.
1995
Works of Marek Łoś being referenced
Chemosensitivity of solid tumor cellsin vitro is related to activation of the CD95 system
1998
HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.
1995
Role of Reactive Oxygen Intermediates in Activation-induced CD95 (APO-1/Fas) Ligand Expression
1998
The tyrosine kinase Lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation
1999
Apoptosis signaling by death receptors
1998
Caspases: more than just killers?
2001
Hydrogen peroxide as a potent activator of T lymphocyte functions
1995
Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent
2005
P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death
1999
PARP is important for genomic stability but dispensable in apoptosis
1997
Targeting the EGFR Pathway for Cancer Therapy
2006
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis
1995 Nature
Functional Characterization of DNase X, a Novel Endonuclease Expressed in Muscle Cells
2000
Cross-Resistance of CD95- and Drug-Induced Apoptosis as a Consequence of Deficient Activation of Caspases (ICE/Ced-3 Proteases)
1997
Expression pattern of the von Hippel-Lindau protein in human tissues.
1996 StandoutNobel
Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis
2008
Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes
1995
Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway
2005
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.
1997
The Role of Caspases in Development, Immunity, and Apoptotic Signal Transduction
1999
Differential Regulation and ATP Requirement for Caspase-8 and Caspase-3 Activation during CD95- and Anticancer Drug–induced Apoptosis
1998
Regulation of the urokinase-type plasminogen activator system by the von Hippel-Lindau tumor suppressor gene.
1999
Anticancer Drugs Induce Caspase-8/FLICE Activation and Apoptosis in the Absence of CD95 Receptor/Ligand Interaction
1999
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.
1995
Activation and Caspase-mediated Inhibition of PARP: A Molecular Switch between Fibroblast Necrosis and Apoptosis in Death Receptor Signaling
2002
Caspases and cancer: mechanisms of inactivation and new treatment modalities.
2004